[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100599299":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":11,"centralContacts":20,"locations":26,"responsibleParty":427,"collaborators":11,"id":429,"slug":430,"hasResults":431,"nctId":432,"briefTitle":433,"officialTitle":434,"acronym":11,"eligibilityCriteria":435,"healthyVolunteers":431,"sex":436,"minAge":437,"maxAge":11,"enrollmentInfo":438,"targetDuration":11,"studyType":441,"phases":442,"briefSummary":444,"conditions":445,"keywords":11,"overallStatus":29,"whyStopped":11,"lastUpdateSubmitDate":447,"lastUpdatePostDateStruct":448,"startDateStruct":451,"completionDateStruct":453,"leadSponsor":455,"locationsCount":456},{"fullName":5,"class":6},"Beijing InnoCare Pharma Tech Co., Ltd.","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"ICP-248Tablets","EXPERIMENTAL",null,[13],"Drug: ICP-248",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":11},"DRUG","ICP-248","Eligible patients will receive ICP-248 orally as per the protocol",[9],[21],{"name":22,"role":23,"phone":24,"phoneExt":11,"email":25},"Alexia Lu","CONTACT","010-66609745","CO_HGRAC@innocarepharma.com",[27,46,61,75,90,101,116,131,142,157,172,183,194,209,224,238,251,266,281,296,307,318,332,347,357,369,383,398,412],{"facility":28,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"The First Affiliated Hospital of Anhui Medical University","RECRUITING","Hefei","Anhui","230022","China","CN",{"type":36,"coordinates":37},"Point",[38,39],117.28083,31.86389,{"lat":39,"lon":38},[42],{"name":43,"role":23,"phone":44,"phoneExt":11,"email":45},"Jian Ge","0551-62922800","Gejian52@163.com",{"facility":47,"status":29,"city":48,"state":49,"zip":50,"country":33,"countryCode":34,"cosmosGeoPoint":51,"geoPoint":55,"contacts":56},"Peking University Third Hospital","Beijing","Beijing Municipality","100919",{"type":36,"coordinates":52},[53,54],116.39723,39.9075,{"lat":54,"lon":53},[57],{"name":58,"role":23,"phone":59,"phoneExt":11,"email":60},"Hongmei Jing","010-82267893","bysyjhm@163.com",{"facility":62,"status":29,"city":63,"state":63,"zip":64,"country":33,"countryCode":34,"cosmosGeoPoint":65,"geoPoint":69,"contacts":70},"West China Hospital of Sichuan University","Chengdu","610041",{"type":36,"coordinates":66},[67,68],104.06667,30.66667,{"lat":68,"lon":67},[71],{"name":72,"role":23,"phone":73,"phoneExt":11,"email":74},"Liqun Zou","028-85422114","hxlcyxy@163.com",{"facility":76,"status":29,"city":77,"state":78,"zip":79,"country":33,"countryCode":34,"cosmosGeoPoint":80,"geoPoint":84,"contacts":85},"The First Affiliated Hospital of Chongqing Medical University","Chongqing","Chongqing Municipality","400016",{"type":36,"coordinates":81},[82,83],106.55771,29.56026,{"lat":83,"lon":82},[86],{"name":87,"role":23,"phone":88,"phoneExt":11,"email":89},"Li Wang","023-68811360","liwangls@yahoo.com",{"facility":91,"status":29,"city":77,"state":78,"zip":92,"country":33,"countryCode":34,"cosmosGeoPoint":93,"geoPoint":95,"contacts":96},"Chongqing University Cancer Hospital","400030",{"type":36,"coordinates":94},[82,83],{"lat":83,"lon":82},[97],{"name":98,"role":23,"phone":99,"phoneExt":11,"email":100},"Qiying Li","023-65301682","349331690@qq.com",{"facility":102,"status":29,"city":103,"state":104,"zip":105,"country":33,"countryCode":34,"cosmosGeoPoint":106,"geoPoint":110,"contacts":111},"Fujian Medical University Union Hospital","Fuzhou","Fujian","350001",{"type":36,"coordinates":107},[108,109],119.30611,26.06139,{"lat":109,"lon":108},[112],{"name":113,"role":23,"phone":114,"phoneExt":11,"email":115},"Jianzhen Shen","0591-83357896","Doctorsjz@163.com",{"facility":117,"status":29,"city":118,"state":119,"zip":120,"country":33,"countryCode":34,"cosmosGeoPoint":121,"geoPoint":125,"contacts":126},"Sun Yat-sen University Cancer Center","Guangzhou","Guangdong","510050",{"type":36,"coordinates":122},[123,124],113.25,23.11667,{"lat":124,"lon":123},[127],{"name":128,"role":23,"phone":129,"phoneExt":11,"email":130},"Zhiming Li","020-87343560","lizhm@sysucc.org.cn",{"facility":132,"status":29,"city":118,"state":119,"zip":133,"country":33,"countryCode":34,"cosmosGeoPoint":134,"geoPoint":136,"contacts":137},"Guangdong Provincial People's Hospital","510080",{"type":36,"coordinates":135},[123,124],{"lat":124,"lon":123},[138],{"name":139,"role":23,"phone":140,"phoneExt":11,"email":141},"Wenyu Li","020-83827812","gcpliwy@126.com",{"facility":143,"status":29,"city":144,"state":145,"zip":146,"country":33,"countryCode":34,"cosmosGeoPoint":147,"geoPoint":151,"contacts":152},"Guangxi Medical University Cancer Hospital","Nanning","Guangxi","530012",{"type":36,"coordinates":148},[149,150],108.31667,22.81667,{"lat":150,"lon":149},[153],{"name":154,"role":23,"phone":155,"phoneExt":11,"email":156},"Zhe Li","0771-5331955","li_zhe811@163.com",{"facility":158,"status":29,"city":159,"state":160,"zip":161,"country":33,"countryCode":34,"cosmosGeoPoint":162,"geoPoint":166,"contacts":167},"Henan Cancer Hospital","Zhengzhou","Henan","450000",{"type":36,"coordinates":163},[164,165],113.64861,34.75778,{"lat":165,"lon":164},[168],{"name":169,"role":23,"phone":170,"phoneExt":11,"email":171},"Keshu Zhou","4000371818","dr_zkshu23810@163.com",{"facility":173,"status":29,"city":159,"state":160,"zip":174,"country":33,"countryCode":34,"cosmosGeoPoint":175,"geoPoint":177,"contacts":178},"Henan Provincial People's Hospital","450003",{"type":36,"coordinates":176},[164,165],{"lat":165,"lon":164},[179],{"name":180,"role":23,"phone":181,"phoneExt":11,"email":182},"Zunmin Zhu","0371-96195","zhuzm1964@163.com",{"facility":184,"status":29,"city":159,"state":160,"zip":185,"country":33,"countryCode":34,"cosmosGeoPoint":186,"geoPoint":188,"contacts":189},"The First Affiliated Hospital of Zhengzhou University","451191",{"type":36,"coordinates":187},[164,165],{"lat":165,"lon":164},[190],{"name":191,"role":23,"phone":192,"phoneExt":11,"email":193},"Xudong Zhang","0371-67966263","feverxxd@126.com",{"facility":195,"status":29,"city":196,"state":197,"zip":198,"country":33,"countryCode":34,"cosmosGeoPoint":199,"geoPoint":203,"contacts":204},"Union Hospital Tongji Medical College Huazhong University of Science and Technology","Wuhan","Hubei","430022",{"type":36,"coordinates":200},[201,202],114.26667,30.58333,{"lat":202,"lon":201},[205],{"name":206,"role":23,"phone":207,"phoneExt":11,"email":208},"Jun Fang","027-85726114","fangjuntj@126.com",{"facility":210,"status":29,"city":211,"state":212,"zip":213,"country":33,"countryCode":34,"cosmosGeoPoint":214,"geoPoint":218,"contacts":219},"Hunan Cancer Hospital","Changsha","Hunan","410000",{"type":36,"coordinates":215},[216,217],112.97087,28.19874,{"lat":217,"lon":216},[220],{"name":221,"role":23,"phone":222,"phoneExt":11,"email":223},"Hui Zhou","0731-88651900","zhouhui9403@126.com",{"facility":225,"status":29,"city":226,"state":212,"zip":227,"country":33,"countryCode":34,"cosmosGeoPoint":228,"geoPoint":232,"contacts":233},"The First Affiliated Hospital of University of South China","Hengyang","421001",{"type":36,"coordinates":229},[230,231],112.61888,26.88946,{"lat":231,"lon":230},[234],{"name":235,"role":23,"phone":236,"phoneExt":11,"email":237},"Zeyu Luo","0734-8279467","luozeyu0827@sina.com",{"facility":239,"status":29,"city":240,"state":241,"zip":242,"country":33,"countryCode":34,"cosmosGeoPoint":243,"geoPoint":247,"contacts":248},"Jiangsu Province Hospital","Nanjing","Jiangsu","210036",{"type":36,"coordinates":244},[245,246],118.77778,32.06167,{"lat":246,"lon":245},[249],{"name":87,"role":23,"phone":11,"phoneExt":11,"email":250},"lilyw7878@163.com",{"facility":252,"status":29,"city":253,"state":254,"zip":255,"country":33,"countryCode":34,"cosmosGeoPoint":256,"geoPoint":260,"contacts":261},"The First Affiliated Hospital of Nanchang University","Nanchang","Jiangxi","330006",{"type":36,"coordinates":257},[258,259],115.85306,28.68396,{"lat":259,"lon":258},[262],{"name":263,"role":23,"phone":264,"phoneExt":11,"email":265},"Fei Li","0791-88603000","lifeigcp2022@163.com",{"facility":267,"status":29,"city":268,"state":269,"zip":270,"country":33,"countryCode":34,"cosmosGeoPoint":271,"geoPoint":275,"contacts":276},"The First Hospital of Jilin University","Changchun","Jilin","130021",{"type":36,"coordinates":272},[273,274],125.32278,43.88,{"lat":274,"lon":273},[277],{"name":278,"role":23,"phone":279,"phoneExt":11,"email":280},"Ou Bai","0431-88782222","lbl2054@163.com",{"facility":282,"status":29,"city":283,"state":284,"zip":285,"country":33,"countryCode":34,"cosmosGeoPoint":286,"geoPoint":290,"contacts":291},"Qilu Hospital of Shandong University","Jinan","Shandong","250012",{"type":36,"coordinates":287},[288,289],116.99722,36.66833,{"lat":289,"lon":288},[292],{"name":293,"role":23,"phone":294,"phoneExt":11,"email":295},"Jingjing Ye","0531-82168888","yejingjing@sdu.edu.cn",{"facility":297,"status":29,"city":283,"state":284,"zip":298,"country":33,"countryCode":34,"cosmosGeoPoint":299,"geoPoint":301,"contacts":302},"Shandong Provincial Hospital Affiliated to Shandong First Medical University","250021",{"type":36,"coordinates":300},[288,289],{"lat":289,"lon":288},[303],{"name":304,"role":23,"phone":305,"phoneExt":11,"email":306},"Xiaosheng Fang","0531-87938911","fxsh_1010@126.com",{"facility":308,"status":29,"city":283,"state":284,"zip":309,"country":33,"countryCode":34,"cosmosGeoPoint":310,"geoPoint":312,"contacts":313},"Shandong Cancer Hospital","250117",{"type":36,"coordinates":311},[288,289],{"lat":289,"lon":288},[314],{"name":315,"role":23,"phone":316,"phoneExt":11,"email":317},"Zengjun Li","0531-87984777","zengjunli@163.com",{"facility":319,"status":29,"city":320,"state":284,"zip":321,"country":33,"countryCode":34,"cosmosGeoPoint":322,"geoPoint":326,"contacts":327},"The Affiliated Hospital of Qingdao University","Qingdao","266003",{"type":36,"coordinates":323},[324,325],120.38042,36.06488,{"lat":325,"lon":324},[328],{"name":329,"role":23,"phone":330,"phoneExt":11,"email":331},"Xia Zhao","0532-82911847","zhaoxia@qdu.edc.cn",{"facility":333,"status":29,"city":334,"state":335,"zip":336,"country":33,"countryCode":34,"cosmosGeoPoint":337,"geoPoint":341,"contacts":342},"Fudan University Shanghai Cancer Center","Shanghai","Shanghai Municipality","200032",{"type":36,"coordinates":338},[339,340],121.45806,31.22222,{"lat":340,"lon":339},[343],{"name":344,"role":23,"phone":345,"phoneExt":11,"email":346},"Qunling Zhang","021-6417 5590","zqldoc@163.com",{"facility":348,"status":29,"city":349,"state":350,"zip":351,"country":33,"countryCode":34,"cosmosGeoPoint":11,"geoPoint":11,"contacts":352},"The Second Affiliated Hospital of Xi'an Jiaotong University","Xian","Shanxi","710004",[353],{"name":354,"role":23,"phone":355,"phoneExt":11,"email":356},"Wanhong Zhao","029-87679000","13991365406@163.com",{"facility":358,"status":29,"city":63,"state":359,"zip":360,"country":33,"countryCode":34,"cosmosGeoPoint":361,"geoPoint":363,"contacts":364},"Sichuan Provincial People's Hospital","Sichuan","610072",{"type":36,"coordinates":362},[67,68],{"lat":68,"lon":67},[365],{"name":366,"role":23,"phone":367,"phoneExt":11,"email":368},"Xiaodong Wang","028-87393999","WXD621025@163.com",{"facility":370,"status":29,"city":371,"state":359,"zip":372,"country":33,"countryCode":34,"cosmosGeoPoint":373,"geoPoint":377,"contacts":378},"The Second People's Hospital of Yibin","Yibin","644000",{"type":36,"coordinates":374},[375,376],104.63994,28.7593,{"lat":376,"lon":375},[379],{"name":380,"role":23,"phone":381,"phoneExt":11,"email":382},"Shihua Huang","0831-8886606","2327208752@qq.com",{"facility":384,"status":29,"city":385,"state":386,"zip":387,"country":33,"countryCode":34,"cosmosGeoPoint":388,"geoPoint":392,"contacts":393},"Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences","Tianjin","Tianjin Municipality","300020",{"type":36,"coordinates":389},[390,391],117.17667,39.14222,{"lat":391,"lon":390},[394],{"name":395,"role":23,"phone":396,"phoneExt":11,"email":397},"Rui Lv","022-23909083","Lvrui.ok2@163.com",{"facility":399,"status":29,"city":400,"state":400,"zip":401,"country":33,"countryCode":34,"cosmosGeoPoint":402,"geoPoint":406,"contacts":407},"The Affiliated Cancer Hospital of Xinjiang Medical University","Xinjiang","830000",{"type":36,"coordinates":403},[404,405],110.38311,40.91904,{"lat":405,"lon":404},[408],{"name":409,"role":23,"phone":410,"phoneExt":11,"email":411},"Shujuan Wen","0991-7968027","736587502@qq.com",{"facility":413,"status":29,"city":414,"state":415,"zip":416,"country":33,"countryCode":34,"cosmosGeoPoint":417,"geoPoint":421,"contacts":422},"The First Affiliated Hospital of Zhejiang University School of Medicine","Hangzhou","Zhejiang","310000",{"type":36,"coordinates":418},[419,420],120.16142,30.29365,{"lat":420,"lon":419},[423],{"name":424,"role":23,"phone":425,"phoneExt":11,"email":426},"Jie Jin","0571-87236114","JIEJ0503@163.com",{"type":428,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100599299","phase-2-a-study-to-evaluate-the-efficacy-and-safety-of-icp-248-in-subjects-with-relapsed-or-refractory-mantle-cell-lymphoma-apex-06-100599299",false,"NCT07082686","A Study to Evaluate the Efficacy and Safety of ICP-248 in Subjects With Relapsed or Refractory Mantle Cell Lymphoma (APEX-06)","A Single-arm, Multi-center, Open-label, Phase 2 Study to Evaluate the Efficacy and Safety of ICP-248 in Subjects With Relapsed or Refractory Mantle Cell Lymphoma","Inclusion Criteria:\n\n* ≥ 18 years old.\n* Histopathologically confirmed MCL expressing Cyclin D1 and\u002For t (11;14) chromosomal translocation.Formalin-fixed paraffin-embedded (FFPE) tissues or sections for diagnosis must be provided. It is for the approval of pathological diagnosis by the central pathology laboratory.\n* The patient was diagnosed with relapsed or refractory mantle cell lymphoma, and the previous treatment needs to meet the following requirements:\n\n  * Failure of at least one adequate prior line of anti-CD20-containing therapy;\n  * Failure of at least one adequate prior line of BTK inhibitor (BTKi)-containing therapy.\n* Failure of the last line of therapy.\n* At least one measurable lesion according to the Lugano 2014 criteria,.\n* ECOG performance status of 0-2 .\n\nExclusion Criteria\n\n* Blastoid or pleomorphic mantle cell lymphoma (MCL).\n* Current or prior history of central nervous system (CNS) lymphoma.\n* Prior use of BCL-2 inhibitors (e.g., venetoclax\u002FABT-199, etc.).\n* Autologous stem cell transplantation or cellular therapy within 3 months prior to the first dose of ICP-248.\n* Prior allogeneic hematopoietic stem cell transplantation.","ALL","18 Years",{"count":439,"type":440},75,"ESTIMATED","INTERVENTIONAL",[443],"PHASE2","This is a single-arm, multi-center, open-label, phase 2 study to evaluate the efficacy and safety of ICP-248 in subjects with relapsed or refractory mantle cell lymphoma.",[446],"Relapsed or Refractory Mantle Cell Lymphoma (MCL)","2026-04-24",{"date":449,"type":450},"2026-04-27","ACTUAL",{"date":452,"type":450},"2025-08-21",{"date":454,"type":440},"2028-07",{"name":5,"class":6},29]