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CRP \\> upper limit of normal.\n  * Have a positive ACPA at screening.\n  * A history of inadequate response, or loss of response, or intolerance to: a. at least one csDMARD treatment, AND\u002FOR b. At least one and at most 2 TNFi.\n  * A history of at least 12 weeks treatment and \\>= 4 weeks stable on a csDMARD and\u002For SC TNFi prior to the day of randomisation.\n* Exclusion\n\n  * History or evidence of an alternate autoimmune or other condition that could confound the diagnosis of RA. Participants with RA and secondary Sjogren's disease are eligible.\n  * Have received or planning to receive any biologic DMARDs (except for TNFi) or targeted synthetic DMARDs.","ALL","18 Years",{"count":1151,"type":1152},320,"ESTIMATED","INTERVENTIONAL",[1155],"PHASE2","Phase II study in participants with moderately-to-severely active rheumatoid Arthritis (RA) to evaluate efficacy and safety of AZD1163.",[1158],"Rheumatoid Arthritis",[1160,31,1161,1162,1163,1164,1165],"Rheumatoid arthritis","placebo-controlled","double-blind","csDMARDs","TNFi","PAD2\u002F4 inhibitor","2026-06-23",{"date":1168,"type":1169},"2026-06-24","ACTUAL",{"date":1171,"type":1169},"2025-12-15",{"date":1173,"type":1152},"2028-08-18",{"name":5,"class":6},144]