[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100542185":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":27,"responsibleParty":56,"collaborators":20,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":60,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":20,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":20,"overallStatus":30,"whyStopped":20,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Guy's and St Thomas' NHS Foundation Trust","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"VT-NMD arm","EXPERIMENTAL","all patients will be trialed on volume targeted non invasive ventilation",[13],"Device: Volume-targeted non-invasive ventilation",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","Volume-targeted non-invasive ventilation","A target tidal volume is set on the ventilation device, and the device will then automatically adjust delivered pressures to reach this target tidal volume.",[9],null,[22],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Patrick Murphy","CONTACT","02071888070","Patrick.murphy@gstt.nhs.uk",[28,45],{"facility":29,"status":30,"city":31,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"Guy's & St Thomas' NHS Foundation Trust","RECRUITING","London","SE1 9RT","United Kingdom","UK",{"type":36,"coordinates":37},"Point",[38,39],-0.12574,51.50853,{"lat":39,"lon":38},[42],{"name":43,"role":24,"phone":25,"phoneExt":20,"email":44},"Gillian Radcliffe","Gillian.Radcliffe@gstt.nhs.uk",{"facility":46,"status":30,"city":31,"state":20,"zip":47,"country":33,"countryCode":34,"cosmosGeoPoint":48,"geoPoint":50,"contacts":51},"Guy's and St. Thomas NHS Foundation Trust","SE1 7EH",{"type":36,"coordinates":49},[38,39],{"lat":39,"lon":38},[52,55],{"name":53,"role":24,"phone":20,"phoneExt":20,"email":54},"Neeraj Shah","neeraj.shah@gstt.nhs.uk",{"name":43,"role":24,"phone":20,"phoneExt":20,"email":44},{"type":57,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100542185","phase-2-assessment-of-volume-targeted-ventilation-in-patients-with-neuromuscular-disease-100542185",false,"NCT06339580","Assessment of Volume-targeted Ventilation in Patients With Neuromuscular Disease","A Proof-on-concept Study to Investigate the Potential Use of Volume-targeted Ventilation in Patients With Slowly Progressive Neuromuscular Disease","VT-NMD","Inclusion Criteria:\n\n* Slowly progressive neuromuscular disease\n* Established on fixed bi-level ventilation\n* Documented clinical respiratory stability by supervising clinician (no hospitalizations, respiratory infections or change to ventilator settings in preceding 6 weeks)\n\nExclusion Criteria:\n\n* Rapidly progressive neuromuscular disease\n* Decompensated respiratory failure (pH \\\u003C 7.35)\n* Pregnancy\n* Aged \\\u003C18, \\>80\n* Poor adherence to NIV (\\\u003C4hrs per night)\n* Significant physical or psychiatric co-morbidity that would prevent compliance with trial protocol","ALL","18 Years","80 Years",{"count":70,"type":71},30,"ESTIMATED","INTERVENTIONAL",[74],"PHASE2","Assessment of safety and efficacy of volume-targeted ventilation in patients with neuromuscular disease.",[77],"Neuromuscular Diseases","2026-06-04",{"date":80,"type":81},"2026-06-08","ACTUAL",{"date":83,"type":81},"2024-04-09",{"date":85,"type":71},"2026-09-30",{"name":5,"class":6},2]