[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100443207":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":33,"locations":39,"responsibleParty":62,"collaborators":25,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":70,"eligibilityCriteria":71,"healthyVolunteers":66,"sex":72,"minAge":73,"maxAge":25,"enrollmentInfo":74,"targetDuration":25,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":87,"overallStatus":42,"whyStopped":25,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"University Hospital, Clermont-Ferrand","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"HYPERCAPNIA","EXPERIMENTAL","Under general anesthesia with mechanical ventilation, PaCO2=50mmHg will be targeted",[13],"Biological: HYPERCAPNIA",{"label":15,"type":16,"description":17,"interventionNames":18},"NORMOCAPNIA","ACTIVE_COMPARATOR","Under general anesthesia with mechanical ventilation, PaCO2=40mmHg will be targeted",[19],"Biological: NORMOCAPNIA",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"BIOLOGICAL","Controlled moderate hypercapnia PaCO2 50mmHg under general anesthesia with mechanical ventilation",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Controlled normocapnia PaCO2 40mmHg under general anesthesia with mechanical ventilation",[15],[30],{"name":31,"affiliation":5,"role":32},"Russell Chabanne, MD MSc","PRINCIPAL_INVESTIGATOR",[34],{"name":35,"role":36,"phone":37,"phoneExt":25,"email":38},"Lise Laclautre","CONTACT","+33 4 73 754963","promo_interne_drci@chu-clermontferrand.fr",[40],{"facility":41,"status":42,"city":43,"state":25,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"CHU","RECRUITING","Clermont-Ferrand","63000","France","FR",{"type":48,"coordinates":49},"Point",[50,51],3.08682,45.77969,{"lat":51,"lon":50},[54,56,57,60],{"name":31,"role":36,"phone":25,"phoneExt":25,"email":55},"rchabanne@chu-clermontferrand.fr",{"name":31,"role":32,"phone":25,"phoneExt":25,"email":25},{"name":58,"role":59,"phone":25,"phoneExt":25,"email":25},"Anna Ferrier, MD","SUB_INVESTIGATOR",{"name":61,"role":59,"phone":25,"phoneExt":25,"email":25},"Ricardo Moreno, MD",{"type":63,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100443207","phase-2-co2-modulation-in-endovascular-thrombectomy-for-acute-ischemic-stroke-100443207",false,"NCT05051397","CO2 Modulation in Endovascular Thrombectomy for Acute Ischemic Stroke","Evaluation of the Effect of Moderate and Controlled Hypercapnia on Ischemic Penumbra Vascular Collaterality During General Anesthesia for Anterior Circulation Acute Ischemic Stroke Mechanical Thrombectomy","COMET-AIS","Inclusion Criteria:\n\n• Large vessel occlusion anterior circulation stroke (terminal carotid artery and\u002For middle cerebral artery M1-M2 segment) eligible to mechanical thrombectomy under general anesthesia\n\nExclusion Criteria :\n\n* Active smoker\n* Chronic respiratory failure with ambulatory oxygen supplementation\n* Obesity with BMI\\>40Kg\u002F m2\n* Intubation before the procedure\n* Heart failure with intolerance to decubitus\n* Severe renal failure\n* Suspected elevated intracranial pressure\n* Pregnant or breastfeeding women","ALL","18 Years",{"count":75,"type":76},50,"ESTIMATED","INTERVENTIONAL",[79],"PHASE2","Acute ischemic stroke due to large vessel occlusion is responsible of cerebral blood flow impairment with a progressive and extensive ischemic process. Cerebral collateral circulation may preserve an ischemic penumbra that could recover providing timely reperfusion of the occluded vessel. Mechanical thrombectomy is the standard of care for anterior circulation large vessel reperfusion. Strategy to promote cerebral blood flow in collateral circulation before reperfusion is scarce and rely mainly on blood pressure maintenance. Carbon dioxide is a potent cerebral vasodilator that could enhance collateral circulation blood flow and cerebral protection before reperfusion. General anesthesia with endotracheal mechanical ventilation could be used for thrombectomy and give the opportunity to modulate and control carbon dioxide tension in the blood. This study will test the effect of moderate hypercapnia on penumbral collateral circulation before reperfusion during mechanical thrombectomy for anterior circulation acute ischemic stroke under general anesthesia.",[82,83,84,85,86],"Ischemic Stroke, Acute","Thrombectomy","Anesthesia, General","Cerebrovascular Circulation","Carbon Dioxide",[88,89,90,91,92,93],"mechanical thrombectomy","large vessel occlusion stroke","carbon dioxide tension","cerebral blood flow","general anesthesia","cerebral collateral circulation","2025-09-30",{"date":96,"type":97},"2025-10-06","ACTUAL",{"date":99,"type":97},"2022-07-20",{"date":101,"type":76},"2026-10-19",{"name":5,"class":6},1]