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7920002","Kayseri","38039",{"type":66,"coordinates":711},[712,713],35.48528,38.73222,{"lat":713,"lon":712},{"facility":716,"status":59,"city":717,"state":718,"zip":719,"country":720,"countryCode":721,"cosmosGeoPoint":722,"geoPoint":726,"contacts":36},"Investigational Site Number : 8260001","Leicester","Leicestershire","LE5 4PW","United Kingdom","UK",{"type":66,"coordinates":723},[724,725],-1.13169,52.6386,{"lat":725,"lon":724},{"facility":728,"status":59,"city":729,"state":730,"zip":731,"country":720,"countryCode":721,"cosmosGeoPoint":732,"geoPoint":736,"contacts":36},"Investigational Site Number : 8260004","Salford","Manchester","M6 8HD",{"type":66,"coordinates":733},[734,735],-2.29042,53.48771,{"lat":735,"lon":734},{"facility":738,"status":59,"city":739,"state":740,"zip":741,"country":720,"countryCode":721,"cosmosGeoPoint":742,"geoPoint":746,"contacts":36},"Investigational Site Number : 8260005","Oxford","Oxfordshire","OX3 7LE",{"type":66,"coordinates":743},[744,745],-1.25596,51.75222,{"lat":745,"lon":744},{"type":748,"investigatorFullName":36,"investigatorTitle":36,"investigatorAffiliation":36,"oldNameTitle":36,"oldOrganization":36},"SPONSOR","100554562","phase-2-a-study-to-evaluate-the-efficacy-and-safety-of-frexalimab-brivekimig-or-rilzabrutinib-in-participants-aged-16-to-75-years-with-primary-focal-segmental-glomerulosclerosis-or-minimal-change-disease-100554562",false,"NCT06500702","A Study to Evaluate the Efficacy and Safety of Frexalimab, Brivekimig, or Rilzabrutinib in Participants Aged 16 to 75 Years With Primary Focal Segmental Glomerulosclerosis or Minimal Change Disease","A Parallel-group Treatment, Phase 2a, Multicenter, Randomized, Double-blind, Placebo-controlled Umbrella Study to Evaluate the Efficacy and Safety of Frexalimab, Brivekimig, and Rilzabrutinib in Participants Aged 16 to 75 Years With Primary Focal Segmental Glomerulosclerosis (FSGS) or Minimal Change Disease (MCD)","RESULT","Inclusion Criteria:\n\n* Biopsy report indicative of primary FSGS or primary MCD, with supportive clinical presentation per Investigator's judgement.\n* UPCR ≥3 g\u002Fg at screening, or ≥ 1.5 g\u002Fg in those with eGFR ≥ 60.\n* eGFR ≥45 mL\u002Fmin\u002F1.73 m\\^2 at screening.\n* Documented history of UPCR (or 24-hour urine protein) reduction by \\>40% in response to corticosteroid or other immunosuppressive therapy when pre-treatment UPCR was ≥3.5 g\u002Fg (or pre-treatment 24-hr urine protein was ≥3.5 g\u002Fday if 24-hour urine protein is used).\n* ≤10 mg\u002Fday prednisone or equivalent and stable starting at least 1 week prior to randomization.\n* For those on a RAAS inhibitor prior to screening, the dose must be stable ≥4 weeks prior to screening; starting RAAS inhibitors or changing the dose will not be allowed during the double-blind or OLE treatment period.\n* For those on an SGLT2 inhibitor prior to screening, the dose must be stable ≥4 weeks prior to screening; starting SGLT2 inhibitor treatment or changing the dose will not be allowed during the double-blind or OLE treatment periods.\n* Body weight within 45 to 120 kg (inclusive) at screening.\n\nExclusion Criteria:\n\n* Genetic or secondary FSGS or MCD. Those with APOL1 risk alleles are eligible.\n* Collapsing variant of FSGS.\n* ESKD requiring dialysis or transplantation.\n\nThe above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.","ALL","16 Years","75 Years",{"count":761,"type":762},84,"ESTIMATED","INTERVENTIONAL",[765],"PHASE2","This is a parallel, Phase 2a, double-blind, 6-arm study for the treatment of primary focal segmental glomerulosclerosis (FSGS) or primary minimal change disease (MCD).\n\nThe purpose of this study is to measure the change in proteinuria and its impact on the rates of remission of nephrotic syndrome with frexalimab, brivekimig, or rilzabrutinib compared with placebo in participants with primary FSGS or primary MCD aged 16 to 75 years.\n\nStudy details for each participant include:\n\nThe study duration will be up to 76 weeks. The treatment duration will be 24 weeks. There will be up to 18 visits.",[768,769],"Focal Segmental Glomerulosclerosis","Glomerulonephritis Minimal Lesion","2026-06-04",{"date":772,"type":773},"2026-06-08","ACTUAL",{"date":775,"type":773},"2024-12-19",{"date":777,"type":762},"2028-02-16",{"name":5,"class":6},71]