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Unit for 2 or more calendar days and is not expected to be discharged from the Intensive Care Unit on the second day\n* Has required Intensive Care Unit level support (i.e. intravenous vasoactive drugs, or invasive mechanical ventilation, or non-invasive ventilation or high flow nasal oxygen at Fraction inspired Oxygen ≥0.4 and\u002For gas flows ≥40L\u002Fm) for a minimum cumulative duration of 6 hours\n* Expected to survive the current hospital admission\n\nExclusion Criteria:\n\n* Cancer related metastatic bone disease or multiple myeloma\n* Paget's disease\n* Pregnancy\n* Current estimated Glomerular Filtration Rate \\\u003C30ml\u002Fmin or receiving renal replacement therapy\n* Known contraindication to denosumab or zoledronic acid\n* Obvious holes in teeth or broken teeth or dental or gum infection\n* Known untreated hypoparathyroidism\n* Current treatment with anti-fracture agent (bisphosphonate, strontium or teriparatide within previous 2 years, or menopausal hormone therapy or romosozumab within previous 12-months or denosumab within previous 6 months)\n* Current fragility fracture of hip, spine, femur or forearm\n* Exceeds weight limit for BMD scan at site or unable to undertake Bone Mineral Density for any reason\n* International Normalised Ratio \\> 3.0 or Platelet count \\\u003C 30 10\\^9\u002FL","ALL","50 Years",{"count":333,"type":334},450,"ESTIMATED","INTERVENTIONAL",[337],"PHASE2","The Bone Zone trial is a prospective, multi-centre, double-blind, phase II, randomised controlled trial evaluating the effect of denosumab or zoledronic acid compared to placebo on change in bone mineral density over one year in women aged 50 years or older and men aged 70 years or older requiring admission to intensive care for greater than 24 hours.\n\n450 women aged 50 years or older and men aged 70 years or older, admitted to intensive care for greater than 24 hours will be recruited into the study from participating study centres.",[340,341],"Critical Illness","Osteoporosis",[343,341,344,16,9],"Intensive Care Unit","Bone densitometry","2026-03-02",{"date":347,"type":348},"2026-03-04","ACTUAL",{"date":350,"type":348},"2021-07-15",{"date":352,"type":334},"2027-02-28",{"name":5,"class":6},22]