[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100526762":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":26,"centralContacts":30,"locations":39,"responsibleParty":55,"collaborators":34,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":34,"eligibilityCriteria":63,"healthyVolunteers":64,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":34,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":34,"overallStatus":41,"whyStopped":34,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"National Skin Centre","NETWORK",[8,13],{"label":9,"type":10,"description":9,"interventionNames":11},"siSPARC microneedle patch","EXPERIMENTAL",[12],"Drug: siSPARC microneedle patch",{"label":14,"type":10,"description":14,"interventionNames":15},"siSPARC + siLR4A microneedle patch",[16],"Drug: siSPARC + siLR4A microneedle patches",[18,23],{"type":19,"name":20,"description":14,"armGroupLabels":21,"otherNames":22},"DRUG","siSPARC + siLR4A microneedle patches",[14],[14],{"type":19,"name":9,"description":9,"armGroupLabels":24,"otherNames":25},[9],[14],[27],{"name":28,"affiliation":5,"role":29},"Hong Liang Tey","PRINCIPAL_INVESTIGATOR",[31,36],{"name":28,"role":32,"phone":33,"phoneExt":34,"email":35},"CONTACT","6350 6666",null,"teyhongliang@ntu.edu.sg",{"name":37,"role":32,"phone":33,"phoneExt":34,"email":38},"Delwyn Lim","delwynlim@Outlook.com",[40],{"facility":5,"status":41,"city":42,"state":34,"zip":43,"country":42,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"RECRUITING","Singapore","308205","SG",{"type":46,"coordinates":47},"Point",[48,49],103.85007,1.28967,{"lat":49,"lon":48},[52],{"name":53,"role":32,"phone":54,"phoneExt":34,"email":34},"General National Skin Centre Contact","(65) 6253 4455",{"type":56,"investigatorFullName":34,"investigatorTitle":34,"investigatorAffiliation":34,"oldNameTitle":34,"oldOrganization":34},"SPONSOR","100526762","phase-2-comparing-the-effect-of-sisparc-microneedle-patch-versus-sisparcsilr4a-microneedle-patch-on-post-surgical-scars-100526762",false,"NCT06138964","Comparing the Effect of siSPARC Microneedle Patch Versus siSPARC+siLR4A Microneedle Patch on Post-surgical Scars","Randomized Intra-individually Controlled Double-blinded Trial Comparing Effect of Small Interfering RNA Against SPARC (siSPARC) Microneedle Patch Versus Small Interfering RNA Against SPARC and IL4-RA (siSPARC + siLR4A) Microneedle Patch on Appearance of Post-surgical Scars","Inclusion Criteria:\n\n* Adult\n* Age 21-75\n* 2 weeks (+\u002F- 7 days) after surgical operation with incision into the dermis\n* Post-stitch removal when stitches were applied\n* Wound closure\u002Funion achieved\n\nExclusion Criteria:\n\n* Pregnant or lactating participant\n* Participants with wound infection\n* Participants assessed to be uncooperative or unable to self-administer the interventions\n* Participants with known contact allergy to ingredients in the patch formulation (comprising hyaluronic acid, siRNA and glue) and\u002For isopropyl alcohol\n* Participants who are unable to personally consent (for e.g., cognitively impaired)",true,"ALL","21 Years","75 Years",{"count":69,"type":70},50,"ESTIMATED","INTERVENTIONAL",[73],"PHASE2","This randomized, double-blind controlled study aims to compare the effect on appearance of post- surgical scars between daily application of siSPARC microneedle patch versus siSPARC + siLR4A microneedle patches. These are patches comprising short microneedles embedded with hydrolysed RNA (siRNAs).",[76,77,78],"Keloid","Wound Heal","Wound","2024-06-20",{"date":81,"type":82},"2024-06-24","ACTUAL",{"date":84,"type":82},"2023-11-14",{"date":86,"type":70},"2024-11-14",{"name":5,"class":6},1]