[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100572590":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":30,"centralContacts":33,"locations":39,"responsibleParty":214,"collaborators":30,"id":216,"slug":217,"hasResults":218,"nctId":219,"briefTitle":220,"officialTitle":221,"acronym":30,"eligibilityCriteria":222,"healthyVolunteers":218,"sex":223,"minAge":224,"maxAge":225,"enrollmentInfo":226,"targetDuration":30,"studyType":229,"phases":230,"briefSummary":232,"conditions":233,"keywords":235,"overallStatus":56,"whyStopped":30,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":238,"startDateStruct":241,"completionDateStruct":243,"leadSponsor":245,"locationsCount":246},{"fullName":5,"class":6},"ModernaTX, Inc.","INDUSTRY",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"mRNA-1195 Dose Level 1 (Low Dose)","EXPERIMENTAL","Participants will receive 3 intramuscular (IM) injections at dose level 1 (low dose) on a 0-, 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2JF",{"type":49,"coordinates":210},[211,212],-1.4659,53.38297,{"lat":212,"lon":211},{"type":215,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100572590","phase-2-a-study-to-investigate-multiple-sclerosis-relapse-prevention-with-mrna-1195-compared-with-placebo-in-participants-aged-18-to-55-years-100572590",false,"NCT06735248","A Study to Investigate Multiple Sclerosis Relapse Prevention With mRNA-1195 Compared With Placebo in Participants Aged 18 to ≤55 Years","A Phase 2, Randomized, Observer-Blind, Placebo-Controlled, Dose-Ranging Study of mRNA-1195 Intramuscular Injection in Participants 18 to ≤55 Years of Age With Multiple Sclerosis","Inclusion Criteria:\n\n* Medically stable as determined by Investigator's medical evaluation, which will include assessment of medical history, physical examination, laboratory testing, and review of any previously conducted cardiac monitoring.\n* Participants who are 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endpoints, assessment of immune response, or adherence to study procedures.\n* Received or plans to receive any non-study vaccine (including authorized or approved vaccines for the prevention of coronavirus disease 2019 \\[COVID-19\\] regardless of vaccine type) within 28 days before or after any study injection, or within 14 days before or after any study injection for the influenza vaccine.\n* Any medical, psychiatric, or occupational condition, including reported history of drug or alcohol abuse, that, in the opinion of the Investigator, might pose additional risk due to participation in the study or could interfere with the interpretation of study results.\n* Received systemic immunosuppressants within the 30 day period prior to screening (for corticosteroids, ≥10 milligrams (mg)\u002Fday of prednisone or equivalent)\n* Participants with any documented history of myocarditis, pericarditis, or myopericarditis.\n* Has donated ≥450 milliliter (mL) of blood products within 28 days prior to screening or plans to donate blood products within 28 days post-study injection.\n\nNote: Other inclusion and exclusion criteria may apply.","ALL","18 Years","55 Years",{"count":227,"type":228},180,"ESTIMATED","INTERVENTIONAL",[231],"PHASE2","The primary objective of this trial is to evaluate the safety and reactogenicity of mRNA-1195 in participants with multiple sclerosis.",[234],"Multiple Sclerosis",[234,27,236],"MS","2026-06-11",{"date":239,"type":240},"2026-06-15","ACTUAL",{"date":242,"type":240},"2025-04-16",{"date":244,"type":228},"2029-01-08",{"name":5,"class":6},17]