[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100377651":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":19,"centralContacts":24,"locations":33,"responsibleParty":53,"collaborators":18,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":18,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":18,"enrollmentInfo":64,"targetDuration":18,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":73,"overallStatus":36,"whyStopped":18,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"University Health Network, Toronto","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"CT and MRI Scans","Each patient will undergo a 3T MRI scan as well as a dynamic contrast-enhanced CT scan within one week prior to the start of treatment. Patients will also undergo a research 3T MRI scan and research dynamic contrast-enhanced CT scan at the one week post radiotherapy mark. An MRI scan during their 3 month post-treatment follow up visits will take place as per routine standard of care.",[12],"Diagnostic Test: CT and MRI Scans",[14],{"type":15,"name":9,"description":16,"armGroupLabels":17,"otherNames":18},"DIAGNOSTIC_TEST","CT and MRI scans will occur before and after radiation therapy.",[9],null,[20],{"name":21,"affiliation":22,"role":23},"Catherine Coolens, Ph. D","Princess Margaret Cancer Center - UHN","PRINCIPAL_INVESTIGATOR",[25,30],{"name":26,"role":27,"phone":28,"phoneExt":18,"email":29},"David Shultz, M.D., Ph. D","CONTACT","416-946-6899","david.shultz@rmp.uhn.on.ca",{"name":21,"role":27,"phone":31,"phoneExt":18,"email":32},"416-946-5011","catherine.coolens@rmp.uhn.ca",[34],{"facility":35,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"University Health Network","RECRUITING","Toronto","Ontario","L4W4C2","Canada","CA",{"type":43,"coordinates":44},"Point",[45,46],-79.39864,43.70643,{"lat":46,"lon":45},[49],{"name":50,"role":27,"phone":51,"phoneExt":18,"email":52},"David Shultz, MD","416 946 4501","david.shultz@rmp.uhn.ca",{"type":54,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100377651","phase-2-brain-imaging-biomarkers-in-patients-with-brain-metastasis-100377651",false,"NCT04197297","Brain Imaging Biomarkers in Patients With Brain Metastasis","Imaging Trial of Biomarkers to Guide Individualized Therapy in Patients With Brain Metastasis Receiving Radiotherapy","Inclusion Criteria:\n\n* Biopsy proven primary malignancy (original biopsy is adequate as long as the brain imaging is consistent with brain metastases)\n* At least one index lesion with diameter \\> 1cm and without imaging evidence of hemorrhage\n* Patients age \\> 18 years of age\n* Patients planned for RT to brain metastases\n* Ability to understand and the willingness to sign a written informed consent document.\n\nExclusion Criteria:\n\n* Previous Whole Brain Radiotherapy\n* Previous radiosurgery to the index lesion\n* Individuals unable to undergo contrasted MRI for whatever reason","ALL","18 Years",{"count":65,"type":66},90,"ESTIMATED","INTERVENTIONAL",[69],"PHASE2","A biomarker is a measurable indicator of the severity or presence of some disease state. In this study, brain metastases patients who will be receiving radiation treatment, will undergo CT (Computed Tomography) and MRI (Magnetic Resonance Imaging) scans prior to and after radiation treatment to measure these biomarkers. This is a single-center phase II study to validate the predictive abilities of biomarkers, in terms of determining how patients will respond to radiation treatment.",[72],"Brain Metastases, Adult",[74,75,76,77,78,79],"Radiation Therapy","Radiotherapy","Biomarkers","Magnetic Resonance Imaging","Computed Tomography","Radiosurgery","2026-03-03",{"date":82,"type":83},"2026-03-05","ACTUAL",{"date":85,"type":83},"2021-10-05",{"date":87,"type":66},"2027-06",{"name":5,"class":6},1]