[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100563699":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":31,"responsibleParty":285,"collaborators":29,"id":287,"slug":288,"hasResults":289,"nctId":290,"briefTitle":291,"officialTitle":292,"acronym":29,"eligibilityCriteria":293,"healthyVolunteers":289,"sex":294,"minAge":295,"maxAge":29,"enrollmentInfo":296,"targetDuration":29,"studyType":299,"phases":300,"briefSummary":302,"conditions":303,"keywords":305,"overallStatus":34,"whyStopped":29,"lastUpdateSubmitDate":325,"lastUpdatePostDateStruct":326,"startDateStruct":329,"completionDateStruct":331,"leadSponsor":333,"locationsCount":334},{"fullName":5,"class":6},"Deciphera Pharmaceuticals, LLC","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Vimseltinib","EXPERIMENTAL","Escalating doses of vimseltinib in 28 day cycles.",[13],"Drug: Vimseltinib",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"DRUG","Administered orally",[9],[20],"DCC-3014",[22],{"name":23,"affiliation":5,"role":24},"Clinical Team","STUDY_DIRECTOR",[26],{"name":23,"role":27,"phone":28,"phoneExt":29,"email":30},"CONTACT","888-724-3274",null,"clinicaltrials@deciphera.com",[32,46,55,64,74,83,93,103,113,123,133,143,153,163,172,182,191,200,210,220,230,240,246,256,265,275],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":29},"City of Hope National Medical Center","RECRUITING","Duarte","California","91010","United States","US",{"type":41,"coordinates":42},"Point",[43,44],-117.97729,34.13945,{"lat":44,"lon":43},{"facility":47,"status":34,"city":48,"state":36,"zip":49,"country":38,"countryCode":39,"cosmosGeoPoint":50,"geoPoint":54,"contacts":29},"Ronald Regan UCLA Medical Center","Los Angeles","90095",{"type":41,"coordinates":51},[52,53],-118.24368,34.05223,{"lat":53,"lon":52},{"facility":56,"status":34,"city":57,"state":36,"zip":58,"country":38,"countryCode":39,"cosmosGeoPoint":59,"geoPoint":63,"contacts":29},"University of California Irvine Health","Orange","92868-3201",{"type":41,"coordinates":60},[61,62],-117.85311,33.78779,{"lat":62,"lon":61},{"facility":65,"status":34,"city":66,"state":67,"zip":68,"country":38,"countryCode":39,"cosmosGeoPoint":69,"geoPoint":73,"contacts":29},"AdventHealth Orlando","Orlando","Florida","32804",{"type":41,"coordinates":70},[71,72],-81.37924,28.53834,{"lat":72,"lon":71},{"facility":75,"status":34,"city":76,"state":67,"zip":77,"country":38,"countryCode":39,"cosmosGeoPoint":78,"geoPoint":82,"contacts":29},"Moffitt Cancer Center","Tampa","33612",{"type":41,"coordinates":79},[80,81],-82.45843,27.94752,{"lat":81,"lon":80},{"facility":84,"status":34,"city":85,"state":86,"zip":87,"country":38,"countryCode":39,"cosmosGeoPoint":88,"geoPoint":92,"contacts":29},"Emory University Winship Cancer Institute","Atlanta","Georgia","30322",{"type":41,"coordinates":89},[90,91],-84.38798,33.749,{"lat":91,"lon":90},{"facility":94,"status":34,"city":95,"state":96,"zip":97,"country":38,"countryCode":39,"cosmosGeoPoint":98,"geoPoint":102,"contacts":29},"University of Illinois Medical Center - Hematology & Oncology","Chicago","Illinois","60612",{"type":41,"coordinates":99},[100,101],-87.65005,41.85003,{"lat":101,"lon":100},{"facility":104,"status":34,"city":105,"state":106,"zip":107,"country":38,"countryCode":39,"cosmosGeoPoint":108,"geoPoint":112,"contacts":29},"University of Kansas Cancer Center-Westwood","Westwood","Kansas","66205",{"type":41,"coordinates":109},[110,111],-94.6169,39.04056,{"lat":111,"lon":110},{"facility":114,"status":34,"city":115,"state":116,"zip":117,"country":38,"countryCode":39,"cosmosGeoPoint":118,"geoPoint":122,"contacts":29},"University of Kentucky Markey Cancer Center","Lexington","Kentucky","40536",{"type":41,"coordinates":119},[120,121],-84.47772,37.98869,{"lat":121,"lon":120},{"facility":124,"status":34,"city":125,"state":126,"zip":127,"country":38,"countryCode":39,"cosmosGeoPoint":128,"geoPoint":132,"contacts":29},"Dana-Farber Cancer Institute","Boston","Massachusetts","02215",{"type":41,"coordinates":129},[130,131],-71.05977,42.35843,{"lat":131,"lon":130},{"facility":134,"status":34,"city":135,"state":136,"zip":137,"country":38,"countryCode":39,"cosmosGeoPoint":138,"geoPoint":142,"contacts":29},"Henry Ford Cancer Institute","Detroit","Michigan","48202",{"type":41,"coordinates":139},[140,141],-83.04575,42.33143,{"lat":141,"lon":140},{"facility":144,"status":34,"city":145,"state":146,"zip":147,"country":38,"countryCode":39,"cosmosGeoPoint":148,"geoPoint":152,"contacts":29},"Washington University School of Medicine - Siteman Cancer Center","St Louis","Missouri","63108",{"type":41,"coordinates":149},[150,151],-90.19789,38.62727,{"lat":151,"lon":150},{"facility":154,"status":34,"city":155,"state":156,"zip":157,"country":38,"countryCode":39,"cosmosGeoPoint":158,"geoPoint":162,"contacts":29},"Levine Cancer Institute","Charlotte","North Carolina","28204",{"type":41,"coordinates":159},[160,161],-80.84313,35.22709,{"lat":161,"lon":160},{"facility":164,"status":34,"city":165,"state":156,"zip":166,"country":38,"countryCode":39,"cosmosGeoPoint":167,"geoPoint":171,"contacts":29},"Duke University Hospital","Durham","27705",{"type":41,"coordinates":168},[169,170],-78.89862,35.99403,{"lat":170,"lon":169},{"facility":173,"status":34,"city":174,"state":175,"zip":176,"country":38,"countryCode":39,"cosmosGeoPoint":177,"geoPoint":181,"contacts":29},"Oncology Hematology Care Clinical Trials, LLC","Cincinnati","Ohio","45242",{"type":41,"coordinates":178},[179,180],-84.51439,39.12711,{"lat":180,"lon":179},{"facility":183,"status":34,"city":184,"state":175,"zip":185,"country":38,"countryCode":39,"cosmosGeoPoint":186,"geoPoint":190,"contacts":29},"Cleveland Clinic","Cleveland","44195",{"type":41,"coordinates":187},[188,189],-81.69541,41.4995,{"lat":189,"lon":188},{"facility":192,"status":34,"city":193,"state":175,"zip":194,"country":38,"countryCode":39,"cosmosGeoPoint":195,"geoPoint":199,"contacts":29},"The Ohio State University Comprehensive Cancer Center","Columbus","43210",{"type":41,"coordinates":196},[197,198],-82.99879,39.96118,{"lat":198,"lon":197},{"facility":201,"status":34,"city":202,"state":203,"zip":204,"country":38,"countryCode":39,"cosmosGeoPoint":205,"geoPoint":209,"contacts":29},"Oregon Health and Science University","Portland","Oregon","97239",{"type":41,"coordinates":206},[207,208],-122.67621,45.52345,{"lat":208,"lon":207},{"facility":211,"status":34,"city":212,"state":213,"zip":214,"country":38,"countryCode":39,"cosmosGeoPoint":215,"geoPoint":219,"contacts":29},"UPMC Hillman Cancer Center","Pittsburgh","Pennsylvania","15232",{"type":41,"coordinates":216},[217,218],-79.99589,40.44062,{"lat":218,"lon":217},{"facility":221,"status":34,"city":222,"state":223,"zip":224,"country":38,"countryCode":39,"cosmosGeoPoint":225,"geoPoint":229,"contacts":29},"Avera Cancer Institute","Sioux Falls","South Dakota","57105",{"type":41,"coordinates":226},[227,228],-96.72796,43.54369,{"lat":228,"lon":227},{"facility":231,"status":34,"city":232,"state":233,"zip":234,"country":38,"countryCode":39,"cosmosGeoPoint":235,"geoPoint":239,"contacts":29},"Tristar Bone Marrow Transplant","Nashville","Tennessee","37203",{"type":41,"coordinates":236},[237,238],-86.78444,36.16589,{"lat":238,"lon":237},{"facility":241,"status":34,"city":232,"state":233,"zip":242,"country":38,"countryCode":39,"cosmosGeoPoint":243,"geoPoint":245,"contacts":29},"Vanderbilt-Ingram Cancer Center","37232",{"type":41,"coordinates":244},[237,238],{"lat":238,"lon":237},{"facility":247,"status":34,"city":248,"state":249,"zip":250,"country":38,"countryCode":39,"cosmosGeoPoint":251,"geoPoint":255,"contacts":29},"St. David's South Austin Medical Center","Austin","Texas","78704",{"type":41,"coordinates":252},[253,254],-97.74306,30.26715,{"lat":254,"lon":253},{"facility":257,"status":34,"city":258,"state":249,"zip":259,"country":38,"countryCode":39,"cosmosGeoPoint":260,"geoPoint":264,"contacts":29},"UT Southwestern Medical Center","Dallas","75390",{"type":41,"coordinates":261},[262,263],-96.80667,32.78306,{"lat":263,"lon":262},{"facility":266,"status":34,"city":267,"state":268,"zip":269,"country":38,"countryCode":39,"cosmosGeoPoint":270,"geoPoint":274,"contacts":29},"Intermountain Health","Salt Lake City","Utah","84143",{"type":41,"coordinates":271},[272,273],-111.89105,40.76078,{"lat":273,"lon":272},{"facility":276,"status":34,"city":277,"state":278,"zip":279,"country":38,"countryCode":39,"cosmosGeoPoint":280,"geoPoint":284,"contacts":29},"Virginia Commonwealth University","Richmond","Virginia","23298",{"type":41,"coordinates":281},[282,283],-77.46026,37.55376,{"lat":283,"lon":282},{"type":286,"investigatorFullName":29,"investigatorTitle":29,"investigatorAffiliation":29,"oldNameTitle":29,"oldOrganization":29},"SPONSOR","100563699","phase-2-a-study-to-evaluate-vimseltinib-in-adults-with-active-chronic-graft-versus-host-disease-cgvhd-100563699",false,"NCT06619561","A Study to Evaluate Vimseltinib in Adults With Active Chronic Graft-Versus-Host Disease (cGVHD)","A Phase 2, Open-label, Multicenter Study to Evaluate the Safety, Tolerability, PK, and Efficacy of Vimseltinib in Adults With Active Chronic GVHD After Failure of Prior Systemic Therapy","Inclusion Criteria:\n\n1. Must be allogeneic hematopoietic stem cell transplant (HSCT) recipients with moderate to severe cGVHD requiring systemic immune suppression.\n\n   a. May have persistent active acute GVHD (aGVHD) and chronic GVHD (cGVHD) manifestations (overlap syndrome).\n2. Participants with active cGVHD who have received and failed at least 2 prior lines of systemic therapy.\n3. Stable dose of systemic corticosteroids is permitted but not required. If being taken, participants should be on a stable dose of corticosteroids for at least 2 weeks prior to starting study drug treatment.\n4. Adequate organ and bone marrow functions.\n5. Participants of reproductive potential agree to follow the contraception requirements.\n6. Karnofsky Performance Scale (KPS) of ≥60.\n\nExclusion Criteria:\n\n1. Has aGVHD without manifestations of cGVHD.\n2. Prior use of colony-stimulating factor 1 receptor (CSF1R) inhibitor for cGVHD.\n3. History or other evidence of severe illness, uncontrolled infection, or any other conditions that would make the participant unsuitable for the study. All wounds must be healed and free of infection or dehiscence.\n4. History of malignancy except for:\n\n   1. Underlying malignancy for which the transplant was performed\n   2. Malignancy treated with curative intent and with no evidence of active disease present for more than 3 years prior to enrollment and felt to be at low risk for recurrence.\n5. Malabsorption syndrome or other illness that could affect oral absorption.","ALL","18 Years",{"count":297,"type":298},48,"ESTIMATED","INTERVENTIONAL",[301],"PHASE2","The purpose of this study is to determine if vimseltinib is safe, tolerable and works effectively to treat adults with active moderate to severe cGVHD. Participants will be treated with vimseltinib in 28-day treatment cycles for approximately 2 years.",[304],"Chronic Graft-Versus-Host Disease (cGVHD)",[306,307,308,309,310,311,312,313,314,315,316,317,318,319,320,321,322,323,324],"Allogeneic hematopoietic stem cell transplant (HSCT)","Graft-Versus-Host Disease","GVHD","cGVHD","Graft versus host disease","Immune System Diseases","Organizing Pneumonia","Bronchiolitis Obliterans","Bronchiolitis","Bronchial Diseases","Respiratory Tract Diseases","Lung Diseases, Obstructive","Lung Diseases","Bronchiolitis Obliterans Syndrome","Graft vs Host Disease","Sclerosis","Fibrosis","Hematopoietic stem cell transplantation","Liver diseases","2025-12-12",{"date":327,"type":328},"2025-12-15","ACTUAL",{"date":330,"type":328},"2024-11-21",{"date":332,"type":298},"2029-10",{"name":5,"class":6},26]