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HCC or clinically confirmed diagnosis of HCC; Has a Child-Pugh class A liver score.\n  * For CC patients: Has persistent, recurrent or metastatic cervical cancer with squamous cell, adenocarcinoma, or adenosquamous histology\n  * For Melanoma patients: Histologically or cytologically confirmed diagnosis of unresectable Stage III or metastatic melanoma.\n  * For PROC patients (Cohort A): Participants must have a confirmed diagnosis of OC, primary peritoneal cancer, or fallopian tube cancer, all of which with high-grade serous histology. Patients must have platinum-resistant disease.\n  * For HNSCC patients: Histologically or cytologically confirmed recurrent (recurrent disease that is not amendable to curative treatment with local\u002F or systemic therapies)\u002F (disseminated) HNSCC of the oral cavity, oropharynx, hypopharynx, and larynx that is considered incurable by local therapies.\n  * For NSCLC patients: Pathologically documented Stage IIIB or IIIC NSCLC not amenable for radical surgery or definitive chemoradiation or Stage IV NSQ NSCLC. Not harboring an EGFR-sensitizing mutation or ALK gene rearrangements or other onco-driver gene mutations\n  * For PSOC: Must have PSOC, defined as radiographically documented disease recurrence or progression occurring \\>6 months after completion of the last dose of platinum-based chemotherapy.\n  * For PDAC: Participants must have histologically or cytologically confirmed metastatic PDAC., who have progressed after at least one prior line of standard systemic treatment ((≥2L PDAC).)\n  * For breast cancer:\n\n    * HR+\u002FHER2-low or HR+\u002FHER2-ultralow or HR+\u002FHER2-negative BC participants: Pathologically or cytologically documented HR-positive unresectable or metastatic BC with HER2-low, HER2-ultralow or HER2-negative expression.\n    * Triple negative breast cancer (TNBC): Pathologically or cytologically documented unresectable or metastatic TNBC\n  * For mCRC: Participants who have metastatic CRC and have relapsed or progressed after 1 prior line of systemic treatment including a fluoropyrimidine plus oxaliplatin with or without anti-vascular endothelial growth factor (VEGF) monoclonal antibody (mAb) or anti-epidermal growth factor receptor mAb therapy, as clinically indicated, or have relapsed or progressed after 2 lines of therapy if the participant has received targeted therapy\n  * For mCRPC: Participants must have histologically or cytologically confirmed adenocarcinoma of the prostate and mCRPC\n\nExclusion Criteria:\n\n* 1\\. Prior treatment with B7H3 targeted therapy.\n* Prior treatment with antibody-drug conjugate with topoisomerase inhibitor.\n* Is a candidate to locoregional treatment with potential to induce complete or near complete response and prolonged tumor control, per investigator's assessment.\n* Has an uncontrolled concomitant or intercurrent illness, that in the opinion of the investigator, contra-indicates trial participation, limits compliance with trial procedures or substantially increases the risk of incurring AEs.\n* Has uncontrolled or significant cardiovascular disease. 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