[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100608995":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":45,"responsibleParty":67,"collaborators":25,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":25,"eligibilityCriteria":78,"healthyVolunteers":74,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":25,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":94,"overallStatus":48,"whyStopped":25,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Nishtar Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Dexamethasone group","ACTIVE_COMPARATOR","In this study dexamethasone sodium phosphate 8 mg (2 mL) will be administered submucosally at the surgical site 30 minutes before incision.",[13],"Drug: Dexamethasone",{"label":15,"type":10,"description":16,"interventionNames":17},"Methylprednisolone group","In this study methylprednisolone sodium succinate 40 mg (2 mL) will be administered submucosally at the surgical site 30 minutes before incision.",[18],"Drug: Methylprednisolone (Corticosteroid)",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Dexamethasone","single dose of dexamethasone 8 mg (2 mL) administered submucosally at the surgical site 30 minutes before incision.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Methylprednisolone (Corticosteroid)","a single dose of methylprednisolone 40 mg (2 mL) will be administered submucosally at the surgical site 30 minutes before incision.",[15],[31],{"name":32,"affiliation":33,"role":34},"Dr amjad ali Bari, M.D.S (OMFS)","NISHTAR INSITUTE OF DENTISTRY, MULTAN","STUDY_DIRECTOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":25,"email":40},"Ammar ali khalid, Bachelor of dental surgery","CONTACT","923129216146","ammaraligoraya@gmail.com",{"name":42,"role":38,"phone":43,"phoneExt":25,"email":44},"Dr amjad Bari, M.D.S (OMFS)","+92 300 9630196","dramjad.omfs@gmail.com",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Nishtar Institute of Dentistry Multan","RECRUITING","Multan","Punjab Province","60000","Pakistan","PK",{"type":55,"coordinates":56},"Point",[57,58],71.47824,30.19679,{"lat":58,"lon":57},[61,64],{"name":62,"role":38,"phone":63,"phoneExt":25,"email":40},"Ammar Ali Dr Ammar Ali, Bachelor in Dental surgery","+923129216146",{"name":65,"role":38,"phone":66,"phoneExt":25,"email":44},"Amjad Bari Dr Amjad Bari, Master in Dental Surgery","+923009630196",{"type":68,"investigatorFullName":69,"investigatorTitle":70,"investigatorAffiliation":71,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Ammar Ali Khalid","Resident, Department of Oral and Maxillofacial Surgery \u002F Principal Investigator","University of Health Sciences Lahore","100608995","phase-2-comparison-of-submucosal-dexamethasone-and-methylprednisolone-in-postoperative-sequelae-of-parasymphsis-fractures-100608995",false,"NCT07208799","Comparison of Submucosal Dexamethasone and Methylprednisolone in Postoperative Sequelae of Parasymphsis Fractures","Comparison of Effectiveness of Submucosal Dexamethasone and Methylprednisolone in Management of Postoperative Sequelae in Mandibular Parasymphysis Fractures","Inclusion Criteria:\n\n1. Patients aged 18 to 40.\n2. Both Gender.\n3. Fracture less than a week old.\n4. Isolated mandibular parasymphysis fractures.\n\nExclusion Criteria:\n\n* 1\\. Immunocompromised patients (due to increased risk of infection and complications).\n\n  2\\. Patients experiencing acute pain from conditions such as pulpitis, abscesses, or other acute infections (to ensure that acute pain does not confound the study results).\n\n  3\\. Patients reporting hypersensitivity to steroids (to avoid adverse reactions).\n\n  4\\. Patients taking or requiring prophylactic antibiotics or anti-inflammatory drugs before surgery (to prevent confounding effects on study outcomes).\n\n  5\\. Patients with a history of systemic steroid administration for 15 days (as this could affect the study's outcomes).\n\n  6\\. Patients with chronic pain problems or mental disorders (to maintain consistency in response to treatment).\n\n  7\\. Patients with comminuted fractures (to maintain consistency in fracture type).\n\n  8\\. Pregnant or lactating women (to avoid potential risks to the fetus and nursing infant).\n\n  9\\. Smokers who smoke at least 10 cigarettes per day for 2 years (to minimize the impact of smoking on healing and recovery).\n\nria:","ALL","18 Years","40 Years",{"count":83,"type":84},72,"ESTIMATED","INTERVENTIONAL",[87],"PHASE2","The rationale of the current research is to address the limitation of existing knowledge as it is not clear which of the two drugs (Dexamethasone or Methylprednisolone) is more effective in reduction of postoperative sequelae in patient with mandibular parasymphysis fracture. This study fills the gap by providing sound evidence on the preferred steroid option to help clinicians have more data to make decisions and improve patients' health. The result of this research will then be added to the evidence-based protocols for the treatment of parasymphysis fractures.",[90,91,92,93],"Mandible Fracture","Edema Face","Pain Management","Corticosteroid Injection",[95,96,97,98,99,100],"mandible fracture","edema","pain","submucosal","dexamethasone","methylprednisolone","2026-04-02",{"date":103,"type":104},"2026-04-06","ACTUAL",{"date":106,"type":104},"2026-01-03",{"date":108,"type":84},"2026-12-01",{"name":5,"class":6},1]