[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100585601":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":24,"locations":29,"responsibleParty":46,"collaborators":11,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":11,"eligibilityCriteria":53,"healthyVolunteers":50,"sex":54,"minAge":55,"maxAge":11,"enrollmentInfo":56,"targetDuration":11,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":68,"overallStatus":32,"whyStopped":11,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Case Comprehensive Cancer Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Haplo-Identical \u002F Cord Blood Transplant","EXPERIMENTAL",null,[13],"Biological: Haplo-Identical \u002F Cord Blood Transplant",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":11},"BIOLOGICAL","Cord Blood Unit Selection Cord Blood Unit Selection should be consistent with published guidelines5 with the understanding that the goal cell dose is 1x105 CD34 cells\u002Fkg in this protocol. ABO matching and donor specific antibodies should be taken into account in the selection of the CB unit.\n\nHaplo-Donor Selection Haplo-identical siblings and younger male donors are preferred. ABO matching, CMV compatibility, and donor specific antibodies should be taken into account in the selection of the donor.",[9],[20],{"name":21,"affiliation":22,"role":23},"Leland Metheny, MD","Case Comprehensive Cancer Center, University Hospitals Cleveland Medical Center","PRINCIPAL_INVESTIGATOR",[25],{"name":21,"role":26,"phone":27,"phoneExt":11,"email":28},"CONTACT","216-844-0139","Leland.Metheny@uhhospitals.org",[30],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Case Comprehensive Cancer Center, University Hospitals Cleveland Medical Center Seidman Cancer Center","RECRUITING","Cleveland","Ohio","44106","United States","US",{"type":39,"coordinates":40},"Point",[41,42],-81.69541,41.4995,{"lat":42,"lon":41},[45],{"name":21,"role":26,"phone":11,"phoneExt":11,"email":11},{"type":47,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100585601","phase-2-co-transplant-of-an-unmodified-haplo-identical-graft-with-cord-blood-100585601",false,"NCT06904482","Co-Transplant of an Unmodified Haplo-Identical Graft With Cord Blood","Inclusion Criteria:\n\n* Participants with the following hematologic malignancies:\n\n  * Acute myelogenous leukemia (AML): High-risk AML including:\n\n    * Antecedent hematological disease (e.g., myelodysplasia (MDS))\n    * Treatment-related\n    * Complete Remission (CR1) with poor or intermediate-risk cytogenetics or molecular markers (e.g. Flt 3 mutation, 11q23, del 5, del 7, TP53 mutations, complex cytogenetics)\n    * Participants must be in CR1, CR2, CR3 or CRi\n  * Acute lymphoblastic leukemia (ALL)\n\n    * High-risk CR1 including:\n\n      * Poor-risk cytogenetics (e.g., t(9;22)or 11q23 rearrangements)\n      * Presence of minimal disease by flow cytometry or PCR or Clonoseq after 2 or more cycles of chemotherapy\n      * No CR within 4 weeks of initial treatment\n    * Participants in CR2 or beyond\n    * Participants must be in CR1, CR2, CR3, or CRi\n  * Myelodysplastic syndromes (MDS), Intermediate, High or Very High Risk by the revised international prognostic scoring system (IPSS-R) or treatment related MDS\n  * High-risk lymphoma\n* Age \\> 18 years\n* Participants without a suitable HLA-matched related or unrelated donor CASE9Z24 Page 17 Version dated 12.16.2025\n* Participants with the following suitable grafts:\n\n  * A 4-8\u002F8 HLA high resolution matched cord blood unit with a cell dose of 1.0x105 CD34 cells\u002Fkg.\n  * A haplo-identical donor with a goal cell dose of \\> 4.0x106 CD34cells\u002Fkg (minimum 2 x106 CD34 cells\u002Fkg)\n* Concurrent Therapy for Extramedullary Leukemia or CNS Lymphoma: Concurrent therapy or prophylaxis for testicular leukemia, CNS leukemia including standard intrathecal chemotherapy and\u002For radiation therapy will be allowed as clinically indicated. Such treatment may continue until the planned course is completed. Participants must be in CNS remission at the time of protocol enrollment if there is a history of CNS involvement. Maintenance therapy after transplant is allowed.\n* Participants must have the ability to understand and the willingness to sign a written informed consent document\n\nExclusion Criteria:\n\n* Participants with inadequate Organ Function as defined by:\n\n  * Creatinine clearance \\\u003C 40ml\u002Fmin (Cockcroft-Gault)\n  * Bilirubin \\> 2X institutional upper limit of normal unless Gilbert syndrome\n  * AST (SGOT) \\> 3X institutional upper limit of normal\n  * ALT (SGPT) \\> 3X institutional upper limit of normal\n  * Pulmonary function: DLCOc \\\u003C 60%\n  * Cardiac: left ventricular ejection fraction \\\u003C 40%\n  * ECOG \\\u003C2\n* Participants with uncontrolled inter-current illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness\u002Fsocial situations that would limit compliance with study requirements.\n* Pregnant or breastfeeding women are excluded from this study because chemotherapy involved with RIC have the significant potential for teratogenic or abortifacient effects.\n* Any condition that would, in the investigator's judgment, interfere with full participation in the study, including administration of study drug and attending required study visits; pose a significant risk to the participant; or interfere with interpretation of study data.\n* Known allergies, hypersensitivity, or intolerance to any of the study medications, excipients, or similar compounds.\n* Prior autologous stem cell transplant or CAR-T within the preceding 6 months or prior allogeneic transplant.","ALL","18 Years",{"count":57,"type":58},36,"ESTIMATED","INTERVENTIONAL",[61],"PHASE2","The purpose of this study is to see if see if adding the specific combination of donors can result in acceptable levels of survival without evidence of disease.",[64,65,66,67],"aGVHD","Acute Myelogenous Leukemia","Acute Lymphocytic Leukemia","Myelodysplastic Syndromes",[69,70],"Unmodified Haplo-Identical Graft with Cord Blood","post-transplant cyclophosphamide aGVHD prophylaxis","2026-02-25",{"date":73,"type":74},"2026-02-27","ACTUAL",{"date":76,"type":74},"2025-08-13",{"date":78,"type":58},"2030-02-25",{"name":5,"class":6},1]