[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100469217":3},{"organization":4,"armGroups":7,"interventions":35,"overallOfficials":58,"centralContacts":62,"locations":67,"responsibleParty":83,"collaborators":85,"id":89,"slug":90,"hasResults":91,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":41,"eligibilityCriteria":95,"healthyVolunteers":96,"sex":97,"minAge":98,"maxAge":99,"enrollmentInfo":100,"targetDuration":41,"studyType":103,"phases":104,"briefSummary":106,"conditions":107,"keywords":112,"overallStatus":69,"whyStopped":41,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":129},{"fullName":5,"class":6},"Brown University","OTHER",[8,15,19,24,31],{"label":9,"type":10,"description":11,"interventionNames":12},"THC-dominant cannabis dose","EXPERIMENTAL","367 mg of cannabis plant material with 9.53% THC and 0.09% CBD and 217 mg of placebo cannabis plant material will be mixed and smoked in a handheld pipe",[13,14],"Drug: Alcohol","Drug: Alcohol placebo",{"label":16,"type":10,"description":17,"interventionNames":18},"CBD-dominant cannabis dose","367 mg of cannabis plant material with 11.27% CBD and 0.35% THC and 217 mg of placebo cannabis plant material will be mixed and smoked in a handheld pipe",[13,14],{"label":20,"type":21,"description":22,"interventionNames":23},"Placebo","PLACEBO_COMPARATOR","584 mg of cannabis plant material will be smoked in a handheld pipe",[13,14],{"label":25,"type":10,"description":26,"interventionNames":27},"Alcohol priming dose","Alcohol: 0.3 g\u002Fkg. Alcohol priming drink is designed to raise blood alcohol levels to 0.03 g\u002Fdl and be consumed in 5 minutes. The drink is mixed using 80-proof liquor and juice. Participants are randomized to receive either the experimental alcohol priming dose or alcohol placebo.",[28,29,30],"Drug: THC-dominant cannabis","Drug: CBD-dominant cannabis","Drug: Cannabis placebo",{"label":32,"type":21,"description":33,"interventionNames":34},"Alcohol placebo dose","Placebo beverage contains only juice and a negligible trace of alcohol for masking. The weight and sex-adjusted volume of alcohol and non-alcohol containing beverages will be equal. Participants are randomized to receive either the experimental alcohol priming dose or alcohol placebo.",[28,29,30],[36,42,46,50,54],{"type":37,"name":38,"description":39,"armGroupLabels":40,"otherNames":41},"DRUG","THC-dominant cannabis","Smoked cannabis with 9.53% THC and 0.09% CBD",[32,25],null,{"type":37,"name":43,"description":44,"armGroupLabels":45,"otherNames":41},"CBD-dominant cannabis","Smoked cannabis with 0.35% THC and 11.27% CBD",[32,25],{"type":37,"name":47,"description":48,"armGroupLabels":49,"otherNames":41},"Cannabis placebo","Smoked placebo cannabis plant material",[32,25],{"type":37,"name":51,"description":52,"armGroupLabels":53,"otherNames":41},"Alcohol","Drink containing 0.3 g\u002Fkg of alcohol",[16,20,9],{"type":37,"name":55,"description":56,"armGroupLabels":57,"otherNames":41},"Alcohol placebo","Placebo beverage contains only juice and a negligible trace of alcohol for masking",[16,20,9],[59],{"name":60,"affiliation":5,"role":61},"Jane Metrik, PhD","PRINCIPAL_INVESTIGATOR",[63],{"name":60,"role":64,"phone":65,"phoneExt":41,"email":66},"CONTACT","401-863-6650","Jane_Metrik@brown.edu",[68],{"facility":5,"status":69,"city":70,"state":71,"zip":72,"country":73,"countryCode":74,"cosmosGeoPoint":75,"geoPoint":80,"contacts":81},"RECRUITING","Providence","Rhode Island","02912","United States","US",{"type":76,"coordinates":77},"Point",[78,79],-71.41283,41.82399,{"lat":79,"lon":78},[82],{"name":60,"role":64,"phone":65,"phoneExt":41,"email":66},{"type":84,"investigatorFullName":41,"investigatorTitle":41,"investigatorAffiliation":41,"oldNameTitle":41,"oldOrganization":41},"SPONSOR",[86],{"name":87,"class":88},"National Institute on Alcohol Abuse and Alcoholism (NIAAA)","NIH","100469217","phase-2-cannabis-impact-on-alcohol-consumption-100469217",false,"NCT05389930","Cannabis' Impact on Alcohol Consumption","Cannabis' Impact on Alcohol Consumption: Integrating Laboratory and Ecological Momentary Assessment Methods","Inclusion Criteria:\n\n* Age 21 to 50\n* English-speaking\n* cannabis smoking in past two months\n* heavy drinking in past two months\n* in good physical health and weighing \\\u003C 250 lbs\n* zero breath alcohol at each visit\n\nExclusion Criteria:\n\n* positive pregnancy test\n* nursing\n* positive urine toxicology screen for drugs other than cannabis\n* interest to quit or receive treatment for cannabis or alcohol use",true,"ALL","21 Years","50 Years",{"count":101,"type":102},350,"ESTIMATED","INTERVENTIONAL",[105],"PHASE2","This study employs a repeated measures experimental design to examine the effect of THC-dominant dose of cannabis and CBD-dominant dose of cannabis, relative to placebo, on subsequent drinking in an alcohol choice task in which participants choose either to drink or receive monetary reinforcement for drinks not consumed. Cannabis will be administered simultaneously with an alcohol-priming dose or alcohol placebo.\n\nThe study will enroll up to 350 nontreatment-seeking heavy episodic alcohol drinkers who use cannabis weekly.",[108,109,110,111],"Alcohol Drinking","Cannabis Use","Cannabis","Alcohol Use Disorder",[113,114,115,116,117,118,119],"alcohol","cannabis","marijuana","addiction","cannabinoid","tetrahydrocannabinol","cannabidiol","2024-08-05",{"date":122,"type":123},"2024-08-06","ACTUAL",{"date":125,"type":123},"2023-03-16",{"date":127,"type":102},"2027-03-31",{"name":5,"class":6},1]