[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100504673":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":29,"centralContacts":34,"locations":42,"responsibleParty":59,"collaborators":61,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":67,"sex":73,"minAge":74,"maxAge":24,"enrollmentInfo":75,"targetDuration":24,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":24,"overallStatus":45,"whyStopped":24,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"University of California, San Francisco","OTHER",[8,13],{"label":9,"type":6,"description":10,"interventionNames":11},"Burst Suppression EEG Target","Anesthetic will be titrated to achieve burst suppression on continuous EEG (50-99% attenuation\u002Fsuppression) for 24 hours.",[12],"Drug: Burst Suppression EEG Target Intravenous Anesthesia",{"label":14,"type":6,"description":15,"interventionNames":16},"Seizure Suppression EEG Target","Anesthetic will be titrated to achieve seizure suppression on continuous EEG for 24 hours.",[17],"Drug: Seizure Suppression EEG Target Intravenous Anesthesia",[19,25],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","Burst Suppression EEG Target Intravenous Anesthesia","The objective of the burst suppression EEG target is to stop seizures by titrating the anesthetic infusion to suppress most of the EEG background (\\>50% suppressed\u002Fattenuated). After this 24-hour period, this target would be continued for 24 hours. The anesthetic will then be tapered under EEG monitoring. In case of PCARSE recurrence, the intervention with the same target will be re-initiated for another cycle of 24 hours.",[9],null,{"type":20,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"Seizure Suppression EEG Target Intravenous Anesthesia","is to stop seizures by titrating the anesthetic infusion without suppressing most of the EEG background. This target would be continued for 24 hours. After this 24-hours period, this target would be continued for 24 hours. The anesthetic will then be tapered under EEG monitoring. In case of PCARSE recurrence, the intervention with the same target will be re-initiated for another cycle of 24 hours.",[14],[30],{"name":31,"affiliation":32,"role":33},"Edilberto Amorim, MD","Assistant Professor of Neurology","PRINCIPAL_INVESTIGATOR",[35,39],{"name":31,"role":36,"phone":37,"phoneExt":24,"email":38},"CONTACT","628-206-3203","restorestudy@ucsf.edu",{"name":40,"role":36,"phone":41,"phoneExt":24,"email":38},"Kevin Bao","(415)514-2120",[43],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Zuckerberg San Francisco General Hospital","RECRUITING","San Francisco","California","94110","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-122.41942,37.77493,{"lat":55,"lon":54},[58],{"name":31,"role":36,"phone":24,"phoneExt":24,"email":24},{"type":60,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR",[62],{"name":63,"class":64},"The ZOLL Foundation","UNKNOWN","100504673","phase-2-burst-suppression-to-stop-refractory-status-epilepticus-post-cardiac-arrest-100504673",false,"NCT05851391","buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac Arrest","buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac Arrest (RESTORE)","RESTORE","Inclusion Criteria:\n\n1. Age ≥18 years old\n2. Non-traumatic, out-of-hospital cardiac arrest\n3. Comatose on admission - defined as not following commands\n4. Return of spontaneous circulation (ROSC) within less than 45 minutes\n5. Admission to the intensive care unit\n6. Diagnosis of post-cardiac arrest refractory status epilepticus confirmed with continuous\n\nEEG monitoring within 7 days from ROSC\n\nExclusion Criteria:\n\n1. Acute cerebral hemorrhage or infarction\n2. Pregnancy\n3. Prisoners","ALL","18 Years",{"count":76,"type":77},30,"ESTIMATED","INTERVENTIONAL",[80],"PHASE2","RESTORE is a randomized clinical trial investigating the safety and feasibility of using EEG treatment targets (burst suppression vs. seizure suppression) for post-cardiac arrest refractory status epilepticus treatment.",[83,84,85,86,87,88,89],"Hypoxia-Ischemia, Brain","Heart Arrest","Status Epilepticus","Refractory Status Epilepticus","Seizures","Anoxic-Ischemic Encephalopathy","Anoxia-Ischemia, Cerebral","2025-05-12",{"date":92,"type":93},"2025-05-15","ACTUAL",{"date":95,"type":93},"2023-08-07",{"date":97,"type":77},"2027-04-30",{"name":5,"class":6},1]