[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622971":3},{"organization":4,"armGroups":7,"interventions":28,"overallOfficials":38,"centralContacts":42,"locations":48,"responsibleParty":111,"collaborators":113,"id":116,"slug":117,"hasResults":118,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":122,"eligibilityCriteria":123,"healthyVolunteers":118,"sex":124,"minAge":125,"maxAge":34,"enrollmentInfo":126,"targetDuration":34,"studyType":129,"phases":130,"briefSummary":132,"conditions":133,"keywords":135,"overallStatus":51,"whyStopped":34,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":146},{"fullName":5,"class":6},"Pluto Inc.","INDUSTRY",[8,14,20,24],{"label":9,"type":10,"description":11,"interventionNames":12},"Placebo","PLACEBO_COMPARATOR","Subjects receive placebo orally in the morning, afternoon, and evening for 12 weeks.",[13],"Drug: Placebo",{"label":15,"type":16,"description":17,"interventionNames":18},"PLH-2301 200mg","EXPERIMENTAL","Subjects receive PLH-2301 in the morning and placebo in the afternoon and evening for 12 weeks.",[19,13],"Drug: PLH-2301",{"label":21,"type":16,"description":22,"interventionNames":23},"PLH-2301 400mg","Subjects receive PLH-2301 in the morning and evening and placebo in the afternoon for 12 weeks.",[19,13],{"label":25,"type":16,"description":26,"interventionNames":27},"PLH-2301 600mg","Subjects receive PLH-2301 in the morning, afternoon, and evening for 12 weeks.",[19],[29,35],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"DRUG","PLH-2301","PLH-2301 administered orally according to assigned dosing regimen.",[15,21,25],null,{"type":30,"name":9,"description":36,"armGroupLabels":37,"otherNames":34},"Matching placebo administered orally according to assigned dosing regimen.",[15,21,9],[39],{"name":40,"affiliation":5,"role":41},"Sun Ahe 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Hospital","Suwon",{"type":56,"coordinates":70},[71,72],127.00889,37.29111,{"lat":72,"lon":71},[75],{"name":63,"role":45,"phone":76,"phoneExt":34,"email":77},"+82-10-4274-6399","nanjingmei@kakao.com",{"facility":79,"status":51,"city":80,"state":80,"zip":81,"country":54,"countryCode":34,"cosmosGeoPoint":82,"geoPoint":86,"contacts":87},"Korea University Anam Hospital","Seoul","02841",{"type":56,"coordinates":83},[84,85],126.9784,37.566,{"lat":85,"lon":84},[88],{"name":63,"role":45,"phone":89,"phoneExt":34,"email":90},"+82-10-4981-6641","sy92675@naver.com",{"facility":92,"status":51,"city":80,"state":80,"zip":93,"country":54,"countryCode":34,"cosmosGeoPoint":94,"geoPoint":96,"contacts":97},"Seoul St. Mary's Hospital","06591",{"type":56,"coordinates":95},[84,85],{"lat":85,"lon":84},[98],{"name":63,"role":45,"phone":99,"phoneExt":34,"email":100},"+82-10-3370-2206","t33702206@cmcnu.or.kr",{"facility":102,"status":51,"city":80,"state":80,"zip":103,"country":54,"countryCode":34,"cosmosGeoPoint":104,"geoPoint":106,"contacts":107},"Korea University Guro Hospital","08308",{"type":56,"coordinates":105},[84,85],{"lat":85,"lon":84},[108],{"name":63,"role":45,"phone":109,"phoneExt":34,"email":110},"+82-10-5445-6587","grkmcgrfm001@kumc.or.kr",{"type":112,"investigatorFullName":34,"investigatorTitle":34,"investigatorAffiliation":34,"oldNameTitle":34,"oldOrganization":34},"SPONSOR",[114],{"name":115,"class":6},"Symyoo","100622971","phase-2-a-study-of-plh-2301-in-subjects-with-sarcopenia-100622971",false,"NCT07390552","A Study of PLH-2301 in Subjects With Sarcopenia","A Prospective, Randomized, Double-blinded, Placebo-controlled, 4-Parallel Arm, Multi-center, Phase 2 Trial to Evaluate Efficacy and Safety of Orally Administered PLH-2301 in Elderly Patients With Sarcopenia","PLH-2301_P2","Inclusion Criteria:\n\n* Male or female subjects aged 65 years or older at the time of consent\n* Diagnosis of sarcopenia based on predefined diagnostic criteria\n* Short Physical Performance Battery (SPPB) total score within the protocol-defined range at screening\n* Stable body weight for at least 3 months prior to screening\n* Able to walk independently with or without assistive devices\n* Willing and able to comply with study procedures\n* Provided written informed consent prior to any study-specific procedures\n\nExclusion Criteria:\n\n* History of clinically significant neuromuscular or musculoskeletal disorders that could affect muscle function\n* Uncontrolled cardiovascular, hepatic, renal, or metabolic disease\n* Use of medications known to affect muscle mass or function within the protocol-defined washout period\n* Participation in another interventional clinical trial within 3 months prior to screening\n* Any medical or psychiatric condition that, in the investigator's opinion, would interfere with study participation","ALL","65 Years",{"count":127,"type":128},168,"ESTIMATED","INTERVENTIONAL",[131],"PHASE2","This is a Phase 2, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of PLH-2301 in subjects with sarcopenia.\n\nEligible subjects aged 65 years and older will be randomized to receive placebo or one of three dose levels of PLH-2301 once daily for 12 weeks.\n\nThe primary objective is to assess the effect of PLH-2301 on physical function compared with placebo.",[134],"Sarcopenia in Elderly",[136],"Sarcopenia","2026-05-10",{"date":139,"type":140},"2026-05-12","ACTUAL",{"date":142,"type":140},"2026-05-08",{"date":144,"type":128},"2027-06-30",{"name":5,"class":6},5]