[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100530777":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":28,"centralContacts":33,"locations":43,"responsibleParty":60,"collaborators":62,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":70,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":25,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":46,"whyStopped":25,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"University of Chicago","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Communication Bridge™","EXPERIMENTAL","Participants receive Communication Bridge™, a multi-component, participation-focused, dyadic intervention in which both the person with PPA and their co-enrolled communication partner are intervention recipients. Communication Bridge™ is modelled on the Living with Aphasia: Framework for Outcome Measurement (A-FROM) and the Care Pathway Model that was developed for persons living with primary progressive aphasia. Consistent with participation-focused intervention models personally salient training stimuli are incorporated into all therapy activities in the Experimental arm.",[13],"Behavioral: Communication Bridge™",{"label":15,"type":16,"description":17,"interventionNames":18},"Evidence-Based Impairment Focused","ACTIVE_COMPARATOR","The Control arm includes a non-dyadic intervention in which the person with PPA is the active intervention recipient and their communication partner is in a supporting role. In the Control arm, participants receive a speech-language intervention designed to address impairment and functional limitations, comprised of activities that address word retrieval and 'automatic' speech production using fixed, non-personalized, stimuli across participants.",[19],"Behavioral: Evidence-Based Impairment Focused",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Evidence-based speech language therapy treatment will be compared and contrasted in the two arms of the study.",[9],null,{"type":22,"name":15,"description":23,"armGroupLabels":27,"otherNames":25},[15],[29],{"name":30,"affiliation":31,"role":32},"Emily Roglaski, PhD","Professor of Neurology","PRINCIPAL_INVESTIGATOR",[34,40],{"name":35,"role":36,"phone":37,"phoneExt":38,"email":39},"Matthew Bona, MPH","CONTACT","773-702-1220","51145","cbtrial@uchicago.edu",{"name":41,"role":36,"phone":42,"phoneExt":25,"email":39},"Emily Cummings","773-702-1221",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"University of Chicago - American School Building","RECRUITING","Chicago","Illinois","60637","United States","US",{"type":53,"coordinates":54},"Point",[55,56],-87.65005,41.85003,{"lat":56,"lon":55},[59],{"name":35,"role":36,"phone":25,"phoneExt":25,"email":39},{"type":61,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[63,65],{"name":64,"class":6},"Western University, Canada",{"name":66,"class":67},"National Institute on Aging (NIA)","NIH","100530777","phase-2-communication-bridge-3-study-100530777",false,"NCT06191198","Communication Bridge 3 Study","Communication Bridge: Optimizing an Evidence-based Intervention for Individuals With Primary Progressive Aphasia","CB3","Inclusion Criteria (person with PPA):\n\n1. Meets diagnostic criteria for PPA based on neurologist and supporting medical assessments (extracted from medical records)\n2. English as primary language used in daily communication activities (by self-report)\n3. Adequate hearing (aided or unaided) for communicating with others in a crowded room (by self-report)\n4. Adequate vision (aided or unaided) for reading a newspaper, or other functional materials (by self-report)\n5. Able to pass technology screening and demonstrates sufficient knowledge for use of video conference and Communication Bridge™ web application use (with or without training)\n6. Geriatric Depression Scale score ≤ 9\n7. Mild-moderate PPA informed by a structured interview with a speech-language pathologist and a standardized testing battery.\n\nInclusion Criteria (Co-enrolled communication partner):\n\n1. 18+ years of age\n2. English as primary language used in daily communication activities (by self-report)\n3. Adequate hearing (aided or unaided) for communicating with others in a crowded room (by self-report)\n4. Able to pass technology screening\\* and demonstrates sufficient knowledge for use of video conference and Communication Bridge™ web application use (with or without training)\n\nExclusion Criteria:\n\n* A dementia diagnosis other than Primary Progressive Aphasia\n* Participation is co-enrolled in an outside speech language therapy program during the study course.\n* Communication partners will be excluded if they have a pre-existing communication impairment that would affect study participation (e.g., aphasia, dementia)\n\nMedical records will be requested and reviewed to determine eligibility","ALL","18 Years","100 Years",{"count":80,"type":81},200,"ESTIMATED","INTERVENTIONAL",[84],"PHASE2","This study will use a randomized controlled trial design to evaluate the effect of two evidence-based treatments for adults with mild-moderate Primary Progressive Aphasia (PPA). The aim of the study is to help us better understand the effects of speech-language therapy on communication abilities in individuals with PPA.",[87],"Primary Progressive Aphasia",[89,90,91,92,93],"Aphasia","Dementia","Communication","Frontotemporal Dementia","Alzheimer Disease","2026-05-27",{"date":96,"type":97},"2026-06-01","ACTUAL",{"date":99,"type":97},"2024-08-23",{"date":101,"type":81},"2028-07-15",{"name":5,"class":6},1]