[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631233":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":31,"responsibleParty":47,"collaborators":20,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":20,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":58,"maxAge":20,"enrollmentInfo":59,"targetDuration":20,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":74,"whyStopped":20,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"University of Miami","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Intraoperative Doxycycline","EXPERIMENTAL","All participants will receive a single injection intraoperative dose of doxycycline (500mg)",[13],"Drug: Doxycycline",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DRUG","Doxycycline","All participants will undergo incision and drainage with seroma washout and receive a single intraoperative injection of doxycycline (500mg) prior to fascial closure.",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Colin McNamara, MD","PRINCIPAL_INVESTIGATOR",[26],{"name":27,"role":28,"phone":29,"phoneExt":20,"email":30},"Robert E Carrier, DO","CONTACT","413-478-8417","rec182@miami.edu",[32],{"facility":5,"status":20,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Coral Gables","Florida","33146","United States","US",{"type":39,"coordinates":40},"Point",[41,42],-80.26838,25.72149,{"lat":42,"lon":41},[45,46],{"name":27,"role":28,"phone":29,"phoneExt":20,"email":30},{"name":23,"role":24,"phone":20,"phoneExt":20,"email":20},{"type":24,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Colin A. McNamara","Assistant Professor of Clinical Medicine","100631233","phase-2-doxycycline-use-in-post-operative-seromas-100631233",false,"NCT07498010","Doxycycline Use in Post-Operative Seromas","The Role of Doxycycline in the Management of Postoperative Seromas: A Pilot Study","Inclusion Criteria:\n\n* Patient with seroma formation following orthopedic procedure\n* \\>18 years old\n* Willing and able to provide informed consent\n* Pre-operative imaging (US, CT) demonstrating seroma formation\n\nExclusion Criteria:\n\n* Pregnancy or lactation\n* Age \\\u003C18 years\n* Known allergy to tetracyclines\n* Significant hepatic or renal dysfunction (Alanine Aminotransferase (ALT)\u002FAspartate Aminotransferase (AST) \\>3× Upper Limit of Normal (ULN), Creatinine Clearance (CrCl \\\u003C30 mL\u002Fmin)\n* History of photosensitivity or photodermatosis\n* Concurrent isotretinoin or retinoid therapy\n* Current use of anticoagulants or immunosuppressants\n* Active GI ulceration or esophageal disease\n* Any condition likely to impair adherence or drug absorption (e.g., malabsorption syndromes)","ALL","18 Years",{"count":60,"type":61},10,"ESTIMATED","INTERVENTIONAL",[64],"PHASE2","Seromas are collections of serous fluid that can develop following surgical procedures and may persist as fibrous-lined pseudocysts if not adequately treated. In orthopedic surgery, particularly after arthroplasty, seromas can impair wound healing, increase pain, and limit postoperative rehabilitation, potentially compromising patient recovery. Current treatment strategies including compression, percutaneous aspiration, and repeat surgical intervention have variable success, and aspiration carries the risk of introducing bacteria into an otherwise sterile fluid collection. Sclerotherapy has been proposed as an alternative strategy to induce fibrosis within the cavity and eliminate the potential space. Doxycycline, a tetracycline antibiotic commonly used for pleurodesis, has demonstrated sclerosing properties through mechanisms including mesothelial cell destruction, inhibition of fibrinolysis, and stimulation of fibroblast activity. While doxycycline sclerotherapy has shown success in treating conditions such as Morel-Lavallée lesions and has been described in isolated orthopedic case reports, its role in managing postoperative seromas after arthroplasty remains poorly studied. Further investigation is needed to determine whether doxycycline injection may serve as a safe and effective treatment to reduce persistent seromas and the need for additional interventions in orthopedic patients.",[67],"Seroma",[69,70,71,72,73],"seroma","doxycycline","post operative complications","sclerotherapy","fibrosis induction","NOT_YET_RECRUITING","2026-05-11",{"date":77,"type":78},"2026-05-12","ACTUAL",{"date":80,"type":61},"2026-07",{"date":82,"type":61},"2027-10-01",{"name":5,"class":6},1]