[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100513254":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":41,"centralContacts":45,"locations":52,"responsibleParty":735,"collaborators":737,"id":740,"slug":741,"hasResults":742,"nctId":743,"briefTitle":744,"officialTitle":745,"acronym":746,"eligibilityCriteria":747,"healthyVolunteers":742,"sex":748,"minAge":749,"maxAge":50,"enrollmentInfo":750,"targetDuration":50,"studyType":753,"phases":754,"briefSummary":756,"conditions":757,"keywords":50,"overallStatus":55,"whyStopped":50,"lastUpdateSubmitDate":760,"lastUpdatePostDateStruct":761,"startDateStruct":764,"completionDateStruct":766,"leadSponsor":768,"locationsCount":769},{"fullName":5,"class":6},"Janssen Research & Development, LLC","INDUSTRY",[8,15,19,23],{"label":9,"type":10,"description":11,"interventionNames":12},"Cohort 1a: Ibrutinib Lead-in+Fixed Duration Ibrutinib+Venetoclax","EXPERIMENTAL","Participants will receive ibrutinib 420 milligrams (mg) capsule every day (QD) for a lead-in of 3 cycles (1 cycle = 28 days). From Cycle 4, venetoclax 400 mg tablet dose ramp-up (from 20 to 400 mg over 5 weeks) will begin, and venetoclax 400 mg QD will be administered with ibrutinib 420 mg QD, orally for 12 cycles through Cycle 15.",[13,14],"Drug: Ibrutinib","Drug: Venetoclax",{"label":16,"type":10,"description":17,"interventionNames":18},"Cohort 1b: Ibrutinib Lead-in+Fixed Duration Ibrutinib+Venetoclax","Participants will receive ibrutinib 420 mg capsule QD for a lead-in of 3 cycles (1 cycle = 28 days). From Cycle 4, venetoclax 400 mg tablet dose ramp-up (from 20 to 400 mg over 5 weeks) will begin and ibrutinib dose will be reduced to 280 mg and will be administered QD, venetoclax 400 mg tablets QD will be administered with ibrutinib 280 mg for 12 cycles through Cycle 15.",[13,14],{"label":20,"type":10,"description":21,"interventionNames":22},"Cohort 2a: Continuous Ibrutinib Monotherapy","Participants will receive ibrutinib 420 mg QD (or last tolerated dose) until disease progression (PD) or unacceptable toxicity.",[13],{"label":24,"type":10,"description":25,"interventionNames":26},"Cohort 2b: Continuous Ibrutinib Monotherapy","Participants will receive ibrutinib 420 mg QD for 1 cycle (1 cycle = 28 days) followed by Ibrutinib 280 mg QD (or last tolerated dose) and continue until disease progression or unacceptable toxicity.",[13],[28,35],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"DRUG","Ibrutinib","Ibrutinib capsules will be administered orally.",[9,16,20,24],[34],"JNJ-54179060, IMBRUVICA",{"type":29,"name":36,"description":37,"armGroupLabels":38,"otherNames":39},"Venetoclax","Venetoclax tablets will be administered orally.",[9,16],[40],"VENCLEXTA, VENCLYXTO",[42],{"name":43,"affiliation":5,"role":44},"Janssen Research & Development, LLC Clinical Trial","STUDY_DIRECTOR",[46],{"name":47,"role":48,"phone":49,"phoneExt":50,"email":51},"Study Contact","CONTACT","844-434-4210",null,"Participate-In-This-Study1@its.jnj.com",[53,67,76,85,94,103,113,123,132,141,151,161,170,180,190,200,210,220,230,240,250,260,269,279,288,297,306,311,321,331,340,350,359,371,381,391,400,409,413,422,428,439,448,457,466,475,484,495,504,513,522,533,542,551,560,566,575,584,593,602,611,617,628,637,646,655,664,673,682,693,702,711,717,726],{"facility":54,"status":55,"city":56,"state":57,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":50},"The Oncology Institute Clinical Research","RECRUITING","Cerritos","California","90703","United States","US",{"type":62,"coordinates":63},"Point",[64,65],-118.06479,33.85835,{"lat":65,"lon":64},{"facility":68,"status":55,"city":69,"state":57,"zip":70,"country":59,"countryCode":60,"cosmosGeoPoint":71,"geoPoint":75,"contacts":50},"Cancer and Blood Specialty Clinic","Los Alamitos","90720",{"type":62,"coordinates":72},[73,74],-118.07256,33.80307,{"lat":74,"lon":73},{"facility":77,"status":55,"city":78,"state":57,"zip":79,"country":59,"countryCode":60,"cosmosGeoPoint":80,"geoPoint":84,"contacts":50},"SLO Oncology and Hematology Health Center","San Luis Obispo","93401",{"type":62,"coordinates":81},[82,83],-120.65962,35.28275,{"lat":83,"lon":82},{"facility":86,"status":55,"city":87,"state":57,"zip":88,"country":59,"countryCode":60,"cosmosGeoPoint":89,"geoPoint":93,"contacts":50},"Providence Medical Foundation","Santa Rosa","95403",{"type":62,"coordinates":90},[91,92],-122.71443,38.44047,{"lat":92,"lon":91},{"facility":95,"status":55,"city":96,"state":57,"zip":97,"country":59,"countryCode":60,"cosmosGeoPoint":98,"geoPoint":102,"contacts":50},"PIH Health Hospital","Whittier","90602",{"type":62,"coordinates":99},[100,101],-118.03284,33.97918,{"lat":101,"lon":100},{"facility":104,"status":55,"city":105,"state":106,"zip":107,"country":59,"countryCode":60,"cosmosGeoPoint":108,"geoPoint":112,"contacts":50},"Grand Valley Oncology","Grand Junction","Colorado","81505",{"type":62,"coordinates":109},[110,111],-108.55065,39.06387,{"lat":111,"lon":110},{"facility":114,"status":55,"city":115,"state":116,"zip":117,"country":59,"countryCode":60,"cosmosGeoPoint":118,"geoPoint":122,"contacts":50},"Mount Sinai Medical Center Campus","Miami Beach","Florida","33140-2948",{"type":62,"coordinates":119},[120,121],-80.13005,25.79065,{"lat":121,"lon":120},{"facility":124,"status":55,"city":125,"state":116,"zip":126,"country":59,"countryCode":60,"cosmosGeoPoint":127,"geoPoint":131,"contacts":50},"The Oncology Institute","North Miami Beach","33169",{"type":62,"coordinates":128},[129,130],-80.16255,25.93315,{"lat":130,"lon":129},{"facility":133,"status":55,"city":134,"state":116,"zip":135,"country":59,"countryCode":60,"cosmosGeoPoint":136,"geoPoint":140,"contacts":50},"Mid Florida Hematology Oncology","Orange","32763",{"type":62,"coordinates":137},[138,139],-85.02492,30.2277,{"lat":139,"lon":138},{"facility":142,"status":55,"city":143,"state":144,"zip":145,"country":59,"countryCode":60,"cosmosGeoPoint":146,"geoPoint":150,"contacts":50},"Boise VA Medical Center","Boise","Idaho","83702",{"type":62,"coordinates":147},[148,149],-116.20345,43.6135,{"lat":149,"lon":148},{"facility":152,"status":55,"city":153,"state":154,"zip":155,"country":59,"countryCode":60,"cosmosGeoPoint":156,"geoPoint":160,"contacts":50},"Hope and Healing Cancer Services","Hinsdale","Illinois","60521",{"type":62,"coordinates":157},[158,159],-87.93701,41.80086,{"lat":159,"lon":158},{"facility":162,"status":55,"city":163,"state":154,"zip":164,"country":59,"countryCode":60,"cosmosGeoPoint":165,"geoPoint":169,"contacts":50},"Springfield Clinic","Springfield","62702",{"type":62,"coordinates":166},[167,168],-89.64371,39.80172,{"lat":168,"lon":167},{"facility":171,"status":55,"city":172,"state":173,"zip":174,"country":59,"countryCode":60,"cosmosGeoPoint":175,"geoPoint":179,"contacts":50},"Iowa City VA Health Care System","Iowa City","Iowa","52246",{"type":62,"coordinates":176},[177,178],-91.53017,41.66113,{"lat":178,"lon":177},{"facility":181,"status":55,"city":182,"state":183,"zip":184,"country":59,"countryCode":60,"cosmosGeoPoint":185,"geoPoint":189,"contacts":50},"Minnesota Oncology Hematology P A","Minneapolis","Minnesota","55404",{"type":62,"coordinates":186},[187,188],-93.26384,44.97997,{"lat":188,"lon":187},{"facility":191,"status":55,"city":192,"state":193,"zip":194,"country":59,"countryCode":60,"cosmosGeoPoint":195,"geoPoint":199,"contacts":50},"Research Medical Center","Kansas City","Missouri","64132",{"type":62,"coordinates":196},[197,198],-94.57857,39.09973,{"lat":198,"lon":197},{"facility":201,"status":55,"city":202,"state":203,"zip":204,"country":59,"countryCode":60,"cosmosGeoPoint":205,"geoPoint":209,"contacts":50},"Hunterdon Hematology Oncology","Flemington","New Jersey","08822",{"type":62,"coordinates":206},[207,208],-74.85933,40.51233,{"lat":208,"lon":207},{"facility":211,"status":212,"city":213,"state":203,"zip":214,"country":59,"countryCode":60,"cosmosGeoPoint":215,"geoPoint":219,"contacts":50},"Summit Medical Group","COMPLETED","Florham Park","07932",{"type":62,"coordinates":216},[217,218],-74.38821,40.78788,{"lat":218,"lon":217},{"facility":221,"status":55,"city":222,"state":223,"zip":224,"country":59,"countryCode":60,"cosmosGeoPoint":225,"geoPoint":229,"contacts":50},"Hematology Oncology Associates of Rockland","Nyack","New York","10960",{"type":62,"coordinates":226},[227,228],-73.91791,41.09065,{"lat":228,"lon":227},{"facility":231,"status":212,"city":232,"state":233,"zip":234,"country":59,"countryCode":60,"cosmosGeoPoint":235,"geoPoint":239,"contacts":50},"Southeastern Medical Oncology Center","Goldsboro","North Carolina","27534",{"type":62,"coordinates":236},[237,238],-77.99277,35.38488,{"lat":238,"lon":237},{"facility":241,"status":55,"city":242,"state":243,"zip":244,"country":59,"countryCode":60,"cosmosGeoPoint":245,"geoPoint":249,"contacts":50},"Oncology Hematology Care","Cincinnati","Ohio","45242",{"type":62,"coordinates":246},[247,248],-84.51439,39.12711,{"lat":248,"lon":247},{"facility":251,"status":55,"city":252,"state":253,"zip":254,"country":59,"countryCode":60,"cosmosGeoPoint":255,"geoPoint":259,"contacts":50},"Willamette Valley Cancer Institute and Research Center","Eugene","Oregon","97401",{"type":62,"coordinates":256},[257,258],-123.08675,44.05207,{"lat":258,"lon":257},{"facility":261,"status":55,"city":262,"state":253,"zip":263,"country":59,"countryCode":60,"cosmosGeoPoint":264,"geoPoint":268,"contacts":50},"OHSU Knight Cancer Institute","Portland","97239",{"type":62,"coordinates":265},[266,267],-122.67621,45.52345,{"lat":267,"lon":266},{"facility":270,"status":212,"city":271,"state":272,"zip":273,"country":59,"countryCode":60,"cosmosGeoPoint":274,"geoPoint":278,"contacts":50},"Renovatio Clinical","El Paso","Texas","79915",{"type":62,"coordinates":275},[276,277],-106.48693,31.75872,{"lat":277,"lon":276},{"facility":280,"status":55,"city":281,"state":272,"zip":282,"country":59,"countryCode":60,"cosmosGeoPoint":283,"geoPoint":287,"contacts":50},"Texas Oncology-Fort Worth Cancer Center","Fort Worth","76104",{"type":62,"coordinates":284},[285,286],-97.32085,32.72541,{"lat":286,"lon":285},{"facility":289,"status":55,"city":290,"state":272,"zip":291,"country":59,"countryCode":60,"cosmosGeoPoint":292,"geoPoint":296,"contacts":50},"The University of Texas MD Anderson Cancer Center","Houston","77030",{"type":62,"coordinates":293},[294,295],-95.36327,29.76328,{"lat":295,"lon":294},{"facility":298,"status":212,"city":299,"state":272,"zip":300,"country":59,"countryCode":60,"cosmosGeoPoint":301,"geoPoint":305,"contacts":50},"Renovatio Clinical 1","The Woodlands","77380",{"type":62,"coordinates":302},[303,304],-95.48938,30.15799,{"lat":304,"lon":303},{"facility":307,"status":55,"city":299,"state":272,"zip":300,"country":59,"countryCode":60,"cosmosGeoPoint":308,"geoPoint":310,"contacts":50},"Texas Oncology-Gulf Coast",{"type":62,"coordinates":309},[303,304],{"lat":304,"lon":303},{"facility":312,"status":55,"city":313,"state":314,"zip":315,"country":59,"countryCode":60,"cosmosGeoPoint":316,"geoPoint":320,"contacts":50},"Community Cancer Trials of Utah","Ogden","Utah","84405",{"type":62,"coordinates":317},[318,319],-111.97383,41.223,{"lat":319,"lon":318},{"facility":322,"status":55,"city":323,"state":324,"zip":325,"country":59,"countryCode":60,"cosmosGeoPoint":326,"geoPoint":330,"contacts":50},"Virginia Cancer Specialists","Manassas","Virginia","20110",{"type":62,"coordinates":327},[328,329],-77.47527,38.75095,{"lat":329,"lon":328},{"facility":332,"status":55,"city":333,"state":324,"zip":334,"country":59,"countryCode":60,"cosmosGeoPoint":335,"geoPoint":339,"contacts":50},"Virginia Oncology Associates","Virginia Beach","23456",{"type":62,"coordinates":336},[337,338],-75.97799,36.85293,{"lat":338,"lon":337},{"facility":341,"status":55,"city":342,"state":343,"zip":344,"country":59,"countryCode":60,"cosmosGeoPoint":345,"geoPoint":349,"contacts":50},"VA Puget Sound Healthcare System","Seattle","Washington","98108",{"type":62,"coordinates":346},[347,348],-122.33207,47.60621,{"lat":348,"lon":347},{"facility":351,"status":55,"city":352,"state":343,"zip":353,"country":59,"countryCode":60,"cosmosGeoPoint":354,"geoPoint":358,"contacts":50},"Northwest Cancer Specialists PC","Vancouver","98684",{"type":62,"coordinates":355},[356,357],-122.66149,45.63873,{"lat":357,"lon":356},{"facility":360,"status":55,"city":361,"state":362,"zip":363,"country":364,"countryCode":365,"cosmosGeoPoint":366,"geoPoint":370,"contacts":50},"QEII Health Sciences Centre","Halifax","Nova Scotia","B3H 1V7","Canada","CA",{"type":62,"coordinates":367},[368,369],-63.57688,44.64269,{"lat":369,"lon":368},{"facility":372,"status":55,"city":373,"state":374,"zip":375,"country":364,"countryCode":365,"cosmosGeoPoint":376,"geoPoint":380,"contacts":50},"Niagara Health System","St. Catharines","Ontario","L2S 0A9",{"type":62,"coordinates":377},[378,379],-79.24267,43.17126,{"lat":379,"lon":378},{"facility":382,"status":55,"city":383,"state":50,"zip":384,"country":385,"countryCode":50,"cosmosGeoPoint":386,"geoPoint":390,"contacts":50},"Fakultni nemocnice Brno","Brno-Bohunice","625 00","Czechia",{"type":62,"coordinates":387},[388,389],16.57751,49.16734,{"lat":389,"lon":388},{"facility":392,"status":55,"city":393,"state":50,"zip":394,"country":385,"countryCode":50,"cosmosGeoPoint":395,"geoPoint":399,"contacts":50},"Fakultni nemocnice Hradec Kralove","Hradec Králové","500 05",{"type":62,"coordinates":396},[397,398],15.83277,50.20923,{"lat":398,"lon":397},{"facility":401,"status":55,"city":402,"state":50,"zip":403,"country":385,"countryCode":50,"cosmosGeoPoint":404,"geoPoint":408,"contacts":50},"Fakultni nemocnice Olomouc","Olomouc","779 00",{"type":62,"coordinates":405},[406,407],17.25175,49.59552,{"lat":407,"lon":406},{"facility":410,"status":55,"city":411,"state":50,"zip":412,"country":385,"countryCode":50,"cosmosGeoPoint":50,"geoPoint":50,"contacts":50},"Fakultni Nemocnice Ostrava","Ostrava - Poruba","708 52",{"facility":414,"status":55,"city":415,"state":50,"zip":416,"country":385,"countryCode":50,"cosmosGeoPoint":417,"geoPoint":421,"contacts":50},"Fakultni nemocnice Kralovske Vinohrady","Prague","100 34",{"type":62,"coordinates":418},[419,420],14.42076,50.08804,{"lat":420,"lon":419},{"facility":423,"status":55,"city":415,"state":50,"zip":424,"country":385,"countryCode":50,"cosmosGeoPoint":425,"geoPoint":427,"contacts":50},"Ustav Hematologie A Krevni Transfuze","128 00",{"type":62,"coordinates":426},[419,420],{"lat":420,"lon":419},{"facility":429,"status":212,"city":430,"state":50,"zip":431,"country":432,"countryCode":433,"cosmosGeoPoint":434,"geoPoint":438,"contacts":50},"CHU de Clermont Ferrand","Clermont-Ferrand","63100","France","FR",{"type":62,"coordinates":435},[436,437],3.08682,45.77969,{"lat":437,"lon":436},{"facility":440,"status":55,"city":441,"state":50,"zip":442,"country":432,"countryCode":433,"cosmosGeoPoint":443,"geoPoint":447,"contacts":50},"CHU Nantes","Nantes","44000",{"type":62,"coordinates":444},[445,446],-1.55336,47.21725,{"lat":446,"lon":445},{"facility":449,"status":55,"city":450,"state":50,"zip":451,"country":432,"countryCode":433,"cosmosGeoPoint":452,"geoPoint":456,"contacts":50},"Hopital Pitie Salpetriere","Paris","75651",{"type":62,"coordinates":453},[454,455],2.3488,48.85341,{"lat":455,"lon":454},{"facility":458,"status":55,"city":459,"state":50,"zip":460,"country":432,"countryCode":433,"cosmosGeoPoint":461,"geoPoint":465,"contacts":50},"CHU Lyon Sud","Pierre-Bénite","69495",{"type":62,"coordinates":462},[463,464],4.82424,45.70359,{"lat":464,"lon":463},{"facility":467,"status":55,"city":468,"state":50,"zip":469,"country":432,"countryCode":433,"cosmosGeoPoint":470,"geoPoint":474,"contacts":50},"CHU de Reims","Reims","51100",{"type":62,"coordinates":471},[472,473],4.02853,49.26526,{"lat":473,"lon":472},{"facility":476,"status":212,"city":477,"state":50,"zip":478,"country":432,"countryCode":433,"cosmosGeoPoint":479,"geoPoint":483,"contacts":50},"Institut de Cancerologie Strasbourg Europe ICANS","Strasbourg","67200",{"type":62,"coordinates":480},[481,482],7.74553,48.58392,{"lat":482,"lon":481},{"facility":485,"status":55,"city":486,"state":50,"zip":487,"country":488,"countryCode":489,"cosmosGeoPoint":490,"geoPoint":494,"contacts":50},"Semmelweis Egyetem","Budapest","1088","Hungary","HU",{"type":62,"coordinates":491},[492,493],19.04045,47.49835,{"lat":493,"lon":492},{"facility":496,"status":55,"city":497,"state":50,"zip":498,"country":488,"countryCode":489,"cosmosGeoPoint":499,"geoPoint":503,"contacts":50},"Gyor Moson Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz","Győr","9024",{"type":62,"coordinates":500},[501,502],17.63512,47.68333,{"lat":502,"lon":501},{"facility":505,"status":55,"city":506,"state":50,"zip":507,"country":488,"countryCode":489,"cosmosGeoPoint":508,"geoPoint":512,"contacts":50},"Szabolcs Szatmar Bereg Varmegyei Oktatokorhaz","Nyíregyháza","4400",{"type":62,"coordinates":509},[510,511],21.71671,47.95539,{"lat":511,"lon":510},{"facility":514,"status":55,"city":515,"state":50,"zip":516,"country":488,"countryCode":489,"cosmosGeoPoint":517,"geoPoint":521,"contacts":50},"University of Szeged","Szeged","6725",{"type":62,"coordinates":518},[519,520],20.14824,46.253,{"lat":520,"lon":519},{"facility":523,"status":55,"city":524,"state":50,"zip":525,"country":526,"countryCode":527,"cosmosGeoPoint":528,"geoPoint":532,"contacts":50},"U.O. Ematologia Istituto Tumori Giovanni Paolo II","Bari","70124","Italy","IT",{"type":62,"coordinates":529},[530,531],16.86982,41.12066,{"lat":531,"lon":530},{"facility":534,"status":55,"city":535,"state":50,"zip":536,"country":526,"countryCode":527,"cosmosGeoPoint":537,"geoPoint":541,"contacts":50},"Azienda Ospedaliero-Universitaria di Ferrara Arcispedale Sant Anna","Ferrara","44124",{"type":62,"coordinates":538},[539,540],11.62057,44.83804,{"lat":540,"lon":539},{"facility":543,"status":55,"city":544,"state":50,"zip":545,"country":526,"countryCode":527,"cosmosGeoPoint":546,"geoPoint":550,"contacts":50},"Azienda Ospedaliero Universitaria Careggi","Florence","50134",{"type":62,"coordinates":547},[548,549],11.24626,43.77925,{"lat":549,"lon":548},{"facility":552,"status":55,"city":553,"state":50,"zip":554,"country":526,"countryCode":527,"cosmosGeoPoint":555,"geoPoint":559,"contacts":50},"Ospedale San Raffaele","Milan","20132",{"type":62,"coordinates":556},[557,558],12.59836,42.78235,{"lat":558,"lon":557},{"facility":561,"status":55,"city":553,"state":50,"zip":562,"country":526,"countryCode":527,"cosmosGeoPoint":563,"geoPoint":565,"contacts":50},"ASST Grande Ospedale Metropolitano Niguarda","20162",{"type":62,"coordinates":564},[557,558],{"lat":558,"lon":557},{"facility":567,"status":55,"city":568,"state":50,"zip":569,"country":526,"countryCode":527,"cosmosGeoPoint":570,"geoPoint":574,"contacts":50},"Ospedale Maggiore della Carita","Novara","28100",{"type":62,"coordinates":571},[572,573],8.62118,45.44694,{"lat":573,"lon":572},{"facility":576,"status":55,"city":577,"state":50,"zip":578,"country":526,"countryCode":527,"cosmosGeoPoint":579,"geoPoint":583,"contacts":50},"Universita degli Studi di Padova Azienda Ospedaliera di Pa","Padova","35129",{"type":62,"coordinates":580},[581,582],11.14261,44.38225,{"lat":582,"lon":581},{"facility":585,"status":55,"city":586,"state":50,"zip":587,"country":526,"countryCode":527,"cosmosGeoPoint":588,"geoPoint":592,"contacts":50},"Ospedale Villa Sofia-Cervello","Palermo","90146",{"type":62,"coordinates":589},[590,591],13.3636,38.1166,{"lat":591,"lon":590},{"facility":594,"status":55,"city":595,"state":50,"zip":596,"country":526,"countryCode":527,"cosmosGeoPoint":597,"geoPoint":601,"contacts":50},"Azienda Ospedaliera di Perugia Ospedale S.Maria della Misericordia","Perugia","06132",{"type":62,"coordinates":598},[599,600],12.38878,43.1122,{"lat":600,"lon":599},{"facility":603,"status":55,"city":604,"state":50,"zip":605,"country":526,"countryCode":527,"cosmosGeoPoint":606,"geoPoint":610,"contacts":50},"Ematologia Fondazione Univ. Policlinico Gemelli Università Cattolica del Sacro Cuore","Roma","00136",{"type":62,"coordinates":607},[608,609],11.10642,44.99364,{"lat":609,"lon":608},{"facility":612,"status":55,"city":604,"state":50,"zip":613,"country":526,"countryCode":527,"cosmosGeoPoint":614,"geoPoint":616,"contacts":50},"Umberto I Policlinico di Roma","00161",{"type":62,"coordinates":615},[608,609],{"lat":609,"lon":608},{"facility":618,"status":55,"city":619,"state":50,"zip":620,"country":621,"countryCode":622,"cosmosGeoPoint":623,"geoPoint":627,"contacts":50},"Wojewodzki Szpital Specjalistyczny","Biała Podlaska","21 500","Poland","PL",{"type":62,"coordinates":624},[625,626],23.11652,52.03238,{"lat":626,"lon":625},{"facility":629,"status":55,"city":630,"state":50,"zip":631,"country":621,"countryCode":622,"cosmosGeoPoint":632,"geoPoint":636,"contacts":50},"Szpital Specjalistyczny w Brzozowie","Brzozów","36 200",{"type":62,"coordinates":633},[634,635],22.01926,49.69501,{"lat":635,"lon":634},{"facility":638,"status":55,"city":639,"state":50,"zip":640,"country":621,"countryCode":622,"cosmosGeoPoint":641,"geoPoint":645,"contacts":50},"Szpitale Pomorskie Sp z o o","Gdynia","81-519",{"type":62,"coordinates":642},[643,644],18.53188,54.51889,{"lat":644,"lon":643},{"facility":647,"status":55,"city":648,"state":50,"zip":649,"country":621,"countryCode":622,"cosmosGeoPoint":650,"geoPoint":654,"contacts":50},"Swietokrzyskie Centrum Onkologii SPZOZ w Kielcach","Kielce","25 734",{"type":62,"coordinates":651},[652,653],20.62752,50.87033,{"lat":653,"lon":652},{"facility":656,"status":55,"city":657,"state":50,"zip":658,"country":621,"countryCode":622,"cosmosGeoPoint":659,"geoPoint":663,"contacts":50},"Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie","Krakow","30 688",{"type":62,"coordinates":660},[661,662],19.93658,50.06143,{"lat":662,"lon":661},{"facility":665,"status":55,"city":666,"state":50,"zip":667,"country":621,"countryCode":622,"cosmosGeoPoint":668,"geoPoint":672,"contacts":50},"Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im M Kopernika w Lodzi","Lodz","93 513",{"type":62,"coordinates":669},[670,671],19.47395,51.77058,{"lat":671,"lon":670},{"facility":674,"status":55,"city":675,"state":50,"zip":676,"country":621,"countryCode":622,"cosmosGeoPoint":677,"geoPoint":681,"contacts":50},"Centrum Onkologii Ziemi Lubelskiej im sw Jana z Dukli","Lublin","20 090",{"type":62,"coordinates":678},[679,680],22.57009,51.25058,{"lat":680,"lon":679},{"facility":683,"status":55,"city":684,"state":50,"zip":685,"country":686,"countryCode":687,"cosmosGeoPoint":688,"geoPoint":692,"contacts":50},"Hosp Univ Vall D Hebron","Barcelona","08035","Spain","ES",{"type":62,"coordinates":689},[690,691],2.15899,41.38879,{"lat":691,"lon":690},{"facility":694,"status":55,"city":695,"state":50,"zip":696,"country":686,"countryCode":687,"cosmosGeoPoint":697,"geoPoint":701,"contacts":50},"Hosp Reina Sofia","Córdoba","14004",{"type":62,"coordinates":698},[699,700],-4.77275,37.89155,{"lat":700,"lon":699},{"facility":703,"status":55,"city":704,"state":50,"zip":705,"country":686,"countryCode":687,"cosmosGeoPoint":706,"geoPoint":710,"contacts":50},"Hosp. Univ. Ramon Y Cajal","Madrid","28034",{"type":62,"coordinates":707},[708,709],-3.70256,40.4165,{"lat":709,"lon":708},{"facility":712,"status":55,"city":704,"state":50,"zip":713,"country":686,"countryCode":687,"cosmosGeoPoint":714,"geoPoint":716,"contacts":50},"Hosp. Univ. 12 de Octubre","28041",{"type":62,"coordinates":715},[708,709],{"lat":709,"lon":708},{"facility":718,"status":55,"city":719,"state":50,"zip":720,"country":686,"countryCode":687,"cosmosGeoPoint":721,"geoPoint":725,"contacts":50},"Hosp. Univ. Marques de Valdecilla","Santander","39008",{"type":62,"coordinates":722},[723,724],-3.80493,43.46589,{"lat":724,"lon":723},{"facility":727,"status":55,"city":728,"state":50,"zip":729,"country":686,"countryCode":687,"cosmosGeoPoint":730,"geoPoint":734,"contacts":50},"Hosp. Clinico Univ. de Santiago","Santiago de Compostela","15706",{"type":62,"coordinates":731},[732,733],-8.54569,42.88052,{"lat":733,"lon":732},{"type":736,"investigatorFullName":50,"investigatorTitle":50,"investigatorAffiliation":50,"oldNameTitle":50,"oldOrganization":50},"SPONSOR",[738],{"name":739,"class":6},"Pharmacyclics LLC.","100513254","phase-2-a-study-to-customize-ibrutinib-treatment-regimens-for-participants-with-previously-untreated-chronic-lymphocytic-leukemia-100513254",false,"NCT05963074","A Study to Customize Ibrutinib Treatment Regimens for Participants With Previously Untreated Chronic Lymphocytic Leukemia","Multicohort Study to Customize Ibrutinib Treatment Regimens for Patients With Previously Untreated Chronic Lymphocytic Leukemia","TAILOR","Inclusion Criteria:\n\n* Diagnosis of chronic lymphocytic leukemia\u002F small lymphocytic lymphoma (CLL\u002FSLL) as per International Workshop on Chronic Lymphocytic Leukemia (iwCLL) 2018 diagnostic criteria\n* For ibruinib + venetocIax (I+V) cohorts: eastern cooperative oncology group (ECOG) performance status of 0-1. For ibrutinib monotherapy cohorts: ECOG performance status of 0-2\n* Measurable nodal disease by computed tomography (CT), defined as at least 1 lymph node greater than and equal to (\\>=) 1.5 centimeters (cm) in longest diameter\n* A participant using oral contraceptives must use an additional contraceptive method\n* A participant must agree not to be pregnant, breastfeeding, or planning to become pregnant while enrolled in this study or until 1 month after last dose or per local label if more conservative (for example, 3 months in European Union or Canada and 1 month in United States)\n\nExclusion Criteria:\n\n* Uncontrolled autoimmune hemolytic anemia or idiopathic thrombocytopenia purpura, such as those participants with a declining hemoglobin level or platelet count secondary to autoimmune destruction within the 4 weeks prior to first dose of study treatment, or the need for prednisone greater than (\\>) 20 milligrams (mg) daily (or corticosteroid equivalent) to treat or control the autoimmune disease\n* Known bleeding disorders (example, von Willebrand's disease or hemophilia)\n* Stroke or intracranial hemorrhage within 6 months prior to enrollment\n* Known or suspected Richter's transformation or central nervous system (CNS) involvement\n* Currently active, clinically significant cardiovascular disease, such as uncontrolled arrhythmia or Class II, III, or IV congestive heart failure as defined by the New York Heart Association Functional Classification","ALL","18 Years",{"count":751,"type":752},320,"ESTIMATED","INTERVENTIONAL",[755],"PHASE2","The purpose of this study is to evaluate the efficacy and safety of ibrutinib + venetoclax (I+V) and ibrutinib monotherapy regimens in which dosing of ibrutinib is either proactively reduced or reactively modified in response to adverse events (AEs).",[758,759],"Leukemia, Lymphocytic, Chronic, B-Cell","Small Lymphocytic Lymphoma","2026-06-04",{"date":762,"type":763},"2026-06-05","ACTUAL",{"date":765,"type":763},"2024-05-30",{"date":767,"type":752},"2029-03-19",{"name":5,"class":6},74]