[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100578033":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":36,"centralContacts":40,"locations":48,"responsibleParty":556,"collaborators":23,"id":558,"slug":559,"hasResults":560,"nctId":561,"briefTitle":562,"officialTitle":563,"acronym":23,"eligibilityCriteria":564,"healthyVolunteers":560,"sex":565,"minAge":566,"maxAge":23,"enrollmentInfo":567,"targetDuration":23,"studyType":570,"phases":571,"briefSummary":573,"conditions":574,"keywords":576,"overallStatus":51,"whyStopped":23,"lastUpdateSubmitDate":596,"lastUpdatePostDateStruct":597,"startDateStruct":600,"completionDateStruct":602,"leadSponsor":604,"locationsCount":605},{"fullName":5,"class":6},"Hoffmann-La Roche","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"R\u002FR Aggressive B-Cell Non-Hodgkin's Lymphoma","EXPERIMENTAL","Participants with R\u002FR aggressive B-cell Non-Hodgkin's Lymphoma will receive obinutuzumab pre-treatment, followed by glofitamab + gemcitabine + oxaliplatin, followed by glofitamab monotherapy.",[13,14,15,16],"Drug: Obinutuzumab","Drug: Glofitamab","Drug: Gemcitabine","Drug: Oxaliplatin",[18,24,28,32],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"DRUG","Obinutuzumab","Participants will receive intravenous (IV) obinutuzumab 7 days prior to the first dose of glofitamab.",[9],null,{"type":19,"name":25,"description":26,"armGroupLabels":27,"otherNames":23},"Glofitamab","Participants will receive IV glofitamab, both in combination with gemcitabine and oxaliplatin and as monotherapy, for up to 12 cycles (cycle length = 21 days).",[9],{"type":19,"name":29,"description":30,"armGroupLabels":31,"otherNames":23},"Gemcitabine","Participants will receive IV gemcitabine in combination with glofitamab and oxaliplatin for up to 8 cycles (cycles length = 21 days).",[9],{"type":19,"name":33,"description":34,"armGroupLabels":35,"otherNames":23},"Oxaliplatin","Participants will receive IV oxaliplatin in combination with glofitamab and gemcitabine for up to 8 cycles (cycle length = 21 days).",[9],[37],{"name":38,"affiliation":5,"role":39},"Study Director","STUDY_DIRECTOR",[41,46],{"name":42,"role":43,"phone":44,"phoneExt":23,"email":45},"Reference Study ID Number: GO45434 https:\u002F\u002Fforpatients.roche.com\u002F No email attachments.","CONTACT","888-662-6728","global-roche-genentech-trials@gene.com",{"name":47,"role":43,"phone":23,"phoneExt":23,"email":23},"Fastest response: use the inquiry form. https:\u002F\u002Fwww.gene.com\u002Fcontact-us\u002Fsubmit-medical-inquiry",[49,63,73,82,91,100,108,117,126,136,146,155,164,174,184,194,204,214,224,234,244,254,263,273,282,288,298,306,316,325,334,344,353,363,376,388,398,409,418,427,437,446,457,463,472,481,493,503,513,522,531,541,550],{"facility":50,"status":51,"city":52,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":23},"Alaska Oncology & Hematology, LLC","RECRUITING","Anchorage","Alaska","99508","United States","US",{"type":58,"coordinates":59},"Point",[60,61],-149.90028,61.21806,{"lat":61,"lon":60},{"facility":64,"status":51,"city":65,"state":66,"zip":67,"country":55,"countryCode":56,"cosmosGeoPoint":68,"geoPoint":72,"contacts":23},"Community Cancer Institute (CCI)","Clovis","California","93611",{"type":58,"coordinates":69},[70,71],-119.70292,36.82523,{"lat":71,"lon":70},{"facility":74,"status":51,"city":75,"state":66,"zip":76,"country":55,"countryCode":56,"cosmosGeoPoint":77,"geoPoint":81,"contacts":23},"Providence Medical Foundation","Fullerton","92835",{"type":58,"coordinates":78},[79,80],-117.92534,33.87029,{"lat":80,"lon":79},{"facility":83,"status":51,"city":84,"state":66,"zip":85,"country":55,"countryCode":56,"cosmosGeoPoint":86,"geoPoint":90,"contacts":23},"Los Angeles Cancer Network","Glendale","91204",{"type":58,"coordinates":87},[88,89],-118.25508,34.14251,{"lat":89,"lon":88},{"facility":92,"status":51,"city":93,"state":66,"zip":94,"country":55,"countryCode":56,"cosmosGeoPoint":95,"geoPoint":99,"contacts":23},"Valkyrie Clinical Trials","Los Angeles","90067",{"type":58,"coordinates":96},[97,98],-118.24368,34.05223,{"lat":98,"lon":97},{"facility":92,"status":51,"city":101,"state":66,"zip":102,"country":55,"countryCode":56,"cosmosGeoPoint":103,"geoPoint":107,"contacts":23},"Panorama City","91402",{"type":58,"coordinates":104},[105,106],-118.44981,34.22473,{"lat":106,"lon":105},{"facility":109,"status":51,"city":110,"state":66,"zip":111,"country":55,"countryCode":56,"cosmosGeoPoint":112,"geoPoint":116,"contacts":23},"Zuckerberg San Francisco General Hospital","San Francisco","94110",{"type":58,"coordinates":113},[114,115],-122.41942,37.77493,{"lat":115,"lon":114},{"facility":118,"status":51,"city":119,"state":66,"zip":120,"country":55,"countryCode":56,"cosmosGeoPoint":121,"geoPoint":125,"contacts":23},"The Lundquist Institute for BioMedical Innovation at Harbor-UCLA Medical Cente","Torrance","90502-2006",{"type":58,"coordinates":122},[123,124],-118.34063,33.83585,{"lat":124,"lon":123},{"facility":127,"status":51,"city":128,"state":129,"zip":130,"country":55,"countryCode":56,"cosmosGeoPoint":131,"geoPoint":135,"contacts":23},"Rocky Mountain Cancer Centers, LLP","Aurora","Colorado","80012",{"type":58,"coordinates":132},[133,134],-104.83192,39.72943,{"lat":134,"lon":133},{"facility":137,"status":51,"city":138,"state":139,"zip":140,"country":55,"countryCode":56,"cosmosGeoPoint":141,"geoPoint":145,"contacts":23},"North Florida\u002F South Georgia VA Medical Center","Gainesville","Florida","32608",{"type":58,"coordinates":142},[143,144],-82.32483,29.65163,{"lat":144,"lon":143},{"facility":147,"status":51,"city":148,"state":139,"zip":149,"country":55,"countryCode":56,"cosmosGeoPoint":150,"geoPoint":154,"contacts":23},"Mount Sinai Comprehensive Cancer Center","Miami","33140",{"type":58,"coordinates":151},[152,153],-80.19366,25.77427,{"lat":153,"lon":152},{"facility":156,"status":51,"city":157,"state":139,"zip":158,"country":55,"countryCode":56,"cosmosGeoPoint":159,"geoPoint":163,"contacts":23},"Orlando Health Cancer Institute","Orlando","32806",{"type":58,"coordinates":160},[161,162],-81.37924,28.53834,{"lat":162,"lon":161},{"facility":165,"status":51,"city":166,"state":167,"zip":168,"country":55,"countryCode":56,"cosmosGeoPoint":169,"geoPoint":173,"contacts":23},"St Luke?s Cancer Institute","Boise","Idaho","83712",{"type":58,"coordinates":170},[171,172],-116.20345,43.6135,{"lat":172,"lon":171},{"facility":175,"status":51,"city":176,"state":177,"zip":178,"country":55,"countryCode":56,"cosmosGeoPoint":179,"geoPoint":183,"contacts":23},"Cancer Care Specialists of Central Illinois","Swansea","Illinois","62226",{"type":58,"coordinates":180},[181,182],-89.98899,38.53394,{"lat":182,"lon":181},{"facility":185,"status":51,"city":186,"state":187,"zip":188,"country":55,"countryCode":56,"cosmosGeoPoint":189,"geoPoint":193,"contacts":23},"Mission Blood and Cancer - MercyOne Cancer Center","Waukee","Iowa","50263",{"type":58,"coordinates":190},[191,192],-93.88523,41.61166,{"lat":192,"lon":191},{"facility":195,"status":51,"city":196,"state":197,"zip":198,"country":55,"countryCode":56,"cosmosGeoPoint":199,"geoPoint":203,"contacts":23},"University of Kentucky - Markey Cancer Center","Lexington","Kentucky","40536",{"type":58,"coordinates":200},[201,202],-84.47772,37.98869,{"lat":202,"lon":201},{"facility":205,"status":51,"city":206,"state":207,"zip":208,"country":55,"countryCode":56,"cosmosGeoPoint":209,"geoPoint":213,"contacts":23},"Mary Bird Perkins Cancer Ctr","Baton Rouge","Louisiana","70809",{"type":58,"coordinates":210},[211,212],-91.18747,30.44332,{"lat":212,"lon":211},{"facility":215,"status":51,"city":216,"state":217,"zip":218,"country":55,"countryCode":56,"cosmosGeoPoint":219,"geoPoint":223,"contacts":23},"Boston Medical Center","Boston","Massachusetts","02118",{"type":58,"coordinates":220},[221,222],-71.05977,42.35843,{"lat":222,"lon":221},{"facility":225,"status":51,"city":226,"state":227,"zip":228,"country":55,"countryCode":56,"cosmosGeoPoint":229,"geoPoint":233,"contacts":23},"Corewell Health","Grand Rapids","Michigan","49503",{"type":58,"coordinates":230},[231,232],-85.66809,42.96336,{"lat":232,"lon":231},{"facility":235,"status":51,"city":236,"state":237,"zip":238,"country":55,"countryCode":56,"cosmosGeoPoint":239,"geoPoint":243,"contacts":23},"Nebraska Cancer Specialists","Omaha","Nebraska","68130",{"type":58,"coordinates":240},[241,242],-95.94043,41.25626,{"lat":242,"lon":241},{"facility":245,"status":51,"city":246,"state":247,"zip":248,"country":55,"countryCode":56,"cosmosGeoPoint":249,"geoPoint":253,"contacts":23},"New York Oncology Hematology, P.C.","Albany","New York","12206",{"type":58,"coordinates":250},[251,252],-73.75623,42.65258,{"lat":252,"lon":251},{"facility":255,"status":51,"city":256,"state":247,"zip":257,"country":55,"countryCode":56,"cosmosGeoPoint":258,"geoPoint":262,"contacts":23},"Hematology Oncology Associates of Central New York","East Syracuse","13057",{"type":58,"coordinates":259},[260,261],-76.07853,43.06534,{"lat":261,"lon":260},{"facility":264,"status":51,"city":265,"state":266,"zip":267,"country":55,"countryCode":56,"cosmosGeoPoint":268,"geoPoint":272,"contacts":23},"Oncology Associates of Oregon, P.C","Eugene","Oregon","97401",{"type":58,"coordinates":269},[270,271],-123.08675,44.05207,{"lat":271,"lon":270},{"facility":274,"status":51,"city":275,"state":266,"zip":276,"country":55,"countryCode":56,"cosmosGeoPoint":277,"geoPoint":281,"contacts":23},"Providence Portland Medical Center","Portland","97213",{"type":58,"coordinates":278},[279,280],-122.67621,45.52345,{"lat":280,"lon":279},{"facility":283,"status":51,"city":275,"state":266,"zip":284,"country":55,"countryCode":56,"cosmosGeoPoint":285,"geoPoint":287,"contacts":23},"Providence St. Vincent Medical Center","97225",{"type":58,"coordinates":286},[279,280],{"lat":280,"lon":279},{"facility":289,"status":51,"city":290,"state":291,"zip":292,"country":55,"countryCode":56,"cosmosGeoPoint":293,"geoPoint":297,"contacts":23},"Tennessee Oncology","Chattanooga","Tennessee","37403",{"type":58,"coordinates":294},[295,296],-85.30968,35.04563,{"lat":296,"lon":295},{"facility":289,"status":51,"city":299,"state":291,"zip":300,"country":55,"countryCode":56,"cosmosGeoPoint":301,"geoPoint":305,"contacts":23},"Nashville","37203",{"type":58,"coordinates":302},[303,304],-86.78444,36.16589,{"lat":304,"lon":303},{"facility":307,"status":51,"city":308,"state":309,"zip":310,"country":55,"countryCode":56,"cosmosGeoPoint":311,"geoPoint":315,"contacts":23},"Baylor Scott & White Health","Temple","Texas","76502",{"type":58,"coordinates":312},[313,314],-97.34278,31.09823,{"lat":314,"lon":313},{"facility":317,"status":51,"city":318,"state":309,"zip":319,"country":55,"countryCode":56,"cosmosGeoPoint":320,"geoPoint":324,"contacts":23},"Texas Oncology - Gulf Coast","The Woodlands","77380",{"type":58,"coordinates":321},[322,323],-95.48938,30.15799,{"lat":323,"lon":322},{"facility":326,"status":51,"city":327,"state":309,"zip":328,"country":55,"countryCode":56,"cosmosGeoPoint":329,"geoPoint":333,"contacts":23},"Texas Oncology- Northeast Texas","Tyler","75702",{"type":58,"coordinates":330},[331,332],-95.30106,32.35126,{"lat":332,"lon":331},{"facility":335,"status":51,"city":336,"state":337,"zip":338,"country":55,"countryCode":56,"cosmosGeoPoint":339,"geoPoint":343,"contacts":23},"Virginia Cancer Specialists, PC","Fairfax","Virginia","22031",{"type":58,"coordinates":340},[341,342],-77.30637,38.84622,{"lat":342,"lon":341},{"facility":345,"status":51,"city":346,"state":337,"zip":347,"country":55,"countryCode":56,"cosmosGeoPoint":348,"geoPoint":352,"contacts":23},"Virginia Oncology Associates - Virginia Beach","Virginia Beach","23456",{"type":58,"coordinates":349},[350,351],-75.97799,36.85293,{"lat":351,"lon":350},{"facility":354,"status":51,"city":355,"state":356,"zip":357,"country":55,"countryCode":56,"cosmosGeoPoint":358,"geoPoint":362,"contacts":23},"Northwest Medical Specialties","Tacoma","Washington","98405",{"type":58,"coordinates":359},[360,361],-122.44429,47.25288,{"lat":361,"lon":360},{"facility":364,"status":365,"city":366,"state":367,"zip":368,"country":369,"countryCode":370,"cosmosGeoPoint":371,"geoPoint":375,"contacts":23},"Epworth Hospital","ACTIVE_NOT_RECRUITING","East Melbourne","Victoria","3002","Australia","AU",{"type":58,"coordinates":372},[373,374],144.9879,-37.81667,{"lat":374,"lon":373},{"facility":377,"status":51,"city":378,"state":379,"zip":380,"country":381,"countryCode":382,"cosmosGeoPoint":383,"geoPoint":387,"contacts":23},"Arthur J.E. Child Comprehensive Cancer Center","Calgary","Alberta","T2N 5G2","Canada","CA",{"type":58,"coordinates":384},[385,386],-114.08529,51.05011,{"lat":386,"lon":385},{"facility":389,"status":51,"city":390,"state":391,"zip":392,"country":381,"countryCode":382,"cosmosGeoPoint":393,"geoPoint":397,"contacts":23},"CancerCare Manitoba (CCMB)","Winnipeg","Manitoba","R3E 0V9",{"type":58,"coordinates":394},[395,396],-97.14704,49.8844,{"lat":396,"lon":395},{"facility":399,"status":51,"city":400,"state":23,"zip":401,"country":402,"countryCode":403,"cosmosGeoPoint":404,"geoPoint":408,"contacts":23},"CHU de Grenoble","La Tronche","38700","France","FR",{"type":58,"coordinates":405},[406,407],5.74629,45.20507,{"lat":407,"lon":406},{"facility":410,"status":51,"city":411,"state":23,"zip":412,"country":402,"countryCode":403,"cosmosGeoPoint":413,"geoPoint":417,"contacts":23},"Chu de Montpellier-St Eloi","Montpellier","34295",{"type":58,"coordinates":414},[415,416],3.87635,43.61093,{"lat":416,"lon":415},{"facility":419,"status":51,"city":420,"state":23,"zip":421,"country":402,"countryCode":403,"cosmosGeoPoint":422,"geoPoint":426,"contacts":23},"CHU de Bordeaux","Pessac","33600",{"type":58,"coordinates":423},[424,425],-0.6324,44.80565,{"lat":425,"lon":424},{"facility":428,"status":429,"city":430,"state":23,"zip":431,"country":402,"countryCode":403,"cosmosGeoPoint":432,"geoPoint":436,"contacts":23},"CHU DE RENNES - CHU Pontchaillou","WITHDRAWN","Rennes","35033",{"type":58,"coordinates":433},[434,435],-1.67431,48.11109,{"lat":435,"lon":434},{"facility":438,"status":51,"city":439,"state":23,"zip":440,"country":402,"countryCode":403,"cosmosGeoPoint":441,"geoPoint":445,"contacts":23},"Chu De Tours","Tours","37000",{"type":58,"coordinates":442},[443,444],0.70398,47.39484,{"lat":444,"lon":443},{"facility":447,"status":365,"city":448,"state":23,"zip":449,"country":450,"countryCode":451,"cosmosGeoPoint":452,"geoPoint":456,"contacts":23},"CAMPUS BENJAMIN FRANKLIN CharitéCentrum 14 Med.Klinik f.Hämatologie u.Onkologie","Berlin","12200","Germany","DE",{"type":58,"coordinates":453},[454,455],13.41053,52.52437,{"lat":455,"lon":454},{"facility":458,"status":365,"city":448,"state":23,"zip":459,"country":450,"countryCode":451,"cosmosGeoPoint":460,"geoPoint":462,"contacts":23},"Charite-Universitaetsmedizin Berlin - Campus Virchow-Klinikum (CVK)","13353",{"type":58,"coordinates":461},[454,455],{"lat":455,"lon":454},{"facility":464,"status":51,"city":465,"state":23,"zip":466,"country":450,"countryCode":451,"cosmosGeoPoint":467,"geoPoint":471,"contacts":23},"Universitätsklinikum Köln","Cologne","50937",{"type":58,"coordinates":468},[469,470],6.95,50.93333,{"lat":470,"lon":469},{"facility":473,"status":51,"city":474,"state":23,"zip":475,"country":450,"countryCode":451,"cosmosGeoPoint":476,"geoPoint":480,"contacts":23},"Otto von Guericke Uni Magdeburg Uniklinik","Magdeburg","39120",{"type":58,"coordinates":477},[478,479],11.63189,52.13129,{"lat":479,"lon":478},{"facility":482,"status":51,"city":483,"state":484,"zip":485,"country":486,"countryCode":487,"cosmosGeoPoint":488,"geoPoint":492,"contacts":23},"Istituto Nazionale Tumori Irccs Fondazione g. Pascale","Naples","Campania","80131","Italy","IT",{"type":58,"coordinates":489},[490,491],14.26811,40.85216,{"lat":491,"lon":490},{"facility":494,"status":51,"city":495,"state":496,"zip":497,"country":486,"countryCode":487,"cosmosGeoPoint":498,"geoPoint":502,"contacts":23},"IRCCS Istituto Romagnolo per lo studio dei tumori \"Dino Amadori\"","Meldola","Emilia-Romagna","47014",{"type":58,"coordinates":499},[500,501],12.0626,44.12775,{"lat":501,"lon":500},{"facility":504,"status":51,"city":505,"state":506,"zip":507,"country":486,"countryCode":487,"cosmosGeoPoint":508,"geoPoint":512,"contacts":23},"A.O. Spedali Civili Di Brescia-P.O. Spedali Civili","Brescia","Lombardy","25123",{"type":58,"coordinates":509},[510,511],10.21472,45.53558,{"lat":511,"lon":510},{"facility":514,"status":51,"city":515,"state":506,"zip":516,"country":486,"countryCode":487,"cosmosGeoPoint":517,"geoPoint":521,"contacts":23},"Irccs Istituto Europeo Di Oncologia (IEO)","Milan","20141",{"type":58,"coordinates":518},[519,520],9.18951,45.46427,{"lat":520,"lon":519},{"facility":523,"status":51,"city":524,"state":506,"zip":525,"country":486,"countryCode":487,"cosmosGeoPoint":526,"geoPoint":530,"contacts":23},"Istituto Clinico Humanitas","Rozzano","20089",{"type":58,"coordinates":527},[528,529],9.1559,45.38193,{"lat":529,"lon":528},{"facility":532,"status":365,"city":533,"state":23,"zip":534,"country":535,"countryCode":23,"cosmosGeoPoint":536,"geoPoint":540,"contacts":23},"Seoul National University Bundang Hospital","Seongnam-si","463-707","South Korea",{"type":58,"coordinates":537},[538,539],127.13778,37.43861,{"lat":539,"lon":538},{"facility":542,"status":429,"city":543,"state":23,"zip":544,"country":535,"countryCode":23,"cosmosGeoPoint":545,"geoPoint":549,"contacts":23},"Seoul National University Hospital","Seoul","03080",{"type":58,"coordinates":546},[547,548],126.9784,37.566,{"lat":548,"lon":547},{"facility":551,"status":365,"city":543,"state":23,"zip":552,"country":535,"countryCode":23,"cosmosGeoPoint":553,"geoPoint":555,"contacts":23},"Asan Medical Center","05505",{"type":58,"coordinates":554},[547,548],{"lat":548,"lon":547},{"type":557,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR","100578033","phase-2-a-study-to-evaluate-the-optimization-of-the-cytokine-release-syndrome-profile-for-glofitamab-in-combination-with-gemcitabine-plus-oxaliplatin-in-participants-with-relapsedrefractory-aggressive-b-cell-non-hodgkins-lymphoma-100578033",false,"NCT06806033","A Study to Evaluate the Optimization of the Cytokine Release Syndrome Profile for Glofitamab in Combination With Gemcitabine Plus Oxaliplatin in Participants With Relapsed\u002FRefractory Aggressive B-Cell Non-Hodgkin's Lymphoma","A Phase II, Open-Label, Multicenter Study to Evaluate the Optimization of the Cytokine Release Syndrome Profile for Glofitamab in Combination With Gemcitabine Plus Oxaliplatin in Patients With Relapsed\u002FRefractory Aggressive B-Cell Non-Hodgkin's Lymphoma","Inclusion Criteria:\n\n* Histologically confirmed large B-cell lymphoma (de novo or transformed from FL) with one of the following diagnoses according to World Health Organization, fifth edition: DLBCL Not Otherwise Specified (NOS); High-Grade B-Cell Lymphoma (HGBL), NOS; DLBCL\u002FHGBL with MYC and BCL2 rearrangements\n* R\u002FR disease, defined as: relapsed = disease that has recurred following a response that lasted \\>\u002F= 6 months after completion of the last line of therapy; refractory = disease that did not respond to or that progressed \\\u003C 6 months after completion of the last line of therapy\n* At least one line of prior systemic therapy\n* Participants who have failed only one prior line of therapy must not be a candidate for high-dose chemotherapy followed by autologous stem cell transplant (ASCT)\n* At least one bi-dimensionally measurable (\\> 1.5 cm) nodal lesion, or one bi-dimensionally measurable (\\> 1 cm) extranodal lesion, as measured on CT scan\n* Eastern Cooperative Oncology Group (ECOG) status of 0, 1, or 2\n* According to the investigator's judgment, participants should be able to receive the step-up dose regimen in an outpatient setting\n* Adequate hematologic and renal function\n\nExclusion Criteria:\n\n* Prior enrollment in Studies GO41943 (NCT04313608), GO41944 (STARGLO; NCT04408638), or Study GO44900 (NCT06624085)\n* Participant has failed only one prior line of therapy and is a candidate for stem cell transplantation\n* Any history of Waldenstrom's macroglobulinemia\n* Primary mediastinal B-cell lymphoma\n* History of severe allergic or anaphylactic reactions to humanized or murine monoclonal antibodies (or recombinant antibody-related fusion proteins) or known sensitivity or allergy to murine products\n* Contraindication to obinutuzumab, gemcitabine or oxaliplatin, or tocilizumab\n* Prior treatment with glofitamab or other bispecific antibodies targeting both CD20 and CD3\n* Prior treatment with gemcitabine or oxaliplatin\n* Peripheral neuropathy or paresthesia assessed to be Grade \\>\u002F= 2 according to the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) v5.0 at enrollment\n* Treatment with radiotherapy, chemotherapy, immunotherapy, immunosuppressive therapy, or any investigational agent for the purposes of treating cancer within 2 weeks prior to first study treatment\n* Treatment with monoclonal antibodies for the purposes of treating cancer within 4 weeks prior to first study treatment\n* Primary or secondary CNS lymphoma at the time of recruitment\n* Prior CNS involvement that has been definitively treated and confirmed via magnetic resonance imaging (MRI) or cerebrospinal fluid analysis to be in complete remission is permissible\n* Current or history of CNS disease, such as stroke, epilepsy, CNS vasculitis, or neurodegenerative disease\n* History of other primary malignancy, with exceptions defined by the protocol\n* Significant or extensive cardiovascular disease\n* Significant pulmonary disease (including moderate or severe obstructive pulmonary disease)\n* Known active bacterial, viral, fungal, mycobacterial, parasitic, or other infection (excluding fungal infections of nail beds) at study enrollment or any major episode of infection (as evaluated by the investigator) within 4 weeks prior to the first study treatment\n* Positive for: severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); tuberculosis; hepatitis B virus (HBV); hepatitis C virus (HCV); chronic active Epstein-Barr viral infection\n* Known or suspected history of hemophagocytic lymphohistiocytosis (HLH) or progressive multifocal leukoencephalopathy\n* Adverse events from prior anti-cancer therapy that have not resolved to Grade 1 or better (with the exception of alopecia and anorexia)\n* Administration of a live, attenuated vaccine within 4 weeks before first study treatment administration or anticipation that such a live, attenuated vaccine will be required during the study\n* Prior solid organ transplantation or prior allogenic stem cell transplant\n* Active autoimmune disease requiring treatment\n* Prior treatment with systemic immunosuppressive medications (including, but not limited to, cyclophosphamide, azathioprine, methotrexate, thalidomide, and antitumor necrosis factor agents), within 4 weeks prior to first dose of study treatment\n* Ongoing systemic corticosteroid use which, in the opinion of the investigator, puts the participant at increased risk of steroid-related iatrogenic adrenal insufficiency\n* Recent major surgery (within 4 weeks before the first study treatment) other than for diagnosis\n* Clinically significant history of cirrhotic liver disease\n* Any other diseases, metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of an investigational drug or that may affect the interpretation of the results or renders the participant at high-risk from treatment complications\n* Pregnancy or breastfeeding, or intention of becoming pregnant during the study or within 18 months after the final dose of study treatment","ALL","18 Years",{"count":568,"type":569},100,"ESTIMATED","INTERVENTIONAL",[572],"PHASE2","This Phase II trial evaluates the optimization of the cytokine release syndrome (CRS) profile for glofitamab in combination with gemcitabine and oxaliplatin (Glofit-GemOx) in participants with relapsed or refractory aggressive B-cell Non-Hodgkin's lymphoma. The study utilizes an optimized steroid premedication regimen and monitoring schedule specifically designed to enable the administration of the treatment regimen in an outpatient setting.",[575],"B-Cell Non-Hodgkins Lymphoma",[577,578,579,25,29,33,20,580,581,582,583,584,585,586,587,588,589,590,591,592,593,594,595],"Phase 2","Outpatient study","Open-label","GemOx","Glofit-GemOx","Bispecific antibody","Aggressive B-cell Non-Hodgkin's lymphoma","Diffuse Large B-Cell Lymphoma (DLBCL)","DLBCL NOS (Not Otherwise Specified)","High-Grade B-Cell Lymphoma (HGBL)","HGBL NOS","Transformed follicular lymphoma","DLBCL\u002FHGBL with MYC and BCL2 rearrangements","Double-hit lymphoma","Relapsed or Refractory (R\u002FR)","Non-Hodgkin Lymphoma (NHL)","Cytokine Release Syndrome (CRS)","CRS optimization","Step-up dosing","2026-06-18",{"date":598,"type":599},"2026-06-23","ACTUAL",{"date":601,"type":599},"2025-03-05",{"date":603,"type":569},"2029-03-30",{"name":5,"class":6},53]