[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100497812":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":31,"centralContacts":31,"locations":44,"responsibleParty":794,"collaborators":31,"id":796,"slug":797,"hasResults":798,"nctId":799,"briefTitle":800,"officialTitle":801,"acronym":802,"eligibilityCriteria":803,"healthyVolunteers":798,"sex":804,"minAge":805,"maxAge":806,"enrollmentInfo":807,"targetDuration":31,"studyType":810,"phases":811,"briefSummary":813,"conditions":814,"keywords":816,"overallStatus":47,"whyStopped":31,"lastUpdateSubmitDate":818,"lastUpdatePostDateStruct":819,"startDateStruct":822,"completionDateStruct":824,"leadSponsor":826,"locationsCount":827},{"fullName":5,"class":6},"Zucara Therapeutics Inc.","INDUSTRY",[8,15,20],{"label":9,"type":10,"description":11,"interventionNames":12},"ZT-01 7 mg","EXPERIMENTAL","Participants receive placebo and ZT-01 7 mg each by subcutaneous injection daily for 28 days, randomized to order",[13,14],"Drug: Placebo","Drug: ZT-01, 7 mg",{"label":16,"type":10,"description":17,"interventionNames":18},"ZT-01 15 mg","Participants receive placebo and ZT-01 15 mg by subcutaneous injection daily for 28 days, randomized to order",[13,19],"Drug: ZT-01, 15 mg",{"label":21,"type":10,"description":22,"interventionNames":23},"ZT-01 22 mg","Participants receive placebo and ZT-01 22 mg by subcutaneous injection daily for 28 days, randomized to order",[13,24],"Drug: ZT-01, 22 mg",[26,32,36,40],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DRUG","Placebo","Subject receives Placebo by subcutaneous injection daily for 28 days",[16,21,9],null,{"type":27,"name":33,"description":34,"armGroupLabels":35,"otherNames":31},"ZT-01, 7 mg","Subject receives ZT-01 7 mg by subcutaneous injection daily for 28 days",[9],{"type":27,"name":37,"description":38,"armGroupLabels":39,"otherNames":31},"ZT-01, 15 mg","Subject receives ZT-01 15 mg by subcutaneous injection daily for 28 days",[16],{"type":27,"name":41,"description":42,"armGroupLabels":43,"otherNames":31},"ZT-01, 22 mg","Subject receives ZT-01 22 mg by subcutaneous injection daily for 28 days",[21],[45,68,85,102,118,128,145,162,179,195,210,226,242,259,275,291,308,325,342,359,376,389,406,423,440,457,473,488,506,523,540,555,572,589,605,621,638,655,672,690,703,720,731,748,764,780],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Kirklin Clinic of UAB Hospital-Endocrinology\u002FDiabetes Clinic","RECRUITING","Birmingham","Alabama","35233","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-86.80249,33.52066,{"lat":57,"lon":56},[60,65],{"name":61,"role":62,"phone":63,"phoneExt":31,"email":64},"Julia Parker","CONTACT","4126487183","juliaparker@uabmc.edu",{"name":66,"role":67,"phone":31,"phoneExt":31,"email":31},"Fernando Ovalle, MD","PRINCIPAL_INVESTIGATOR",{"facility":69,"status":47,"city":70,"state":71,"zip":72,"country":51,"countryCode":52,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"Medical Investigations Indications Inc.","Little Rock","Arkansas","72211",{"type":54,"coordinates":74},[75,76],-92.28959,34.74648,{"lat":76,"lon":75},[79,83],{"name":80,"role":62,"phone":81,"phoneExt":31,"email":82},"Lesa Thrasher","5018314087","lesathrasher@yahoo.com",{"name":84,"role":67,"phone":31,"phoneExt":31,"email":31},"James Thrasher, MD",{"facility":86,"status":47,"city":87,"state":88,"zip":89,"country":51,"countryCode":52,"cosmosGeoPoint":90,"geoPoint":94,"contacts":95},"Headlands Research","Escondido","California","92025",{"type":54,"coordinates":91},[92,93],-117.08642,33.11921,{"lat":93,"lon":92},[96,100],{"name":97,"role":62,"phone":98,"phoneExt":31,"email":99},"Yvonne Bedolla","760-466-1537","yvonne.bedolla@headlandsresearchamcr.com",{"name":101,"role":67,"phone":31,"phoneExt":31,"email":31},"Timothy Bailey, MD",{"facility":103,"status":47,"city":104,"state":88,"zip":105,"country":51,"countryCode":52,"cosmosGeoPoint":106,"geoPoint":110,"contacts":111},"USC Keck Medicine Eastside Center for Diabetes","Los Angeles","90022",{"type":54,"coordinates":107},[108,109],-118.24368,34.05223,{"lat":109,"lon":108},[112,116],{"name":113,"role":62,"phone":114,"phoneExt":31,"email":115},"Valerie Ruelas","(323) 361-8416","vruelas@med.usc.edu",{"name":117,"role":67,"phone":31,"phoneExt":31,"email":31},"Anne Peters, MD",{"facility":119,"status":120,"city":121,"state":88,"zip":122,"country":51,"countryCode":52,"cosmosGeoPoint":123,"geoPoint":127,"contacts":31},"LCGK Research","TERMINATED","San Carlos","94070",{"type":54,"coordinates":124},[125,126],-122.26052,37.50716,{"lat":126,"lon":125},{"facility":129,"status":47,"city":130,"state":131,"zip":132,"country":51,"countryCode":52,"cosmosGeoPoint":133,"geoPoint":137,"contacts":138},"Barbara Davis Center for Diabetes","Aurora","Colorado","80045",{"type":54,"coordinates":134},[135,136],-104.83192,39.72943,{"lat":136,"lon":135},[139,143],{"name":140,"role":62,"phone":141,"phoneExt":31,"email":142},"Emma Mason","3037245895","emma.mason@cuanschutz.edu",{"name":144,"role":67,"phone":31,"phoneExt":31,"email":31},"Halis Akturk, MD",{"facility":146,"status":47,"city":147,"state":148,"zip":149,"country":51,"countryCode":52,"cosmosGeoPoint":150,"geoPoint":154,"contacts":155},"Yale University - Diabetes Research Office","New Haven","Connecticut","06511",{"type":54,"coordinates":151},[152,153],-72.92816,41.30815,{"lat":153,"lon":152},[156,160],{"name":157,"role":62,"phone":158,"phoneExt":31,"email":159},"Amy Steffen","2037378852","amy.steffen@yale.edu",{"name":161,"role":67,"phone":31,"phoneExt":31,"email":31},"Laura Nally, MD",{"facility":163,"status":47,"city":164,"state":165,"zip":166,"country":51,"countryCode":52,"cosmosGeoPoint":167,"geoPoint":171,"contacts":172},"East Coast Institute for Research LLC","Jacksonville","Florida","32216",{"type":54,"coordinates":168},[169,170],-81.65565,30.33218,{"lat":170,"lon":169},[173,177],{"name":174,"role":62,"phone":175,"phoneExt":31,"email":176},"Stephanie Niman","904-740-4107","stephanie.niman@eastcoastresearch.com",{"name":178,"role":67,"phone":31,"phoneExt":31,"email":31},"Wasim Deeb, MD",{"facility":180,"status":47,"city":181,"state":165,"zip":182,"country":51,"countryCode":52,"cosmosGeoPoint":183,"geoPoint":187,"contacts":188},"Suncoast Clinical Research","New Port Richey","34652",{"type":54,"coordinates":184},[185,186],-82.71927,28.24418,{"lat":186,"lon":185},[189,193],{"name":190,"role":62,"phone":191,"phoneExt":31,"email":192},"Jasmine Dodson","727-855-7103","jasmine.dodson@atlas-clinical.com",{"name":194,"role":67,"phone":31,"phoneExt":31,"email":31},"Antonio Pinero Pilona, MD",{"facility":196,"status":47,"city":197,"state":165,"zip":198,"country":51,"countryCode":52,"cosmosGeoPoint":199,"geoPoint":203,"contacts":204},"Hanson Diabetes Center","Port Charlotte","33952",{"type":54,"coordinates":200},[201,202],-82.09064,26.97617,{"lat":202,"lon":201},[205,209],{"name":206,"role":62,"phone":207,"phoneExt":31,"email":208},"Lenita Hanson, MD","941-654-4800","lhansonmd@hansoncrc.com",{"name":206,"role":67,"phone":31,"phoneExt":31,"email":31},{"facility":211,"status":47,"city":212,"state":165,"zip":213,"country":51,"countryCode":52,"cosmosGeoPoint":214,"geoPoint":218,"contacts":219},"University of South Florida Diabetes & Endocrinology Clinic","Tampa","33612",{"type":54,"coordinates":215},[216,217],-82.45843,27.94752,{"lat":217,"lon":216},[220,224],{"name":221,"role":62,"phone":222,"phoneExt":31,"email":223},"Chloe Lee","8139745499","chloelee@usf.edu",{"name":225,"role":67,"phone":31,"phoneExt":31,"email":31},"Henry Rodriguez, MD",{"facility":227,"status":47,"city":228,"state":165,"zip":229,"country":51,"countryCode":52,"cosmosGeoPoint":230,"geoPoint":234,"contacts":235},"Metabolic Research Institute","West Palm Beach","33401",{"type":54,"coordinates":231},[232,233],-80.05337,26.71534,{"lat":233,"lon":232},[236,240],{"name":237,"role":62,"phone":238,"phoneExt":31,"email":239},"Cossett Allegue","561-802-3060","callegue@metabolic-institute.com",{"name":241,"role":67,"phone":31,"phoneExt":31,"email":31},"Barry Horowitz, MD",{"facility":243,"status":47,"city":244,"state":245,"zip":246,"country":51,"countryCode":52,"cosmosGeoPoint":247,"geoPoint":251,"contacts":252},"Atlanta Diabetes Associates","Atlanta","Georgia","21044",{"type":54,"coordinates":248},[249,250],-84.38798,33.749,{"lat":250,"lon":249},[253,257],{"name":254,"role":62,"phone":255,"phoneExt":31,"email":256},"Amanda Maxson","404-355-4393","studyadmin@atlantadiabetes.com",{"name":258,"role":67,"phone":31,"phoneExt":31,"email":31},"Bruce Bode, MD",{"facility":260,"status":47,"city":261,"state":245,"zip":262,"country":51,"countryCode":52,"cosmosGeoPoint":263,"geoPoint":267,"contacts":268},"Physicians Research Associates LLC","Lawrenceville","30046",{"type":54,"coordinates":264},[265,266],-83.98796,33.95621,{"lat":266,"lon":265},[269,273],{"name":270,"role":62,"phone":271,"phoneExt":31,"email":272},"Karla Wardell","678-252-2375","karlaw@northatlantaendo.com",{"name":274,"role":67,"phone":31,"phoneExt":31,"email":31},"Adeniyi Odugbesan, MD",{"facility":276,"status":47,"city":277,"state":245,"zip":278,"country":51,"countryCode":52,"cosmosGeoPoint":279,"geoPoint":283,"contacts":284},"East Coast Institute for Research","Macon","31210",{"type":54,"coordinates":280},[281,282],-83.6324,32.84069,{"lat":282,"lon":281},[285,289],{"name":286,"role":62,"phone":287,"phoneExt":31,"email":288},"Lilly Dasher Anthony","478-219-2017","lilly.dasher@eastcoastresearch.net",{"name":290,"role":67,"phone":31,"phoneExt":31,"email":31},"Thomas Jones, MD",{"facility":292,"status":47,"city":293,"state":294,"zip":295,"country":51,"countryCode":52,"cosmosGeoPoint":296,"geoPoint":300,"contacts":301},"University of Chicago Medical Center","Chicago","Illinois","60637",{"type":54,"coordinates":297},[298,299],-87.65005,41.85003,{"lat":299,"lon":298},[302,306],{"name":303,"role":62,"phone":304,"phoneExt":31,"email":305},"Triniece Pearson","7733597556","tpearson1@bsd.uchicago.edu",{"name":307,"role":67,"phone":31,"phoneExt":31,"email":31},"Louis Philipson, MD",{"facility":309,"status":47,"city":310,"state":311,"zip":312,"country":51,"countryCode":52,"cosmosGeoPoint":313,"geoPoint":317,"contacts":318},"IU Health University Hospital","Indianapolis","Indiana","46202",{"type":54,"coordinates":314},[315,316],-86.15804,39.76838,{"lat":316,"lon":315},[319,323],{"name":320,"role":62,"phone":321,"phoneExt":31,"email":322},"Kathy Bohanan","317-278-0651","kkremer@iu.edu",{"name":324,"role":67,"phone":31,"phoneExt":31,"email":31},"Viral Shah, MD",{"facility":326,"status":47,"city":327,"state":328,"zip":329,"country":51,"countryCode":52,"cosmosGeoPoint":330,"geoPoint":334,"contacts":335},"University of Kansas Medical Center","Kansas City","Kansas","66160",{"type":54,"coordinates":331},[332,333],-94.62746,39.11417,{"lat":333,"lon":332},[336,340],{"name":337,"role":62,"phone":338,"phoneExt":31,"email":339},"Frieda Tresvan","913-588-2607","ftresvan@kumc.edu",{"name":341,"role":67,"phone":31,"phoneExt":31,"email":31},"Chitra Choudhary, MD",{"facility":343,"status":47,"city":344,"state":345,"zip":346,"country":51,"countryCode":52,"cosmosGeoPoint":347,"geoPoint":351,"contacts":352},"Ochsner Clinic Foundation","New Orleans","Louisiana","70121",{"type":54,"coordinates":348},[349,350],-90.07507,29.95465,{"lat":350,"lon":349},[353,357],{"name":354,"role":62,"phone":355,"phoneExt":31,"email":356},"Teva Williams","5047030922","teva.williams@ochsner.org",{"name":358,"role":67,"phone":31,"phoneExt":31,"email":31},"Lawrence Blonde, MD",{"facility":360,"status":47,"city":361,"state":362,"zip":363,"country":51,"countryCode":52,"cosmosGeoPoint":364,"geoPoint":368,"contacts":369},"Baltimore VA Medical Center","Baltimore","Maryland","21201",{"type":54,"coordinates":365},[366,367],-76.61219,39.29038,{"lat":367,"lon":366},[370,374],{"name":371,"role":62,"phone":372,"phoneExt":31,"email":373},"William Scott","410-605-7000","william.scott5@va.gov",{"name":375,"role":67,"phone":31,"phoneExt":31,"email":31},"Ilias Spanakis, MD",{"facility":377,"status":47,"city":361,"state":362,"zip":378,"country":51,"countryCode":52,"cosmosGeoPoint":379,"geoPoint":381,"contacts":382},"MedStar Good Samaritan Hospital","21239",{"type":54,"coordinates":380},[366,367],{"lat":367,"lon":366},[383,387],{"name":384,"role":62,"phone":385,"phoneExt":31,"email":386},"Lumanti Manandhar","443-444-4858","Lumanti.Manandhar@medstar.net",{"name":388,"role":67,"phone":31,"phoneExt":31,"email":31},"Jean Park, MD",{"facility":390,"status":47,"city":391,"state":392,"zip":393,"country":51,"countryCode":52,"cosmosGeoPoint":394,"geoPoint":398,"contacts":399},"Elite Research Center","Flint","Michigan","48532",{"type":54,"coordinates":395},[396,397],-83.68746,43.01253,{"lat":397,"lon":396},[400,404],{"name":401,"role":62,"phone":402,"phoneExt":31,"email":403},"Wafaa Hammoud","810-820-9853","wh@researcherc.com",{"name":405,"role":67,"phone":31,"phoneExt":31,"email":31},"Jamal Hammoud, MD",{"facility":407,"status":47,"city":408,"state":409,"zip":410,"country":51,"countryCode":52,"cosmosGeoPoint":411,"geoPoint":415,"contacts":416},"University of Nebraska Medical Center","Omaha","Nebraska","68198",{"type":54,"coordinates":412},[413,414],-95.94043,41.25626,{"lat":414,"lon":413},[417,421],{"name":418,"role":62,"phone":419,"phoneExt":31,"email":420},"Susan Burbach","4025594228","susan.burbach@unmc.edu",{"name":422,"role":67,"phone":31,"phoneExt":31,"email":31},"Shubham Agarwal, MD",{"facility":424,"status":47,"city":425,"state":426,"zip":427,"country":51,"countryCode":52,"cosmosGeoPoint":428,"geoPoint":432,"contacts":433},"Palm Research Center, Inc.","Las Vegas","Nevada","89148",{"type":54,"coordinates":429},[430,431],-115.13722,36.17497,{"lat":431,"lon":430},[434,438],{"name":435,"role":62,"phone":436,"phoneExt":31,"email":437},"Ellen Neylon","702-736-5161","studynurse@palmresearch.com",{"name":439,"role":67,"phone":31,"phoneExt":31,"email":31},"Samer Nakhle, MD",{"facility":441,"status":47,"city":442,"state":443,"zip":444,"country":51,"countryCode":52,"cosmosGeoPoint":445,"geoPoint":449,"contacts":450},"Albany Medical Center","Albany","New York","12203",{"type":54,"coordinates":446},[447,448],-73.75623,42.65258,{"lat":448,"lon":447},[451,455],{"name":452,"role":62,"phone":453,"phoneExt":31,"email":454},"Judy Carter","518-264-4723","carterj3@amc.edu",{"name":456,"role":67,"phone":31,"phoneExt":31,"email":31},"Gregg Gerety, MD",{"facility":458,"status":47,"city":459,"state":443,"zip":460,"country":51,"countryCode":52,"cosmosGeoPoint":461,"geoPoint":465,"contacts":466},"NYC Research Inc.","Long Island City","11106",{"type":54,"coordinates":462},[463,464],-73.94875,40.74482,{"lat":464,"lon":463},[467,471],{"name":468,"role":62,"phone":469,"phoneExt":31,"email":470},"John Bell","718-704-5376","jbell@endocrinenyc.com",{"name":472,"role":67,"phone":31,"phoneExt":31,"email":31},"Anastasios Manessis, MD",{"facility":474,"status":47,"city":443,"state":443,"zip":475,"country":51,"countryCode":52,"cosmosGeoPoint":476,"geoPoint":480,"contacts":481},"NYU Langone Health CTSI","10016",{"type":54,"coordinates":477},[478,479],-74.00597,40.71427,{"lat":479,"lon":478},[482,486],{"name":483,"role":62,"phone":484,"phoneExt":31,"email":485},"Amanda Baly","212-263-1432","Amanda.Baly@nyulangone.org",{"name":487,"role":67,"phone":31,"phoneExt":31,"email":31},"Ramachandra Naik, MD",{"facility":489,"status":47,"city":490,"state":491,"zip":492,"country":51,"countryCode":52,"cosmosGeoPoint":493,"geoPoint":497,"contacts":498},"Lucas Research Inc.","Morehead City","North Carolina","28557",{"type":54,"coordinates":494},[495,496],-76.72604,34.72294,{"lat":496,"lon":495},[499,504],{"name":500,"role":62,"phone":501,"phoneExt":502,"email":503},"Mari Dunn","252-222-5700","161","mari.dunn@lucasresearch.com",{"name":505,"role":67,"phone":31,"phoneExt":31,"email":31},"Kathryn J Lucas, MD",{"facility":507,"status":47,"city":508,"state":509,"zip":510,"country":51,"countryCode":52,"cosmosGeoPoint":511,"geoPoint":515,"contacts":516},"Ohio State University Wexner Medical Center","Columbia","Ohio","43210",{"type":54,"coordinates":512},[513,514],-84.43466,39.11173,{"lat":514,"lon":513},[517,521],{"name":518,"role":62,"phone":519,"phoneExt":31,"email":520},"Maryam Bhatti","6148140821","maryam.bhatti@osumc.edu",{"name":522,"role":67,"phone":31,"phoneExt":31,"email":31},"Kathleen Wyne, MD",{"facility":524,"status":47,"city":525,"state":526,"zip":527,"country":51,"countryCode":52,"cosmosGeoPoint":528,"geoPoint":532,"contacts":533},"Thomas Jefferson University","Philadelphia","Pennsylvania","19107",{"type":54,"coordinates":529},[530,531],-75.16362,39.95238,{"lat":531,"lon":530},[534,538],{"name":535,"role":62,"phone":536,"phoneExt":31,"email":537},"Marsha Simmons","215-955-1925","Marsha.Simmons@jefferson.edu",{"name":539,"role":67,"phone":31,"phoneExt":31,"email":31},"Serge Jabbour, MD",{"facility":541,"status":47,"city":542,"state":526,"zip":543,"country":51,"countryCode":52,"cosmosGeoPoint":544,"geoPoint":548,"contacts":549},"UPMC Presbyterian Hospital","Pittsburgh","15213",{"type":54,"coordinates":545},[546,547],-79.99589,40.44062,{"lat":547,"lon":546},[550,553],{"name":551,"role":62,"phone":63,"phoneExt":31,"email":552},"Wanda Ferrara","ferrarawa@upmc.edu",{"name":554,"role":67,"phone":31,"phoneExt":31,"email":31},"Jagdeesh Ullal, MD",{"facility":556,"status":47,"city":557,"state":558,"zip":559,"country":51,"countryCode":52,"cosmosGeoPoint":560,"geoPoint":564,"contacts":565},"University Diabetes & Endocrine Consultants","Chattanooga","Tennessee","37411",{"type":54,"coordinates":561},[562,563],-85.30968,35.04563,{"lat":563,"lon":562},[566,570],{"name":567,"role":62,"phone":568,"phoneExt":31,"email":569},"Jason Hughes-Palmer","426-265-3561","jhughes-palmer@drhuffman.com",{"name":571,"role":67,"phone":31,"phoneExt":31,"email":31},"David Huffman, MD",{"facility":573,"status":47,"city":574,"state":575,"zip":576,"country":51,"countryCode":52,"cosmosGeoPoint":577,"geoPoint":581,"contacts":582},"Texas Diabetes & Endocrinology, PA","Austin","Texas","78749",{"type":54,"coordinates":578},[579,580],-97.74306,30.26715,{"lat":580,"lon":579},[583,587],{"name":584,"role":62,"phone":585,"phoneExt":31,"email":586},"Cory Fields","512-334-3505","cfields@texasdiabetes.com",{"name":588,"role":67,"phone":31,"phoneExt":31,"email":31},"Jean Chen, MD",{"facility":590,"status":47,"city":591,"state":575,"zip":592,"country":51,"countryCode":52,"cosmosGeoPoint":593,"geoPoint":597,"contacts":598},"North Texas Endocrine Center","Dallas","75231",{"type":54,"coordinates":594},[595,596],-96.80667,32.78306,{"lat":596,"lon":595},[599,603],{"name":600,"role":62,"phone":601,"phoneExt":31,"email":602},"Michelle Katz","469-364-6918","mkatz@endocenter.com",{"name":604,"role":67,"phone":31,"phoneExt":31,"email":31},"Peter Bressler, MD",{"facility":606,"status":47,"city":607,"state":575,"zip":608,"country":51,"countryCode":52,"cosmosGeoPoint":609,"geoPoint":613,"contacts":614},"Southern Endocrinology Associates","Mesquite","75149",{"type":54,"coordinates":610},[611,612],-96.59916,32.7668,{"lat":612,"lon":611},[615,619],{"name":616,"role":62,"phone":617,"phoneExt":31,"email":618},"Michelle Ormeno","214-693-0904","mormeno@southerenendocrinology.com",{"name":620,"role":67,"phone":31,"phoneExt":31,"email":31},"Sumana Gangi, MD",{"facility":622,"status":47,"city":623,"state":575,"zip":624,"country":51,"countryCode":52,"cosmosGeoPoint":625,"geoPoint":629,"contacts":630},"Diabetes & Glandular Disease Clinic","San Antonio","78229",{"type":54,"coordinates":626},[627,628],-98.49363,29.42412,{"lat":628,"lon":627},[631,636],{"name":632,"role":62,"phone":633,"phoneExt":634,"email":635},"Terri Ryan","210-614-8612","1630","terri.ryan@dgdclinic.com",{"name":637,"role":67,"phone":31,"phoneExt":31,"email":31},"Mark Kipnes, MD",{"facility":639,"status":47,"city":640,"state":641,"zip":642,"country":51,"countryCode":52,"cosmosGeoPoint":643,"geoPoint":647,"contacts":648},"Diabetes & Endocrine Treatment Specialists","Sandy City","Utah","84093",{"type":54,"coordinates":644},[645,646],-111.8841,40.59161,{"lat":646,"lon":645},[649,653],{"name":650,"role":62,"phone":651,"phoneExt":31,"email":652},"Ryan Luker","801-816-1010","ryan@detsutah.com",{"name":654,"role":67,"phone":31,"phoneExt":31,"email":31},"Timothy Graham, MD",{"facility":656,"status":47,"city":657,"state":658,"zip":659,"country":51,"countryCode":52,"cosmosGeoPoint":660,"geoPoint":664,"contacts":665},"University of Washington Diabetes Institute - Clinical Research Unit","Seattle","Washington","98109",{"type":54,"coordinates":661},[662,663],-122.33207,47.60621,{"lat":663,"lon":662},[666,670],{"name":667,"role":62,"phone":668,"phoneExt":31,"email":669},"Caelan Ruiz","2066166858","ccr20@uw.edu",{"name":671,"role":67,"phone":31,"phoneExt":31,"email":31},"Subbulaxmi Trikudanathan, MD",{"facility":673,"status":47,"city":674,"state":675,"zip":676,"country":677,"countryCode":678,"cosmosGeoPoint":679,"geoPoint":683,"contacts":684},"Centricity Research Calgary Endocrinology","Calgary","Alberta","T2H 2G4","Canada","CA",{"type":54,"coordinates":680},[681,682],-114.08529,51.05011,{"lat":682,"lon":681},[685,689],{"name":686,"role":62,"phone":687,"phoneExt":31,"email":688},"Buki Ajala, MBBS","403-288-3224","ajalaresearch@centricityresearch.com",{"name":686,"role":67,"phone":31,"phoneExt":31,"email":31},{"facility":691,"status":47,"city":674,"state":675,"zip":692,"country":677,"countryCode":678,"cosmosGeoPoint":693,"geoPoint":695,"contacts":696},"Richmond Road Diagnostic & Treatment Centre, Clinical Trials Unit","T2T5C7",{"type":54,"coordinates":694},[681,682],{"lat":682,"lon":681},[697,701],{"name":698,"role":62,"phone":699,"phoneExt":31,"email":700},"Michelle Smith","4039558117","mahunter@ucalgary.ca",{"name":702,"role":67,"phone":31,"phoneExt":31,"email":31},"Ronald Sigal, MD",{"facility":704,"status":47,"city":705,"state":706,"zip":707,"country":677,"countryCode":678,"cosmosGeoPoint":708,"geoPoint":712,"contacts":713},"BC Diabetes","Vancouver","British Columbia","V5Y 3W2",{"type":54,"coordinates":709},[710,711],-123.11934,49.24966,{"lat":711,"lon":710},[714,718],{"name":715,"role":62,"phone":716,"phoneExt":31,"email":717},"Alireza Moshiri","604-628-7253","amoshiri@bcdiabetes.ca",{"name":719,"role":67,"phone":31,"phoneExt":31,"email":31},"Thomas Elliott, MBBS",{"facility":721,"status":722,"city":723,"state":724,"zip":725,"country":677,"countryCode":678,"cosmosGeoPoint":726,"geoPoint":730,"contacts":31},"Centricity Research Barrie Endocrinology","WITHDRAWN","Barrie","Ontario","L4N 7L3",{"type":54,"coordinates":727},[728,729],-79.66634,44.40011,{"lat":729,"lon":728},{"facility":732,"status":47,"city":733,"state":724,"zip":734,"country":677,"countryCode":678,"cosmosGeoPoint":735,"geoPoint":739,"contacts":740},"Centricity Research Vaughan Endocrinology","Concord","L4K 4M2",{"type":54,"coordinates":736},[737,738],-79.48291,43.80011,{"lat":738,"lon":737},[741,746],{"name":742,"role":62,"phone":743,"phoneExt":744,"email":745},"Sanjida Nishat","905-288-5667","4296","sanjida.nishat@centricityresearch.com",{"name":747,"role":67,"phone":31,"phoneExt":31,"email":31},"Robert Schlosser, MD",{"facility":749,"status":47,"city":750,"state":724,"zip":751,"country":677,"countryCode":678,"cosmosGeoPoint":752,"geoPoint":756,"contacts":757},"Centricity Research Etobicoke Endocrinology","Etobicoke","M9R 4E1",{"type":54,"coordinates":753},[754,755],-79.56985,43.64415,{"lat":755,"lon":754},[758,762],{"name":759,"role":62,"phone":760,"phoneExt":31,"email":761},"Sneha Sharma","416-645-1035","sneha.sharma@centricityresearch.com",{"name":763,"role":67,"phone":31,"phoneExt":31,"email":31},"Hasnain Khandwala, MBBS",{"facility":765,"status":47,"city":766,"state":724,"zip":767,"country":677,"countryCode":678,"cosmosGeoPoint":768,"geoPoint":772,"contacts":773},"Centricity Research Toronto","Toronto","M4G 3E8",{"type":54,"coordinates":769},[770,771],-79.39864,43.70643,{"lat":771,"lon":770},[774,778],{"name":775,"role":62,"phone":776,"phoneExt":31,"email":777},"Janessa Gabuyo","647-374-5285","janessa.gabuyo@centricityresearch.com",{"name":779,"role":67,"phone":31,"phoneExt":31,"email":31},"Alexander Abitbol, MDCM",{"facility":781,"status":47,"city":766,"state":724,"zip":782,"country":677,"countryCode":678,"cosmosGeoPoint":783,"geoPoint":785,"contacts":786},"Mount Sinai Hospital: Leadership Sinai Centre for Diabetes","M5T 3L9",{"type":54,"coordinates":784},[770,771],{"lat":771,"lon":770},[787,792],{"name":788,"role":62,"phone":789,"phoneExt":790,"email":791},"Andrej Orszag","416-586-4800","7625","andrej.orszag@uhn.ca",{"name":793,"role":67,"phone":31,"phoneExt":31,"email":31},"Bruce Perkins, MD",{"type":795,"investigatorFullName":31,"investigatorTitle":31,"investigatorAffiliation":31,"oldNameTitle":31,"oldOrganization":31},"SPONSOR","100497812","phase-2-a-study-of-the-effect-of-zt-01-on-night-time-hypoglycemia-in-type-1-diabetes-100497812",false,"NCT05762107","A Study of the Effect of ZT-01 on Night-time Hypoglycemia in Type 1 Diabetes","A Phase 2a Randomized, Double-blind, Placebo-controlled, Multiple-dose, Crossover Study of the Effect of ZT-01 on Frequency of Nocturnal Hypoglycemia in Type 1 Diabetes Mellitus","ZONE","Inclusion Criteria:\n\n* Has type 1 diabetes for at least 5 years\n* is at risk of nocturnal hypoglycemia (if using personal CGM, time below 54 mg\u002FdL at least 1% over previous 4 weeks at screening; if not using personal CGM then recent history suggestive of nocturnal hypoglycemia at screening and time below 54 mg\u002FdL at least 1% over 4 weeks using blinded study CGM during additional screening)\n* HbA1c at screening \\\u003C\u002F= 10.0%\n* Body mass index (BMI) at screening \\>\u002F=18.5 to \\\u003C33 kg\u002Fm2\n\nExclusion Criteria:\n\n* Has been hospitalized for diabetic ketoacidosis (DKA) more than once within previous 6 months\n* Has experienced \\>\u002F= 1 severe hypoglycemia (requiring assistance) during previous 4 weeks or \\>2 in previous 3 months\n* Diagnosis of type 2 diabetes, pheochromocytoma, insulinoma, glucagonoma, acromegaly, Cushing's disease, glycogen storage disease, adrenal insufficiency\n* Clinically significant kidney disease\n* Abnormal liver function","ALL","18 Years","75 Years",{"count":808,"type":809},186,"ESTIMATED","INTERVENTIONAL",[812],"PHASE2","The goal of this clinical trial is to learn about the effect of the study drug (ZT-01) on low blood sugar (hypoglycemia) in adults with type 1 diabetes (T1D) who have been having low blood sugars (\"hypos\") at night. ZT-01 increases the amount of a hormone called glucagon during low blood sugar, and this may help prevent the occurrence of hypos. The main questions this trial aims to answer are whether ZT-01 lowers the number of hypos happening at night, and what its effects are on blood sugar levels. The safety of ZT-01 will also be measured.\n\nParticipants will be asked to wear a study-provided continuous glucose monitor (CGM) during two 4-week periods when they will self-inject the study drug before bed. They will get ZT-01 at one of three dose levels during one period, and placebo (which looks like the study drug but doesn't contain the active ingredient) during the other. Neither the participant nor the study site will know what they are receiving during each treatment period or see data from the CGM. The participant will continue to use their usual methods of measuring blood sugar (including their personal CGM) and giving insulin during the study. The participant will be asked to complete a short diary each evening, and will be asked to upload the CGM data to a study phone every day.\n\nIf a participant uses their own CGM and is willing to share information on how often they have low blood sugar with the study site at the first visit to see if they meet study entry requirements, they will have 6 study visits, 2 study phone calls, and be in the study for about 16 weeks. If they don't use CGM or don't want to share their information, then they will be asked to wear a study CGM for an extra 4 weeks to find out how many low blood sugars they have, and will have an extra visit.\n\nStudy participants will be asked to give blood and urine for testing to see whether they meet the requirements to enter the study, and at the start and end of each treatment period to see if the study treatment has any effects. They will also have their blood pressure and temperature taken at each study visit, and have an ECG at 4 visits to measure the electrical activity of their heart.\n\nSome participants will be asked to also take part in a sub-study where their blood level of ZT-01 and glucagon is measured, after the first and last dose. They will be asked to stay at the study site overnight for each set of measurements (4 in total).",[815],"Type 1 Diabetes Mellitus With Hypoglycemia",[817],"nocturnal hypoglycemia","2026-04-23",{"date":820,"type":821},"2026-04-29","ACTUAL",{"date":823,"type":821},"2023-07-28",{"date":825,"type":809},"2027-05",{"name":5,"class":6},46]