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Participants will receive talquetamab subcutaneously (SC) at a recommended Phase 2 dose (RP2D) selected after review of safety, efficacy, PK, and pharmacodynamic data from Part 1 and Part 2 of this study. All participants (ongoing and those who are in follow-up) will transition to OLE phase and will continue to receive the study treatment. Upon approval of amendment 19 and notification from the sponsor, participants will transition to the LTE and will continue to receive study treatment.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Part 3: Cohort C (Talquetamab)","Cohort C will enroll participants with multiple myeloma who have previously received \\>= 3 prior lines of therapy and have not been exposed to T cell redirection therapies. Participants will receive talquetamab SC biweekly at a RP2D selected after review of safety, efficacy, PK, and pharmacodynamic data from Part 1 and Part 2 of this study. All participants (ongoing and those who are in follow-up) will transition to OLE phase and will continue to receive the study treatment. Upon approval of amendment 19 and notification from the sponsor, participants will transition to the LTE and will continue to receive study treatment.",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Part 3: Cohort D (Talquetamab)","Cohort D will enroll participants with multiple myeloma who have previously received \\>= 3 prior lines of therapy. Participants will receive talquetamab SC biweekly at a RP2D selected after review of safety, efficacy, PK, and pharmacodynamic data from Part 1 and Part 2 of this study. Participants in this cohort will receive tocilizumab prophylaxis for cytokine release syndrome (CRS) including all outpatient dosing. Participants will transition to OLE upon communication by the sponsor. 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Virgen de La Arrixaca","Murcia","30120",{"type":59,"coordinates":693},[694,695],-1.13004,37.98704,{"lat":695,"lon":694},{"facility":698,"status":52,"city":699,"state":47,"zip":700,"country":651,"countryCode":652,"cosmosGeoPoint":701,"geoPoint":705,"contacts":47},"Clinica Univ. de Navarra","Pamplona","31008",{"type":59,"coordinates":702},[703,704],-1.64323,42.81687,{"lat":704,"lon":703},{"facility":707,"status":147,"city":708,"state":47,"zip":709,"country":651,"countryCode":652,"cosmosGeoPoint":710,"geoPoint":714,"contacts":47},"Hosp. Quiron Madrid Pozuelo","Pozuelo de Alarcón","28223",{"type":59,"coordinates":711},[712,713],-3.81338,40.43293,{"lat":713,"lon":712},{"facility":716,"status":52,"city":717,"state":47,"zip":718,"country":651,"countryCode":652,"cosmosGeoPoint":719,"geoPoint":723,"contacts":47},"Hosp Clinico Univ de Salamanca","Salamanca","37007",{"type":59,"coordinates":720},[721,722],-5.66388,40.96882,{"lat":722,"lon":721},{"facility":725,"status":52,"city":726,"state":47,"zip":727,"country":651,"countryCode":652,"cosmosGeoPoint":728,"geoPoint":732,"contacts":47},"Hosp. Univ. Marques de Valdecilla","Santander","39008",{"type":59,"coordinates":729},[730,731],-3.80493,43.46589,{"lat":731,"lon":730},{"facility":734,"status":52,"city":735,"state":47,"zip":736,"country":651,"countryCode":652,"cosmosGeoPoint":737,"geoPoint":741,"contacts":47},"Hosp. Virgen Del Rocio","Seville","41013",{"type":59,"coordinates":738},[739,740],-5.97317,37.38283,{"lat":740,"lon":739},{"type":743,"investigatorFullName":47,"investigatorTitle":47,"investigatorAffiliation":47,"oldNameTitle":47,"oldOrganization":47},"SPONSOR","100411210","phase-2-a-study-of-talquetamab-in-participants-with-relapsed-or-refractory-multiple-myeloma-100411210",false,"NCT04634552","A Study of Talquetamab in Participants With Relapsed or Refractory Multiple Myeloma","A Phase 1\u002F2, First-in-Human, Open-Label, Dose Escalation Study of Talquetamab, a Humanized GPRC5D x CD3 Bispecific Antibody, in Subjects With Relapsed or Refractory Multiple Myeloma","MonumenTAL-1","Inclusion Criteria:\n\n* Documented initial diagnosis of multiple myeloma according to international myeloma working group (IMWG) diagnostic criteria\n* Part 3: Measurable disease cohort A, cohort B, cohort C and cohort D: multiple myeloma must be measurable by central laboratory assessment; Cohort E: Multiple myeloma must be measurable by local laboratory assessment\n* Eastern Cooperative Oncology Group (ECOG) performance status score of 0 to 2\n* Women of childbearing potential must have a negative pregnancy test at screening and prior to the first dose of study drug using a highly sensitive pregnancy test either serum (beta human chorionic gonadotropin \\[hCG\\]) or urine\n* Willing and able to adhere to the prohibitions and restrictions specified in this protocol\n\nExclusion Criteria:\n\n* Part 3 only: Cohort A and Cohort C only: exposed to a CAR-T or T cell redirection therapy at any time. Cohort B, Cohort D and Cohort E: T cell redirection therapy within 3 months\n* Toxicities from previous anticancer therapies should have resolved to baseline levels or to Grade 1 or less except for alopecia or peripheral neuropathy\n* Received a cumulative dose of corticosteroids equivalent to \\>= 140 milligram (mg) of prednisone within the 14-day period before the first dose of study drug (does not include pretreatment medication)\n* Stroke or seizure within 6 months prior to signing the informed consent form (ICF)","ALL","18 Years",{"count":755,"type":756},510,"ESTIMATED","INTERVENTIONAL",[759],"PHASE2","The purpose of this study is to evaluate the efficacy and safety of talquetamab in participants with relapsed or refractory multiple myeloma at the recommended Phase 2 dose(s) (RP2Ds) (Part 3).",[762],"Hematological Malignancies",[764],"Multiple Myeloma","2026-06-04",{"date":767,"type":768},"2026-06-05","ACTUAL",{"date":770,"type":768},"2021-02-01",{"date":772,"type":756},"2029-03-30",{"name":5,"class":6},78]