[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100516595":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":24,"centralContacts":28,"locations":35,"responsibleParty":241,"collaborators":24,"id":243,"slug":244,"hasResults":245,"nctId":246,"briefTitle":247,"officialTitle":248,"acronym":24,"eligibilityCriteria":249,"healthyVolunteers":245,"sex":250,"minAge":251,"maxAge":252,"enrollmentInfo":253,"targetDuration":24,"studyType":256,"phases":257,"briefSummary":259,"conditions":260,"keywords":262,"overallStatus":38,"whyStopped":24,"lastUpdateSubmitDate":263,"lastUpdatePostDateStruct":264,"startDateStruct":267,"completionDateStruct":269,"leadSponsor":271,"locationsCount":272},{"fullName":5,"class":6},"Novartis","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"EYU688","EXPERIMENTAL","EYU688 administered by oral route",[13],"Drug: EYU688",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Matching placebo",[19],"Drug: Placebo",[21,25],{"type":22,"name":9,"description":11,"armGroupLabels":23,"otherNames":24},"DRUG",[9],null,{"type":22,"name":15,"description":26,"armGroupLabels":27,"otherNames":24},"Matching placebo administered orally as capsules",[15],[29,34],{"name":30,"role":31,"phone":32,"phoneExt":24,"email":33},"Novartis Pharmaceuticals","CONTACT","+41613241111","novartis.email@novartis.com",{"name":30,"role":31,"phone":24,"phoneExt":24,"email":24},[36,50,59,67,76,79,90,99,108,119,129,137,146,155,166,175,184,193,201,210,215,225,233],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":24},"Novartis Investigative Site","RECRUITING","Manaus","Amazonas","69040-000","Brazil","BR",{"type":45,"coordinates":46},"Point",[47,48],-60.025,-3.10194,{"lat":48,"lon":47},{"facility":37,"status":38,"city":51,"state":52,"zip":53,"country":42,"countryCode":43,"cosmosGeoPoint":54,"geoPoint":58,"contacts":24},"Brasília","Federal District","71635-580",{"type":45,"coordinates":55},[56,57],-47.92972,-15.77972,{"lat":57,"lon":56},{"facility":37,"status":38,"city":60,"state":60,"zip":61,"country":42,"countryCode":43,"cosmosGeoPoint":62,"geoPoint":66,"contacts":24},"Rio de Janeiro","21040-360",{"type":45,"coordinates":63},[64,65],-43.18223,-22.90642,{"lat":65,"lon":64},{"facility":37,"status":38,"city":68,"state":69,"zip":70,"country":42,"countryCode":43,"cosmosGeoPoint":71,"geoPoint":75,"contacts":24},"Sorocaba","São Paulo","18040-425",{"type":45,"coordinates":72},[73,74],-47.45806,-23.50167,{"lat":74,"lon":73},{"facility":37,"status":38,"city":77,"state":24,"zip":78,"country":42,"countryCode":43,"cosmosGeoPoint":24,"geoPoint":24,"contacts":24},"Sao Jose Rio Preto","15090 000",{"facility":37,"status":38,"city":80,"state":81,"zip":82,"country":83,"countryCode":84,"cosmosGeoPoint":85,"geoPoint":89,"contacts":24},"Barranquilla","Atlántico","080012","Colombia","CO",{"type":45,"coordinates":86},[87,88],-74.78132,10.96854,{"lat":88,"lon":87},{"facility":37,"status":38,"city":91,"state":92,"zip":93,"country":83,"countryCode":84,"cosmosGeoPoint":94,"geoPoint":98,"contacts":24},"Bucaramanga","Santander Department","681017",{"type":45,"coordinates":95},[96,97],-73.11895,7.125,{"lat":97,"lon":96},{"facility":37,"status":38,"city":100,"state":101,"zip":102,"country":83,"countryCode":84,"cosmosGeoPoint":103,"geoPoint":107,"contacts":24},"Cali","Valle del Cauca Department","760032",{"type":45,"coordinates":104},[105,106],-76.5199,3.43054,{"lat":106,"lon":105},{"facility":37,"status":38,"city":109,"state":110,"zip":111,"country":112,"countryCode":113,"cosmosGeoPoint":114,"geoPoint":118,"contacts":24},"Belagavi","Karnataka","590010","India","IN",{"type":45,"coordinates":115},[116,117],74.50447,15.85212,{"lat":117,"lon":116},{"facility":37,"status":120,"city":121,"state":122,"zip":123,"country":112,"countryCode":113,"cosmosGeoPoint":124,"geoPoint":128,"contacts":24},"WITHDRAWN","Mumbai","Maharashtra","400008",{"type":45,"coordinates":125},[126,127],72.88261,19.07283,{"lat":127,"lon":126},{"facility":37,"status":38,"city":130,"state":122,"zip":131,"country":112,"countryCode":113,"cosmosGeoPoint":132,"geoPoint":136,"contacts":24},"Pune","411013",{"type":45,"coordinates":133},[134,135],73.85535,18.51957,{"lat":135,"lon":134},{"facility":37,"status":38,"city":138,"state":139,"zip":140,"country":112,"countryCode":113,"cosmosGeoPoint":141,"geoPoint":145,"contacts":24},"Jaipur","Rajasthan","302017",{"type":45,"coordinates":142},[143,144],75.78781,26.91962,{"lat":144,"lon":143},{"facility":37,"status":38,"city":147,"state":148,"zip":149,"country":112,"countryCode":113,"cosmosGeoPoint":150,"geoPoint":154,"contacts":24},"Chennai","Tamil Nadu","600113",{"type":45,"coordinates":151},[152,153],80.27847,13.08784,{"lat":153,"lon":152},{"facility":37,"status":38,"city":156,"state":157,"zip":158,"country":159,"countryCode":160,"cosmosGeoPoint":161,"geoPoint":165,"contacts":24},"Kuantan","Pahang","25200","Malaysia","MY",{"type":45,"coordinates":162},[163,164],103.326,3.8077,{"lat":164,"lon":163},{"facility":37,"status":38,"city":167,"state":168,"zip":169,"country":159,"countryCode":160,"cosmosGeoPoint":170,"geoPoint":174,"contacts":24},"Ipoh","Perak","30450",{"type":45,"coordinates":171},[172,173],101.0829,4.5841,{"lat":173,"lon":172},{"facility":37,"status":38,"city":176,"state":177,"zip":178,"country":159,"countryCode":160,"cosmosGeoPoint":179,"geoPoint":183,"contacts":24},"Seberang Jaya","Pulau Pinang","13700",{"type":45,"coordinates":180},[181,182],100.41044,5.39085,{"lat":182,"lon":181},{"facility":37,"status":38,"city":185,"state":186,"zip":187,"country":159,"countryCode":160,"cosmosGeoPoint":188,"geoPoint":192,"contacts":24},"Miri","Sarawak","98000",{"type":45,"coordinates":189},[190,191],113.99163,4.39928,{"lat":191,"lon":190},{"facility":37,"status":38,"city":194,"state":24,"zip":195,"country":159,"countryCode":160,"cosmosGeoPoint":196,"geoPoint":200,"contacts":24},"Kuala Selangor","68000",{"type":45,"coordinates":197},[198,199],101.25,3.35,{"lat":199,"lon":198},{"facility":37,"status":38,"city":202,"state":24,"zip":203,"country":202,"countryCode":204,"cosmosGeoPoint":205,"geoPoint":209,"contacts":24},"Singapore","169608","SG",{"type":45,"coordinates":206},[207,208],103.85007,1.28967,{"lat":208,"lon":207},{"facility":37,"status":38,"city":202,"state":24,"zip":211,"country":202,"countryCode":204,"cosmosGeoPoint":212,"geoPoint":214,"contacts":24},"S308433",{"type":45,"coordinates":213},[207,208],{"lat":208,"lon":207},{"facility":37,"status":38,"city":216,"state":24,"zip":217,"country":218,"countryCode":219,"cosmosGeoPoint":220,"geoPoint":224,"contacts":24},"Haiphong","180000","Vietnam","VN",{"type":45,"coordinates":221},[222,223],106.68345,20.86481,{"lat":223,"lon":222},{"facility":37,"status":38,"city":226,"state":24,"zip":227,"country":218,"countryCode":219,"cosmosGeoPoint":228,"geoPoint":232,"contacts":24},"Hanoi","100000",{"type":45,"coordinates":229},[230,231],105.84117,21.0245,{"lat":231,"lon":230},{"facility":37,"status":38,"city":234,"state":24,"zip":235,"country":218,"countryCode":219,"cosmosGeoPoint":236,"geoPoint":240,"contacts":24},"Ho Chi Minh City","700000",{"type":45,"coordinates":237},[238,239],106.62965,10.82302,{"lat":239,"lon":238},{"type":242,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR","100516595","phase-2-a-study-to-assess-the-efficacy-safety-and-pharmacokinetics-of-eyu688-in-patients-with-dengue-fever-100516595",false,"NCT06006559","A Study to Assess the Efficacy, Safety and Pharmacokinetics of EYU688 in Patients With Dengue Fever","A Randomized, Participant- and Investigator-blinded, Placebo-controlled, Parallel Group Study to Assess the Efficacy, Safety and Pharmacokinetics of EYU688 in Patients With Dengue Fever","Inclusion Criteria:\n\n* Male or female, 18 - 60 years old (inclusive).\n* History or presence of fever (≥ 38°C). At least one of the following criteria indicating dengue infection:\n* Nausea or vomiting.\n* Presence of rash, aches or pains including headache, muscle or joint pain.\n* Onset of fever ≤ 48 hours prior to treatment start.\n* Positive test on dengue fever.\n\nExclusion Criteria:\n\n* Participants with any of abnormalities of clinical laboratory parameters.\n* Usage of any anticoagulant drugs.\n* Current significant medical conditions or illness that the investigator considers should exclude the participants, especially those that require continuation of other medications likely to have an interaction with the study drug.\n* Pregnant or nursing (lactating) women.\n* Clinical signs and symptoms for severe dengue according to Dengue Guideline (WHO 2009) at screening.\n* Participants with any of the following abnormalities of clinical laboratory parameters at screening:\n\n  * Hemoglobin \\\u003C12.0 g\u002FdL in males; \\\u003C11.0 g\u002FdL in females\n  * Hematocrit \\>52 % in males; \\>46 % in females\n  * Absolute neutrophil count \\\u003C1500\u002FμL\n  * Platelet count \\\u003C80,000\u002Fmm3\n  * Creatinine \\>165 μmol\u002FL in males; \\>130 μmol\u002FL in females\n  * Serum creatine kinase \\> 600 U\u002FL\n  * ALT, AST levels more than 1.5X upper limit of normal (ULN)\n  * Total bilirubin \\>24 μmol\u002FL\n* Usage of PPIs (proton pump inhibitor) which could affect absorption of EYU688 due to stomach pH value increase up to 48 hours prior to screening.\n* Women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unless they are using highly effective methods of contraception during dosing and for 4 days after stopping of investigational drug.\n* History or long-QT syndrome, or clinically significant ECG abnormalities, or any of the following ECG abnormalities at screening:\n\n  * QTcF \\> 450 msec (males)\n  * QTcF \\> 460 msec (females)\n\nOther protocol-defined inclusion\u002Fexclusion criteria may apply.","ALL","18 Years","60 Years",{"count":254,"type":255},108,"ESTIMATED","INTERVENTIONAL",[258],"PHASE2","The purpose of this study is to characterize the effect on dengue viral load, fever clearance time as well as on clinical signs and symptoms with the treatment of EYU688 compared with placebo in patients with dengue fever.",[261],"Dengue",[261,9],"2026-03-23",{"date":265,"type":266},"2026-03-24","ACTUAL",{"date":268,"type":266},"2024-02-20",{"date":270,"type":255},"2027-01-15",{"name":30,"class":6},23]