[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100614667":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":44,"centralContacts":48,"locations":56,"responsibleParty":841,"collaborators":33,"id":843,"slug":844,"hasResults":845,"nctId":846,"briefTitle":847,"officialTitle":848,"acronym":849,"eligibilityCriteria":850,"healthyVolunteers":845,"sex":851,"minAge":852,"maxAge":853,"enrollmentInfo":854,"targetDuration":33,"studyType":857,"phases":858,"briefSummary":860,"conditions":861,"keywords":33,"overallStatus":59,"whyStopped":33,"lastUpdateSubmitDate":863,"lastUpdatePostDateStruct":864,"startDateStruct":867,"completionDateStruct":869,"leadSponsor":871,"locationsCount":872},{"fullName":5,"class":6},"Hoffmann-La Roche","INDUSTRY",[8,15,18,21],{"label":9,"type":10,"description":11,"interventionNames":12},"RO7268489 Dose 1 + Ocrelizumab","EXPERIMENTAL","Participants will receive RO7268489 along with ocrelizumab as per the pre-defined regimen.",[13,14],"Drug: RO7268489","Drug: Ocrelizumab",{"label":16,"type":10,"description":11,"interventionNames":17},"RO7268489 Dose 2 + Ocrelizumab",[13,14],{"label":19,"type":10,"description":11,"interventionNames":20},"RO7268489 Dose 3 + Ocrelizumab",[13,14],{"label":22,"type":23,"description":24,"interventionNames":25},"Placebo + Ocrelizumab","PLACEBO_COMPARATOR","Participants will receive RO7268489 matching placebo along with ocrelizumab as per the pre-defined regimen.",[14,26],"Drug: Placebo",[28,34,40],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"DRUG","RO7268489","RO7268489 will be administered per schedule as specified in the arms.",[9,16,19],null,{"type":29,"name":35,"description":36,"armGroupLabels":37,"otherNames":38},"Ocrelizumab","Ocrelizumab will be administered per schedule as specified in the arms.",[22,9,16,19],[39],"RO4964913, Ocrevus",{"type":29,"name":41,"description":42,"armGroupLabels":43,"otherNames":33},"Placebo","Placebo will be administered per schedule as specified in the arms.",[22],[45],{"name":46,"affiliation":5,"role":47},"Clinical Trials","STUDY_DIRECTOR",[49,54],{"name":50,"role":51,"phone":52,"phoneExt":33,"email":53},"Reference Study ID Number: BP46016 https:\u002F\u002Fforpatients.roche.com\u002F","CONTACT","888-662-6728 (U.S. Only)","global-roche-genentech-trials@gene.com",{"name":55,"role":51,"phone":33,"phoneExt":33,"email":33},"Fastest response: use the inquiry form. No email attachments. https:\u002F\u002Fwww.gene.com\u002Fcontact-us\u002Fsubmit-medical-inquiry",[57,71,80,90,99,111,121,131,141,151,161,171,181,190,199,208,220,229,238,248,257,263,273,283,292,301,313,322,328,334,346,352,361,371,381,387,393,402,409,418,425,435,441,445,449,455,464,473,479,488,494,503,512,516,525,536,545,554,566,576,586,596,606,616,626,635,643,649,655,661,669,675,681,687,696,705,714,725,734,740,746,755,761,767,776,788,798,808,817,823,832],{"facility":58,"status":59,"city":60,"state":61,"zip":62,"country":63,"countryCode":64,"cosmosGeoPoint":65,"geoPoint":70,"contacts":33},"Southern Neurology","RECRUITING","Kogarah","New South Wales","2217","Australia","AU",{"type":66,"coordinates":67},"Point",[68,69],151.13564,-33.9681,{"lat":69,"lon":68},{"facility":72,"status":59,"city":73,"state":61,"zip":74,"country":63,"countryCode":64,"cosmosGeoPoint":75,"geoPoint":79,"contacts":33},"John Hunter Hospital","New Lambton Heights","2305",{"type":66,"coordinates":76},[77,78],151.69364,-32.92466,{"lat":78,"lon":77},{"facility":81,"status":59,"city":82,"state":83,"zip":84,"country":63,"countryCode":64,"cosmosGeoPoint":85,"geoPoint":89,"contacts":33},"Box Hill Hospital","Box Hill","Victoria","3128",{"type":66,"coordinates":86},[87,88],145.12545,-37.81887,{"lat":88,"lon":87},{"facility":91,"status":59,"city":92,"state":83,"zip":93,"country":63,"countryCode":64,"cosmosGeoPoint":94,"geoPoint":98,"contacts":33},"Austin Health","Heidelberg","3084",{"type":66,"coordinates":95},[96,97],145.06667,-37.75,{"lat":97,"lon":96},{"facility":100,"status":59,"city":101,"state":102,"zip":103,"country":104,"countryCode":105,"cosmosGeoPoint":106,"geoPoint":110,"contacts":33},"CHU Strasbourg Hpital Hautepierre","Strasbourg","Bas Rhin","67098","France","FR",{"type":66,"coordinates":107},[108,109],7.74553,48.58392,{"lat":109,"lon":108},{"facility":112,"status":59,"city":113,"state":114,"zip":115,"country":104,"countryCode":105,"cosmosGeoPoint":116,"geoPoint":120,"contacts":33},"Hopital Caremeau","Nîmes","Gard","30029",{"type":66,"coordinates":117},[118,119],4.35788,43.83665,{"lat":119,"lon":118},{"facility":122,"status":59,"city":123,"state":124,"zip":125,"country":104,"countryCode":105,"cosmosGeoPoint":126,"geoPoint":130,"contacts":33},"Groupe Hospitalier Pellegrin","Bordeaux","Gironde","33800",{"type":66,"coordinates":127},[128,129],-0.58046,44.84124,{"lat":129,"lon":128},{"facility":132,"status":59,"city":133,"state":134,"zip":135,"country":104,"countryCode":105,"cosmosGeoPoint":136,"geoPoint":140,"contacts":33},"Hopital Purpan","Toulouse","Haute Garonne","31059",{"type":66,"coordinates":137},[138,139],1.44367,43.60426,{"lat":139,"lon":138},{"facility":142,"status":59,"city":143,"state":144,"zip":145,"country":104,"countryCode":105,"cosmosGeoPoint":146,"geoPoint":150,"contacts":33},"Hopital Gui de Chauliac","Montpellier","Herault","34295",{"type":66,"coordinates":147},[148,149],3.87635,43.61093,{"lat":149,"lon":148},{"facility":152,"status":59,"city":153,"state":154,"zip":155,"country":104,"countryCode":105,"cosmosGeoPoint":156,"geoPoint":160,"contacts":33},"CHU Nantes - Hopital Nord Laënnec","Saint-Herblain","Loire Atlantique","44800",{"type":66,"coordinates":157},[158,159],-1.651,47.21154,{"lat":159,"lon":158},{"facility":162,"status":59,"city":163,"state":164,"zip":165,"country":104,"countryCode":105,"cosmosGeoPoint":166,"geoPoint":170,"contacts":33},"CHU Nancy Hôpital Central","Nancy","Meurthe Et Moselle","54035",{"type":66,"coordinates":167},[168,169],6.18496,48.68439,{"lat":169,"lon":168},{"facility":172,"status":59,"city":173,"state":174,"zip":175,"country":104,"countryCode":105,"cosmosGeoPoint":176,"geoPoint":180,"contacts":33},"CHU Hopital Gabriel Montpied","Clermont-Ferrand","Puy De Dome","63003",{"type":66,"coordinates":177},[178,179],3.08682,45.77969,{"lat":179,"lon":178},{"facility":182,"status":59,"city":183,"state":33,"zip":184,"country":104,"countryCode":105,"cosmosGeoPoint":185,"geoPoint":189,"contacts":33},"Hopital Neurologique Pierre Wertheimer","Bron","69500",{"type":66,"coordinates":186},[187,188],4.91303,45.73865,{"lat":188,"lon":187},{"facility":191,"status":59,"city":192,"state":33,"zip":193,"country":104,"countryCode":105,"cosmosGeoPoint":194,"geoPoint":198,"contacts":33},"Groupe Hospitalier Pitie-Salpetriere","Paris","75013",{"type":66,"coordinates":195},[196,197],2.3488,48.85341,{"lat":197,"lon":196},{"facility":200,"status":59,"city":201,"state":33,"zip":202,"country":104,"countryCode":105,"cosmosGeoPoint":203,"geoPoint":207,"contacts":33},"CHU Rennes - Hopital Pontchaillou","Rennes","35033",{"type":66,"coordinates":204},[205,206],-1.67431,48.11109,{"lat":206,"lon":205},{"facility":209,"status":59,"city":210,"state":211,"zip":212,"country":213,"countryCode":214,"cosmosGeoPoint":215,"geoPoint":219,"contacts":33},"Universitaetsklinikum Freiburg","Freiburg im Breisgau","Baden-Wurttemberg","79106","Germany","DE",{"type":66,"coordinates":216},[217,218],7.85222,47.9959,{"lat":218,"lon":217},{"facility":221,"status":59,"city":222,"state":211,"zip":223,"country":213,"countryCode":214,"cosmosGeoPoint":224,"geoPoint":228,"contacts":33},"Universitaetsklinikum Tuebingen","Tübingen","72076",{"type":66,"coordinates":225},[226,227],9.05222,48.52266,{"lat":227,"lon":226},{"facility":230,"status":59,"city":231,"state":211,"zip":232,"country":213,"countryCode":214,"cosmosGeoPoint":233,"geoPoint":237,"contacts":33},"Studienzentrum Neuropoint GmbH,","Ulm","89073",{"type":66,"coordinates":234},[235,236],9.99155,48.39841,{"lat":236,"lon":235},{"facility":239,"status":59,"city":240,"state":241,"zip":242,"country":213,"countryCode":214,"cosmosGeoPoint":243,"geoPoint":247,"contacts":33},"Universitaetsklinikum Erlangen","Erlangen","Bavaria","91054",{"type":66,"coordinates":244},[245,246],11.00783,49.59099,{"lat":246,"lon":245},{"facility":249,"status":59,"city":250,"state":241,"zip":251,"country":213,"countryCode":214,"cosmosGeoPoint":252,"geoPoint":256,"contacts":33},"LMU-Campus Grosshadern","Munich","81377",{"type":66,"coordinates":253},[254,255],11.57549,48.13743,{"lat":255,"lon":254},{"facility":258,"status":59,"city":250,"state":241,"zip":259,"country":213,"countryCode":214,"cosmosGeoPoint":260,"geoPoint":262,"contacts":33},"Klinikum rechts der Isar der TU Muenchen","81675",{"type":66,"coordinates":261},[254,255],{"lat":255,"lon":254},{"facility":264,"status":59,"city":265,"state":266,"zip":267,"country":213,"countryCode":214,"cosmosGeoPoint":268,"geoPoint":272,"contacts":33},"St. Josef-Hospital Universitaetsklinikum","Bochum","North Rhine-Westphalia","44791",{"type":66,"coordinates":269},[270,271],7.21648,51.48165,{"lat":271,"lon":270},{"facility":274,"status":59,"city":275,"state":276,"zip":277,"country":213,"countryCode":214,"cosmosGeoPoint":278,"geoPoint":282,"contacts":33},"Universitaetsklinikum Carl Gustav Carus TU Dresden","Dresden","Saxony","01307",{"type":66,"coordinates":279},[280,281],13.73832,51.05089,{"lat":281,"lon":280},{"facility":284,"status":59,"city":285,"state":276,"zip":286,"country":213,"countryCode":214,"cosmosGeoPoint":287,"geoPoint":291,"contacts":33},"Universitaetsklinikum Leipzig","Leipzig","04103",{"type":66,"coordinates":288},[289,290],12.37129,51.33962,{"lat":290,"lon":289},{"facility":293,"status":59,"city":294,"state":33,"zip":295,"country":213,"countryCode":214,"cosmosGeoPoint":296,"geoPoint":300,"contacts":33},"Charité Universitaetsmedizin Berlin - Campus Ch","Berlin","10117",{"type":66,"coordinates":297},[298,299],13.41053,52.52437,{"lat":299,"lon":298},{"facility":302,"status":59,"city":303,"state":304,"zip":305,"country":306,"countryCode":307,"cosmosGeoPoint":308,"geoPoint":312,"contacts":33},"Pecsi Tudomanyegyetem Klinikai Kozpont","Pécs","Baranya","7623","Hungary","HU",{"type":66,"coordinates":309},[310,311],18.22814,46.07617,{"lat":311,"lon":310},{"facility":314,"status":59,"city":315,"state":33,"zip":316,"country":306,"countryCode":307,"cosmosGeoPoint":317,"geoPoint":321,"contacts":33},"Clinexpert Kft.","Budapest","1033",{"type":66,"coordinates":318},[319,320],19.04045,47.49835,{"lat":320,"lon":319},{"facility":323,"status":59,"city":315,"state":33,"zip":324,"country":306,"countryCode":307,"cosmosGeoPoint":325,"geoPoint":327,"contacts":33},"S-Medicon Egeszsegugyi Szolgaltato Kft.","1045",{"type":66,"coordinates":326},[319,320],{"lat":320,"lon":319},{"facility":329,"status":59,"city":315,"state":33,"zip":330,"country":306,"countryCode":307,"cosmosGeoPoint":331,"geoPoint":333,"contacts":33},"Budapesti Uzsoki Utcai Kórház","1145",{"type":66,"coordinates":332},[319,320],{"lat":320,"lon":319},{"facility":335,"status":59,"city":336,"state":337,"zip":338,"country":339,"countryCode":340,"cosmosGeoPoint":341,"geoPoint":345,"contacts":33},"Azienda Ospedaliera Universitaria Federico II","Naples","Campania","80131","Italy","IT",{"type":66,"coordinates":342},[343,344],14.26811,40.85216,{"lat":344,"lon":343},{"facility":347,"status":59,"city":336,"state":337,"zip":348,"country":339,"countryCode":340,"cosmosGeoPoint":349,"geoPoint":351,"contacts":33},"Azienda Ospedaliera Universitaria- Universit degli Studi della Campania Luigi Vanvitelli","80138",{"type":66,"coordinates":350},[343,344],{"lat":344,"lon":343},{"facility":353,"status":59,"city":354,"state":337,"zip":355,"country":339,"countryCode":340,"cosmosGeoPoint":356,"geoPoint":360,"contacts":33},"Az. Osp. OO.RR. S. Giovanni di Dio e Ruggi D' Aragona","Salerno","84131",{"type":66,"coordinates":357},[358,359],14.79328,40.67545,{"lat":359,"lon":358},{"facility":362,"status":59,"city":363,"state":364,"zip":365,"country":339,"countryCode":340,"cosmosGeoPoint":366,"geoPoint":370,"contacts":33},"IRCCS AOM Azienda Ospedaliera Metropolitana","Genoa","Liguria","16132",{"type":66,"coordinates":367},[368,369],8.94439,44.40478,{"lat":369,"lon":368},{"facility":372,"status":59,"city":373,"state":374,"zip":375,"country":339,"countryCode":340,"cosmosGeoPoint":376,"geoPoint":380,"contacts":33},"Ospedale San Raffaele","Milan","Lombardy","20132",{"type":66,"coordinates":377},[378,379],9.18951,45.46427,{"lat":379,"lon":378},{"facility":382,"status":59,"city":373,"state":374,"zip":383,"country":339,"countryCode":340,"cosmosGeoPoint":384,"geoPoint":386,"contacts":33},"Fondazione IRCCS Istituto Neurologico Carlo Besta","20133",{"type":66,"coordinates":385},[378,379],{"lat":379,"lon":378},{"facility":388,"status":59,"city":373,"state":374,"zip":389,"country":339,"countryCode":340,"cosmosGeoPoint":390,"geoPoint":392,"contacts":33},"Azienda Socio Sanitaria Territoriale Niguarda (Grande Ospedale Metropolitano Niguarda)","20162",{"type":66,"coordinates":391},[378,379],{"lat":379,"lon":378},{"facility":394,"status":59,"city":395,"state":374,"zip":396,"country":339,"countryCode":340,"cosmosGeoPoint":397,"geoPoint":401,"contacts":33},"Fondazione Istituto Neurologico Nazionale Casimiro Mondino","Pavia","27100",{"type":66,"coordinates":398},[399,400],9.15917,45.19205,{"lat":400,"lon":399},{"facility":403,"status":59,"city":404,"state":405,"zip":406,"country":407,"countryCode":408,"cosmosGeoPoint":33,"geoPoint":33,"contacts":33},"Optimal Clinical Trials - Christchurch","Christchurch Central City","South Island","8011","New Zealand","NZ",{"facility":410,"status":59,"city":411,"state":33,"zip":412,"country":407,"countryCode":408,"cosmosGeoPoint":413,"geoPoint":417,"contacts":33},"Optimal Clinical Trials - Central","Auckland","1010",{"type":66,"coordinates":414},[415,416],174.76349,-36.84853,{"lat":416,"lon":415},{"facility":419,"status":59,"city":420,"state":421,"zip":422,"country":423,"countryCode":424,"cosmosGeoPoint":33,"geoPoint":33,"contacts":33},"Nmedis sp. z o.o.","Rzeszw","Podkarpackie Voivodeship","35-323","Poland","PL",{"facility":426,"status":59,"city":427,"state":428,"zip":429,"country":423,"countryCode":424,"cosmosGeoPoint":430,"geoPoint":434,"contacts":33},"Centrum Medyczne Pratia Katowice I","Katowice","Silesian Voivodeship","40-081",{"type":66,"coordinates":431},[432,433],19.02173,50.2597,{"lat":433,"lon":432},{"facility":436,"status":59,"city":427,"state":428,"zip":437,"country":423,"countryCode":424,"cosmosGeoPoint":438,"geoPoint":440,"contacts":33},"NEURO-CARE Sp. z o.o. Sp. Komandytowa","40-749",{"type":66,"coordinates":439},[432,433],{"lat":433,"lon":432},{"facility":442,"status":59,"city":443,"state":33,"zip":444,"country":423,"countryCode":424,"cosmosGeoPoint":33,"geoPoint":33,"contacts":33},"ProNeuro Centrum Medyczne","?ory","44-240",{"facility":446,"status":59,"city":447,"state":33,"zip":448,"country":423,"countryCode":424,"cosmosGeoPoint":33,"geoPoint":33,"contacts":33},"SOMED - Lodzkie Centrum Osteoporozy","?ód?","90-368",{"facility":450,"status":59,"city":427,"state":33,"zip":451,"country":423,"countryCode":424,"cosmosGeoPoint":452,"geoPoint":454,"contacts":33},"M.A. LEK A.M.Maciejowscy SC.","40-571",{"type":66,"coordinates":453},[432,433],{"lat":433,"lon":432},{"facility":456,"status":59,"city":457,"state":33,"zip":458,"country":423,"countryCode":424,"cosmosGeoPoint":459,"geoPoint":463,"contacts":33},"Resmedica NZOZ Kielce","Kielce","25-726",{"type":66,"coordinates":460},[461,462],20.62752,50.87033,{"lat":462,"lon":461},{"facility":465,"status":59,"city":466,"state":33,"zip":467,"country":423,"countryCode":424,"cosmosGeoPoint":468,"geoPoint":472,"contacts":33},"Samodzielny Publiczny Zakad Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie","Krakow","31-503",{"type":66,"coordinates":469},[470,471],19.93658,50.06143,{"lat":471,"lon":470},{"facility":474,"status":59,"city":466,"state":33,"zip":475,"country":423,"countryCode":424,"cosmosGeoPoint":476,"geoPoint":478,"contacts":33},"Szpital Specjalistyczny im. L. Rydygiera w Krakowie","31-826",{"type":66,"coordinates":477},[470,471],{"lat":471,"lon":470},{"facility":480,"status":59,"city":481,"state":33,"zip":482,"country":423,"countryCode":424,"cosmosGeoPoint":483,"geoPoint":487,"contacts":33},"Indywidualna Praktyka Lekarska Prof. Dr Hab. N. Med. Konrad Rejdak.","Lublin","20-410",{"type":66,"coordinates":484},[485,486],22.57009,51.25058,{"lat":486,"lon":485},{"facility":489,"status":59,"city":481,"state":33,"zip":490,"country":423,"countryCode":424,"cosmosGeoPoint":491,"geoPoint":493,"contacts":33},"Zanamed Medical Clinic sp z o o","20-601",{"type":66,"coordinates":492},[485,486],{"lat":486,"lon":485},{"facility":495,"status":59,"city":496,"state":33,"zip":497,"country":423,"countryCode":424,"cosmosGeoPoint":498,"geoPoint":502,"contacts":33},"Centrum Medyczne Medyk","Rzeszów","35-055",{"type":66,"coordinates":499},[500,501],21.99901,50.04132,{"lat":501,"lon":500},{"facility":504,"status":59,"city":505,"state":33,"zip":506,"country":423,"countryCode":424,"cosmosGeoPoint":507,"geoPoint":511,"contacts":33},"Centrum Medyczne NeuroProtect","Warsaw","01-684",{"type":66,"coordinates":508},[509,510],21.01178,52.22977,{"lat":510,"lon":509},{"facility":513,"status":59,"city":514,"state":33,"zip":515,"country":423,"countryCode":424,"cosmosGeoPoint":33,"geoPoint":33,"contacts":33},"Penta Hospitals Przychodnie, Wroclaw Wejherowska","Wroc?aw","54-239",{"facility":517,"status":59,"city":518,"state":33,"zip":519,"country":423,"countryCode":424,"cosmosGeoPoint":520,"geoPoint":524,"contacts":33},"Samodzielny Publiczny Szpital Kliniczny Nr 1 im. Prof. Stanislawa SzyszkoSUM w Katowicach","Zabrze","41-800",{"type":66,"coordinates":521},[522,523],18.78576,50.32492,{"lat":523,"lon":522},{"facility":526,"status":59,"city":527,"state":33,"zip":528,"country":529,"countryCode":530,"cosmosGeoPoint":531,"geoPoint":535,"contacts":33},"Hospital de Braga","Braga","4710-243","Portugal","PT",{"type":66,"coordinates":532},[533,534],-8.42311,41.5514,{"lat":534,"lon":533},{"facility":537,"status":59,"city":538,"state":33,"zip":539,"country":529,"countryCode":530,"cosmosGeoPoint":540,"geoPoint":544,"contacts":33},"ULS São José - Hospital de Sto António dos Capuchos;CRI Esclerose Múltipla","Lisbon","1169-050",{"type":66,"coordinates":541},[542,543],-9.1498,38.72509,{"lat":543,"lon":542},{"facility":546,"status":59,"city":547,"state":33,"zip":548,"country":529,"countryCode":530,"cosmosGeoPoint":549,"geoPoint":553,"contacts":33},"Centro Hospitalar Entre o Douro e Vouga E.P.E. - Hospital de São Sebastião","Santa Maria da Feira","4520-211",{"type":66,"coordinates":550},[551,552],-8.54839,40.92726,{"lat":552,"lon":551},{"facility":555,"status":59,"city":556,"state":557,"zip":558,"country":559,"countryCode":560,"cosmosGeoPoint":561,"geoPoint":565,"contacts":33},"Hospital Universitari de Bellvitge","L'Hospitalet de Llobregat","Barcelona","08907","Spain","ES",{"type":66,"coordinates":562},[563,564],2.10028,41.35967,{"lat":564,"lon":563},{"facility":567,"status":59,"city":568,"state":569,"zip":570,"country":559,"countryCode":560,"cosmosGeoPoint":571,"geoPoint":575,"contacts":33},"Hospital Santa Caterina","Salt","Girona","17190",{"type":66,"coordinates":572},[573,574],2.79281,41.97489,{"lat":574,"lon":573},{"facility":577,"status":59,"city":578,"state":579,"zip":580,"country":559,"countryCode":560,"cosmosGeoPoint":581,"geoPoint":585,"contacts":33},"Hospital Universitari Arnau de Vilanova","Lleida","Lerida","25198",{"type":66,"coordinates":582},[583,584],0.62218,41.61674,{"lat":584,"lon":583},{"facility":587,"status":59,"city":588,"state":589,"zip":590,"country":559,"countryCode":560,"cosmosGeoPoint":591,"geoPoint":595,"contacts":33},"Hospital Universitario Quironsalud Madrid","Pozuelo de Alarcón","Madrid","28223",{"type":66,"coordinates":592},[593,594],-3.81338,40.43293,{"lat":594,"lon":593},{"facility":597,"status":59,"city":598,"state":599,"zip":600,"country":559,"countryCode":560,"cosmosGeoPoint":601,"geoPoint":605,"contacts":33},"Hospital Universitario Virgen de La Arrixaca","El Palmar","Murcia","30120",{"type":66,"coordinates":602},[603,604],-1.16095,37.93939,{"lat":604,"lon":603},{"facility":607,"status":59,"city":608,"state":609,"zip":610,"country":559,"countryCode":560,"cosmosGeoPoint":611,"geoPoint":615,"contacts":33},"Hospital Alvaro Cunqueiro","Vigo","Pontevedra","36312",{"type":66,"coordinates":612},[613,614],-8.72264,42.23282,{"lat":614,"lon":613},{"facility":617,"status":59,"city":618,"state":619,"zip":620,"country":559,"countryCode":560,"cosmosGeoPoint":621,"geoPoint":625,"contacts":33},"Hospital de Cruces","Barakaldo","Vizcaya","48903",{"type":66,"coordinates":622},[623,624],-2.98813,43.29639,{"lat":624,"lon":623},{"facility":627,"status":59,"city":628,"state":33,"zip":629,"country":559,"countryCode":560,"cosmosGeoPoint":630,"geoPoint":634,"contacts":33},"Complejo Hospitalario Universitario de Albacete","Albacete","02008",{"type":66,"coordinates":631},[632,633],-1.85643,38.99424,{"lat":633,"lon":632},{"facility":636,"status":59,"city":557,"state":33,"zip":637,"country":559,"countryCode":560,"cosmosGeoPoint":638,"geoPoint":642,"contacts":33},"Hospital del Mar","08003",{"type":66,"coordinates":639},[640,641],2.15899,41.38879,{"lat":641,"lon":640},{"facility":644,"status":59,"city":557,"state":33,"zip":645,"country":559,"countryCode":560,"cosmosGeoPoint":646,"geoPoint":648,"contacts":33},"Hospital Universitari Vall d Hebron","08035",{"type":66,"coordinates":647},[640,641],{"lat":641,"lon":640},{"facility":650,"status":59,"city":557,"state":33,"zip":651,"country":559,"countryCode":560,"cosmosGeoPoint":652,"geoPoint":654,"contacts":33},"Hospital Clinic de Barcelona","08036",{"type":66,"coordinates":653},[640,641],{"lat":641,"lon":640},{"facility":656,"status":59,"city":557,"state":33,"zip":657,"country":559,"countryCode":560,"cosmosGeoPoint":658,"geoPoint":660,"contacts":33},"Hospital de la Santa Creu i Sant Pau","08041",{"type":66,"coordinates":659},[640,641],{"lat":641,"lon":640},{"facility":662,"status":59,"city":589,"state":33,"zip":663,"country":559,"countryCode":560,"cosmosGeoPoint":664,"geoPoint":668,"contacts":33},"Hospital Universitario de la Princesa","28006",{"type":66,"coordinates":665},[666,667],-3.70256,40.4165,{"lat":667,"lon":666},{"facility":670,"status":59,"city":589,"state":33,"zip":671,"country":559,"countryCode":560,"cosmosGeoPoint":672,"geoPoint":674,"contacts":33},"Hospital General Universitario Gregorio Maranon","28007",{"type":66,"coordinates":673},[666,667],{"lat":667,"lon":666},{"facility":676,"status":59,"city":589,"state":33,"zip":677,"country":559,"countryCode":560,"cosmosGeoPoint":678,"geoPoint":680,"contacts":33},"Hospital Universitario Ramon y Cajal","28034",{"type":66,"coordinates":679},[666,667],{"lat":667,"lon":666},{"facility":682,"status":59,"city":589,"state":33,"zip":683,"country":559,"countryCode":560,"cosmosGeoPoint":684,"geoPoint":686,"contacts":33},"Hospital Clinico San Carlos","28040",{"type":66,"coordinates":685},[666,667],{"lat":667,"lon":666},{"facility":688,"status":59,"city":689,"state":33,"zip":690,"country":559,"countryCode":560,"cosmosGeoPoint":691,"geoPoint":695,"contacts":33},"Hospital Regional Universitario de Malaga","Málaga","29010",{"type":66,"coordinates":692},[693,694],-4.42034,36.72016,{"lat":694,"lon":693},{"facility":697,"status":59,"city":698,"state":33,"zip":699,"country":559,"countryCode":560,"cosmosGeoPoint":700,"geoPoint":704,"contacts":33},"Hospital Universitario Virgen Macarena","Seville","41009",{"type":66,"coordinates":701},[702,703],-5.97317,37.38283,{"lat":703,"lon":702},{"facility":706,"status":59,"city":707,"state":33,"zip":708,"country":559,"countryCode":560,"cosmosGeoPoint":709,"geoPoint":713,"contacts":33},"Hospital Universitari i Politecnic La Fe","Valencia","46026",{"type":66,"coordinates":710},[711,712],-0.37966,39.47391,{"lat":712,"lon":711},{"facility":715,"status":59,"city":716,"state":717,"zip":718,"country":719,"countryCode":33,"cosmosGeoPoint":720,"geoPoint":724,"contacts":33},"Kocaeli University Medical Faculty","Kocaeli","Izmit","41380","Turkey (Türkiye)",{"type":66,"coordinates":721},[722,723],27.51145,39.62497,{"lat":723,"lon":722},{"facility":726,"status":59,"city":727,"state":33,"zip":728,"country":719,"countryCode":33,"cosmosGeoPoint":729,"geoPoint":733,"contacts":33},"Hacettepe University of Medicine","Ankara","06100",{"type":66,"coordinates":730},[731,732],32.85427,39.91987,{"lat":732,"lon":731},{"facility":735,"status":59,"city":727,"state":33,"zip":736,"country":719,"countryCode":33,"cosmosGeoPoint":737,"geoPoint":739,"contacts":33},"Gazi University Medical Faculty","06500",{"type":66,"coordinates":738},[731,732],{"lat":732,"lon":731},{"facility":741,"status":59,"city":727,"state":33,"zip":742,"country":719,"countryCode":33,"cosmosGeoPoint":743,"geoPoint":745,"contacts":33},"Ankara City Hospital","06800",{"type":66,"coordinates":744},[731,732],{"lat":732,"lon":731},{"facility":747,"status":59,"city":748,"state":33,"zip":749,"country":719,"countryCode":33,"cosmosGeoPoint":750,"geoPoint":754,"contacts":33},"Istanbul University Istanbul Medical Faculty","Istanbul","34093",{"type":66,"coordinates":751},[752,753],28.94966,41.01384,{"lat":753,"lon":752},{"facility":756,"status":59,"city":748,"state":33,"zip":757,"country":719,"countryCode":33,"cosmosGeoPoint":758,"geoPoint":760,"contacts":33},"Istanbul University Cerrahpasa Medical Faculty","34098",{"type":66,"coordinates":759},[752,753],{"lat":753,"lon":752},{"facility":762,"status":59,"city":748,"state":33,"zip":763,"country":719,"countryCode":33,"cosmosGeoPoint":764,"geoPoint":766,"contacts":33},"Sancaktepe Sehit Prof Dr Ilhan Varank Training and Research Hospital","34785",{"type":66,"coordinates":765},[752,753],{"lat":753,"lon":752},{"facility":768,"status":59,"city":769,"state":33,"zip":770,"country":719,"countryCode":33,"cosmosGeoPoint":771,"geoPoint":775,"contacts":33},"Selcuk Universitesi Selcuklu Tip Fakultesi Hastanesi","Konya","42075",{"type":66,"coordinates":772},[773,774],32.48464,37.87135,{"lat":774,"lon":773},{"facility":777,"status":59,"city":778,"state":779,"zip":780,"country":781,"countryCode":782,"cosmosGeoPoint":783,"geoPoint":787,"contacts":33},"Royal Cornwall Hospital","Truro","Cornwall","TR1 3HD","United Kingdom","UK",{"type":66,"coordinates":784},[785,786],-5.05436,50.26526,{"lat":786,"lon":785},{"facility":789,"status":59,"city":790,"state":791,"zip":792,"country":781,"countryCode":782,"cosmosGeoPoint":793,"geoPoint":797,"contacts":33},"Charing Cross Hospital","London","Greater London","W6 8RF",{"type":66,"coordinates":794},[795,796],-0.12574,51.50853,{"lat":796,"lon":795},{"facility":799,"status":59,"city":800,"state":801,"zip":802,"country":781,"countryCode":782,"cosmosGeoPoint":803,"geoPoint":807,"contacts":33},"Queen Elizabeth University Hospital","Glasgow","Strathclyde","G51 4TF",{"type":66,"coordinates":804},[805,806],-4.25763,55.86515,{"lat":806,"lon":805},{"facility":809,"status":59,"city":810,"state":33,"zip":811,"country":781,"countryCode":782,"cosmosGeoPoint":812,"geoPoint":816,"contacts":33},"University Hospital of Wales","Cardiff","CF14 4XW",{"type":66,"coordinates":813},[814,815],-3.18,51.48,{"lat":815,"lon":814},{"facility":818,"status":59,"city":790,"state":33,"zip":819,"country":781,"countryCode":782,"cosmosGeoPoint":820,"geoPoint":822,"contacts":33},"Royal London Hospital","E1 2AT",{"type":66,"coordinates":821},[795,796],{"lat":796,"lon":795},{"facility":824,"status":59,"city":825,"state":33,"zip":826,"country":781,"countryCode":782,"cosmosGeoPoint":827,"geoPoint":831,"contacts":33},"Salford Care Organisation","Salford","M6 8HD",{"type":66,"coordinates":828},[829,830],-2.29042,53.48771,{"lat":830,"lon":829},{"facility":833,"status":59,"city":834,"state":33,"zip":835,"country":781,"countryCode":782,"cosmosGeoPoint":836,"geoPoint":840,"contacts":33},"Morriston Hospital","Swansea","SA6 6NL",{"type":66,"coordinates":837},[838,839],-3.94323,51.62079,{"lat":839,"lon":838},{"type":842,"investigatorFullName":33,"investigatorTitle":33,"investigatorAffiliation":33,"oldNameTitle":33,"oldOrganization":33},"SPONSOR","100614667","phase-2-a-study-to-evaluate-the-safety-pharmacokinetics-pharmacodynamics-and-efficacy-of-ro7268489-as-add-on-therapy-to-ocrelizumab-in-participants-with-progressive-forms-of-multiple-sclerosis-ms-100614667",false,"NCT07282574","A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of RO7268489 as Add-on Therapy to Ocrelizumab, in Participants With Progressive Forms of Multiple Sclerosis (MS)","A Multi-center, Double-blind, Placebo-controlled, Phase II Study Evaluating the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of RO7268489, a Monoacylglycerol Lipase Inhibitor, as Add-on Therapy to Ocrelizumab, in Participants With Progressive Forms of Multiple Sclerosis","Mintaka","Inclusion Criteria:\n\n* PMS, in accordance with the revised 2017 McDonald criteria\n* Expanded disability status scale (EDSS) at screening between 3.0 and 6.0 inclusive\n\nExclusion Criteria:\n\n* MS relapse during the 6 months preceding the randomization date\n* Lack of peripheral venous access\n* History of alcohol or other drug abuse, in the opinion of the investigator, within 5 years prior to screening\n* Inability to complete an magnetic resonance imaging (MRI)\n* Contraindications to ocrelizumab mandatory pre-medications\n* Treatment with intravenous immunoglobulin (IV Ig) or plasmapheresis within 12 weeks prior to screening","ALL","18 Years","60 Years",{"count":855,"type":856},360,"ESTIMATED","INTERVENTIONAL",[859],"PHASE2","The main purpose of this study is to assess the efficacy of RO7268489 in adults with progressive multiple sclerosis (PMS) receiving ocrelizumab. After the end of the double-blind period, an open-label (OL) extension may allow eligible participants to receive open-label RO7268489.",[862],"Progressive Multiple Sclerosis","2026-06-19",{"date":865,"type":866},"2026-06-23","ACTUAL",{"date":868,"type":866},"2026-03-10",{"date":870,"type":856},"2030-05-30",{"name":5,"class":6},91]