[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100574721":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":33,"locations":43,"responsibleParty":59,"collaborators":11,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":11,"eligibilityCriteria":68,"healthyVolunteers":64,"sex":69,"minAge":70,"maxAge":11,"enrollmentInfo":71,"targetDuration":11,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":82,"overallStatus":45,"whyStopped":11,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Dapagliflozin","EXPERIMENTAL",null,[13],"Drug: Dapagliflozin tablet",{"label":15,"type":16,"description":11,"interventionNames":17},"Placebo","PLACEBO_COMPARATOR",[18],"Drug: Placebo Tablet",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DRUG","Dapagliflozin tablet","Patient will take a 10mg tablet of Dapagliflozin once daily for 12 weeks",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Placebo Tablet","Patient will take 10mg placebo tablet once daily for 12 weeks",[15],[30],{"name":31,"affiliation":5,"role":32},"Luke Burchill, M.B.B.S., Ph.D.","PRINCIPAL_INVESTIGATOR",[34,39],{"name":35,"role":36,"phone":37,"phoneExt":11,"email":38},"Amanda Wozniak","CONTACT","507-266-1976","Wozniak.Amanda@mayo.edu",{"name":40,"role":36,"phone":41,"phoneExt":11,"email":42},"Yusef Maarouf","507-422-5755","Maarouf.Yusef@mayo.edu",[44],{"facility":5,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Rochester","Minnesota","55905","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-92.4699,44.02163,{"lat":55,"lon":54},[58],{"name":31,"role":32,"phone":11,"phoneExt":11,"email":11},{"type":32,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Luke J. Burchill","Principal Investigator","100574721","phase-2-cameo-fontan--dapagliflozin-in-the-failing-fontan-circulation-100574721",false,"NCT06762964","CAMEO-FONTAN -Dapagliflozin in the Failing Fontan Circulation","Cardiac and Metabolic Effects of Dapagliflozin in the Failing Fontan Circulation: A Phase II, Prospective, Double-Blind Study","Inclusion Criteria\n\n1. Signed informed consent prior to any study specific procedures\n2. History of Fontan procedure\n3. Male or female subject\n4. Age ≥ 18\n5. Symptoms of dyspnea (NYHA II-IV) with no non-cardiac or ischemia explanation\n6. Elevated peripheral venous pressure (PVP) at rest or during exercise (≥20 mmHg) ascertained at Visit 1. Patients that have consented to study procedures but do not meet this invasive criterion will be considered as screen failures and will not be randomized.\n\nExclusion Criteria\n\n1. Type I diabetes\n2. Any of the following medications: Insulin or Pramlintide, Sandostatin, Akeega (abiraterone acetate), Growth Hormone (Somatogrogon-GHLA), Lithium, Chloroquine, Hydroxychloroquine, Thioctic acid (alpha lipoic acid), Empagliflozin or Canagliflozin\n3. Recent hospitalization (\\\u003C30 days) or revascularization (\\\u003C90 days)\n4. Significant valvular heart disease (≥moderate stenosis, \\>moderate regurgitation)\n5. Significant Fontan obstruction with resting SVC-IVC gradient \\>4 mmHg\n6. Primary cardiomyopathy (such as amyloid)\n7. Dyspnea due to primary lung disease or myocardial ischemia in the opinion of the investigator\n8. Severe anemia (hemoglobin \\\u003C9 gm\u002Fdl)\n9. Severe kidney disease (estimated GFR\\\u003C30) or liver disease\n10. Women of childbearing potential not willing to use a medically accepted method of contraception OR who are currently pregnant (confirmed with positive pregnancy test) or breast feeding.\n11. History of serious hypersensitivity reaction to dapagliflozin\n12. Subjects on dialysis\n13. Subjects with severe liver disease with history of decompensation including ascites or encephalopathy or variceal bleeding\n14. Single ventricle heart disease without Fontan palliation\n15. Those with a history of Fontan takedown","ALL","18 Years",{"count":72,"type":73},27,"ESTIMATED","INTERVENTIONAL",[76],"PHASE2","The purpose of this research is to determine whether treatment with the study drug dapagliflozin for 3 months affects peripheral venous pressure at rest and during exercise in adults with failing Fontan circulation.",[79,80,81],"Fontan Circulation","Single Ventricle Heart Disease","HFpEF - Heart Failure With Preserved Ejection Fraction",[83,84,85],"Fontan","HFpEF","SGLT2 inhibitors","2026-05-05",{"date":88,"type":89},"2026-05-06","ACTUAL",{"date":91,"type":89},"2025-05-16",{"date":93,"type":73},"2027-02",{"name":5,"class":6},1]