[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641669":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":11,"centralContacts":20,"locations":11,"responsibleParty":26,"collaborators":11,"id":28,"slug":29,"hasResults":30,"nctId":31,"briefTitle":32,"officialTitle":33,"acronym":11,"eligibilityCriteria":34,"healthyVolunteers":30,"sex":35,"minAge":36,"maxAge":37,"enrollmentInfo":38,"targetDuration":11,"studyType":41,"phases":42,"briefSummary":44,"conditions":45,"keywords":11,"overallStatus":47,"whyStopped":11,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":11},{"fullName":5,"class":6},"Dongguan People's Hospital","OTHER_GOV",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Chidamide , Venetoclax, Azacitidine, Homoharringtonine","EXPERIMENTAL",null,[13],"Drug: Chidamide (Chi)+VAH",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":11},"DRUG","Chidamide (Chi)+VAH","Induction (Chi+VAH Regimen):\n\nCycle 1: Chi+VAH regimen (28-day cycle).\n\nAssessment \\& Cycle 2:\n\nCR\u002FCRi: Repeat one cycle → Proceed to post-remission therapy. PR: Repeat one cycle → Re-assess. If CR\u002FCRi → Proceed to post-remission therapy.\n\nNR: Discontinue study.\n\nPost-Remission \u002F Consolidation:\n\n1-2 cycles of either intermediate-dose Cytarabine (± targeted therapy) OR the Chi+VAH regimen.\n\nEligible patients should proceed to allogeneic HSCT.\n\nMaintenance (Non-transplant):\n\nMRD-negative: VA (Venetoclax + Azacitidine) until relapse, intolerance, or 1 year.\n\nMRD-positive: Chi+VAH or clinical trial until MRD negativity, then switch to VA maintenance.",[9],[21],{"name":22,"role":23,"phone":24,"phoneExt":11,"email":25},"Zhangkun Li","CONTACT","0769-28637333","lzk8239@163.com",{"type":27,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100641669","phase-2-chidamide-venetoclax-azacitidine-and-homoharringtonine-for-high-risk-fit-aml-100641669",false,"NCT07643636","Chidamide, Venetoclax, Azacitidine, and Homoharringtonine for High-risk Fit AML","A Single-arm, Single-center Clinical Trial Evaluating the Efficacy and Safety of a Regimen Combining Chidamide With Venetoclax, Azacitidine, and Homoharringtonine in the Treatment of Intermediate- to High-risk Fit AML Patients","Inclusion Criteria:\n\n1. Newly diagnosed fit-AML patients classified per the World Health Organization (WHO) classification criteria.\n2. Age ranging from 18 to 60 years, no restriction on gender.\n3. No prior anti-AML systemic therapy after AML diagnosis; cytoreductive treatment (e.g., hydroxyurea or cytarabine at a daily dose \\\u003C1.0 g) is permitted as exception.\n4. Estimated overall survival ≥12 weeks.\n5. Eastern Cooperative Oncology Group (ECOG) performance status ≤3 points.\n6. Renal function: calculated creatinine clearance (CrCl) ≥30 mL\u002Fmin.\n7. Hepatic function: alanine aminotransferase (ALT) \\\u003C5× upper limit of normal (ULN); total bilirubin \\\u003C3× ULN.\n8. Able to provide written informed consent and understand as well as comply with all study-specified procedures.\n\nExclusion Criteria:\n\n1. Patients stratified as favorable-risk AML defined by NCCN Guidelines 2022, including cytogenetic aberrations: t(8;21)(q22;q22.1); RUNX1-RUNX1T1, inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11.\n2. Confirmed acute promyelocytic leukemia (APL). AML complicated with central nervous system (CNS) leukemia infiltration.\n3. Cardiac function exceeding NYHA functional class II.\n4. Confirmed human immunodeficiency virus (HIV) infection or other uncontrolled clinically significant comorbidities, including but not limited to:\n\n   * Uncontrolled or active systemic infection (viral, bacterial or fungal); ② Concurrent second primary malignancy requiring urgent clinical intervention.\n\n6\\. Patients unable to receive oral chidamide and\u002For venetoclax administration. 7. Known hypersensitivity to any investigational product. 8. Pregnant or breastfeeding female subjects. 9. Inability to understand or adhere to the study protocol requirements. 10.Subjects deemed unsuitable for enrollment at the investigator's discretion","ALL","18 Years","60 Years",{"count":39,"type":40},46,"ESTIMATED","INTERVENTIONAL",[43],"PHASE2","This study aims to explore a superior first-line induction remission regimen by incorporating Chidamide into the modified VAH chemotherapy combined with targeted therapy regimen, leveraging its dual epigenetic modulation mechanism.",[46],"AML (Acute Myeloid Leukemia)","NOT_YET_RECRUITING","2026-06-16",{"date":50,"type":51},"2026-06-18","ACTUAL",{"date":53,"type":40},"2026-06-30",{"date":55,"type":40},"2029-06-01",{"name":5,"class":6}]