[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100577526":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":28,"centralContacts":32,"locations":42,"responsibleParty":54,"collaborators":12,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":12,"enrollmentInfo":67,"targetDuration":12,"studyType":70,"phases":71,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":79,"whyStopped":12,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Assiut University","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Group dexmedetomidine","ACTIVE_COMPARATOR","Patients will be placed in lateral position with the surgical site upward. A high-frequency linear ultrasound probe will be placed in a longitudinal parasagittal orientation 2.5-3 cm lateral to the T9 spinous process. The erector spinae muscles will be identified superficial to the tip of the T9 transverse process. An echogenic needle needle will be inserted using an in-plane approach and craniocaudally direction. The tip of the needle will be placed into the fascial plane on the deep aspect of the erector spinae muscle. The location of the needle tip will be confirmed by visible fluid spread lifting the erector spinae muscle off the bony shadow of the transverse process on ultrasonographic imaging.\n\nGroup D patients: A total of 30 ml Bupivacaine 0. 25%+ 50 mic dexmedetomidine which is diluted to 2ml.",null,{"label":14,"type":10,"description":15,"interventionNames":12},"Group fentanyl","Patients will be placed in lateral position with the surgical site upward. A high-frequency linear ultrasound probe will be placed in a longitudinal parasagittal orientation 2.5-3 cm lateral to the T9 spinous process. The erector spinae muscles will be identified superficial to the tip of the T9 transverse process. An echogenic needle needle will be inserted using an in-plane approach and craniocaudally direction. The tip of the needle will be placed into the fascial plane on the deep aspect of the erector spinae muscle. The location of the needle tip will be confirmed by visible fluid spread lifting the erector spinae muscle off the bony shadow of the transverse process on ultrasonographic imaging.\n\nGroup F patients : A total of 30 ml Bupivacaine 0.25% + 100 mic fentanyl which is also diluted to 2 ml.",[17,21,25],{"type":18,"name":19,"description":20,"armGroupLabels":12,"otherNames":12},"PROCEDURE","Erector Spinae Plane Block","Patients will be placed in lateral position with the surgical site upward. A high-frequency linear ultrasound probe will be placed in a longitudinal parasagittal orientation 2.5-3 cm lateral to the T9 spinous process. The erector spinae muscles will be identified superficial to the tip of the T9 transverse process. An echogenic needle needle will be inserted using an in-plane approach and craniocaudally direction. The tip of the needle will be placed into the fascial plane on the deep aspect of the erector spinae muscle. The location of the needle tip will be confirmed by visible fluid spread lifting the erector spinae muscle off the bony shadow of the transverse process on ultrasonographic imaging.",{"type":22,"name":23,"description":24,"armGroupLabels":12,"otherNames":12},"DRUG","Dexmedetomidine","50 mic dexmedetomidine which is diluted to 2ml.",{"type":22,"name":26,"description":27,"armGroupLabels":12,"otherNames":12},"fentanyl","100 mic fentanylwhich is also diluted to 2 ml.",[29],{"name":30,"affiliation":5,"role":31},"Moamen Mostafa Makkey, Doctor","STUDY_CHAIR",[33,38],{"name":34,"role":35,"phone":36,"phoneExt":12,"email":37},"Alaa Mohamed Atia, Professor","CONTACT","01099923117","alaaguhina@aun.edu.eg",{"name":39,"role":35,"phone":40,"phoneExt":12,"email":41},"Abdelrahman Hamdy Mohamed, Doctor","+20 1060989574","Abdelrahmanhm89@gmail.com",[43],{"facility":5,"status":12,"city":44,"state":45,"zip":12,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":12},"Asyut","Asyut Governorate","Egypt","EG",{"type":49,"coordinates":50},"Point",[51,52],31.18368,27.18096,{"lat":52,"lon":51},{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"PRINCIPAL_INVESTIGATOR","Emad Bahgat Haleem Zaki","Resident physican","100577526","phase-2-dexmedetomidine-versus-fentanyl-as-adjuvants-to-erector-spinae-plane-block-for-postoperative-analgesia-following-simple-nephrectomy-a-randomized-clinical-trial-100577526",false,"NCT06799442","Dexmedetomidine Versus Fentanyl as Adjuvants to Erector Spinae Plane Block for Postoperative Analgesia Following Simple Nephrectomy: A Randomized Clinical Trial","DEX\u002FFentanyl","Inclusion Criteria:\n\n* Age \\>18 years old Both sex patients who are American society of Anesthesiologists class I or\n\nExclusion Criteria:\n\n* Patient's refusal.\n* body mass index (BMI) ≥40 kg\u002Fm2.\n* Local infection at site of block.\n* Spine deformities\n* History of hypersensitivity to the drugs being evaluated\n* Inability to comprehend postoperatively the pain assessment scale\u002Fneuropsychiatric disorders.\n* Chronic use of opioids and opioid addiction","ALL","18 Years",{"count":68,"type":69},46,"ESTIMATED","INTERVENTIONAL",[72,73],"PHASE2","PHASE3","The aim of this clinical trial is to compare the time to first analgesic request between dexmedetomidine and fentanyl as adjuvants in erector spinae plane block in patients undergoing simple nephrectomy .\n\n• Secondary outcome Pain scores; Numerical Rating Scale (NRS) at rest and when coughing \\[at 1, 2, 4, 8, 16 and 24 hours postoperatively.\\] The total opiod dose in the first 24 hours postoperatively. Duration of analgesia is defined as duration between block administration and time of first analgesic request.\n\nAny adverse effects related to anesthesia or the technique. Incidence of Postoperative nausea \\& vomiting . Block related complication during and after block procedure till 24hours postoperatively (local anesthetic systemic toxicity, pneumothorax and vascular puncture during block procedure).\n\nIntraoperative haemodynamics parameters MAP ,HR , co2 and SP O2 . Postoperative haemodynamics parameters MAP , HR and SP O2 \\[at 1, 2, 4, 8, 16 and 24 hours postoperatively. \\]",[76],"Nephrectomy",[78],"Postoperative pain relief","NOT_YET_RECRUITING","2025-01-23",{"date":82,"type":83},"2025-01-29","ACTUAL",{"date":85,"type":69},"2025-03-01",{"date":87,"type":69},"2026-03-01",{"name":5,"class":6},1]