[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100635511":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":27,"locations":32,"responsibleParty":475,"collaborators":11,"id":477,"slug":478,"hasResults":479,"nctId":480,"briefTitle":481,"officialTitle":482,"acronym":11,"eligibilityCriteria":483,"healthyVolunteers":479,"sex":484,"minAge":485,"maxAge":486,"enrollmentInfo":487,"targetDuration":11,"studyType":490,"phases":491,"briefSummary":493,"conditions":494,"keywords":11,"overallStatus":58,"whyStopped":11,"lastUpdateSubmitDate":496,"lastUpdatePostDateStruct":497,"startDateStruct":500,"completionDateStruct":502,"leadSponsor":504,"locationsCount":505},{"fullName":5,"class":6},"Alto Neuroscience","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"ALTO-207","EXPERIMENTAL",null,[13],"Drug: ALTO-207",{"label":15,"type":16,"description":11,"interventionNames":17},"Placebo","PLACEBO_COMPARATOR",[18],"Drug: Placebo",[20,24],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":11},"DRUG","ALTO-207 BID",[9],{"type":21,"name":15,"description":25,"armGroupLabels":26,"otherNames":11},"Matching Placebo",[15],[28],{"name":5,"role":29,"phone":30,"phoneExt":11,"email":31},"CONTACT","650-200-0412","clinical@altoneuroscience.com",[33,47,56,67,77,86,95,104,113,122,131,141,151,160,169,178,188,198,207,217,227,236,246,255,264,273,283,293,302,312,322,331,340,349,355,364,374,384,394,404,411,419,427,435,443,451,459,467],{"facility":34,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":11},"Site 7074","NOT_YET_RECRUITING","Birmingham","Alabama","35294","United States","US",{"type":42,"coordinates":43},"Point",[44,45],-86.80249,33.52066,{"lat":45,"lon":44},{"facility":48,"status":35,"city":49,"state":37,"zip":50,"country":39,"countryCode":40,"cosmosGeoPoint":51,"geoPoint":55,"contacts":11},"Site 7173","Dothan","36345",{"type":42,"coordinates":52},[53,54],-85.39049,31.22323,{"lat":54,"lon":53},{"facility":57,"status":58,"city":59,"state":60,"zip":61,"country":39,"countryCode":40,"cosmosGeoPoint":62,"geoPoint":66,"contacts":11},"Site 7000","RECRUITING","Phoenix","Arizona","85012",{"type":42,"coordinates":63},[64,65],-112.07404,33.44838,{"lat":65,"lon":64},{"facility":68,"status":35,"city":69,"state":70,"zip":71,"country":39,"countryCode":40,"cosmosGeoPoint":72,"geoPoint":76,"contacts":11},"Site 7153","Chino","California","91710",{"type":42,"coordinates":73},[74,75],-117.68894,34.01223,{"lat":75,"lon":74},{"facility":78,"status":35,"city":79,"state":70,"zip":80,"country":39,"countryCode":40,"cosmosGeoPoint":81,"geoPoint":85,"contacts":11},"Site 7156","Oakland","94610",{"type":42,"coordinates":82},[83,84],-122.2708,37.80437,{"lat":84,"lon":83},{"facility":87,"status":58,"city":88,"state":70,"zip":89,"country":39,"countryCode":40,"cosmosGeoPoint":90,"geoPoint":94,"contacts":11},"Site 7082","Oceanside","92056",{"type":42,"coordinates":91},[92,93],-117.37948,33.19587,{"lat":93,"lon":92},{"facility":96,"status":35,"city":97,"state":70,"zip":98,"country":39,"countryCode":40,"cosmosGeoPoint":99,"geoPoint":103,"contacts":11},"Site 7159","Palo Alto","94304",{"type":42,"coordinates":100},[101,102],-122.14302,37.44188,{"lat":102,"lon":101},{"facility":105,"status":35,"city":106,"state":70,"zip":107,"country":39,"countryCode":40,"cosmosGeoPoint":108,"geoPoint":112,"contacts":11},"Site 7016","Sacramento","95655",{"type":42,"coordinates":109},[110,111],-121.4944,38.58157,{"lat":111,"lon":110},{"facility":114,"status":58,"city":115,"state":70,"zip":116,"country":39,"countryCode":40,"cosmosGeoPoint":117,"geoPoint":121,"contacts":11},"Site 7144","San Diego","92123",{"type":42,"coordinates":118},[119,120],-117.16472,32.71571,{"lat":120,"lon":119},{"facility":123,"status":35,"city":124,"state":70,"zip":125,"country":39,"countryCode":40,"cosmosGeoPoint":126,"geoPoint":130,"contacts":11},"Site 7171","Valley Village","91607",{"type":42,"coordinates":127},[128,129],-118.3965,34.16488,{"lat":129,"lon":128},{"facility":132,"status":58,"city":133,"state":134,"zip":135,"country":39,"countryCode":40,"cosmosGeoPoint":136,"geoPoint":140,"contacts":11},"Site 7152","Saint Augustine","Florida","32086",{"type":42,"coordinates":137},[138,139],-81.31452,29.89469,{"lat":139,"lon":138},{"facility":142,"status":58,"city":143,"state":144,"zip":145,"country":39,"countryCode":40,"cosmosGeoPoint":146,"geoPoint":150,"contacts":11},"Site 7148","Albany","Georgia","31707",{"type":42,"coordinates":147},[148,149],-84.15574,31.57851,{"lat":149,"lon":148},{"facility":152,"status":35,"city":153,"state":144,"zip":154,"country":39,"countryCode":40,"cosmosGeoPoint":155,"geoPoint":159,"contacts":11},"Site 7146","Atlanta","30060",{"type":42,"coordinates":156},[157,158],-84.38798,33.749,{"lat":158,"lon":157},{"facility":161,"status":35,"city":162,"state":144,"zip":163,"country":39,"countryCode":40,"cosmosGeoPoint":164,"geoPoint":168,"contacts":11},"Site 7064","Peachtree Corners","30078",{"type":42,"coordinates":165},[166,167],-84.22159,33.9701,{"lat":167,"lon":166},{"facility":170,"status":58,"city":171,"state":144,"zip":172,"country":39,"countryCode":40,"cosmosGeoPoint":173,"geoPoint":177,"contacts":11},"Site 7141","Savannah","31406",{"type":42,"coordinates":174},[175,176],-81.09983,32.08354,{"lat":176,"lon":175},{"facility":179,"status":35,"city":180,"state":181,"zip":182,"country":39,"countryCode":40,"cosmosGeoPoint":183,"geoPoint":187,"contacts":11},"Site 7169","Indianapolis","Indiana","46202",{"type":42,"coordinates":184},[185,186],-86.15804,39.76838,{"lat":186,"lon":185},{"facility":189,"status":58,"city":190,"state":191,"zip":192,"country":39,"countryCode":40,"cosmosGeoPoint":193,"geoPoint":197,"contacts":11},"Site 7151","Annapolis","Maryland","21401",{"type":42,"coordinates":194},[195,196],-76.49184,38.97859,{"lat":196,"lon":195},{"facility":199,"status":35,"city":200,"state":191,"zip":201,"country":39,"countryCode":40,"cosmosGeoPoint":202,"geoPoint":206,"contacts":11},"Site 7054","Pikesville","21208",{"type":42,"coordinates":203},[204,205],-76.72247,39.37427,{"lat":205,"lon":204},{"facility":208,"status":35,"city":209,"state":210,"zip":211,"country":39,"countryCode":40,"cosmosGeoPoint":212,"geoPoint":216,"contacts":11},"Site 7166","Worcester","Massachusetts","01606",{"type":42,"coordinates":213},[214,215],-71.80229,42.26259,{"lat":215,"lon":214},{"facility":218,"status":35,"city":219,"state":220,"zip":221,"country":39,"countryCode":40,"cosmosGeoPoint":222,"geoPoint":226,"contacts":11},"Site 7155","Ann Arbor","Michigan","48109",{"type":42,"coordinates":223},[224,225],-83.74088,42.27756,{"lat":225,"lon":224},{"facility":228,"status":58,"city":229,"state":220,"zip":230,"country":39,"countryCode":40,"cosmosGeoPoint":231,"geoPoint":235,"contacts":11},"Site 7154","Bloomfield Hills","48302",{"type":42,"coordinates":232},[233,234],-83.24549,42.58364,{"lat":234,"lon":233},{"facility":237,"status":35,"city":238,"state":239,"zip":240,"country":39,"countryCode":40,"cosmosGeoPoint":241,"geoPoint":245,"contacts":11},"Site 7170","Amherst","New York","14226",{"type":42,"coordinates":242},[243,244],-78.79976,42.97839,{"lat":244,"lon":243},{"facility":247,"status":35,"city":248,"state":239,"zip":249,"country":39,"countryCode":40,"cosmosGeoPoint":250,"geoPoint":254,"contacts":11},"Site 7055","Cedarhurst","11516",{"type":42,"coordinates":251},[252,253],-73.7243,40.62288,{"lat":253,"lon":252},{"facility":256,"status":35,"city":257,"state":239,"zip":258,"country":39,"countryCode":40,"cosmosGeoPoint":259,"geoPoint":263,"contacts":11},"Site 7162","Lewiston","14214",{"type":42,"coordinates":260},[261,262],-79.03588,43.17256,{"lat":262,"lon":261},{"facility":265,"status":35,"city":266,"state":239,"zip":267,"country":39,"countryCode":40,"cosmosGeoPoint":268,"geoPoint":272,"contacts":11},"Site 7157","Syracuse","13210",{"type":42,"coordinates":269},[270,271],-76.14742,43.04812,{"lat":271,"lon":270},{"facility":274,"status":58,"city":275,"state":276,"zip":277,"country":39,"countryCode":40,"cosmosGeoPoint":278,"geoPoint":282,"contacts":11},"Site 7143","Charlotte","North Carolina","28287",{"type":42,"coordinates":279},[280,281],-80.84313,35.22709,{"lat":281,"lon":280},{"facility":284,"status":58,"city":285,"state":286,"zip":287,"country":39,"countryCode":40,"cosmosGeoPoint":288,"geoPoint":292,"contacts":11},"Site 7029","Cincinnati","Ohio","45215",{"type":42,"coordinates":289},[290,291],-84.51439,39.12711,{"lat":291,"lon":290},{"facility":294,"status":35,"city":295,"state":286,"zip":296,"country":39,"countryCode":40,"cosmosGeoPoint":297,"geoPoint":301,"contacts":11},"Site 7158","Garfield Heights","44125",{"type":42,"coordinates":298},[299,300],-81.60596,41.417,{"lat":300,"lon":299},{"facility":303,"status":35,"city":304,"state":305,"zip":306,"country":39,"countryCode":40,"cosmosGeoPoint":307,"geoPoint":311,"contacts":11},"Site 7172","East Providence","Rhode Island","02914",{"type":42,"coordinates":308},[309,310],-71.37005,41.81371,{"lat":310,"lon":309},{"facility":313,"status":35,"city":314,"state":315,"zip":316,"country":39,"countryCode":40,"cosmosGeoPoint":317,"geoPoint":321,"contacts":11},"Site 7176","Dallas","Texas","75243",{"type":42,"coordinates":318},[319,320],-96.80667,32.78306,{"lat":320,"lon":319},{"facility":323,"status":35,"city":324,"state":315,"zip":325,"country":39,"countryCode":40,"cosmosGeoPoint":326,"geoPoint":330,"contacts":11},"Site 7160","Fort Worth","76104",{"type":42,"coordinates":327},[328,329],-97.32085,32.72541,{"lat":329,"lon":328},{"facility":332,"status":35,"city":333,"state":315,"zip":334,"country":39,"countryCode":40,"cosmosGeoPoint":335,"geoPoint":339,"contacts":11},"Site 7150","Galveston","77555",{"type":42,"coordinates":336},[337,338],-94.7977,29.30135,{"lat":338,"lon":337},{"facility":341,"status":35,"city":342,"state":315,"zip":343,"country":39,"countryCode":40,"cosmosGeoPoint":344,"geoPoint":348,"contacts":11},"Site 7175","Houston","77007",{"type":42,"coordinates":345},[346,347],-95.36327,29.76328,{"lat":347,"lon":346},{"facility":350,"status":58,"city":342,"state":315,"zip":351,"country":39,"countryCode":40,"cosmosGeoPoint":352,"geoPoint":354,"contacts":11},"Site 7145","77030",{"type":42,"coordinates":353},[346,347],{"lat":347,"lon":346},{"facility":356,"status":58,"city":357,"state":315,"zip":358,"country":39,"countryCode":40,"cosmosGeoPoint":359,"geoPoint":363,"contacts":11},"Site 7161","Irving","75062",{"type":42,"coordinates":360},[361,362],-96.94889,32.81402,{"lat":362,"lon":361},{"facility":365,"status":35,"city":366,"state":367,"zip":368,"country":39,"countryCode":40,"cosmosGeoPoint":369,"geoPoint":373,"contacts":11},"Site 7177","Fairfax","Virginia","22030",{"type":42,"coordinates":370},[371,372],-77.30637,38.84622,{"lat":372,"lon":371},{"facility":375,"status":35,"city":376,"state":377,"zip":378,"country":39,"countryCode":40,"cosmosGeoPoint":379,"geoPoint":383,"contacts":11},"Site 7128","Seattle","Washington","98004",{"type":42,"coordinates":380},[381,382],-122.33207,47.60621,{"lat":382,"lon":381},{"facility":385,"status":35,"city":386,"state":387,"zip":388,"country":39,"countryCode":40,"cosmosGeoPoint":389,"geoPoint":393,"contacts":11},"Site 7163","South Charleston","West Virginia","25303",{"type":42,"coordinates":390},[391,392],-81.69957,38.36843,{"lat":392,"lon":391},{"facility":395,"status":35,"city":396,"state":11,"zip":11,"country":397,"countryCode":398,"cosmosGeoPoint":399,"geoPoint":403,"contacts":11},"Site 7419","Antrim","United Kingdom","UK",{"type":42,"coordinates":400},[401,402],-6.211,54.7175,{"lat":402,"lon":401},{"facility":405,"status":35,"city":36,"state":11,"zip":11,"country":397,"countryCode":398,"cosmosGeoPoint":406,"geoPoint":410,"contacts":11},"Site 7411",{"type":42,"coordinates":407},[408,409],-1.89983,52.48142,{"lat":409,"lon":408},{"facility":412,"status":35,"city":413,"state":11,"zip":11,"country":397,"countryCode":398,"cosmosGeoPoint":414,"geoPoint":418,"contacts":11},"Site 7414","Bristol",{"type":42,"coordinates":415},[416,417],-2.59665,51.45523,{"lat":417,"lon":416},{"facility":420,"status":35,"city":421,"state":11,"zip":11,"country":397,"countryCode":398,"cosmosGeoPoint":422,"geoPoint":426,"contacts":11},"Site 7412","Cardiff",{"type":42,"coordinates":423},[424,425],-3.18,51.48,{"lat":425,"lon":424},{"facility":428,"status":35,"city":429,"state":11,"zip":11,"country":397,"countryCode":398,"cosmosGeoPoint":430,"geoPoint":434,"contacts":11},"Site 7418","Exeter",{"type":42,"coordinates":431},[432,433],-3.52751,50.7236,{"lat":433,"lon":432},{"facility":436,"status":35,"city":437,"state":11,"zip":11,"country":397,"countryCode":398,"cosmosGeoPoint":438,"geoPoint":442,"contacts":11},"Site 7415","London",{"type":42,"coordinates":439},[440,441],-0.12574,51.50853,{"lat":441,"lon":440},{"facility":444,"status":35,"city":445,"state":11,"zip":11,"country":397,"countryCode":398,"cosmosGeoPoint":446,"geoPoint":450,"contacts":11},"Site 7413","Nottingham",{"type":42,"coordinates":447},[448,449],-1.15047,52.9536,{"lat":449,"lon":448},{"facility":452,"status":35,"city":453,"state":11,"zip":11,"country":397,"countryCode":398,"cosmosGeoPoint":454,"geoPoint":458,"contacts":11},"Site 7410","Oxford",{"type":42,"coordinates":455},[456,457],-1.25596,51.75222,{"lat":457,"lon":456},{"facility":460,"status":35,"city":461,"state":11,"zip":11,"country":397,"countryCode":398,"cosmosGeoPoint":462,"geoPoint":466,"contacts":11},"Site 7402","Prescot",{"type":42,"coordinates":463},[464,465],-2.80031,53.42948,{"lat":465,"lon":464},{"facility":468,"status":35,"city":469,"state":11,"zip":11,"country":397,"countryCode":398,"cosmosGeoPoint":470,"geoPoint":474,"contacts":11},"Site 7416","Sheffield",{"type":42,"coordinates":471},[472,473],-1.4659,53.38297,{"lat":473,"lon":472},{"type":476,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100635511","phase-2-alto-207-in-adults-with-treatment-resistant-depression-trd-100635511",false,"NCT07553637","ALTO-207 in Adults With Treatment-resistant Depression (TRD)","A Randomized, Double-blind, Placebo-controlled Trial of ALTO-207 in Adults With Treatment-resistant Depression","Inclusion Criteria:\n\n* Male and female participants, ages 18 to 75 years, inclusive, at the time of signing the ICF.\n* Prior diagnosis of MDD without psychotic symptoms (in the current episode) and have confirmatory diagnosis of current MDD (moderate to severe).\n* Failure to respond (\\\u003C50% improvement) to at least 2-5 antidepressant treatments (including the current treatment)\n* Currently taking a stable dose of at least 1 but no more than 2 oral antidepressants at baseline\n\nExclusion Criteria:\n\n* Evidence of unstable medical condition\n* Concurrent use of any prohibited medications or substance use disorder\n* Diagnosed bipolar disorder or a psychotic disorder or symptoms\n* Significant current PTSD symptoms or history of PTSD\n* Clinically significant current impulse control difficulties\n* Has a history of hypersensitivity or allergic reaction to ALTO-207 or any of its components\u002Fexcipients\n* Concurrent or recent participation in another clinical trial for mental illness involving an investigational product or device","ALL","18 Years","75 Years",{"count":488,"type":489},178,"ESTIMATED","INTERVENTIONAL",[492],"PHASE2","The purpose of this trial is to measure depressive symptoms following treatment with ALTO-207 compared with placebo in participants with TRD.",[495],"Treatment-resistant Depression (TRD)","2026-04-23",{"date":498,"type":499},"2026-04-28","ACTUAL",{"date":501,"type":489},"2026-05",{"date":503,"type":489},"2027-12",{"name":5,"class":6},48]