[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616664":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":36,"centralContacts":49,"locations":58,"responsibleParty":96,"collaborators":36,"id":98,"slug":99,"hasResults":100,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":100,"sex":106,"minAge":107,"maxAge":108,"enrollmentInfo":109,"targetDuration":36,"studyType":112,"phases":113,"briefSummary":115,"conditions":116,"keywords":118,"overallStatus":80,"whyStopped":36,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":130},{"fullName":5,"class":6},"Hinova Pharmaceuticals Inc.","INDUSTRY",[8,15,20,24],{"label":9,"type":10,"description":11,"interventionNames":12},"HP515 40mg group","EXPERIMENTAL","Two HP515 20 mg Tablets +Two Placebos of HP515 10mg Tablets",[13,14],"Drug: Placebo of HP515 10 mg Tablet","Drug: HP515 20 mg Tablet",{"label":16,"type":10,"description":17,"interventionNames":18},"HP515 50mg group","Two HP515 20mg Tablets + One HP515 10mg Tablet + One Placebo of HP515 10mg Tablet",[19,13,14],"Drug: HP515 10 mg Tablet",{"label":21,"type":10,"description":22,"interventionNames":23},"HP515 60mg group","Two HP515 20mg Tablets + Two HP515 10mg Tablets",[13,14],{"label":25,"type":26,"description":27,"interventionNames":28},"Placebo","PLACEBO_COMPARATOR","Two Placebos of HP515 20mg Tablet +Two Placebos of HP515 10mg Tablet",[13,29],"Drug: Placebo of HP515 20mg Tablet",[31,37,41,45],{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"DRUG","HP515 10 mg Tablet","Provided by provided by Hinova Pharmaceuticals Inc .Storage: Protect from light, keep sealed, store at ≤25°C. HP515 10mg Tablet, qd",[16],null,{"type":32,"name":38,"description":39,"armGroupLabels":40,"otherNames":36},"Placebo of HP515 10 mg Tablet","Provided by provided by Hinova Pharmaceuticals Inc .Storage: Protect from light, keep sealed, store at ≤25°C. Placebo of HP515 10 mg Tablet ,qd , 12 weeks.",[9,16,21,25],{"type":32,"name":42,"description":43,"armGroupLabels":44,"otherNames":36},"HP515 20 mg Tablet","Provided by provided by Hinova Pharmaceuticals Inc .Storage: Protect from light, keep sealed, store at ≤25°C; HP515 20 mg Tablet, qd,12 weeks",[9,16,21],{"type":32,"name":46,"description":47,"armGroupLabels":48,"otherNames":36},"Placebo of HP515 20mg Tablet","Provided by provided by Hinova Pharmaceuticals Inc .Storage: Protect from light, keep sealed, store at ≤25°C; Placebo of HP515 20 mg Tablet, qd,12 weeks",[25],[50,55],{"name":51,"role":52,"phone":53,"phoneExt":36,"email":54},"Yang Ming YM Chief physician","CONTACT","+86-15810092973","ymicecream@163.com",{"name":56,"role":52,"phone":53,"phoneExt":36,"email":57},"Wei WL chief physician","weelai@163.com",[59,78],{"facility":60,"status":61,"city":62,"state":63,"zip":64,"country":65,"countryCode":66,"cosmosGeoPoint":67,"geoPoint":72,"contacts":73},"Beijing Tsinghua Changgung Hospital","NOT_YET_RECRUITING","Beijing","Beijing Municipality","102218","China","CN",{"type":68,"coordinates":69},"Point",[70,71],116.39723,39.9075,{"lat":71,"lon":70},[74],{"name":75,"role":52,"phone":76,"phoneExt":36,"email":77},"Liu Man Ting LMT Liu","+86-01056118567","IRB@btch.edu.cn",{"facility":79,"status":80,"city":81,"state":82,"zip":83,"country":65,"countryCode":66,"cosmosGeoPoint":84,"geoPoint":88,"contacts":89},"Chengdu Seventh People's Hospital","RECRUITING","Chengdu","Sichuan","610041",{"type":68,"coordinates":85},[86,87],104.06667,30.66667,{"lat":87,"lon":86},[90,94],{"name":91,"role":52,"phone":92,"phoneExt":36,"email":93},"Liu JingYu LJY chief physician","+86-13540087274","liujy92@163.com",{"name":95,"role":52,"phone":36,"phoneExt":36,"email":36},"chief physician",{"type":97,"investigatorFullName":36,"investigatorTitle":36,"investigatorAffiliation":36,"oldNameTitle":36,"oldOrganization":36},"SPONSOR","100616664","phase-2-a-trial-to-evaluate-the-efficacy-safety-pk-and-pd-of-hp515-in-non---alcoholic-fatty-liver-disease--nashmash--100616664",false,"NCT07308548","A Trial to Evaluate the Efficacy, Safety, PK, and PD of HP515 in Non - Alcoholic Fatty Liver Disease ( NASH\u002FMASH )","A Phase IIa Clinical Trial to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of HP515 Tablets in Participants With Non - Alcoholic Fatty Liver Disease","NASH\u002FMASH","Inclusion Criteria:\n\n1. Participants must voluntarily sign the informed consent form before the trial and fully understand the trial content, process, and possible adverse reactions.\n2. Participants must be aged between 18 and 65 years old, including those at the borderline age.\n3. At the screening stage, the liver fat fraction must be ≥ 10%\n4. Female participants must not donate eggs from the start of the screening until the end of the study and within 28 days after discontinuing the study drug; male participants must not donate sperm from the start of the screening until the end of the study and within 28 days after discontinuing the study drug.\n5. Participants must agree to use contraception during the study period and for the next 6 months after the last administration of the study drug, and must agree to continuously use effective contraceptive measures.\n\nExclusion Criteria:\n\n1. The participants have known or suspected allergic reactions\n2. Liver biopsy indicates cirrhosis or the participant has been clinically diagnosed with cirrhosis\n3. Type 1 diabetic patients or those with poorly controlled type 2 diabetes (HbA1c ≥ 8.0%);\n4. Suspected other liver and gallbladder diseases through medical history and laboratory tests, which, based on the investigator's judgment, may affect safety or efficacy evaluation\n5. Any abnormality in thyroid function tests with clinical significance or a previous history of thyroid disease\n6. Within the previous 1 year, had myocardial infarction, unstable angina pectoris, coronary artery bypass surgery, cerebral infarction, cerebral hemorrhage, subarachnoid hemorrhage or transient ischemic attack, or other cardiovascular and cerebrovascular events that led to hospitalization;\n7. History of liver transplantation or planning to undergo liver transplantation;\n8. Had significant changes in diet or exercise habits in the past 2 months or a weight change of more than 5%;\n9. Participants who used drugs that changed the activity of CYP2C8 of liver enzymes within 4 weeks or 5 half-lives (whichever is longer), including strong inhibitors and inducers of liver metabolic enzymes;\n10. Pregnant or lactating women;\n11. Participants with contraindications to MRI scans;\n12. Participants judged by the investigator to be unsuitable for participation in the study.","ALL","18 Years","65 Years",{"count":110,"type":111},80,"ESTIMATED","INTERVENTIONAL",[114],"PHASE2","Primary Objective:\n\n• To evaluate the efficacy of HP515 tablets in participants with non-alcoholic fatty liver disease.\n\nSecondary objectives:\n\n* To evaluate the safety of HP515 tablets in participants with non-alcoholic fatty liver disease;\n* To evaluate the pharmacokinetic of HP515 tablets in participants with non-alcoholic fatty liver disease;\n* To evaluate the pharmacodynamic effects of HP515 tablets in participants with non-alcoholic fatty liver disease;\n\nExploratory objective:\n\n• To evaluate the impact of HP515 tablets on target markers in participants with non-alcoholic fatty liver disease.\n\nThe study includes a screening period of 4 weeks, a treatment period of 12 weeks, and a safety follow-up period of 4 weeks.",[117],"NAFLD (Non-alcoholic Fatty Liver Disease)",[119,120],"non-alcoholic","Fatty Liver","2025-12-19",{"date":123,"type":124},"2025-12-29","ACTUAL",{"date":126,"type":124},"2025-10-11",{"date":128,"type":111},"2026-12-31",{"name":5,"class":6},2]