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242458","1122",{"type":130,"coordinates":573},[566,567],{"lat":567,"lon":566},{"facility":576,"status":137,"city":577,"state":578,"zip":579,"country":580,"countryCode":581,"cosmosGeoPoint":582,"geoPoint":586,"contacts":82},"Rabin Medical Center. \u002FID# 243014","Petah Tikva","Central District","4941492","Israel","IL",{"type":130,"coordinates":583},[584,585],34.88747,32.08707,{"lat":585,"lon":584},{"facility":588,"status":137,"city":589,"state":589,"zip":590,"country":580,"countryCode":581,"cosmosGeoPoint":591,"geoPoint":595,"contacts":82},"Hadassah Medical Center-Hebrew University \u002FID# 243013","Jerusalem","91120",{"type":130,"coordinates":592},[593,594],35.21633,31.76904,{"lat":594,"lon":593},{"facility":597,"status":137,"city":598,"state":599,"zip":600,"country":580,"countryCode":581,"cosmosGeoPoint":601,"geoPoint":605,"contacts":82},"The Chaim Sheba Medical Center \u002FID# 243010","Ramat Gan","Tel Aviv","5265601",{"type":130,"coordinates":602},[603,604],34.81065,32.08227,{"lat":604,"lon":603},{"facility":607,"status":137,"city":599,"state":599,"zip":608,"country":580,"countryCode":581,"cosmosGeoPoint":609,"geoPoint":613,"contacts":82},"Tel Aviv Sourasky Medical Center \u002FID# 243012","6423906",{"type":130,"coordinates":610},[611,612],34.78057,32.08088,{"lat":612,"lon":611},{"facility":615,"status":137,"city":616,"state":617,"zip":618,"country":619,"countryCode":620,"cosmosGeoPoint":621,"geoPoint":625,"contacts":82},"Hokkaido University Hospital \u002FID# 248999","Sapporo","Hokkaido","060-8648","Japan","JP",{"type":130,"coordinates":622},[623,624],141.35,43.06667,{"lat":624,"lon":623},{"facility":627,"status":123,"city":628,"state":628,"zip":629,"country":619,"countryCode":620,"cosmosGeoPoint":630,"geoPoint":634,"contacts":82},"Kyoto University Hospital \u002FID# 248997","Kyoto","606-8507",{"type":130,"coordinates":631},[632,633],135.75385,35.02107,{"lat":633,"lon":632},{"facility":636,"status":137,"city":637,"state":638,"zip":639,"country":619,"countryCode":620,"cosmosGeoPoint":82,"geoPoint":82,"contacts":82},"National Cancer Center Hospital \u002FID# 248995","Chuo-ku","Tokyo","104-0045",{"facility":641,"status":123,"city":642,"state":643,"zip":644,"country":645,"countryCode":646,"cosmosGeoPoint":647,"geoPoint":651,"contacts":82},"Maastricht Universitair Medisch Centrum \u002FID# 243317","Maastricht","Limburg","6229 HX","Netherlands","NL",{"type":130,"coordinates":648},[649,650],5.68889,50.84833,{"lat":650,"lon":649},{"facility":653,"status":137,"city":654,"state":655,"zip":656,"country":645,"countryCode":646,"cosmosGeoPoint":657,"geoPoint":661,"contacts":82},"Vrije Universiteit Medisch Centrum \u002FID# 243319","Amsterdam","North Holland","1081 HV",{"type":130,"coordinates":658},[659,660],4.88969,52.37403,{"lat":660,"lon":659},{"facility":663,"status":123,"city":664,"state":665,"zip":666,"country":645,"countryCode":646,"cosmosGeoPoint":667,"geoPoint":671,"contacts":82},"Leids Universitair Medisch Centrum \u002FID# 243316","Leiden","South Holland","2333 ZA",{"type":130,"coordinates":668},[669,670],4.49306,52.15833,{"lat":670,"lon":669},{"facility":673,"status":123,"city":674,"state":665,"zip":675,"country":645,"countryCode":646,"cosmosGeoPoint":676,"geoPoint":680,"contacts":82},"Duplicate_Erasmus Medisch Centrum \u002FID# 243315","Rotterdam","3015 GD",{"type":130,"coordinates":677},[678,679],4.47917,51.9225,{"lat":679,"lon":678},{"facility":682,"status":123,"city":683,"state":82,"zip":684,"country":645,"countryCode":646,"cosmosGeoPoint":685,"geoPoint":689,"contacts":82},"Universitair Medisch Centrum Groningen \u002FID# 243318","Groningen","9713 GZ",{"type":130,"coordinates":686},[687,688],6.56667,53.21917,{"lat":688,"lon":687},{"facility":691,"status":137,"city":692,"state":693,"zip":694,"country":695,"countryCode":82,"cosmosGeoPoint":696,"geoPoint":700,"contacts":82},"Seoul National University Bundang Hospital \u002FID# 242404","Seongnam-si","Gyeonggido","13620","South Korea",{"type":130,"coordinates":697},[698,699],127.13778,37.43861,{"lat":699,"lon":698},{"facility":702,"status":137,"city":703,"state":704,"zip":705,"country":695,"countryCode":82,"cosmosGeoPoint":706,"geoPoint":710,"contacts":82},"Seoul National University Hospital \u002FID# 242402","Seoul","Seoul Teugbyeolsi","03080",{"type":130,"coordinates":707},[708,709],126.9784,37.566,{"lat":709,"lon":708},{"facility":712,"status":137,"city":703,"state":704,"zip":713,"country":695,"countryCode":82,"cosmosGeoPoint":714,"geoPoint":716,"contacts":82},"Asan Medical Center \u002FID# 242400","05505",{"type":130,"coordinates":715},[708,709],{"lat":709,"lon":708},{"facility":718,"status":137,"city":703,"state":704,"zip":719,"country":695,"countryCode":82,"cosmosGeoPoint":720,"geoPoint":722,"contacts":82},"Samsung Medical Center \u002FID# 242401","06351",{"type":130,"coordinates":721},[708,709],{"lat":709,"lon":708},{"facility":724,"status":137,"city":703,"state":704,"zip":725,"country":695,"countryCode":82,"cosmosGeoPoint":726,"geoPoint":728,"contacts":82},"The Catholic University of Korea, Seoul St. Marys Hospital \u002FID# 242403","06591",{"type":130,"coordinates":727},[708,709],{"lat":709,"lon":708},{"facility":730,"status":137,"city":731,"state":732,"zip":733,"country":734,"countryCode":735,"cosmosGeoPoint":736,"geoPoint":740,"contacts":82},"Instituto Catalan de Oncologia (ICO) Badalona \u002FID# 243265","Badalona","Barcelona","08916","Spain","ES",{"type":130,"coordinates":737},[738,739],2.24741,41.45004,{"lat":739,"lon":738},{"facility":742,"status":137,"city":743,"state":732,"zip":744,"country":734,"countryCode":735,"cosmosGeoPoint":745,"geoPoint":749,"contacts":82},"Institut Catala dOncologia (ICO) - LHospitalet \u002FID# 243261","L'Hospitalet de Llobregat","08907",{"type":130,"coordinates":746},[747,748],2.10028,41.35967,{"lat":748,"lon":747},{"facility":751,"status":137,"city":752,"state":753,"zip":754,"country":734,"countryCode":735,"cosmosGeoPoint":755,"geoPoint":759,"contacts":82},"Clinica Universidad de Navarra - Pamplona \u002FID# 245031","Pamplona","Navarre","31008",{"type":130,"coordinates":756},[757,758],-1.64323,42.81687,{"lat":758,"lon":757},{"facility":761,"status":137,"city":732,"state":82,"zip":762,"country":734,"countryCode":735,"cosmosGeoPoint":763,"geoPoint":767,"contacts":82},"Hospital Universitario Vall de Hebron \u002FID# 243260","08035",{"type":130,"coordinates":764},[765,766],2.15899,41.38879,{"lat":766,"lon":765},{"facility":769,"status":137,"city":770,"state":82,"zip":771,"country":734,"countryCode":735,"cosmosGeoPoint":772,"geoPoint":776,"contacts":82},"CLINICA UNIVERSIDAD DE NAVARRA-Madrid \u002FID# 243268","Madrid","28027",{"type":130,"coordinates":773},[774,775],-3.70256,40.4165,{"lat":775,"lon":774},{"facility":778,"status":137,"city":770,"state":82,"zip":779,"country":734,"countryCode":735,"cosmosGeoPoint":780,"geoPoint":782,"contacts":82},"Hospital Universitario Fundacion Jimenez Diaz \u002FID# 243264","28040",{"type":130,"coordinates":781},[774,775],{"lat":775,"lon":774},{"facility":784,"status":137,"city":770,"state":82,"zip":785,"country":734,"countryCode":735,"cosmosGeoPoint":786,"geoPoint":788,"contacts":82},"Hospital Universitario 12 de Octubre \u002FID# 243262","28041",{"type":130,"coordinates":787},[774,775],{"lat":775,"lon":774},{"facility":790,"status":137,"city":791,"state":82,"zip":792,"country":734,"countryCode":735,"cosmosGeoPoint":793,"geoPoint":797,"contacts":82},"Hospital Universitario de Salamanca \u002FID# 243368","Salamanca","37711",{"type":130,"coordinates":794},[795,796],-3.67975,40.42972,{"lat":796,"lon":795},{"facility":799,"status":137,"city":800,"state":82,"zip":801,"country":734,"countryCode":735,"cosmosGeoPoint":802,"geoPoint":806,"contacts":82},"Hospital Universitario Virgen del Rocio \u002FID# 243267","Seville","41013",{"type":130,"coordinates":803},[804,805],-5.97317,37.38283,{"lat":805,"lon":804},{"facility":808,"status":137,"city":809,"state":82,"zip":810,"country":734,"countryCode":735,"cosmosGeoPoint":811,"geoPoint":815,"contacts":82},"Hospital Clinico Universitario de Valencia \u002FID# 243269","Valencia","46010",{"type":130,"coordinates":812},[813,814],-0.37966,39.47391,{"lat":814,"lon":813},{"facility":817,"status":137,"city":818,"state":82,"zip":819,"country":820,"countryCode":821,"cosmosGeoPoint":822,"geoPoint":826,"contacts":82},"China Medical University Hospital \u002FID# 242893","Taichung","40447","Taiwan","TW",{"type":130,"coordinates":823},[824,825],120.6839,24.1469,{"lat":825,"lon":824},{"facility":828,"status":137,"city":829,"state":82,"zip":830,"country":820,"countryCode":821,"cosmosGeoPoint":831,"geoPoint":835,"contacts":82},"National Cheng Kung University Hospital \u002FID# 242894","Tainan","704",{"type":130,"coordinates":832},[833,834],120.21333,22.99083,{"lat":834,"lon":833},{"facility":837,"status":137,"city":838,"state":82,"zip":839,"country":820,"countryCode":821,"cosmosGeoPoint":840,"geoPoint":844,"contacts":82},"Taipei Veterans General Hosp \u002FID# 242892","Taipei","11217",{"type":130,"coordinates":841},[842,843],121.52639,25.05306,{"lat":843,"lon":842},{"type":846,"investigatorFullName":82,"investigatorTitle":82,"investigatorAffiliation":82,"oldNameTitle":82,"oldOrganization":82},"SPONSOR",[848],{"name":112,"class":6},"100461060","phase-2-a-study-to-evaluate-adverse-events-and-change-in-disease-activity-of-subcutaneous-sc-epcoritamab-in-combination-with-oral-and-intravenous-anti-neoplastic-agents-in-adult-participants-with-non-hodgkin-lymphoma-100461060",false,"NCT05283720","A Study to Evaluate Adverse Events and Change in Disease Activity of Subcutaneous (SC) Epcoritamab in Combination With Oral and Intravenous Anti-Neoplastic Agents in Adult Participants With Non-Hodgkin Lymphoma","Phase 1b\u002F2, Open-Label Study to Evaluate Safety and Tolerability of Epcoritamab in Combination With Anti-Neoplastic Agents in Subjects With Non-Hodgkin Lymphoma","Inclusion Criteria:\n\n* Diagnosis of:\n\n  \\-- Diffuse large B-cell lymphoma (DLBCL) (de novo or histologically transformed from follicular lymphoma (FL) or nodal marginal zone lymphoma) with histologically confirmed CD20+ disease, inclusive of the following according to World Health Organization (WHO) 2016 classification and documented in pathology report:\n  * DLBCL, not otherwise specified (NOS).\n  * High-grade B cell lymphoma with MYC and BCL-2 and\u002For BCL-6 translocations per WHO 2016 (\"double-hit\" or \"triple-hit\") Note: High-grade B-cell lymphomas NOS or other double- \u002Ftriple-hit lymphomas (with histologies not consistent with DLBCL) are not eligible.\n  * Follicular lymphoma (FL) Grade 3B. OR\n* FL with histologically confirmed CD20+ Grade 1 to 3a and no evidence of histologic transformation to an aggressive lymphoma at most recent representative tumor biopsy, according to WHO 2016 classification. OR\n* Mantle cell lymphoma (MCL) with histologically confirmed CD20+ disease at most recent representative tumor biopsy according to the WHO 2016 classification with evidence of overexpression of cyclin D1 in association with relevant markers or evidence of t(11;14) assessed by flow cytometry, fluorescence in situ hybridization (FISH), or polymerase chain reaction (PCR).\n* Eastern Cooperative Oncology Group (ECOG) performance status 0 - 2, except for Arm 6A where ECOG performance status must be 0-1.\n* Must have 1 or more measurable disease sites:\n\n  * A positron emission tomography (PET) \u002Fcomputed tomography (CT) scan demonstrating PET-positive lesion(s) AND\n  * At least 1 measurable nodal lesion (long axis \\> 1.5 cm) or \\>= 1 measurable extra-nodal lesion (long axis \\> 1.0 cm) on CT scan or magnetic resonance imaging (MRI).\n\nExclusion Criteria:\n\n* Prior treatment with epcoritamab or any other bispecific antibody targeting CD3 and CD20.\n* Toxicities from prior anticancer therapy that have not resolved to Common Terminology Criteria for Adverse Events (CTCAE, v 5.0), Grade 2 or below, with the exception of alopecia. Other eligibility criteria (e.g., laboratory, cardiac criteria) must also be met.","ALL","18 Years",{"count":859,"type":860},496,"ESTIMATED","INTERVENTIONAL",[863],"PHASE2","B-cell Lymphoma is an aggressive and rare cancer of a type of immune cell (a white blood cell responsible for fighting infections). The purpose of this study is to assess the safety and tolerability of epcoritamab in combination with anti-neoplastic agents in adult participants with Non-Hodgkin lymphoma (NHL). Adverse events and change in disease activity will be assessed.\n\nEpcoritamab is an investigational drug being developed for the treatment of NHL. Study doctors put the participants in groups called treatment arms. The combination of epcoritamab with anti-neoplastic agents will be explored. Each treatment arm receives a different treatment combination depending on eligibility. Approximately 496 adult participants with NHL will be enrolled in 100 sites globally.\n\nIn both the dose escalation and dose expansion arms participants will receive subcutaneous (SC) epcoritamab in 28 day, 21 day, or 56 day cycles dependent on the arm in combination with the anti-neoplastic agents described below:\n\n1: Oral lenalidomide in participants (PPTS) with relapsed\u002Frefractory (R\u002FR) diffuse large B-cell lymphoma (DLBCL); 2: Oral ibrutinib and oral lenalidomide in PPTS with R\u002FR DLBCL; 3: Intravenous (IV) polatuzumab vedotin, IV rituximab, IV cyclophosphamide, IV doxorubicin hydrochloride (HCl), and oral prednisone (pola-R-CHP) in PPTS with newly diagnosed treatment-naïve DLBCL, or completion of treatment in 3B; 4: Oral CC-99282 in PPTS with R\u002FR DLBCL; 5: Oral CC-99282 in PPTS with R\u002FR follicular lymphoma (FL); 6A: Oral ibrutinib in PPTS with R\u002FR mantle cell lymphoma (MCL).\n\nThere may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at an approved institution (hospital or clinic). The effect of the treatment will be frequently checked by medical assessments, blood tests, questionnaires and side effects.",[866],"Non-Hodgkin Lymphoma",[866,73,79,84,104,89,93,868,869,870,871,872,873,874,875,107,876,877,878],"Doxorubicin Hydrochloride (HCl]","Prednisone (pola-R-CHP)","ABBV-GMAB-3013","Cancer","Relapsed\u002FRefractory (R\u002FR) Diffuse Large B-Cell Lymphoma (DLBCL), Venetoclax,","Venclexta","ABT-199","GDC-0199","EPCORE","Pirtobrutinib","Mantle Cell Lymhoma","2026-06-01",{"date":881,"type":882},"2026-06-02","ACTUAL",{"date":884,"type":882},"2022-06-14",{"date":886,"type":860},"2032-11",{"name":5,"class":6},76]