[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100610668":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":29,"locations":18,"responsibleParty":40,"collaborators":42,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":18,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":18,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":74,"overallStatus":79,"whyStopped":18,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":18},{"fullName":5,"class":6},"The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"NK cell perfusion group","EXPERIMENTAL","Accepting NK cell therapy",[13],"Biological: NK cell perfusion group",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","NO_INTERVENTION","Not accepting NK cell therapy",null,[20],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":18},"BIOLOGICAL","Completing two rounds of NK cell therapy",[9],[25],{"name":26,"affiliation":27,"role":28},"Yali Hu","The Affiliated Drum Tower Hospital of Nanjing University","PRINCIPAL_INVESTIGATOR",[30,35],{"name":26,"role":31,"phone":32,"phoneExt":33,"email":34},"CONTACT","86-025-83106666","11201","glyyhuyali@163.com",{"name":36,"role":31,"phone":37,"phoneExt":38,"email":39},"Hui Zhu","86-025-8310666","54330","zhuhui1231@126.com",{"type":28,"investigatorFullName":26,"investigatorTitle":41,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"M.D., Ph.D.",[43,45,47,49,51],{"name":44,"class":6},"The University of Science and Technology of China",{"name":46,"class":6},"Sir Run Run Shaw Hospital",{"name":48,"class":6},"Second Affiliated Hospital of Soochow University",{"name":50,"class":6},"The First Affiliated Hospital of Anhui Medical University",{"name":52,"class":6},"The First Affiliated Hospital of University of Science and Technology of China","100610668","phase-2-autologous-decidual-like-natural-killer-cells-therapy-for-reproductive-failure-100610668",false,"NCT07230574","Autologous Decidual-like Natural Killer Cells Therapy for Reproductive Failure","A Prospective, Multicenter, Randomized Controlled Clinical Study on Autologous Decidual-like NK Cells Therapy for Reproductive Failure Associated With Abnormal Uterine Natural Killer Cells","Inclusion Criteria:\n\n* Reproductive failure with abnormal endometrial natural killer (NK) cells in menstrual blood;\n* With a clear intention to conceive;\n* Normal ovarian function, or premature ovarian insufficiency with ≥2 high-quality cryopreserved embryos available for transfer;\n* Endometrial thickness measured by transvaginal ultrasound during the periovulatory period ≥7 mm;\n* Body mass index (BMI) between 18 kg\u002Fm² and 28 kg\u002Fm²;\n* Willing to comply with the follow-up plan of this study.\n\nExclusion Criteria:\n\n* Use of progesterone receptor modulators;\n* One of the couple's chromosomal karyotype abnormalities, with no euploid embryo identified via preimplantation genetic testing for aneuploidy;\n* Severe endometriosis or adenomyosis, uterine fibroids affecting uterine cavity morphology, uterine malformations, intrauterine adhesions, or thin endometrium;\n* Uncontrolled autoimmune or endocrine disorders;\n* Contraindications to pregnancy;\n* History of malignant tumors;\n* Participating in other clinical studies;\n* Allergy to blood products.","FEMALE","22 Years","38 Years",{"count":64,"type":65},159,"ESTIMATED","INTERVENTIONAL",[68],"PHASE2","The aim of this study is to verify the efficacy of in vitro induction of autologous decidual-like NK cells therapy for reproductive failure associated with uterine NK cells abnormalities.",[71,72,73],"Abortion, Missed","Infertility Unexplained","Reproductive Disorder",[75,76,77,78],"Recurrent Pregnancy Loss","Repeated Implantation Failure","Unexplained Infertility","Decidual Natural Killer Cells","NOT_YET_RECRUITING","2025-11-13",{"date":82,"type":83},"2025-11-17","ACTUAL",{"date":85,"type":65},"2025-11",{"date":87,"type":65},"2028-09",{"name":5,"class":6}]