[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100521088":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":41,"locations":47,"responsibleParty":70,"collaborators":72,"id":98,"slug":99,"hasResults":100,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":45,"eligibilityCriteria":104,"healthyVolunteers":100,"sex":105,"minAge":106,"maxAge":107,"enrollmentInfo":108,"targetDuration":45,"studyType":111,"phases":112,"briefSummary":114,"conditions":115,"keywords":117,"overallStatus":50,"whyStopped":45,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":132},{"fullName":5,"class":6},"Tang-Du Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control group","SHAM_COMPARATOR","Participants will receive standard treatment and care according to the current management guidelines for traumatic brain injury, e.g. the guideline made by U.S. Brain Trauma Foundation (BTF)",[13],"Other: Standard treatment",{"label":15,"type":16,"description":17,"interventionNames":18},"Baricitinib group","EXPERIMENTAL","Besides receiving standard treatment and care, baricitinib will be administrated orally (or crushed for nasogastric tube delivery) and given daily at the dosage of 4mg, for consecutive 14 days after patients' brain injury.",[19],"Drug: Baricitinib 4 MG",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Baricitinib 4 MG","Baricitinib with be be administrated orally (or crushed for nasogastric tube delivery) and given daily at the dosage of 4mg for consecutive 14 days",[15],[27],"Baricitinib",{"type":6,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Standard treatment","Patients will receive standard treatment and care according to the current management guidelines for traumatic brain injury.",[9],[33],"Blank control",[35,38],{"name":36,"affiliation":5,"role":37},"Yan Qu, M.D,Ph.D","STUDY_CHAIR",{"name":39,"affiliation":5,"role":40},"Shunnan Ge, M.D,Ph.D","STUDY_DIRECTOR",[42],{"name":39,"role":43,"phone":44,"phoneExt":45,"email":46},"CONTACT","+8618165295569",null,"gesn8561@fmmu.edu.cn",[48],{"facility":49,"status":50,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"Tandu Hospital, Fourth Military Medical University","RECRUITING","Xi'an","Shaanxi","710038","China","CN",{"type":57,"coordinates":58},"Point",[59,60],108.92861,34.25833,{"lat":60,"lon":59},[63,66,68],{"name":64,"role":43,"phone":65,"phoneExt":45,"email":46},"Shunnan Ge, M.D Ph.D","+86 18165295569",{"name":36,"role":67,"phone":45,"phoneExt":45,"email":45},"PRINCIPAL_INVESTIGATOR",{"name":39,"role":69,"phone":45,"phoneExt":45,"email":45},"SUB_INVESTIGATOR",{"type":71,"investigatorFullName":45,"investigatorTitle":45,"investigatorAffiliation":45,"oldNameTitle":45,"oldOrganization":45},"SPONSOR",[73,76,78,80,82,84,86,88,90,92,94,96],{"name":74,"class":75},"Qianxian People's Hospital","UNKNOWN",{"name":77,"class":6},"Weinan Central Hospital",{"name":79,"class":6},"Second Affiliated Hospital of Xi'an Jiaotong University",{"name":81,"class":75},"The First Hospital of Yulin",{"name":83,"class":75},"Xidian Group Hospital",{"name":85,"class":75},"Chongqing University Central Hospital & Chongqing Emergency Medical Center",{"name":87,"class":6},"The Peoples' Hospital of Jiaozuo City",{"name":89,"class":6},"First People's Hospital of Xianyang",{"name":91,"class":6},"987th Hospital of the Chinese People's Liberation Army Joint Logistic Support Force",{"name":93,"class":75},"Chongqing Hospital of PAP",{"name":95,"class":75},"Baoji Fengxiang District Hospital",{"name":97,"class":75},"GEM Flower Xian Changqing Staff Hospital","100521088","phase-2-baricitinib-for-moderate-and-severe-traumatic-intracerebral-hemorrhagecontusions-100521088",false,"NCT06065046","Baricitinib for Moderate and Severe Traumatic Intracerebral Hemorrhage\u002FContusions","A Randomized Control Trial of Baricitinib Administration in Patients With Moderate and Severe Traumatic Intracerebral Hemorrhage\u002FContusions","Inclusion Criteria:\n\n1. Age 18 years older and younger than 80 years old.\n2. Definite history of traumatic brain injury.\n3. Admission within≤24 hours after the traumatic brain injury.\n4. CT scans demonstrate intracerebral hemorrhage\u002Fcontusions with and without extracerebral hemorrhage (epi- and sub- dural hemorrhage)\n5. GCS score of 5 or greater and no more than 12 at time of enrollment.\n6. Closed head injury.\n7. Admission without infections\n8. Signed and dated informed consent by the subject, legally authorized representative, or surrogate obtained.\n\nExclusion Criteria:\n\n1. Time of head injury cannot be reliably assessed.\n2. Subjects is considered a candidate for immediate surgical intervention because of severe extracranial injury.\n3. Open head injury.\n4. Pregnancy or parturition within previous 30 days or active lactation.\n5. Use of Janus kinase inhibitors (baricinitib,abroctinib, AG490 and etc.)\n6. Pre-traumatic dementia or disability.\n7. With severe liver, kidney disease, or malignancy, life expectancy is less than 14 days.\n8. Severe pulmonary infection.\n9. Severe or acute heart failure.\n10. Severe infections within previous 30 days.\n11. History of myocardial infarction.\n12. Known sensitivity to baricinitib.\n13. Severe decreases in neutrophil, lymphocyte and platelet counts, severe decrease in hemoglobin.\n14. Severe liver and kidney dysfunction.\n15. Currently participating in other interventional clinical trials.","ALL","18 Years","80 Years",{"count":109,"type":110},100,"ESTIMATED","INTERVENTIONAL",[113],"PHASE2","The purpose of the present study is to study the effect of baricitinib administration on outcome of participants with moderate and severe traumatic intracerebral hemorrhage\u002Fcontusions. A multi-center randomized control trial will be conducted. Participants with a radiological diagnosis of traumatic intracerebral hemorrhage\u002Fcontusions and an initial GCS score of 5-12 will be screened and enrolled in the first 24 hours after traumatic brain injury.",[116],"Traumatic Brain Injury",[118,119,120,121,122],"traumatic intracerebral Hemorrhage","traumatic intracerebral Contusions","baricitinib","Janus kinase inhibitor","neuro-inflammatory responses","2026-04-07",{"date":125,"type":126},"2026-04-13","ACTUAL",{"date":128,"type":126},"2023-11-24",{"date":130,"type":110},"2026-12-31",{"name":5,"class":6},1]