[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640253":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":28,"locations":34,"responsibleParty":48,"collaborators":24,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":54,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":24,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":72,"overallStatus":74,"whyStopped":24,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Liaquat National Hospital & Medical College","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group B (Bolus)","ACTIVE_COMPARATOR","Group B patients will be given a bolus dose of hyperbaric bupivacaine in a bolus fashion mean all of calculated drug will be given in one shot",[13],"Drug: Spinal Anesthesia (bupivacaine)",{"label":15,"type":10,"description":16,"interventionNames":17},"Group F (Fractionated)","In group F Spinal Anesthesia will be given as 2\u002F3 of the initial dose will be give and then after 90 seconds remaining 1\u002F3 dose will be given of hyperbaric bupivacaine.",[13],[19,25],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","Spinal Anesthesia (bupivacaine)","In this group B spinal Anesthesia will be given in one single shot",[9],null,{"type":20,"name":21,"description":26,"armGroupLabels":27,"otherNames":24},"In this intervention spinal Anesthesia of bupivacaine will be given in a fractionated manner that is 2\u002F3 of dose initially and then 1\u002F3 after 90 seconds",[15],[29],{"name":30,"role":31,"phone":32,"phoneExt":24,"email":33},"Usama, MBBS","CONTACT","+923008978791","bhurgriusama@gmail.com",[35],{"facility":36,"status":24,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":24},"Liaquat National Hospital","Karachi","Sindh","74000","Pakistan","PK",{"type":43,"coordinates":44},"Point",[45,46],67.0104,24.8608,{"lat":46,"lon":45},{"type":49,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Usama Bhurgri","Principal Investigator","100640253","phase-2-comparison-of-hemodynamic-effects-of-bupivacaine-in-spinal-anesthesia-100640253",false,"NCT07616882","Comparison of Hemodynamic Effects of Bupivacaine in Spinal Anesthesia","Comparison of Hemodynamic Effects of Fractionated Dose Versus Bolus Dose of Hyperbaric Bupivacaine (0.5%) in Spinal Anesthesia for Lower Limb Surgery","Nill","Inclusion Criteria:\n\n* ASA I and II\n* Adults 18 to 60 years of age of either gender\n* height from 160 to 182cm and BMI from 15 to 29.9kg\u002Fm2\n\nExclusion Criteria:\n\n* ASA III and IV\n* Refusal of consent\n* any known renal, hepatic, cardiac or cerebrovascular disease\n* hypersensitivity to local anaesthetics drug\n* spinal deformity or any contra indications to spinal anesthesia","ALL","18 Years","60 Years",{"count":64,"type":65},100,"ESTIMATED","INTERVENTIONAL",[68],"PHASE2","To assess hemodynamic changes with hyperbaric bupivacaine with spinal anesthesia",[71],"Hemondynamic Changes in Spinal Anesthesia",[73],"Spinal ansethesia, Fractionated, Bolus","NOT_YET_RECRUITING","2026-05-26",{"date":77,"type":78},"2026-06-01","ACTUAL",{"date":80,"type":65},"2027-04-01",{"date":82,"type":65},"2027-10-01",{"name":5,"class":6},1]