[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100579143":3},{"organization":4,"armGroups":7,"interventions":47,"overallOfficials":71,"centralContacts":75,"locations":81,"responsibleParty":589,"collaborators":53,"id":591,"slug":53,"hasResults":592,"nctId":593,"briefTitle":594,"officialTitle":595,"acronym":596,"eligibilityCriteria":597,"healthyVolunteers":592,"sex":598,"minAge":599,"maxAge":53,"enrollmentInfo":600,"targetDuration":53,"studyType":603,"phases":604,"briefSummary":606,"conditions":607,"keywords":609,"overallStatus":84,"whyStopped":53,"lastUpdateSubmitDate":611,"lastUpdatePostDateStruct":612,"startDateStruct":615,"completionDateStruct":617,"leadSponsor":619,"locationsCount":620},{"fullName":5,"class":6},"AbbVie","INDUSTRY",[8,18,22,26,30,35,39,43],{"label":9,"type":10,"description":11,"interventionNames":12},"Substudy 1: Dose Escalation Telisotuzumab Adizutecan","EXPERIMENTAL","Participants will receive various doses of telisotuzumab adizutecan in combination with a fixed dose of fluorouracil, leucovorin, and oxaliplatin (FOLFOX) and bevacizumab as part of the approximately 6 year study duration.",[13,14,15,16,17],"Drug: Telisotuzumab Adizutecan","Drug: Fluorouracil","Drug: Oxaliplatin","Drug: Leucovorin","Drug: Bevacizumab",{"label":19,"type":10,"description":20,"interventionNames":21},"Substudy 1: Dose Expansion Telisotuzumab Adizutecan High Dose","Participants will receive the high dose of telisotuzumab adizutecan determined in the dose expansion arm in combination with a fixed dose of FOLFOX and bevacizumab as part of the approximately 6 year study duration.",[13,14,15,16,17],{"label":23,"type":10,"description":24,"interventionNames":25},"Substudy 1: Dose Expansion Telisotuzumab Adizutecan Low Dose","Participants will receive the low dose of telisotuzumab adizutecandetermined in the dose expansion arm in combination with a fixed dose of FOLFOX and bevacizumab as part of the approximately 6 year study duration.",[13,14,15,16,17],{"label":27,"type":10,"description":28,"interventionNames":29},"Substudy 1: Dose Expansion Compatator","Participants will receive a fixed dose of FOLFOX and bevacizumab as part of the approximately 6 year study duration.",[14,15,16,17],{"label":31,"type":10,"description":32,"interventionNames":33},"Substudy 2: Dose Escalation Telisotuzumab Adizutecan","Participants will receive various doses of telisotuzumab adizutecan in combination with a fixed dose of fluorouracil (5-FU) and leucovorin (LV) and panitumumab as part of the approximately 6 year study duration.",[13,14,16,34],"Drug: Panitumumab",{"label":36,"type":10,"description":37,"interventionNames":38},"Substudy 2: Dose Expansion Telisotuzumab Adizutecan High Dose","Participants will receive the high dose of telisotuzumab adizutecan determined in the dose expansion arm in combination with a fixed dose of 5-FU\u002FLV and panitumumab as part of the approximately 6 year study duration.",[13,14,16,34],{"label":40,"type":10,"description":41,"interventionNames":42},"Substudy 2: Dose Expansion Telisotuzumab Adizutecan Low Dose","Participants will receive the low dose of telisotuzumab adizutecan determined in the dose expansion arm in combination with a fixed dose of 5-FU\u002FLV and panitumumab as part of the approximately 6 year study duration.",[13,14,16,34],{"label":44,"type":10,"description":45,"interventionNames":46},"Substudy 2: Dose Expansion Compatator","Participants will receive a fixed dose of FOLFOX and panitumumab as part of the approximately 6 year study duration.",[14,15,16,34],[48,54,58,62,65,68],{"type":49,"name":50,"description":51,"armGroupLabels":52,"otherNames":53},"DRUG","Telisotuzumab Adizutecan","Intravenous (IV) Infusion",[9,19,23,31,36,40],null,{"type":49,"name":55,"description":56,"armGroupLabels":57,"otherNames":53},"Fluorouracil","IV Infusion; IV Injection",[9,27,19,23,31,44,36,40],{"type":49,"name":59,"description":60,"armGroupLabels":61,"otherNames":53},"Oxaliplatin","IV Infusion",[9,27,19,23,44],{"type":49,"name":63,"description":56,"armGroupLabels":64,"otherNames":53},"Leucovorin",[9,27,19,23,31,44,36,40],{"type":49,"name":66,"description":60,"armGroupLabels":67,"otherNames":53},"Bevacizumab",[9,27,19,23],{"type":49,"name":69,"description":60,"armGroupLabels":70,"otherNames":53},"Panitumumab",[31,44,36,40],[72],{"name":73,"affiliation":5,"role":74},"ABBVIE INC.","STUDY_DIRECTOR",[76],{"name":77,"role":78,"phone":79,"phoneExt":53,"email":80},"ABBVIE CALL CENTER","CONTACT","844-663-3742","abbvieclinicaltrials@abbvie.com",[82,96,105,115,125,134,144,154,164,174,184,194,203,213,223,235,249,259,269,279,290,302,312,322,331,339,345,356,365,377,387,396,408,416,428,437,446,455,461,473,478,483,493,498,509,518,530,539,550,556,565,574,580],{"facility":83,"status":84,"city":85,"state":86,"zip":87,"country":88,"countryCode":89,"cosmosGeoPoint":90,"geoPoint":95,"contacts":53},"City of Hope National Medical Center \u002FID# 270255","RECRUITING","Duarte","California","91010","United States","US",{"type":91,"coordinates":92},"Point",[93,94],-117.97729,34.13945,{"lat":94,"lon":93},{"facility":97,"status":84,"city":98,"state":86,"zip":99,"country":88,"countryCode":89,"cosmosGeoPoint":100,"geoPoint":104,"contacts":53},"UCLA - Santa Monica \u002FID# 270621","Santa Monica","90404",{"type":91,"coordinates":101},[102,103],-118.49138,34.01949,{"lat":103,"lon":102},{"facility":106,"status":84,"city":107,"state":108,"zip":109,"country":88,"countryCode":89,"cosmosGeoPoint":110,"geoPoint":114,"contacts":53},"Yale New Haven Hospital \u002FID# 270565","New Haven","Connecticut","06510",{"type":91,"coordinates":111},[112,113],-72.92816,41.30815,{"lat":113,"lon":112},{"facility":116,"status":84,"city":117,"state":118,"zip":119,"country":88,"countryCode":89,"cosmosGeoPoint":120,"geoPoint":124,"contacts":53},"University of Chicago Medical Center \u002FID# 271688","Chicago","Illinois","60637",{"type":91,"coordinates":121},[122,123],-87.65005,41.85003,{"lat":123,"lon":122},{"facility":126,"status":84,"city":127,"state":118,"zip":128,"country":88,"countryCode":89,"cosmosGeoPoint":129,"geoPoint":133,"contacts":53},"Hope And Healing Cancer Services \u002FID# 271562","Hinsdale","60521",{"type":91,"coordinates":130},[131,132],-87.93701,41.80086,{"lat":132,"lon":131},{"facility":135,"status":84,"city":136,"state":137,"zip":138,"country":88,"countryCode":89,"cosmosGeoPoint":139,"geoPoint":143,"contacts":53},"Dana-Farber Cancer Institute \u002FID# 270624","Boston","Massachusetts","02215",{"type":91,"coordinates":140},[141,142],-71.05977,42.35843,{"lat":142,"lon":141},{"facility":145,"status":84,"city":146,"state":147,"zip":148,"country":88,"countryCode":89,"cosmosGeoPoint":149,"geoPoint":153,"contacts":53},"Saint Lukes Hospital of Kansas City \u002FID# 270633","Kansas City","Missouri","64111",{"type":91,"coordinates":150},[151,152],-94.57857,39.09973,{"lat":152,"lon":151},{"facility":155,"status":84,"city":156,"state":157,"zip":158,"country":88,"countryCode":89,"cosmosGeoPoint":159,"geoPoint":163,"contacts":53},"Nebraska Cancer Specialists - Omaha - Wright Street \u002FID# 271646","Omaha","Nebraska","68130",{"type":91,"coordinates":160},[161,162],-95.94043,41.25626,{"lat":162,"lon":161},{"facility":165,"status":84,"city":166,"state":167,"zip":168,"country":88,"countryCode":89,"cosmosGeoPoint":169,"geoPoint":173,"contacts":53},"University of North Carolina Medical Center \u002FID# 267786","Chapel Hill","North Carolina","27514",{"type":91,"coordinates":170},[171,172],-79.05584,35.9132,{"lat":172,"lon":171},{"facility":175,"status":84,"city":176,"state":177,"zip":178,"country":88,"countryCode":89,"cosmosGeoPoint":179,"geoPoint":183,"contacts":53},"Oncology Hematology Care - Eastgate \u002FID# 271493","Cincinnati","Ohio","45245",{"type":91,"coordinates":180},[181,182],-84.51439,39.12711,{"lat":182,"lon":181},{"facility":185,"status":84,"city":186,"state":187,"zip":188,"country":88,"countryCode":89,"cosmosGeoPoint":189,"geoPoint":193,"contacts":53},"Texas Oncology - Austin Midtown \u002FID# 271354","Austin","Texas","78705",{"type":91,"coordinates":190},[191,192],-97.74306,30.26715,{"lat":192,"lon":191},{"facility":195,"status":84,"city":196,"state":187,"zip":197,"country":88,"countryCode":89,"cosmosGeoPoint":198,"geoPoint":202,"contacts":53},"Texas Oncology - Deke Slayton Cancer Center \u002FID# 271355","Webster","77598",{"type":91,"coordinates":199},[200,201],-95.11826,29.53773,{"lat":201,"lon":200},{"facility":204,"status":84,"city":205,"state":206,"zip":207,"country":88,"countryCode":89,"cosmosGeoPoint":208,"geoPoint":212,"contacts":53},"Virginia Cancer Specialists - Fairfax \u002FID# 271351","Fairfax","Virginia","22031",{"type":91,"coordinates":209},[210,211],-77.30637,38.84622,{"lat":211,"lon":210},{"facility":214,"status":84,"city":215,"state":216,"zip":217,"country":88,"countryCode":89,"cosmosGeoPoint":218,"geoPoint":222,"contacts":53},"University Of Washington-Fred Hutchinson Cancer Center - Seattle \u002FID# 271298","Seattle","Washington","98109",{"type":91,"coordinates":219},[220,221],-122.33207,47.60621,{"lat":221,"lon":220},{"facility":224,"status":84,"city":225,"state":226,"zip":227,"country":228,"countryCode":229,"cosmosGeoPoint":230,"geoPoint":234,"contacts":53},"Macquarie University \u002FID# 271514","Sydney","New South Wales","2109","Australia","AU",{"type":91,"coordinates":231},[232,233],151.20732,-33.86785,{"lat":233,"lon":232},{"facility":236,"status":84,"city":237,"state":238,"zip":239,"country":228,"countryCode":229,"cosmosGeoPoint":240,"geoPoint":244,"contacts":245},"Mater Hospital Brisbane \u002FID# 270694","South Brisbane","Queensland","4101",{"type":91,"coordinates":241},[242,243],153.02049,-27.48034,{"lat":243,"lon":242},[246],{"name":247,"role":78,"phone":248,"phoneExt":53,"email":53},"Site Coordinator","+61731632341",{"facility":250,"status":84,"city":251,"state":252,"zip":253,"country":228,"countryCode":229,"cosmosGeoPoint":254,"geoPoint":258,"contacts":53},"The Queen Elizabeth Hospital \u002FID# 270693","Woodville South","South Australia","5011",{"type":91,"coordinates":255},[256,257],138.53477,-34.88186,{"lat":257,"lon":256},{"facility":260,"status":84,"city":261,"state":262,"zip":263,"country":228,"countryCode":229,"cosmosGeoPoint":264,"geoPoint":268,"contacts":53},"Austin Health \u002FID# 270692","Heidelberg","Victoria","3084",{"type":91,"coordinates":265},[266,267],145.06667,-37.75,{"lat":267,"lon":266},{"facility":270,"status":84,"city":271,"state":272,"zip":273,"country":228,"countryCode":229,"cosmosGeoPoint":274,"geoPoint":278,"contacts":53},"One Clinical Research \u002FID# 270695","Nedlands","Western Australia","6009",{"type":91,"coordinates":275},[276,277],115.8073,-31.98184,{"lat":277,"lon":276},{"facility":280,"status":84,"city":281,"state":53,"zip":282,"country":283,"countryCode":284,"cosmosGeoPoint":285,"geoPoint":289,"contacts":53},"Medizinische Universitaet Wien \u002FID# 268872","Vienna","1090","Austria","AT",{"type":91,"coordinates":286},[287,288],16.37208,48.20849,{"lat":288,"lon":287},{"facility":291,"status":84,"city":292,"state":293,"zip":294,"country":295,"countryCode":296,"cosmosGeoPoint":297,"geoPoint":301,"contacts":53},"Hospital Sao Rafael \u002FID# 271681","Salvador","Estado de Bahia","41253-190","Brazil","BR",{"type":91,"coordinates":298},[299,300],-38.49096,-12.97563,{"lat":300,"lon":299},{"facility":303,"status":84,"city":304,"state":305,"zip":306,"country":295,"countryCode":296,"cosmosGeoPoint":307,"geoPoint":311,"contacts":53},"Oncosite - Centro de Pesquisa Clinica em Oncologia \u002FID# 270147","Ijuí","Rio Grande do Sul","98700-000",{"type":91,"coordinates":308},[309,310],-53.91472,-28.38778,{"lat":310,"lon":309},{"facility":313,"status":84,"city":314,"state":315,"zip":316,"country":295,"countryCode":296,"cosmosGeoPoint":317,"geoPoint":321,"contacts":53},"Hospital De Amor \u002FID# 271874","Barretos","São Paulo","14784-400",{"type":91,"coordinates":318},[319,320],-48.56778,-20.55722,{"lat":320,"lon":319},{"facility":323,"status":84,"city":324,"state":315,"zip":325,"country":295,"countryCode":296,"cosmosGeoPoint":326,"geoPoint":330,"contacts":53},"Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto \u002FID# 271651","São José do Rio Preto","15090-000",{"type":91,"coordinates":327},[328,329],-49.37944,-20.81972,{"lat":329,"lon":328},{"facility":332,"status":84,"city":315,"state":53,"zip":333,"country":295,"countryCode":296,"cosmosGeoPoint":334,"geoPoint":338,"contacts":53},"Instituto D'Or de Pesquisa e Ensino - Regional Sao Paulo \u002FID# 270546","01401-002",{"type":91,"coordinates":335},[336,337],-46.63611,-23.5475,{"lat":337,"lon":336},{"facility":340,"status":84,"city":315,"state":53,"zip":341,"country":295,"countryCode":296,"cosmosGeoPoint":342,"geoPoint":344,"contacts":53},"Nucleo De Pesquisa Clinica Da Rede Sao Camilo \u002FID# 272311","04014-002",{"type":91,"coordinates":343},[336,337],{"lat":337,"lon":336},{"facility":346,"status":84,"city":347,"state":348,"zip":349,"country":350,"countryCode":53,"cosmosGeoPoint":351,"geoPoint":355,"contacts":53},"Fakultni Thomayerova nemocnice \u002FID# 269632","Prague","Praha, Hlavni Mesto","140 59","Czechia",{"type":91,"coordinates":352},[353,354],14.42076,50.08804,{"lat":354,"lon":353},{"facility":357,"status":84,"city":358,"state":53,"zip":359,"country":350,"countryCode":53,"cosmosGeoPoint":360,"geoPoint":364,"contacts":53},"Fakultni nemocnice Hradec Kralove - Sokolska \u002FID# 268773","Hradec Králové","500 05",{"type":91,"coordinates":361},[362,363],15.83277,50.20923,{"lat":363,"lon":362},{"facility":366,"status":84,"city":367,"state":368,"zip":369,"country":370,"countryCode":371,"cosmosGeoPoint":372,"geoPoint":376,"contacts":53},"Chu De Lille - Hopital Claude Huriez \u002FID# 270222","Lille","Hauts-de-France","59037","France","FR",{"type":91,"coordinates":373},[374,375],3.05512,50.63391,{"lat":375,"lon":374},{"facility":378,"status":84,"city":379,"state":380,"zip":381,"country":370,"countryCode":371,"cosmosGeoPoint":382,"geoPoint":386,"contacts":53},"Centre Hospitalier Universitaire de Poitiers \u002FID# 270225","Poitiers","New Aquitaine","86021",{"type":91,"coordinates":383},[384,385],0.34348,46.58261,{"lat":385,"lon":384},{"facility":388,"status":84,"city":389,"state":53,"zip":390,"country":370,"countryCode":371,"cosmosGeoPoint":391,"geoPoint":395,"contacts":53},"Hôpital Européen Georges Pompidou \u002FID# 270224","Paris","75015",{"type":91,"coordinates":392},[393,394],2.3488,48.85341,{"lat":394,"lon":393},{"facility":397,"status":84,"city":398,"state":399,"zip":400,"country":401,"countryCode":402,"cosmosGeoPoint":403,"geoPoint":407,"contacts":53},"St. Luke's Hospital \u002FID# 269963","Panórama","Thessaloniki","55236","Greece","GR",{"type":91,"coordinates":404},[405,406],23.0315,40.58779,{"lat":406,"lon":405},{"facility":409,"status":84,"city":399,"state":53,"zip":410,"country":401,"countryCode":402,"cosmosGeoPoint":411,"geoPoint":415,"contacts":53},"Theagenio Cancer Hospital \u002FID# 269640","54639",{"type":91,"coordinates":412},[413,414],22.93493,40.64072,{"lat":414,"lon":413},{"facility":417,"status":84,"city":418,"state":419,"zip":420,"country":421,"countryCode":422,"cosmosGeoPoint":423,"geoPoint":427,"contacts":53},"Rabin Medical Center. \u002FID# 268008","Petah Tikva","Central District","4941492","Israel","IL",{"type":91,"coordinates":424},[425,426],34.88747,32.08707,{"lat":426,"lon":425},{"facility":429,"status":84,"city":430,"state":430,"zip":431,"country":421,"countryCode":422,"cosmosGeoPoint":432,"geoPoint":436,"contacts":53},"Tel Aviv Sourasky Medical Center \u002FID# 268010","Tel Aviv","6423906",{"type":91,"coordinates":433},[434,435],34.78057,32.08088,{"lat":435,"lon":434},{"facility":438,"status":84,"city":439,"state":53,"zip":440,"country":421,"countryCode":422,"cosmosGeoPoint":441,"geoPoint":445,"contacts":53},"Rambam Health Care Campus- Haifa \u002FID# 268006","Haifa","3109601",{"type":91,"coordinates":442},[443,444],34.99928,32.81303,{"lat":444,"lon":443},{"facility":447,"status":84,"city":448,"state":53,"zip":449,"country":421,"countryCode":422,"cosmosGeoPoint":450,"geoPoint":454,"contacts":53},"Shaare Zedek Medical Center \u002FID# 268009","Jerusalem","9103102",{"type":91,"coordinates":451},[452,453],35.21633,31.76904,{"lat":453,"lon":452},{"facility":456,"status":84,"city":448,"state":53,"zip":457,"country":421,"countryCode":422,"cosmosGeoPoint":458,"geoPoint":460,"contacts":53},"Hadassah Medical Center-Hebrew University \u002FID# 268007","91120",{"type":91,"coordinates":459},[452,453],{"lat":453,"lon":452},{"facility":462,"status":84,"city":463,"state":464,"zip":465,"country":466,"countryCode":467,"cosmosGeoPoint":468,"geoPoint":472,"contacts":53},"Aichi Cancer Center \u002FID# 270113","Nagoya","Aichi-ken","464-8681","Japan","JP",{"type":91,"coordinates":469},[470,471],136.90641,35.18147,{"lat":471,"lon":470},{"facility":474,"status":84,"city":475,"state":476,"zip":477,"country":466,"countryCode":467,"cosmosGeoPoint":53,"geoPoint":53,"contacts":53},"National Cancer Center Hospital East \u002FID# 270114","Kashiwa-shi","Chiba","277-8577",{"facility":479,"status":84,"city":480,"state":481,"zip":482,"country":466,"countryCode":467,"cosmosGeoPoint":53,"geoPoint":53,"contacts":53},"St Marianna University School Of Medicine \u002FID# 270111","Kawasaki-shi","Kanagawa","216-8511",{"facility":484,"status":84,"city":485,"state":486,"zip":487,"country":466,"countryCode":467,"cosmosGeoPoint":488,"geoPoint":492,"contacts":53},"Tohoku University Hospital \u002FID# 270966","Sendai","Miyagi","980-8574",{"type":91,"coordinates":489},[490,491],140.86667,38.26667,{"lat":491,"lon":490},{"facility":494,"status":84,"city":495,"state":496,"zip":497,"country":466,"countryCode":467,"cosmosGeoPoint":53,"geoPoint":53,"contacts":53},"National Cancer Center Hospital \u002FID# 270112","Chuo-Ku","Tokyo","104-0045",{"facility":499,"status":84,"city":500,"state":53,"zip":501,"country":502,"countryCode":503,"cosmosGeoPoint":504,"geoPoint":508,"contacts":53},"Pan American Center for Oncology Trials - Rio Piedras \u002FID# 268809","Rio Piedras","00935","Puerto Rico","PR",{"type":91,"coordinates":505},[506,507],-66.04989,18.39745,{"lat":507,"lon":506},{"facility":510,"status":84,"city":511,"state":53,"zip":512,"country":502,"countryCode":503,"cosmosGeoPoint":513,"geoPoint":517,"contacts":53},"Puerto Rico Medical Research Center \u002FID# 268825","San Juan","00917-5022",{"type":91,"coordinates":514},[515,516],-66.10572,18.46633,{"lat":516,"lon":515},{"facility":519,"status":84,"city":520,"state":521,"zip":522,"country":523,"countryCode":524,"cosmosGeoPoint":525,"geoPoint":529,"contacts":53},"Hospital Universitario Marques de Valdecilla \u002FID# 269732","Santander","Cantabria","39008","Spain","ES",{"type":91,"coordinates":526},[527,528],-3.80493,43.46589,{"lat":528,"lon":527},{"facility":531,"status":84,"city":532,"state":53,"zip":533,"country":523,"countryCode":524,"cosmosGeoPoint":534,"geoPoint":538,"contacts":53},"Hospital Universitario Vall de Hebron \u002FID# 270191","Barcelona","08035",{"type":91,"coordinates":535},[536,537],2.15899,41.38879,{"lat":537,"lon":536},{"facility":540,"status":84,"city":541,"state":53,"zip":542,"country":543,"countryCode":544,"cosmosGeoPoint":545,"geoPoint":549,"contacts":53},"Kaohsiung Medical University Chung-Ho Memorial Hospital \u002FID# 269724","Kaohsiung City","807","Taiwan","TW",{"type":91,"coordinates":546},[547,548],120.31333,22.61626,{"lat":548,"lon":547},{"facility":551,"status":84,"city":541,"state":53,"zip":552,"country":543,"countryCode":544,"cosmosGeoPoint":553,"geoPoint":555,"contacts":53},"Kaohsiung Chang Gung Memorial Hospital \u002FID# 269726","833",{"type":91,"coordinates":554},[547,548],{"lat":548,"lon":547},{"facility":557,"status":84,"city":558,"state":53,"zip":559,"country":543,"countryCode":544,"cosmosGeoPoint":560,"geoPoint":564,"contacts":53},"National Cheng Kung University Hospital \u002FID# 270835","Tainan","704",{"type":91,"coordinates":561},[562,563],120.21333,22.99083,{"lat":563,"lon":562},{"facility":566,"status":84,"city":567,"state":53,"zip":568,"country":543,"countryCode":544,"cosmosGeoPoint":569,"geoPoint":573,"contacts":53},"National Taiwan University Hospital \u002FID# 269717","Taipei","100",{"type":91,"coordinates":570},[571,572],121.52639,25.05306,{"lat":572,"lon":571},{"facility":575,"status":84,"city":567,"state":53,"zip":576,"country":543,"countryCode":544,"cosmosGeoPoint":577,"geoPoint":579,"contacts":53},"Taipei Veterans General Hospital \u002FID# 269718","112",{"type":91,"coordinates":578},[571,572],{"lat":572,"lon":571},{"facility":581,"status":84,"city":582,"state":53,"zip":583,"country":543,"countryCode":544,"cosmosGeoPoint":584,"geoPoint":588,"contacts":53},"Linkou Chang Gung Memorial Hospital \u002FID# 269725","Taoyuan City","333",{"type":91,"coordinates":585},[586,587],121.29696,24.99368,{"lat":587,"lon":586},{"type":590,"investigatorFullName":53,"investigatorTitle":53,"investigatorAffiliation":53,"oldNameTitle":53,"oldOrganization":53},"SPONSOR","100579143",false,"NCT06820463","A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid\u002FLeucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer","A Phase 2, Open-Label, Randomized, Master Protocol Study to Evaluate Safety and Efficacy of Multiple Treatment Combinations With Telisotuzumab Adizutecan in Subjects With Metastatic Colorectal Cancer","AndroMETa-CRC","Inclusion Criteria:\n\n* Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.\n* Laboratory values meeting the criteria within the protocol.\n* Has measurable disease per response evaluation criteria in solid tumors (RECIST) v1.1.\n\nExclusion Criteria:\n\n* Prior systemic regimen containing c-Met targeting agent(s) (e.g., antibody, antibody drug conjugate, bispecific) and\u002For any topoisomerase inhibitor(s) (e.g., irinotecan).\n* History of other malignancies within 5 years prior to screening, except for malignancies with a negligible risk of metastasis or death.","ALL","18 Years",{"count":601,"type":602},390,"ESTIMATED","INTERVENTIONAL",[605],"PHASE2","CRC is the third most common type of cancer diagnosed worldwide with developed countries at highest risk. The purpose of this study is to assess adverse events and change in disease activity when telisotuzumab adizutecan is given in combination with oxaliplatin, fluorouracil (5FU), leucovorin (LV) (FOLFOX), and bevacizumab or panitumumab.\n\nTelisotuzumab adizutecan is an investigational drug being developed for the treatment of mCRC. Fluorouracil and leucovorin are drugs approved for the treatment of mCRC. This study will be divided into two stages, with the first stage treating participants with increasing doses of telisotuzumab adizutecan with FOLFOX and bevacizumab or 5FU\u002FLV and panitumumab until the dose reached is tolerable and expected to be efficacious. Participants will then be randomized into 3 groups called treatment arms where one group will receive one of two optimized doses of telisotuzumab adizutecan from the dose escalation phase with FOLFOX and bevacizumab or 5FU\u002FLV and panitumumab, or a comparator of FOLFOX and bevacizumab or panitumumab. Approximately 390 adult participants with mCRC will be enrolled in the study in 100 sites worldwide.\n\nIn the dose escalation stage participants will be treated with increasing intravenous (IV) doses of telisotuzumab adizutecan with FOLFOX and bevacizumab or 5FU\u002FLV and panitumumab until the dose reached is tolerable and expected to be efficacious. In the dose optimization stage participants will be receive FOLFOX or receive 5FU\u002FLV, but with one of two optimized doses of telisotuzumab adizutecan, or a comparator of FOLFOX and bevacizumab\u002Fpantitumumab. The study will run for a duration of approximately 6 years.\n\nThere may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at an approved institution (hospital or clinic). The effect of the treatment will be frequently checked by medical assessments, blood tests, questionnaires and side effects.",[608],"Metastatic Colorectal Cancer",[608,610,50],"AndroMETa-CRC-533","2026-06-26",{"date":613,"type":614},"2026-06-30","ACTUAL",{"date":616,"type":614},"2025-04-24",{"date":618,"type":602},"2028-04",{"name":5,"class":6},53]