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Received for ≥ 6 months prior to screening\n  2. Receiving a once-monthly regimen (approximately every 4 weeks). Note: participants on stable regimens of other durations (for example, every 3 or 6 weeks) are not eligible\n* Must be a partial responder to SSAs defined as \\> 20% relative IGF 1 reduction during the course of SSA therapy\n* Serum IGF-1 levels \\> 1.3 to 5\\*ULN inclusive, as assessed at a central laboratory and adjusted for age and sex, based on average of 2 consecutive values obtained during the Screening Period and obtained ≥ 7 days apart\n\nExclusion Criteria:\n\n* Had surgery for pituitary adenoma within the last 6 months before Day 1 or planning to receive surgery for pituitary adenoma during the study\n* Pituitary adenoma that, per Investigator's judgment, is worsening as assessed by pituitary\u002Fsellar MRI or computed tomography scan obtained ≤ 6 months prior to screening\n* Pituitary adenoma causing compression of the chiasm\n* Clinical evidence of symptomatic hyperprolactinemia that would necessitate treatment with dopamine agonists\n* Known hypothyroidism or hypocortisolism not adequately treated with a stable dose of thyroid or glucocorticoid hormone replacement therapy for ≥ 3 months prior to Screening\n* Active, clinically significant cardiac disease as judged by the Investigator\n* History of unstable angina, stroke, or acute myocardial infarction ≤ 3 months prior to screening\n* Known uncontrolled type 2 diabetes (HbA1c \\> 10%)\n* Active malignant disease ≤ 2 years prior to screening with exception of basal and squamous cell carcinoma of the skin\n* Received any type of fractionated radiotherapy or a second surgical adenectomy for pituitary adenoma within the last 3 years (5 years for conventional radiation) before starting treatment and\u002For are planning to receive radiotherapy or a second surgical adenectomy during the study\n* Received pegvisomant ≤ 8 weeks prior to screening\n* Received dopamine agonists ≤ 4 weeks prior to screening\n* Received pasireotide LAR ≤ 4 months prior to screening\n* Clinically significant renal or hepatic disease at the time of screening, as judged by the Investigator\n* eGFR (CKD-EPI formula) \\\u003C 30 mL\u002Fminute\u002F1.73 m\\^2 documented based on recent value (\\\u003C 3 months prior to randomization)\n* Clinically significant abnormal values for hematology, biochemistry, coagulation, or urinalysis, as judged by the Investigator, including, but not limited to, total bilirubin \\> 1.5\\*ULN (except if in free bilirubin linked to a known Gilbert Syndrome) or AST, ALT, or alkaline phosphatase \\> 2\\*ULN","ALL","18 Years","80 Years",{"count":419,"type":420},60,"ESTIMATED","INTERVENTIONAL",[423],"PHASE2","The primary objective of this study is to evaluate the efficacy of 15-week treatment with ALXN2420 versus placebo for decreasing insulin-like growth factor IGF-1 levels, when administered in combination with somatostatin analog (SSA) therapy to adult participants with acromegaly.",[426],"Acromegaly",[426,9,428,429,430,431,432,433],"Somatostatin Analog","insulin-like growth factor 1","IGF-1","SSA therapy","GHRA","Growth Hormone Receptor Antagonist","2026-04-06",{"date":436,"type":437},"2026-04-07","ACTUAL",{"date":439,"type":437},"2025-10-28",{"date":441,"type":420},"2027-11-11",{"name":5,"class":6},45]