[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100478222":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":21,"centralContacts":26,"locations":33,"responsibleParty":51,"collaborators":31,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":31,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":31,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":31,"overallStatus":35,"whyStopped":31,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Rutgers, The State University of New Jersey","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Temporo-masseteric Nerve Block Administration","Non-randomized administration of the TMNB injection (unilateral) followed by bite force distribution and surface EMG assessment of the temporalis and masseter muscles on the side of the injection",[12],"Drug: Temporomasseteric Nerve Block",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"DRUG","Temporomasseteric Nerve Block","The TMNB injection is a local anesthetic injection technique that targets the anterior deep temporal and masseteric branches of the mandibular division of the Trigeminal Nerve. The surface landmark for the twin block injection site is located by palpating for the depression created by the greater wing of the sphenoid bone at the superior border of the zygomatic process and approximately 1 cm posterior to the posterior border of the frontal process of the zygomatic bone. This site is first disinfected with alcohol wipes prior to inserting a 27- or 25-gauge long dental needle (32 mm). Angled 35-45° away from the calvarium (skull) and perpendicular to the zygomatic arch (along the coronal plane), the needle is advanced to its length before injecting 1.8 mL of 2% lidocaine with 1:100,000 epinephrine.",[9],[20],"Twin Block",[22],{"name":23,"affiliation":24,"role":25},"Gayathri D Subramanian, DMD","Rutgers School of Dental Medicine","PRINCIPAL_INVESTIGATOR",[27],{"name":28,"role":29,"phone":30,"phoneExt":31,"email":32},"Gayathri D Subramanian","CONTACT","9739723418",null,"subramga@sdm.rutgers.edu",[34],{"facility":24,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"RECRUITING","Newark","New Jersey","07103","United States","US",{"type":42,"coordinates":43},"Point",[44,45],-74.17237,40.73566,{"lat":45,"lon":44},[48],{"name":49,"role":29,"phone":50,"phoneExt":31,"email":32},"Gayathri Subramanian","973-972-3418",{"type":25,"investigatorFullName":49,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"Associate Professor","100478222","phase-2-characterization-of-the-temporo-masseteric-nerve-block-tmnb-in-healthy-subjects-100478222",false,"NCT05507164","Characterization of the Temporo-masseteric Nerve Block (TMNB) in Healthy Subjects","Non-randomized Pilot Study to Characterize Temporo-masseteric Nerve Block (TMNB) in","Inclusion Criteria:\n\n* 18-64 years of age\n* All ethnicity\n* Male and female sex\n* Fluent in written\u002Fspoken English\n* Never been diagnosed with TMD\n* No significant history of orofacial pain\n* \\\u003C5 headaches\u002Fmonth in the 3 months before enrollment\n* No reported use of a nightguard or occlusal splint 'No' to all questions on self-administered questionnaire for TMD screening:\n* Pain in jaw or temple on either side of the face in the last 30 days\n* Stiffness or pain in jaw upon awakening in the last 30 days\n* Any pain increase\u002Freduction in the jaw\u002Ftemple region during the last 30 days with\n\n  * Chewing hard or tough food\n  * Opening mouth or moving jaw forward or to the side\n  * Hold teeth together\u002Fclenching\u002Fgrinding\u002Fchewing gum\n  * Using the jaw during activities such as talking, kissing or yawning\n\nExclusion Criteria:\n\n* Traumatic injury\u002F surgery on face or jaw \\\u003C 6 months\n* current orthodontic treatment\n* pregnant or nursing,\n* kidney failure or renal dialysis,\n* heart disease or heart failure,\n* uncontrolled chronic respiratory disease\u002F hypertension\u002F diabetes\n* history of\n* seizures\n* hyperthyroidism\n* drug or alcohol abuse\n* psychiatric disorder\u002Fconditions requiring hospitalization\n* chemotherapy\u002Fradiation",true,"ALL","18 Years","64 Years",{"count":65,"type":66},20,"ESTIMATED","INTERVENTIONAL",[69],"PHASE2","The proposed pilot study is aimed at preliminary characterization of the TMNB injection in 20 healthy volunteers. Assessment of bite-force distribution and surface electromyographic activity of the temporalis and the masseter muscles, at rest and clench, before and after unilateral TMNB injection, will be the primary outcome measures. Post-injection assessments will be performed at 30 minutes, 2 hours, and 2 weeks after the injection. Participants will be surveyed regarding their experience receiving the TMNB injection (secondary outcomes).",[72],"Occlusion","2025-12-04",{"date":75,"type":76},"2025-12-05","ACTUAL",{"date":78,"type":76},"2022-10-10",{"date":80,"type":66},"2026-12",{"name":5,"class":6},1]