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The route of administration is intradermal injection at subject's limbs at 0.5 mL\u002Finjection. The schedule is 1 injection every three weeks for the first 4 injections, and then one injection every 3 months until a total of 7 injections has been given.",[13],"Biological: 0.5 mL Candin®\u002Finjection",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Seven placebo injections (sterile 0.9% Normal Saline). The route of administration is intradermal injection at subject's limbs at 0.5 mL\u002Finjection. The schedule is 1 injection every three weeks for the first 4 injections, and then one injection every 3 months until a total of 7 injections has been given.",[19],"Other: Placebo: 0.5 mL Intravenous 0.9% NaCl solution (Saline)",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BIOLOGICAL","0.5 mL Candin®\u002Finjection","Candin or placebo injection every 3 weeks until 4 injections then every 3 months until a total of 7 injections.",[9],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo: 0.5 mL Intravenous 0.9% NaCl solution (Saline)","Placebo injection every 3 weeks until 4 injections then every 3 months until a total of 7 injections.",[15],[32],{"name":33,"affiliation":5,"role":34},"Omar Atiq","PRINCIPAL_INVESTIGATOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Madison Trujillo","CONTACT","501-686-8274","MTrujillo@uams.edu",{"name":42,"role":38,"phone":39,"phoneExt":26,"email":43},"Aaron 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in Head and Neck Cancer Patients to Reduce Recurrence","Inclusion Criteria:\n\n* Able to provide informed consent\n* Male or female 18 years of age or older\n* Squamous cell carcinoma of the head and neck who have completed curative therapy (surgery and\u002For radiation and\u002For chemotherapy and\u002For immunotherapy) within the 120 days prior to the screening visit\n* No Evidence of Disease (NED) based on clinical and radiographic evaluations\n* Willing and able to comply with the requirements of the protocol\n\nExclusion Criteria:\n\n* Positive urine pregnancy test for women of childbearing potential\n* Being pregnant or attempting to be pregnant with the period of study participation\n* Women who are breast feeding or plan to breast feed within the period of study participation\n* Patients who are allergic to Candin®\n* If in the opinion of the PIs or other Investigators, it is not in the best interest of the patient to enter or continue in this study","ALL","18 Years","100 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It is designed to show the efficacy and safety of a 7-dose regimen of Candin over a two-year period in terms of reducing cancer recurrence rate by comparing the recurrence rates between the Candin and the placebo arm. The ratio of the number of subjects who will receive Candin versus placebo will be 3:1. Up to 100 subjects will be screened until 80 subjects are eligible for injection.",[159],"Squamous Cell Carcinoma of Head and Neck","2026-04-02",{"date":162,"type":163},"2026-04-08","ACTUAL",{"date":165,"type":163},"2024-02-12",{"date":167,"type":153},"2031-07-31",{"name":5,"class":6},6]