[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100564430":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":32,"centralContacts":37,"locations":43,"responsibleParty":64,"collaborators":66,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":22,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":22,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":46,"whyStopped":22,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"University of Wisconsin, Madison","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Middle-Aged Adults","EXPERIMENTAL","Middle-Aged Adults between 55-69 years of age.",[13,14,15],"Device: MRI","Drug: Prazosin","Drug: Placebo",[17,23,28],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"DEVICE","MRI","Participants will undergo an MRI scan while performing breathing and a simulated postural change task.",[9],null,{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":22},"DRUG","Prazosin","A dose of prazosin will be administered based on body weight.",[9],{"type":24,"name":29,"description":30,"armGroupLabels":31,"otherNames":22},"Placebo","Oral placebo",[9],[33],{"name":34,"affiliation":35,"role":36},"Jill Barnes, PhD","UW Madison","PRINCIPAL_INVESTIGATOR",[38],{"name":39,"role":40,"phone":41,"phoneExt":22,"email":42},"Anna Howery","CONTACT","608-262-9572","ahowery@wisc.edu",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"University of Wisconsin","RECRUITING","Madison","Wisconsin","53705","United States","US",{"type":53,"coordinates":54},"Point",[55,56],-89.40123,43.07305,{"lat":56,"lon":55},[59,62],{"name":60,"role":40,"phone":41,"phoneExt":22,"email":61},"Anna J Howery, MS","barneslab@education.wisc.edu",{"name":63,"role":36,"phone":22,"phoneExt":22,"email":22},"Jill N Barnes, PhD",{"type":65,"investigatorFullName":22,"investigatorTitle":22,"investigatorAffiliation":22,"oldNameTitle":22,"oldOrganization":22},"SPONSOR",[67],{"name":68,"class":69},"National Institute of Neurological Disorders and Stroke (NINDS)","NIH","100564430","phase-2-brain-blood-vessel-responses-to-changes-in-blood-flow-100564430",false,"NCT06629077","Brain Blood Vessel Responses to Changes in Blood Flow","Cerebrovascular Responses to Acute Hypoperfusion","Inclusion Criteria:\n\n* Between the ages of 55-69 years\n* Have a BMI less than or equal to 34.5 kg\u002Fm2\n* Nonsmoker\n* are less than 72 in (182.88 cm) height\n* Females must be postmenopausal\n\nExclusion Criteria:\n\n* Diagnosis of Mild Cognitive Impairment (MCI) or Alzheimer's disease (AD)\n* History or evidence of hepatic disease, hematological disease, or peripheral vascular disease; severe kidney injury requiring hemodialysis\n* History of cardiovascular disease including: severe congestive heart failure, coronary artery disease, ischemic heart disease (stents, coronary artery bypass grafts) and tachycardia\n* Uncontrolled hypertension\n* History of clinically significant ischemic or hemorrhagic stroke, or significant cerebrovascular disease\n* Severe untreated obstructive sleep apnea\n* History of diabetes with HbA1c greater than 9.5%\n* Major neurologic disorders other than dementia (e.g., MS, ALS, brain surgery, etc.)\n* Current or recent (\\<1 year) major psychiatric condition (Axis I) or addictive disorders\n* Significant surgical history\n* Other significant medical conditions at investigators' discretion\n* Contraindications to MRI\n* Prescribed medications that interfere with prazosin\n* Lactose allergy\n* lower body will not fit in lower body negative pressure (LBNP) chamber (regardless of overall height and BMI).",true,"ALL","55 Years","69 Years",{"count":82,"type":83},36,"ESTIMATED","INTERVENTIONAL",[86],"PHASE2","Brain blood flow will be measured during a simulated postural change test and while breathing increased levels of carbon dioxide using magnetic resonance imaging.",[89,90],"Magnetic Resonance Imaging","Cerebrovascular Circulation",[89,92,93,94],"Brain Blood Flow","Lower Body Negative Pressure","Carbon Dioxide","2026-02-27",{"date":97,"type":98},"2026-03-02","ACTUAL",{"date":100,"type":98},"2026-02-26",{"date":102,"type":83},"2027-01",{"name":5,"class":6},1]