[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100574556":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":22,"locations":28,"responsibleParty":537,"collaborators":21,"id":539,"slug":540,"hasResults":541,"nctId":542,"briefTitle":543,"officialTitle":544,"acronym":545,"eligibilityCriteria":546,"healthyVolunteers":541,"sex":547,"minAge":548,"maxAge":21,"enrollmentInfo":549,"targetDuration":21,"studyType":552,"phases":553,"briefSummary":555,"conditions":556,"keywords":559,"overallStatus":31,"whyStopped":21,"lastUpdateSubmitDate":582,"lastUpdatePostDateStruct":583,"startDateStruct":586,"completionDateStruct":588,"leadSponsor":590,"locationsCount":591},{"fullName":5,"class":6},"Bayer","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"BAY2927088","EXPERIMENTAL","Adult participants with metastatic or unresectable solid tumors with HER-2 activating mutations including: colorectal, biliary tract, bladder, cervical, endometrial, breast, and other solid tumor types. Participants will receive BAY2927088 20 mg BID until disease progression per RECICST 1.1, unacceptable toxicity, or until any other withdrawal criteria.\n\nRECIST 1.1 = Response Evaluation Criteria in Solid Tumors, version 1.1; BID: twice a day",[13],"Drug: BAY2927088",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"DRUG","tablet, oral",[9],[20],"Sevabertinib",null,[23],{"name":24,"role":25,"phone":26,"phoneExt":21,"email":27},"Bayer Clinical Trials Contact","CONTACT","(+)1-888-84 22937","clinical-trials-contact@bayer.com",[29,43,53,63,73,84,93,103,113,123,133,143,155,164,174,186,196,206,218,224,234,244,254,260,272,282,292,304,314,324,334,344,354,365,371,380,389,401,411,421,431,436,440,451,457,463,469,481,486,494,500,508,519,528],{"facility":30,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":21},"UAB O'Neal Comprehensive Cancer Center - The Kirklin Clinic of UAB Hospital","RECRUITING","Birmingham","Alabama","35233","United States","US",{"type":38,"coordinates":39},"Point",[40,41],-86.80249,33.52066,{"lat":41,"lon":40},{"facility":44,"status":31,"city":45,"state":46,"zip":47,"country":35,"countryCode":36,"cosmosGeoPoint":48,"geoPoint":52,"contacts":21},"City of Hope - Duarte Cancer Center","Duarte","California","91010",{"type":38,"coordinates":49},[50,51],-117.97729,34.13945,{"lat":51,"lon":50},{"facility":54,"status":31,"city":55,"state":56,"zip":57,"country":35,"countryCode":36,"cosmosGeoPoint":58,"geoPoint":62,"contacts":21},"Florida Cancer Specialists & Research Institute - Fort Myers Cancer Center - Gladiolus","Fort Myers","Florida","33908",{"type":38,"coordinates":59},[60,61],-81.84059,26.62168,{"lat":61,"lon":60},{"facility":64,"status":31,"city":65,"state":66,"zip":67,"country":35,"countryCode":36,"cosmosGeoPoint":68,"geoPoint":72,"contacts":21},"Dana-Farber Cancer Institute - Oncology Department","Boston","Massachusetts","02215",{"type":38,"coordinates":69},[70,71],-71.05977,42.35843,{"lat":71,"lon":70},{"facility":74,"status":75,"city":76,"state":77,"zip":78,"country":35,"countryCode":36,"cosmosGeoPoint":79,"geoPoint":83,"contacts":21},"Brigette Harris Cancer Pavilion at Henry Ford Cancer Center - Detroit","WITHDRAWN","Detroit","Michigan","48202",{"type":38,"coordinates":80},[81,82],-83.04575,42.33143,{"lat":82,"lon":81},{"facility":85,"status":31,"city":86,"state":77,"zip":87,"country":35,"countryCode":36,"cosmosGeoPoint":88,"geoPoint":92,"contacts":21},"Profound Research -OMG - TriAtria Cancer Center","Farmington Hills","48334",{"type":38,"coordinates":89},[90,91],-83.37716,42.48531,{"lat":91,"lon":90},{"facility":94,"status":31,"city":95,"state":96,"zip":97,"country":35,"countryCode":36,"cosmosGeoPoint":98,"geoPoint":102,"contacts":21},"Cleveland Clinic - Oncology Department","Cleveland","Ohio","44195",{"type":38,"coordinates":99},[100,101],-81.69541,41.4995,{"lat":101,"lon":100},{"facility":104,"status":31,"city":105,"state":106,"zip":107,"country":35,"countryCode":36,"cosmosGeoPoint":108,"geoPoint":112,"contacts":21},"SCRI Oncology Partners","Nashville","Tennessee","37203",{"type":38,"coordinates":109},[110,111],-86.78444,36.16589,{"lat":111,"lon":110},{"facility":114,"status":31,"city":115,"state":116,"zip":117,"country":35,"countryCode":36,"cosmosGeoPoint":118,"geoPoint":122,"contacts":21},"The University of Texas MD Anderson Cancer Center - Texas Medical Center","Houston","Texas","77030",{"type":38,"coordinates":119},[120,121],-95.36327,29.76328,{"lat":121,"lon":120},{"facility":124,"status":75,"city":125,"state":126,"zip":127,"country":35,"countryCode":36,"cosmosGeoPoint":128,"geoPoint":132,"contacts":21},"Gynecology Oncology clinic at UW Medical Center - Montlake","Seattle","Washington","98195",{"type":38,"coordinates":129},[130,131],-122.33207,47.60621,{"lat":131,"lon":130},{"facility":134,"status":31,"city":135,"state":136,"zip":137,"country":35,"countryCode":36,"cosmosGeoPoint":138,"geoPoint":142,"contacts":21},"UW Health Carbone Cancer Center","Madison","Wisconsin","53792",{"type":38,"coordinates":139},[140,141],-89.40123,43.07305,{"lat":141,"lon":140},{"facility":144,"status":31,"city":145,"state":146,"zip":147,"country":148,"countryCode":149,"cosmosGeoPoint":150,"geoPoint":154,"contacts":21},"NSW Health - Blacktown Hospital","Blacktown","New South Wales","2148","Australia","AU",{"type":38,"coordinates":151},[152,153],150.91667,-33.76667,{"lat":153,"lon":152},{"facility":156,"status":31,"city":157,"state":146,"zip":158,"country":148,"countryCode":149,"cosmosGeoPoint":159,"geoPoint":163,"contacts":21},"Macquarie University Hospital - Oncology Department","Sydney","2109",{"type":38,"coordinates":160},[161,162],151.20732,-33.86785,{"lat":162,"lon":161},{"facility":165,"status":31,"city":166,"state":167,"zip":168,"country":148,"countryCode":149,"cosmosGeoPoint":169,"geoPoint":173,"contacts":21},"ICON Cancer Centre - Southport","Southport","Queensland","4215",{"type":38,"coordinates":170},[171,172],153.39796,-27.96724,{"lat":172,"lon":171},{"facility":175,"status":31,"city":176,"state":177,"zip":178,"country":179,"countryCode":180,"cosmosGeoPoint":181,"geoPoint":185,"contacts":21},"Queen Elizabeth II Health Sciences Centre | Oncology","Halifax","Nova Scotia","B3H 2Y9","Canada","CA",{"type":38,"coordinates":182},[183,184],-63.57688,44.64269,{"lat":184,"lon":183},{"facility":187,"status":31,"city":188,"state":189,"zip":190,"country":179,"countryCode":180,"cosmosGeoPoint":191,"geoPoint":195,"contacts":21},"Princess Margaret Cancer Centre - University Health Network - Department of Medical Oncology and Hematology","Toronto","Ontario","M5G 2C4",{"type":38,"coordinates":192},[193,194],-79.39864,43.70643,{"lat":194,"lon":193},{"facility":197,"status":31,"city":198,"state":199,"zip":200,"country":179,"countryCode":180,"cosmosGeoPoint":201,"geoPoint":205,"contacts":21},"McGill University Health Centre - Glen Site - Women Health's Research Unit","Montreal","Quebec","H4A 3J1",{"type":38,"coordinates":202},[203,204],-73.58781,45.50884,{"lat":204,"lon":203},{"facility":207,"status":31,"city":208,"state":209,"zip":210,"country":211,"countryCode":212,"cosmosGeoPoint":213,"geoPoint":217,"contacts":21},"Peking University First Hospital - Oncology Department","Beijing","Beijing Municipality","100034","China","CN",{"type":38,"coordinates":214},[215,216],116.39723,39.9075,{"lat":216,"lon":215},{"facility":219,"status":31,"city":208,"state":209,"zip":220,"country":211,"countryCode":212,"cosmosGeoPoint":221,"geoPoint":223,"contacts":21},"Beijing Cancer Hospital - Oncology Department","100142",{"type":38,"coordinates":222},[215,216],{"lat":216,"lon":215},{"facility":225,"status":31,"city":226,"state":227,"zip":228,"country":211,"countryCode":212,"cosmosGeoPoint":229,"geoPoint":233,"contacts":21},"Hunan Cancer Hospital - Oncology Department","Changsha","Hunan","410013",{"type":38,"coordinates":230},[231,232],112.97087,28.19874,{"lat":232,"lon":231},{"facility":235,"status":31,"city":236,"state":237,"zip":238,"country":211,"countryCode":212,"cosmosGeoPoint":239,"geoPoint":243,"contacts":21},"Zhongshan Hospital, Fudan University","Shanghai","Shanghai Municipality","200032",{"type":38,"coordinates":240},[241,242],121.45806,31.22222,{"lat":242,"lon":241},{"facility":245,"status":31,"city":246,"state":247,"zip":248,"country":211,"countryCode":212,"cosmosGeoPoint":249,"geoPoint":253,"contacts":21},"Sir Run Run Shaw Hospital, Zhejiang Univ. School of Medicine - Oncology Department","Hangzhou","Zhejiang","310016",{"type":38,"coordinates":250},[251,252],120.16142,30.29365,{"lat":252,"lon":251},{"facility":255,"status":31,"city":236,"state":21,"zip":256,"country":211,"countryCode":212,"cosmosGeoPoint":257,"geoPoint":259,"contacts":21},"Fudan University Shanghai Cancer Center - Oncology Department","200000",{"type":38,"coordinates":258},[241,242],{"lat":242,"lon":241},{"facility":261,"status":31,"city":262,"state":263,"zip":264,"country":265,"countryCode":266,"cosmosGeoPoint":267,"geoPoint":271,"contacts":21},"Rigshospitalet Copenhagen University Hospital | Oncology Department","Copenhagen","Capital Region","2100","Denmark","DK",{"type":38,"coordinates":268},[269,270],12.56553,55.67594,{"lat":270,"lon":269},{"facility":273,"status":31,"city":274,"state":275,"zip":276,"country":265,"countryCode":266,"cosmosGeoPoint":277,"geoPoint":281,"contacts":21},"Aarhus University Hospital | Oncology Department - Clinical Research Unit","Aarhus N","Central Jutland","8200",{"type":38,"coordinates":278},[279,280],10.17317,56.20367,{"lat":280,"lon":279},{"facility":283,"status":31,"city":284,"state":285,"zip":286,"country":265,"countryCode":266,"cosmosGeoPoint":287,"geoPoint":291,"contacts":21},"Odense University Hospital | Svendborg Sygehus - Oncology Department","Odense","Region Syddanmark","5000",{"type":38,"coordinates":288},[289,290],10.38831,55.39594,{"lat":290,"lon":289},{"facility":293,"status":31,"city":294,"state":295,"zip":296,"country":297,"countryCode":298,"cosmosGeoPoint":299,"geoPoint":303,"contacts":21},"Centre Hospitalier Lyon Sud - Service oncologie medicale","Pierre-Bénite","Auvergne-Rhône-Alpes","69310","France","FR",{"type":38,"coordinates":300},[301,302],4.82424,45.70359,{"lat":302,"lon":301},{"facility":305,"status":31,"city":306,"state":307,"zip":308,"country":297,"countryCode":298,"cosmosGeoPoint":309,"geoPoint":313,"contacts":21},"CHU Brest - Hopital La Cavale Blanche - service oncologie medicale","Brest","Brittany Region","29200",{"type":38,"coordinates":310},[311,312],-4.48628,48.39029,{"lat":312,"lon":311},{"facility":315,"status":31,"city":316,"state":317,"zip":318,"country":297,"countryCode":298,"cosmosGeoPoint":319,"geoPoint":323,"contacts":21},"Centre Oscar Lambret - Service Oncologie","Lille","Hauts-de-France","59000",{"type":38,"coordinates":320},[321,322],3.05512,50.63391,{"lat":322,"lon":321},{"facility":325,"status":31,"city":326,"state":327,"zip":328,"country":297,"countryCode":298,"cosmosGeoPoint":329,"geoPoint":333,"contacts":21},"Institut Bergonie - Unicancer Nouvelle Aquitaine - Service Oncologie medicale","Bordeaux","New Aquitaine","33000",{"type":38,"coordinates":330},[331,332],-0.58046,44.84124,{"lat":332,"lon":331},{"facility":335,"status":31,"city":336,"state":337,"zip":338,"country":297,"countryCode":298,"cosmosGeoPoint":339,"geoPoint":343,"contacts":21},"ICM - Institut du Cancer de Montpellier - Val d'Aurelle - CIPP","Montpellier","Occitanie","34298",{"type":38,"coordinates":340},[341,342],3.87635,43.61093,{"lat":342,"lon":341},{"facility":345,"status":31,"city":346,"state":347,"zip":348,"country":297,"countryCode":298,"cosmosGeoPoint":349,"geoPoint":353,"contacts":21},"Institut Gustave Roussy - Departement d'Innovation Therapeutique et d'Essais Precoces (DITEP)","Villejuif","Île-de-France Region","94805",{"type":38,"coordinates":350},[351,352],2.35992,48.7939,{"lat":352,"lon":351},{"facility":355,"status":31,"city":356,"state":21,"zip":357,"country":358,"countryCode":359,"cosmosGeoPoint":360,"geoPoint":364,"contacts":21},"Fondazione IRCCS Istituto Nazionale dei Tumori - S. C. Oncologia Medica 1","Milan","20133","Italy","IT",{"type":38,"coordinates":361},[362,363],12.59836,42.78235,{"lat":363,"lon":362},{"facility":366,"status":31,"city":356,"state":21,"zip":367,"country":358,"countryCode":359,"cosmosGeoPoint":368,"geoPoint":370,"contacts":21},"Istituto Europeo di Oncologia s.r.l - Ginecologia Oncologica Medica","20141",{"type":38,"coordinates":369},[362,363],{"lat":363,"lon":362},{"facility":372,"status":31,"city":373,"state":21,"zip":374,"country":358,"countryCode":359,"cosmosGeoPoint":375,"geoPoint":379,"contacts":21},"Azienda USL IRCCS di Reggio Emilia_Arcispedale Santa Maria Nuova - S.C. Oncologia Provinciale","Reggio Emilia","42123",{"type":38,"coordinates":376},[377,378],10.63125,44.69825,{"lat":378,"lon":377},{"facility":381,"status":31,"city":382,"state":21,"zip":383,"country":358,"countryCode":359,"cosmosGeoPoint":384,"geoPoint":388,"contacts":21},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOC Oncologia Medica","Roma","00168",{"type":38,"coordinates":385},[386,387],11.10642,44.99364,{"lat":387,"lon":386},{"facility":390,"status":31,"city":391,"state":392,"zip":393,"country":394,"countryCode":395,"cosmosGeoPoint":396,"geoPoint":400,"contacts":21},"Aichi Cancer Center Hospital","Nagoya","Aichi-ken","464-8681","Japan","JP",{"type":38,"coordinates":397},[398,399],136.90641,35.18147,{"lat":399,"lon":398},{"facility":402,"status":31,"city":403,"state":404,"zip":405,"country":394,"countryCode":395,"cosmosGeoPoint":406,"geoPoint":410,"contacts":21},"National Cancer Center Hospital East (NCCHE) - Kashiwa Campus","Kashiwa","Chiba","277-8577",{"type":38,"coordinates":407},[408,409],139.97732,35.86224,{"lat":409,"lon":408},{"facility":412,"status":31,"city":413,"state":414,"zip":415,"country":394,"countryCode":395,"cosmosGeoPoint":416,"geoPoint":420,"contacts":21},"Hokkaido University Hospital","Sapporo","Hokkaido","060-8648",{"type":38,"coordinates":417},[418,419],141.35,43.06667,{"lat":419,"lon":418},{"facility":422,"status":31,"city":423,"state":424,"zip":425,"country":394,"countryCode":395,"cosmosGeoPoint":426,"geoPoint":430,"contacts":21},"Kindai University Hospital","Sakai","Osaka","590-0197",{"type":38,"coordinates":427},[428,429],135.46653,34.58216,{"lat":429,"lon":428},{"facility":432,"status":31,"city":433,"state":434,"zip":435,"country":394,"countryCode":395,"cosmosGeoPoint":21,"geoPoint":21,"contacts":21},"National Cancer Center Hospital","Chuo-ku","Tokyo","104-0045",{"facility":437,"status":31,"city":438,"state":434,"zip":439,"country":394,"countryCode":395,"cosmosGeoPoint":21,"geoPoint":21,"contacts":21},"The Cancer Institute Hospital of JFCR","Koto-ku","135-8550",{"facility":441,"status":31,"city":442,"state":443,"zip":444,"country":445,"countryCode":21,"cosmosGeoPoint":446,"geoPoint":450,"contacts":21},"Severance Hospital, Yonsei University Health System - Oncology Department","Seoul","Seoul Teugbyeolsi","03722","South Korea",{"type":38,"coordinates":447},[448,449],126.9784,37.566,{"lat":449,"lon":448},{"facility":452,"status":31,"city":442,"state":443,"zip":453,"country":445,"countryCode":21,"cosmosGeoPoint":454,"geoPoint":456,"contacts":21},"Asan Medical Center | Oncology","05505",{"type":38,"coordinates":455},[448,449],{"lat":449,"lon":448},{"facility":458,"status":31,"city":442,"state":443,"zip":459,"country":445,"countryCode":21,"cosmosGeoPoint":460,"geoPoint":462,"contacts":21},"Seoul National University Hospital","3080",{"type":38,"coordinates":461},[448,449],{"lat":449,"lon":448},{"facility":464,"status":31,"city":442,"state":21,"zip":465,"country":445,"countryCode":21,"cosmosGeoPoint":466,"geoPoint":468,"contacts":21},"Samsung Medical Center - Oncology Department","06351",{"type":38,"coordinates":467},[448,449],{"lat":449,"lon":448},{"facility":470,"status":31,"city":471,"state":472,"zip":473,"country":474,"countryCode":475,"cosmosGeoPoint":476,"geoPoint":480,"contacts":21},"Institut Catala D'oncologia | Hospitalet | Oncologia","L'Hospitalet de Llobregat","Barcelona","08908","Spain","ES",{"type":38,"coordinates":477},[478,479],2.10028,41.35967,{"lat":479,"lon":478},{"facility":482,"status":31,"city":483,"state":484,"zip":485,"country":474,"countryCode":475,"cosmosGeoPoint":21,"geoPoint":21,"contacts":21},"Clinica Universidad De Navarra | Madrid | Oncologia","Madrid","Navarre","28027",{"facility":487,"status":31,"city":472,"state":21,"zip":488,"country":474,"countryCode":475,"cosmosGeoPoint":489,"geoPoint":493,"contacts":21},"Instituto Oncologico Dr. Rosell S.L. | Oncologia","08028",{"type":38,"coordinates":490},[491,492],2.15899,41.38879,{"lat":492,"lon":491},{"facility":495,"status":31,"city":472,"state":21,"zip":496,"country":474,"countryCode":475,"cosmosGeoPoint":497,"geoPoint":499,"contacts":21},"Hospital Universitari Vall D Hebron | Oncologia Medica","08035",{"type":38,"coordinates":498},[491,492],{"lat":492,"lon":491},{"facility":501,"status":31,"city":483,"state":21,"zip":502,"country":474,"countryCode":475,"cosmosGeoPoint":503,"geoPoint":507,"contacts":21},"Hospital Universitario Fundacion Jimenez Diaz | Oncologia Medica","28040",{"type":38,"coordinates":504},[505,506],-3.70256,40.4165,{"lat":506,"lon":505},{"facility":509,"status":31,"city":510,"state":21,"zip":511,"country":512,"countryCode":513,"cosmosGeoPoint":514,"geoPoint":518,"contacts":21},"Inselspital Bern - Universitätsklinik für Medizinische Onkologie","Bern","3010","Switzerland","CH",{"type":38,"coordinates":515},[516,517],7.44744,46.94809,{"lat":517,"lon":516},{"facility":520,"status":31,"city":521,"state":21,"zip":522,"country":512,"countryCode":513,"cosmosGeoPoint":523,"geoPoint":527,"contacts":21},"Hopitaux Universitaires de Geneve - Oncology Department","Geneva","1205",{"type":38,"coordinates":524},[525,526],6.14569,46.20222,{"lat":526,"lon":525},{"facility":529,"status":31,"city":530,"state":21,"zip":531,"country":512,"countryCode":513,"cosmosGeoPoint":532,"geoPoint":536,"contacts":21},"Univestitätsspital Zürich (USZ)","Zurich","8091",{"type":38,"coordinates":533},[534,535],8.55,47.36667,{"lat":535,"lon":534},{"type":538,"investigatorFullName":21,"investigatorTitle":21,"investigatorAffiliation":21,"oldNameTitle":21,"oldOrganization":21},"SPONSOR","100574556","phase-2-a-study-to-learn-more-about-how-well-treatment-with-sevabertinib-bay-2927088-tablets-works-and-how-safe-it-is-in-participants-who-have-a-solid-tumor-with-mutations-of-the-human-epidermal-growth-factor-receptor-2-her2-100574556",false,"NCT06760819","A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)","A Phase 2 Open-label Basket Study to Evaluate the Efficacy and Safety of Orally Administered Reversible Tyrosine Kinase Inhibitor BAY 2927088 in Participants With Metastatic or Unresectable Solid Tumors With HER2-activating Mutations","panSOHO","Inclusion Criteria:\n\n* Documented histologically or cytologically confirmed locally advanced, unresectable or metastatic solid tumor cancer (colorectal carcinoma; biliary tract cancer; bladder and urothelial tract cancer; cervical cancer; endometrial cancer; breast cancer; other solid tumor cancer, excluding NSCLC)\n* Participant must be ≥18 years of age or over the legal age of consent\n* Patients who have received prior standard therapy appropriate for their tumor type and stage of disease, or who have no satisfactory alternative treatments\n* Documented activating HER2 mutation\n* At least one measurable lesion that would qualify as a target lesion by RECIST 1.1 criteria\n\nExclusion Criteria:\n\n* Primary diagnosis of non-small cell lung cancer (NSCLC)\n* Prior treatment with a HER2 tyrosine kinase inhibitor (TKI)\n* Active brain metastases\n* Uncontrolled, severe, intercurrent illness","ALL","18 Years",{"count":550,"type":551},111,"ESTIMATED","INTERVENTIONAL",[554],"PHASE2","Researchers are looking for a better way to treat people who have solid tumors with HER2-activating mutations. Before a treatment can be approved for people to take, researchers do clinical trials to better understand its safety and how it works.\n\nIn this trial, the researchers want to learn how well BAY2927088 (sevabertinib) works in people with different types of solid tumors with HER2 mutations. These include tumors in the colon or rectum, the uterus and the cervix (lower part of the uterus), the breast, the bladder, and the biliary tract (includes gall bladder and bile ducts) as well as other types of solid tumors with the exception of people with advanced non-small cell lung cancer (NSCLC).\n\nSolid tumors may have specific changes or mutations to a gene called human epidermal growth receptor-2 (HER2). This leads to the formation of an abnormal form of HER2 protein in the cancer cells, resulting in increased cell growth. The study treatment, BAY2927088, is expected to block the abnormal HER2 protein which may stop the spread of cancer.\n\nThe trial will include about 111 participants who are at least 18 years old. All the participants will take 20 mg of BAY2927088 as tablets by mouth.\n\nThe participants will take treatments in 3-week periods called cycles. These 3-week cycles will be repeated throughout the trial. The participants can take BAY2927088 until their cancer gets worse, until they have medical problems, or until they leave the trial.\n\nDuring the trial, the doctors will take imaging scans of different parts of the body to study the spread of cancer and will check heart health using echocardiogram or cardiac magnetic resonance imaging (MRI) and electrocardiogram (ECG). The doctors will also take blood and urine samples and do physical examinations to check the participants' health. They will ask questions about how the participants are feeling and if they have any medical problems.",[557,558],"Advanced Solid Tumors","HER2 Mutation",[560,561,562,563,564,565,566,567,568,569,570,571,572,573,574,575,576,577,578,579,580,581],"Colorectal cancer","CRC","Biliary tract cancer","BTC","Bladder cancer","Cervical cancer","Endometrial cancer","Sarcoma","Gastrointestinal stromal tumor","GIST","Breast cancer","Gastrointestinal cancer","GI cancer","Gastric cancer","Esophageal cancer","Gallbladder cancer","Pancreatic cancer","Ovarian Cancer","Salivary cancer","Ampullary cancer","Urothelial cancer","HER2 mutant cancer","2026-06-03",{"date":584,"type":585},"2026-06-04","ACTUAL",{"date":587,"type":585},"2025-02-13",{"date":589,"type":551},"2027-10-25",{"name":5,"class":6},54]