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Virgen Del Rocio","41013",{"type":59,"coordinates":644},[631,632],{"lat":632,"lon":631},{"type":647,"investigatorFullName":34,"investigatorTitle":34,"investigatorAffiliation":34,"oldNameTitle":34,"oldOrganization":34},"SPONSOR","100617688","phase-2-a-study-to-evaluate-the-efficacy-and-safety-of-jnj-88545223-for-the-treatment-of-participants-with-active-psoriatic-arthritis-100617688",false,"NCT07321873","A Study to Evaluate the Efficacy and Safety of JNJ-88545223 for the Treatment of Participants With Active Psoriatic Arthritis","A Phase 2b, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy and Safety of JNJ-88545223 For the Treatment of Participants With Active Psoriatic Arthritis","VELOTA","Inclusion Criteria:\n\n* Have a diagnosis of psoriatic arthritis (PsA) for at least 3 months before the first administration of study intervention and meet classification criteria for Psoriatic Arthritis (CASPAR) at screening\n* Have active PsA as defined by: (a) At least 3 swollen joints and at least 3 tender joints at screening and at baseline (Week 0\u002FDay 1) based on the 66\u002F68 joint assessment; AND (b) C-reactive protein (CRP) greater than or equal to (\\>=) 0.1 milligrams per deciliter (mg\u002FdL) at screening from the central laboratory\n* Have \\>= 1 of the following PsA subsets: distal interphalangeal joint involvement, polyarticular arthritis with absence of rheumatoid nodules, asymmetric peripheral arthritis, or spondylitis with peripheral arthritis\n* Have active plaque psoriasis with at least one psoriatic plaque of \\>= 2 centimeter (cm) diameter or nail changes consistent with psoriasis\n* A female participant of childbearing potential must have a negative highly sensitive serum pregnancy test (Beta-hCG) at screening and a negative urine pregnancy test at Week 0 prior to administration of study intervention\n\nExclusion Criteria:\n\n* Has a nonplaque form of psoriasis (for example, erythrodermic, guttate, or pustular)\n* Has a history or current signs or symptoms of severe, progressive, or uncontrolled renal, hepatic, cardiac, vascular, pulmonary, gastrointestinal, endocrine, neurologic, hematologic, rheumatologic (except PsA), psychiatric, genitourinary, or metabolic disturbances\n* Has suspected or known allergies, hypersensitivity, or intolerance to JNJ-88545223 or excipients used in the investigational medicinal product (IMP), including placebo (JNJ-88545223 investigator's brochure); or has a history of severe allergic reaction, angioedema, or anaphylaxis to drugs or food\n* Has fibromyalgia or osteoarthritis symptoms that, in the opinion of the investigator, would have potential to interfere with efficacy assessments\n* Currently has a malignancy or has a history of malignancy within 5 years prior to screening","ALL","18 Years",{"count":659,"type":660},240,"ESTIMATED","INTERVENTIONAL",[663],"PHASE2","The purpose of this study is to evaluate how well the study drug JNJ-88545223 works compared with a placebo (an inactive substance) in adults with active psoriatic arthritis (PsA). The study aims to see whether treatment with JNJ-88545223 can help reduce the signs and symptoms of PsA and improve joint and skin health.",[666],"Arthritis, Psoriatic","2026-06-04",{"date":669,"type":670},"2026-06-05","ACTUAL",{"date":672,"type":670},"2026-01-15",{"date":674,"type":660},"2027-08-02",{"name":5,"class":6},68]