[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639167":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":33,"centralContacts":37,"locations":48,"responsibleParty":68,"collaborators":42,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":42,"eligibilityCriteria":78,"healthyVolunteers":79,"sex":80,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":42,"studyType":86,"phases":87,"briefSummary":90,"conditions":91,"keywords":42,"overallStatus":51,"whyStopped":42,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Sahiwal medical college sahiwal","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"GROUP A","OTHER","GROUP BUPIVACAINE+DEXAMETHASONE",[13],"Drug: Bupivacaine Hcl 0.25% Inj_#1",{"label":15,"type":10,"description":16,"interventionNames":17},"GROUP B","GROUP BUPIVACAINE+DEXAMETHASONE+DEXMEDETOMIDINE",[18],"Drug: Bupivacaine Hcl 0.25% Inj_#2",[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Bupivacaine Hcl 0.25% Inj_#1","At the end of the surgery, bilateral Ultrasound (U\u002FS) guided TAP block will be performed using ultrasound machine. The patient will be in supine position and a high frequency linear probe will be placed transverse to abdominal wall between the costal margin and iliac crest at mid axillary line. The needle will be introduced in plane of the ultrasound probe directly under the probe and advanced until it reaches the plane between the internal oblique and transverse abdominis muscles. Upon reaching the plane and after negative aspiration test for blood, 2ml of saline will be injected to confirm correct needle position, after which the patient will receive the TAP block as per the group allocation.",[9],[26],"Bupivacaine+Dexamethasone",{"type":21,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Bupivacaine Hcl 0.25% Inj_#2","At the end of the surgery, bilateral Ultrasound (U\u002FS) guided TAP block will be performed in both groups using ultrasound machine. The patient will be in supine position and a high frequency linear probe will be placed transverse to abdominal wall between the costal margin and iliac crest at mid axillary line. The needle will be introduced in plane of the ultrasound probe directly under the probe and advanced until it reaches the plane between the internal oblique and transverse abdominis muscles. Upon reaching the plane and after negative aspiration test for blood, 2ml of saline will be injected to confirm correct needle position, after which the patient will receive the TAP block as per the group allocation.",[15],[32],"Bupivacaine+ Dexamethasone +Dexmedetomidine",[34],{"name":35,"affiliation":5,"role":36},"Adeel Riaz, MD","STUDY_DIRECTOR",[38,44],{"name":39,"role":40,"phone":41,"phoneExt":42,"email":43},"Dr Maryam Mumtaz, MBBS","CONTACT","00923336238201",null,"Maryamsumra3@gmail.com",{"name":45,"role":40,"phone":46,"phoneExt":42,"email":47},"Dr Muhammad Shahid","00923336173056","shahidnishtar@gmail.com",[49],{"facility":50,"status":51,"city":52,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"Sahiwal Medical College","RECRUITING","Sahiwal","Punjab Province","57000","Pakistan","PK",{"type":58,"coordinates":59},"Point",[60,61],73.10186,30.66595,{"lat":61,"lon":60},[64],{"name":65,"role":40,"phone":66,"phoneExt":42,"email":67},"Dr Rao Riaz ul Haq, FCPS","009240452470","slmcswl@gmail.com",{"type":69,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":42,"oldOrganization":42},"PRINCIPAL_INVESTIGATOR","Mariam Mumtaz","Resident Anesthetist","100639167","phase-2-dexa-vs-dexmedetomidine-with-bupivacaine-in-tap-block-for-laparotomy-analgesia-100639167",false,"NCT07590752","\"Dexa vs Dexmedetomidine With Bupivacaine in TAP Block for Laparotomy Analgesia","Comparison Of Dexamethasone Versus Dexmedetomidine As An Adjuvant To 0.25% Bupivacaine In Ultrasound Guided Tap Block On Post-Op Analgesia Duration In Patients Undergoing Laparotomy","Inclusion Criteria:\n\n* Patients undergoing laparotomy.\n* Patients aged 25 to 65 years.\n* Both genders.\n* Patients with ASA Class I, II.\n\nExclusion Criteria:\n\n* Patients who do not give consent.\n* Patients with Comorbidities like DM, HTN, CKD, CLD.\n* Patients with bleeding disorders.\n* Infection at site of injection.\n* Allergy to any drug, local anaesthetic, or other drugs used.\n* Patients with polytrauma.",true,"ALL","25 Years","65 Years",{"count":84,"type":85},96,"ESTIMATED","INTERVENTIONAL",[88,89],"PHASE2","PHASE3","Transversus abdominis plane block is a regional anesthetic technique which blocks the abdominal neural afferents by introducing local anesthetic into the neuro-fascial plane between the internal oblique and the transversus abdominis muscle and gives analgesia from the skin to parietal peritoneum. There are studies showing evidence of improved post operative analgesia with addition of adjuvants such as dexmedetomidine or dexamethasone in comparison with plane local anesthesia in terms of time to rescue analgesia and the overall quantity of analgesic used post operatively.",[92,93,94],"Pain, Postoperative","Opioid Use","Laparotomy","2026-05-08",{"date":97,"type":98},"2026-05-15","ACTUAL",{"date":100,"type":98},"2024-03-03",{"date":102,"type":85},"2026-07-04",{"name":5,"class":6},1]