[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100570837":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":28,"centralContacts":33,"locations":43,"responsibleParty":62,"collaborators":66,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":72,"sex":78,"minAge":79,"maxAge":21,"enrollmentInfo":80,"targetDuration":21,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":94,"whyStopped":21,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"University of Pittsburgh","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"BD + Intranasal Mupirocin + Chlorhexidine","EXPERIMENTAL","Bacterial Decolonization with 2% intranasal mupirocin ointment twice daily (BID) and 4% chlorhexidine gluconate body cleanser, once daily (QD) for 5 consecutive days prior to RT, and this will be repeated for 5 days every 2 weeks throughout Radiation Therapy.\n\nThe treatment will also be administered for 5 consecutive days prior to index surgery. RT can be prescribed in one of three dose\u002Ffractionation regimens at the investigator's discretion: 50 Gy in 25 fractions, 42.75 Gy in 15 fractions, or 36 Gy in 18 fractions",[13,14],"Drug: 2% intranasal mupirocin ointment","Drug: 4% chlorhexidine gluconate body cleanser",[16,22],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"DRUG","2% intranasal mupirocin ointment","Mupirocin nasal ointment is used to treat or prevent infections in the nose due to certain strains of Staphylococcus aureus bacteria. This medicine works by killing bacteria or preventing their growth.",[9],null,{"type":17,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"4% chlorhexidine gluconate body cleanser","Chlorhexidine Gluconate (CHG) Solution Antiseptic Skin Cleanser solution is a topical skin cleanser that keeps working after it is used. CHG is a strong antiseptic (liquid used to kill germs and bacteria) that lowers the risk of infection.",[9],[27],"Hibiclens®",[29],{"name":30,"affiliation":31,"role":32},"Adam M Olson, MD","UPMC Hillman Cancer Center","PRINCIPAL_INVESTIGATOR",[34,39],{"name":35,"role":36,"phone":37,"phoneExt":21,"email":38},"Samantha Demko, RN","CONTACT","412-623-1400","albesl@upmc.edu",{"name":40,"role":36,"phone":41,"phoneExt":21,"email":42},"Brieanna Marino, MS","412-647-8258","rowlesbm@upmc.edu",[44],{"facility":45,"status":21,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"UPMC Hillman Cancer Centers","Pittsburgh","Pennsylvania","15232","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-79.99589,40.44062,{"lat":55,"lon":54},[58,59,60],{"name":35,"role":36,"phone":37,"phoneExt":21,"email":38},{"name":40,"role":36,"phone":41,"phoneExt":21,"email":42},{"name":61,"role":32,"phone":21,"phoneExt":21,"email":21},"Adam Olson, MD",{"type":63,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":21,"oldOrganization":21},"SPONSOR_INVESTIGATOR","Adam Olson","Assistant Professor, Radiation Oncology",[67],{"name":68,"class":69},"Pittsburgh Cure Sarcoma","UNKNOWN","100570837","phase-2-bacterial-decolonization-plus-intraoperative-angiography-for-soft-tissue-sarcomas-receiving-preoperative-radiotherapy-concerto-100570837",false,"NCT06712433","Bacterial Decolonization Plus Intraoperative Angiography for Soft Tissue Sarcomas Receiving Preoperative Radiotherapy (CONCERTO)","Bacterial Decolonization Plus Intraoperative Indocyanine Green Angiography for Soft Tissue Sarcomas of the Lower Extremity Receiving Preoperative Radiotherapy (CONCERTO)","CONCERTO","Inclusion Criteria:\n\n1. Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-2\n2. Newly diagnosed soft tissue sarcoma arising from the lower extremity (defined as the tumor center arising at the level of the iliac crest or below)\n3. Eligible for wide local excision\n4. Eligible for external beam radiation therapy\n5. Negative serum pregnancy test for women of childbearing potential \\\u003C 28 days prior to RT.\n6. Informed consent signed and dated to participate in the study.\n7. Willingness and ability to comply\n\nExclusion Criteria:\n\n1. Allergy to mupirocin and\u002For chlorhexidine\n2. Active dermatologic condition in RT field\n3. Tumor size \\> 32cm\n4. Prior RT overlapping with fields\n5. Concurrent\u002Fprior invasive malignancy that could potentially interfere with proposed treatment. Individual cases can be discussed with PI prior to registration","ALL","18 Years",{"count":81,"type":82},31,"ESTIMATED","INTERVENTIONAL",[85],"PHASE2","This trial will investigate the combination of two low-cost, non-toxic strategies to assess whether they can reduce the risk of acute major wound complications in soft tissue sarcoma of the lower extremity. Intranasal mupirocin ointment twice daily and chlorhexidine body cleanser once daily for 5 days prior to radiation therapy and repeated for 5 days every 2 weeks during radiation therapy may significantly reduce the risk of acute radiation dermatitis. That, along with use of indocyanine green (ICG) angiography at the time of wound closure.",[88],"Sarcoma,Soft Tissue",[90,91,92,93],"bacterial decolonization (BD)","external beam radiotherapy (RT)","wide local excision (WLE)","intraoperative IICG angiography","NOT_YET_RECRUITING","2026-02-04",{"date":97,"type":98},"2026-02-09","ACTUAL",{"date":100,"type":82},"2026-09-30",{"date":102,"type":82},"2028-09-30",{"name":64,"class":6},1]