[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636161":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":28,"centralContacts":34,"locations":39,"responsibleParty":203,"collaborators":205,"id":208,"slug":209,"hasResults":210,"nctId":211,"briefTitle":212,"officialTitle":213,"acronym":28,"eligibilityCriteria":214,"healthyVolunteers":215,"sex":216,"minAge":217,"maxAge":218,"enrollmentInfo":219,"targetDuration":28,"studyType":222,"phases":223,"briefSummary":225,"conditions":226,"keywords":228,"overallStatus":42,"whyStopped":28,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":245,"startDateStruct":248,"completionDateStruct":250,"leadSponsor":252,"locationsCount":253},{"fullName":5,"class":6},"Tarsus Pharmaceuticals, Inc.","INDUSTRY",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"TP-05 (lotilaner) High Dose","ACTIVE_COMPARATOR","Oral Tablet",[13],"Drug: TP-05 (lotilaner) High Dose",{"label":15,"type":16,"description":11,"interventionNames":17},"Placebo","PLACEBO_COMPARATOR",[18],"Drug: Placebo",{"label":20,"type":10,"description":11,"interventionNames":21},"TP-05 (lotilaner) Low Dose",[22],"Drug: TP-05 (lotilaner) Low Dose",[24,29,31],{"type":25,"name":20,"description":26,"armGroupLabels":27,"otherNames":28},"DRUG","TP05 administered orally at the protocol-defined preventative dose.",[20],null,{"type":25,"name":9,"description":26,"armGroupLabels":30,"otherNames":28},[9],{"type":25,"name":15,"description":32,"armGroupLabels":33,"otherNames":28},"Matching placebo administered orally according to the same dosing schedule as TP05.",[15],[35],{"name":36,"role":37,"phone":38,"phoneExt":28,"email":28},"Study Director","CONTACT","949-418-1801",[40,54,63,71,80,89,98,106,114,122,130,137,145,154,162,170,178,186,194],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":28},"Study Site","RECRUITING","Pikesville","Maryland","21208","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-76.72247,39.37427,{"lat":52,"lon":51},{"facility":41,"status":42,"city":55,"state":56,"zip":57,"country":46,"countryCode":47,"cosmosGeoPoint":58,"geoPoint":62,"contacts":28},"Brookline","Massachusetts","02445",{"type":49,"coordinates":59},[60,61],-71.12116,42.33176,{"lat":61,"lon":60},{"facility":41,"status":42,"city":64,"state":56,"zip":65,"country":46,"countryCode":47,"cosmosGeoPoint":66,"geoPoint":70,"contacts":28},"Fall River","02723",{"type":49,"coordinates":67},[68,69],-71.15505,41.70149,{"lat":69,"lon":68},{"facility":41,"status":42,"city":72,"state":73,"zip":74,"country":46,"countryCode":47,"cosmosGeoPoint":75,"geoPoint":79,"contacts":28},"Minneapolis","Minnesota","55402",{"type":49,"coordinates":76},[77,78],-93.26384,44.97997,{"lat":78,"lon":77},{"facility":41,"status":42,"city":81,"state":82,"zip":83,"country":46,"countryCode":47,"cosmosGeoPoint":84,"geoPoint":88,"contacts":28},"Marlboro","New Jersey","07746",{"type":49,"coordinates":85},[86,87],-74.24626,40.31539,{"lat":87,"lon":86},{"facility":41,"status":42,"city":90,"state":91,"zip":92,"country":46,"countryCode":47,"cosmosGeoPoint":93,"geoPoint":97,"contacts":28},"Albany","New York","12205",{"type":49,"coordinates":94},[95,96],-73.75623,42.65258,{"lat":96,"lon":95},{"facility":41,"status":42,"city":99,"state":91,"zip":100,"country":46,"countryCode":47,"cosmosGeoPoint":101,"geoPoint":105,"contacts":28},"Binghamton","13905",{"type":49,"coordinates":102},[103,104],-75.91797,42.09869,{"lat":104,"lon":103},{"facility":41,"status":42,"city":107,"state":91,"zip":108,"country":46,"countryCode":47,"cosmosGeoPoint":109,"geoPoint":113,"contacts":28},"Buffalo","14217",{"type":49,"coordinates":110},[111,112],-78.87837,42.88645,{"lat":112,"lon":111},{"facility":41,"status":42,"city":115,"state":91,"zip":116,"country":46,"countryCode":47,"cosmosGeoPoint":117,"geoPoint":121,"contacts":28},"East Syracuse","13057",{"type":49,"coordinates":118},[119,120],-76.07853,43.06534,{"lat":120,"lon":119},{"facility":41,"status":42,"city":123,"state":91,"zip":124,"country":46,"countryCode":47,"cosmosGeoPoint":125,"geoPoint":129,"contacts":28},"Middletown","10941",{"type":49,"coordinates":126},[127,128],-74.42293,41.44593,{"lat":128,"lon":127},{"facility":41,"status":42,"city":91,"state":91,"zip":131,"country":46,"countryCode":47,"cosmosGeoPoint":132,"geoPoint":136,"contacts":28},"10036",{"type":49,"coordinates":133},[134,135],-74.00597,40.71427,{"lat":135,"lon":134},{"facility":41,"status":42,"city":138,"state":91,"zip":139,"country":46,"countryCode":47,"cosmosGeoPoint":140,"geoPoint":144,"contacts":28},"Rochester","14609",{"type":49,"coordinates":141},[142,143],-77.61556,43.15478,{"lat":143,"lon":142},{"facility":41,"status":42,"city":146,"state":147,"zip":148,"country":46,"countryCode":47,"cosmosGeoPoint":149,"geoPoint":153,"contacts":28},"Erie","Pennsylvania","16508",{"type":49,"coordinates":150},[151,152],-80.08506,42.12922,{"lat":152,"lon":151},{"facility":41,"status":42,"city":155,"state":147,"zip":156,"country":46,"countryCode":47,"cosmosGeoPoint":157,"geoPoint":161,"contacts":28},"Hatboro","19040",{"type":49,"coordinates":158},[159,160],-75.10684,40.17428,{"lat":160,"lon":159},{"facility":41,"status":42,"city":163,"state":147,"zip":164,"country":46,"countryCode":47,"cosmosGeoPoint":165,"geoPoint":169,"contacts":28},"Philadelphia","19107",{"type":49,"coordinates":166},[167,168],-75.16362,39.95238,{"lat":168,"lon":167},{"facility":41,"status":42,"city":171,"state":147,"zip":172,"country":46,"countryCode":47,"cosmosGeoPoint":173,"geoPoint":177,"contacts":28},"Pittsburgh","15236",{"type":49,"coordinates":174},[175,176],-79.99589,40.44062,{"lat":176,"lon":175},{"facility":41,"status":42,"city":179,"state":147,"zip":180,"country":46,"countryCode":47,"cosmosGeoPoint":181,"geoPoint":185,"contacts":28},"Pottstown","19464",{"type":49,"coordinates":182},[183,184],-75.64963,40.24537,{"lat":184,"lon":183},{"facility":41,"status":42,"city":187,"state":147,"zip":188,"country":46,"countryCode":47,"cosmosGeoPoint":189,"geoPoint":193,"contacts":28},"West Chester","19380",{"type":49,"coordinates":190},[191,192],-75.60804,39.96097,{"lat":192,"lon":191},{"facility":41,"status":42,"city":195,"state":196,"zip":197,"country":46,"countryCode":47,"cosmosGeoPoint":198,"geoPoint":202,"contacts":28},"Warwick","Rhode Island","02886",{"type":49,"coordinates":199},[200,201],-71.41617,41.7001,{"lat":201,"lon":200},{"type":204,"investigatorFullName":28,"investigatorTitle":28,"investigatorAffiliation":28,"oldNameTitle":28,"oldOrganization":28},"SPONSOR",[206],{"name":207,"class":6},"PPD Development, LP","100636161","phase-2-a-study-to-evaluate-safety-and-efficacy-of-tp-05-in-healthy-participants-with-tick-exposure-100636161",false,"NCT07562087","A Study to Evaluate Safety and Efficacy of TP-05 in Healthy Participants With Tick Exposure","A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of TP-05 in Healthy Participants at High Risk of Tick Exposure","Inclusion Criteria:\n\n* Overtly healthy adult participants aged 18 to 70 years\n* Able to provide written informed consent\n* Willing and able to comply with study procedures\n* At high risk of exposure to ticks\n* Contraceptive use by men and women consistent with local regulations\n\nExclusion Criteria:\n\n* Prior exposure to TP05 or any isooxazoline in the last 12 months\n* Known hypersensitivity to TP05 or related compounds\n* Clinically significant medical conditions that may interfere with study participation\n* Use of investigational products within 30 days prior to screening.\n* Received previous vaccination against Lyme borreliosis, including investigational vaccines intended to prevent Lyme borreliosis\n* Receiving long-term antibiotic therapy\n* Received active or passive immunization within 4 weeks prior to Day\n* Pregnant or breastfeeding individuals",true,"ALL","18 Years","70 Years",{"count":220,"type":221},700,"ESTIMATED","INTERVENTIONAL",[224],"PHASE2","This study is designed to evaluate the safety, tolerability, and pharmacokinetics of TP05 administered orally to healthy adult participants.",[227],"Lyme Disease",[227,229,230,231,232,233,234,235,236,237,238,239,240,241,242,243],"Lyme Borreliosis","Lyme","Borrelia","Preventative Therapeutic","Prophylaxis","Healthy Volunteers","Randomized Controlled Trial","Gram-Negative Bacterial Infections","Bacterial Infections","Bacterial Infections and Mycoses","Infections","Borrelia Infections","Spirochaetales Infections","Tick-Borne Diseases","Vector Borne Diseases","2026-05-18",{"date":246,"type":247},"2026-05-20","ACTUAL",{"date":249,"type":247},"2026-03-09",{"date":251,"type":221},"2027-12",{"name":5,"class":6},19]