[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100614449":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":31,"centralContacts":25,"locations":36,"responsibleParty":57,"collaborators":59,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":67,"sex":73,"minAge":25,"maxAge":25,"enrollmentInfo":74,"targetDuration":25,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":88,"overallStatus":38,"whyStopped":25,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Sunnybrook Health Sciences Centre","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Methylphenidate + iTBS","EXPERIMENTAL","Participants are currently receiving methylphenidate and receive iTBS in this study.",[13,14],"Device: intermittent theta burst stimulation (iTBS)","Drug: Methylphenidate (MPH)",{"label":16,"type":10,"description":17,"interventionNames":18},"iTBS only","iTBS only, no medication for apathy",[13],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","intermittent theta burst stimulation (iTBS)","iTBS is a form of repetitive transcranial magnetic simulation (rTMS), a non-invasive form of brain stimulation.",[9,16],null,{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":25},"DRUG","Methylphenidate (MPH)","Participants will be on methylphenidate clinically prior to the trial",[9],[32],{"name":33,"affiliation":34,"role":35},"Krista Lanctot, PhD","Sunnybrook Research Institute","PRINCIPAL_INVESTIGATOR",[37],{"facility":34,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"RECRUITING","Toronto","Ontario","M4N 3M5","Canada","CA",{"type":45,"coordinates":46},"Point",[47,48],-79.39864,43.70643,{"lat":48,"lon":47},[51],{"name":52,"role":53,"phone":54,"phoneExt":55,"email":56},"Study Coordinator","CONTACT","416-480-6100","63185","memoryresearch@sunnybrook.ca",{"type":58,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[60,62,63],{"name":61,"class":6},"Alzheimer Society of Canada",{"name":34,"class":6},{"name":64,"class":6},"Brain Canada","100614449","phase-2-combined-brain-stimulation-and-methylphenidate-treatment-for-apathy-in-dementia-100614449",false,"NCT07279740","Combined Brain Stimulation and Methylphenidate Treatment for Apathy in Dementia","Methylphenidate Primed iTBS for Apathy in Neurocognitive Disorders","PRIME","Inclusion Criteria:\n\n* Alzheimer's disease or mixed Alzheimer's disease and vascular disease\n* MMSE score 10-28 inclusive\n* Clinically significant apathy\n* Stable dose of psychotropic medication\n* Care partner must spend at least 10hrs\u002Fweek with the participant\n\nExclusion Criteria:\n\n* Major Depressive Episode\n* Clinically significant agitation, delusions, hallucinations\n* Currently talking a dopaminergic agent other than methylphenidate\n* Failure to clear the TMS adult safety scale (e.g. unapproved pacemakers, metallic implants, history of epilepsy)\n* Central nervous system abnormalities (other than Alzheimer's disease) deemed clinically significant by study physician or seizures\n* Any condition that in the opinion of the study physician, makes it medically unsafe for the patient to enroll in the trial","ALL",{"count":75,"type":76},12,"ESTIMATED","INTERVENTIONAL",[79],"PHASE2","This study evaluates whether the combined treatment of methylphenidate and non-invasive brain stimulation, called intermittent theta burst stimulation, can effectively treat apathy in individuals with Alzheimer's disease or mixed AD\u002Fvascular dementia",[82,83,84,85,86,87],"Alzheimer s Disease","Alzheimer Dementia (AD)","Alzheimer Dementia","Alzheimer Disease","Apathy","Apathy in Dementia",[89,90,91,92,93,94,95,96],"apathy","dementia","Alzheimer's disease","methylphenidate","rTMS","iTBS","repetitive transcranial magnetic stimulation","intermittent theta burst stimulation","2025-12-11",{"date":99,"type":100},"2025-12-12","ACTUAL",{"date":102,"type":76},"2026-01",{"date":104,"type":76},"2027-10-01",{"name":5,"class":6},1]