[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100614835":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":26,"centralContacts":37,"locations":43,"responsibleParty":177,"collaborators":21,"id":179,"slug":180,"hasResults":181,"nctId":182,"briefTitle":183,"officialTitle":184,"acronym":185,"eligibilityCriteria":186,"healthyVolunteers":181,"sex":187,"minAge":188,"maxAge":21,"enrollmentInfo":189,"targetDuration":21,"studyType":192,"phases":193,"briefSummary":195,"conditions":196,"keywords":199,"overallStatus":46,"whyStopped":21,"lastUpdateSubmitDate":202,"lastUpdatePostDateStruct":203,"startDateStruct":206,"completionDateStruct":208,"leadSponsor":210,"locationsCount":211},{"fullName":5,"class":6},"C4 Therapeutics, Inc.","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Cemsidomide + Dexamethasone:","EXPERIMENTAL","Participants receive cemsidomide plus dexamethasone during a 28-day treatment cycle, and will continue to receive treatment until the participant meets one of the discontinuation criteria.",[13,14],"Drug: Cemsidomide","Drug: Dexamethasone",[16,22],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"DRUG","Cemsidomide","dosed orally (PO) once a day (QD) 14 days on\u002F14 days off for each 28-day cycle",[9],null,{"type":17,"name":23,"description":24,"armGroupLabels":25,"otherNames":21},"Dexamethasone","dosed PO once a week (QW) on Days 1, 8, 15, and 22 for each 28-day cycle",[9],[27,31,34],{"name":28,"affiliation":29,"role":30},"Binod Dhakal, M.D.","Medical College of Wisconsin","PRINCIPAL_INVESTIGATOR",{"name":32,"affiliation":33,"role":30},"Martin Kaiser, M.D.","The Royal Marsden",{"name":35,"affiliation":36,"role":30},"Aurore Perrot, M.D.","Universite de Toulouse",[38],{"name":39,"role":40,"phone":41,"phoneExt":21,"email":42},"Study Medical Officer","CONTACT","(617) 231-0700","clinicaltrials@c4therapeutics.com",[44,61,74,87,100,113,126,139,151,164],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"HonorHealth","RECRUITING","Scottsdale","Arizona","85258","United States","US",{"type":53,"coordinates":54},"Point",[55,56],-111.89903,33.50921,{"lat":56,"lon":55},[59],{"name":60,"role":40,"phone":21,"phoneExt":21,"email":21},"Rizwan Khawaja, MD",{"facility":62,"status":46,"city":63,"state":64,"zip":65,"country":50,"countryCode":51,"cosmosGeoPoint":66,"geoPoint":70,"contacts":71},"Berenson Cancer Center","West Hollywood","California","90069",{"type":53,"coordinates":67},[68,69],-118.36174,34.09001,{"lat":69,"lon":68},[72],{"name":73,"role":40,"phone":21,"phoneExt":21,"email":21},"James Berenson, MD",{"facility":75,"status":46,"city":76,"state":77,"zip":78,"country":50,"countryCode":51,"cosmosGeoPoint":79,"geoPoint":83,"contacts":84},"Winship Cancer Institute, Emory University","Atlanta","Georgia","30322",{"type":53,"coordinates":80},[81,82],-84.38798,33.749,{"lat":82,"lon":81},[85],{"name":86,"role":40,"phone":21,"phoneExt":21,"email":21},"Nisha Joseph, MD",{"facility":88,"status":46,"city":89,"state":90,"zip":91,"country":50,"countryCode":51,"cosmosGeoPoint":92,"geoPoint":96,"contacts":97},"Indiana University Health","Indianapolis","Indiana","46202",{"type":53,"coordinates":93},[94,95],-86.15804,39.76838,{"lat":95,"lon":94},[98],{"name":99,"role":40,"phone":21,"phoneExt":21,"email":21},"Attaya Suvannasankha, MD",{"facility":101,"status":46,"city":102,"state":103,"zip":104,"country":50,"countryCode":51,"cosmosGeoPoint":105,"geoPoint":109,"contacts":110},"START Midwest","Grand Rapids","Michigan","49546",{"type":53,"coordinates":106},[107,108],-85.66809,42.96336,{"lat":108,"lon":107},[111],{"name":112,"role":40,"phone":21,"phoneExt":21,"email":21},"Andrew Sochacki, MD",{"facility":114,"status":46,"city":115,"state":116,"zip":117,"country":50,"countryCode":51,"cosmosGeoPoint":118,"geoPoint":122,"contacts":123},"Washington University\u002FSiteman Cancer Center","St Louis","Missouri","63108",{"type":53,"coordinates":119},[120,121],-90.19789,38.62727,{"lat":121,"lon":120},[124],{"name":125,"role":40,"phone":21,"phoneExt":21,"email":21},"Mark Schroeder, MD",{"facility":127,"status":46,"city":128,"state":129,"zip":130,"country":50,"countryCode":51,"cosmosGeoPoint":131,"geoPoint":135,"contacts":136},"University of Nebraska Medical Center","Omaha","Nebraska","68198",{"type":53,"coordinates":132},[133,134],-95.94043,41.25626,{"lat":134,"lon":133},[137],{"name":138,"role":40,"phone":21,"phoneExt":21,"email":21},"Sarah Holstein, MD",{"facility":140,"status":46,"city":141,"state":141,"zip":142,"country":50,"countryCode":51,"cosmosGeoPoint":143,"geoPoint":147,"contacts":148},"Memorial Sloan Kettering Cancer Center","New York","10065",{"type":53,"coordinates":144},[145,146],-74.00597,40.71427,{"lat":146,"lon":145},[149],{"name":150,"role":40,"phone":21,"phoneExt":21,"email":21},"Hamza Hashmi, MD",{"facility":152,"status":46,"city":153,"state":154,"zip":155,"country":50,"countryCode":51,"cosmosGeoPoint":156,"geoPoint":160,"contacts":161},"START San Antonio","San Antonio","Texas","78229",{"type":53,"coordinates":157},[158,159],-98.49363,29.42412,{"lat":159,"lon":158},[162],{"name":163,"role":40,"phone":21,"phoneExt":21,"email":21},"Kyriakos Papadopoulos, MD",{"facility":165,"status":46,"city":166,"state":167,"zip":168,"country":50,"countryCode":51,"cosmosGeoPoint":169,"geoPoint":173,"contacts":174},"University of Wisconsin - Carbone Cancer Center","Madison","Wisconsin","53792",{"type":53,"coordinates":170},[171,172],-89.40123,43.07305,{"lat":172,"lon":171},[175],{"name":176,"role":40,"phone":21,"phoneExt":21,"email":21},"Natalie Callander, MD",{"type":178,"investigatorFullName":21,"investigatorTitle":21,"investigatorAffiliation":21,"oldNameTitle":21,"oldOrganization":21},"SPONSOR","100614835","phase-2-a-study-to-evaluate-the-efficacy-of-cemsidomide--dexamethasone-in-participants-with-relapsedrefractory-multiple-myeloma-100614835",false,"NCT07284758","A Study to Evaluate the Efficacy of Cemsidomide + Dexamethasone in Participants With Relapsed\u002FRefractory Multiple Myeloma","A Phase 2, Open-Label, Single-Arm, Multicenter Study to Evaluate the Efficacy of Cemsidomide + Dexamethasone in Subjects With Relapsed\u002FRefractory Multiple Myeloma","MOMENTUM","Inclusion Criteria:\n\n1. Be willing and able to provide signed informed consent for the study.\n2. Age ≥ 18 years at the time of signed consent.\n3. Subjects must have a documented diagnosis of MM and measurable disease at enrollment.\n4. Received at least 3 prior anti-myeloma regimens (for a minimum of 2 or more consecutive cycles) that must have included an immunomodulatory drug (i.e., IKZF 1\u002F3 degrader), a proteasome inhibitor, an anti-CD38 antibody, and a T-cell engager (TCE) or chimeric antigen receptor T-cell (CAR-T) therapy, unless not available per local standard of care.\n5. Subjects need to have adequate organ function.\n6. Toxicities from prior anticancer therapies must have resolved to baseline severity or CTCAE ≤ Grade 1.\n7. Female subjects may not be pregnant or intend to become pregnant, may not breastfeed or intend to breastfeed, or donate ova during their participation in this study until 30 days after the last dose of study treatment.\n8. Male subjects must agree to use a condom when having intercourse with a person of childbearing potential during the Treatment Period and for at least 30 days after the last dose of study treatment.\n9. Male subjects must refrain from donating sperm during the Treatment Period and for 30 days after discontinuation.\n10. Subjects must refrain from donating blood during study treatment and for 30 days after discontinuation.\n\nExclusion Criteria:\n\n1. Presence of myeloma in the central nervous system (CNS).\n2. Subjects with any of the following:\n\n   * Systemic light chain amyloidosis\n   * Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, and Skin changes (POEMS) Syndrome\n   * Myelodysplastic syndrome (MDS).\n3. Previously treated with cemsidomide.\n4. Clinically significant impaired cardiac function or cardiac disease.\n5. Thromboembolic event within 3 months prior to enrollment.\n6. Known malignancy other than study indication that has progressed or required treatment within the past 3 years.\n7. Uncontrolled active bacterial, fungal, or viral infection.\n8. Inability or difficulty swallowing tablets.\n\nNOTE: Other inclusion\u002Fexclusion criteria may apply, per protocol.","ALL","18 Years",{"count":190,"type":191},100,"ESTIMATED","INTERVENTIONAL",[194],"PHASE2","This is a Phase 2, open-label, single-arm, multicenter study to assess the antimyeloma activity and further characterize the safety, tolerability, PK, and PD of cemsidomide in combination with dexamethasone in participants with relapsed\u002Frefractory multiple myeloma (r\u002Fr MM).",[197,198],"Multiple Myeloma","Relapsed\u002FRefractory Multiple Myeloma",[200,201,197],"cemsidomide","dexamethasone","2026-06-30",{"date":204,"type":205},"2026-07-01","ACTUAL",{"date":207,"type":205},"2026-02-18",{"date":209,"type":191},"2030-03",{"name":5,"class":6},10]