[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100560224":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":26,"locations":31,"responsibleParty":51,"collaborators":26,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":26,"eligibilityCriteria":58,"healthyVolunteers":55,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":26,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":34,"whyStopped":26,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"China Medical University Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"S1R agonist (S1RA) plus NMDAE","EXPERIMENTAL","An S1R agonist plus an NMDA enhancer",[13],"Drug: S1RA plus NMDAE",{"label":15,"type":16,"description":17,"interventionNames":18},"S1R agonist (S1RA) plus placebo","PLACEBO_COMPARATOR","An S1R agonist plus placebo",[19],"Drug: S1RA plus Placebo Cap",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","S1RA plus NMDAE","Use of an S1R agonist plus an NMDA enhancer for the treatment of treatment-resistant schizophrenia.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"S1RA plus Placebo Cap","Use of an S1R agonist plus placebo as a comparator",[15],[32],{"facility":33,"status":34,"city":35,"state":26,"zip":26,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Department of Psychiatry, China Medical University Hospital","RECRUITING","Taichung","Taiwan","TW",{"type":39,"coordinates":40},"Point",[41,42],120.6839,24.1469,{"lat":42,"lon":41},[45],{"name":46,"role":47,"phone":48,"phoneExt":49,"email":50},"Hsien-Yuan Lane, M.D., Ph.D","CONTACT","886 4 22052121","1855","hylane@gmail.com",{"type":52,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100560224","phase-2-dual-modulation-of-sigma-1-and-nmda-receptors-in-the-treatment-of-schizophrenia-100560224",false,"NCT06574360","Dual Modulation of Sigma-1 and NMDA Receptors in the Treatment of Schizophrenia","Inclusion Criteria:\n\n* Have a DSM-5 (American Psychiatric Association) diagnosis of schizophrenia\n* Are resistant to adequate treatments of at least two antipsychotics (excluding clozapine)\n* Remain symptomatic but without clinically significant fluctuation, while their antipsychotic doses are unchanged for at least 3 months and will be maintained during the period of the 8-week trial\n* PANSS total score \\>70\n* Hamilton Depression Rating Scale-17 items (HAMD) \\\u003C7\n* Are physically healthy and laboratory assessments (including blood routine, biochemical tests) are clinically insignificant.\n* Have sufficient education to communicate effectively and are capable of completing the assessments of the study.\n* Agree to participate in the study and provide informed consent\n\nExclusion Criteria:\n\n* DSM-5 diagnosis of intellectual disability or substance (including alcohol) use disorder\n* History of epilepsy, head trauma, central nervous system diseases or mental disorders other than schizophrenia (including major depressive disorder, bipolar disorders, persistent depressive disorder, obsessive-compulsive disorder)\n* Pregnancy or lactation\n* Inability to follow protocol","ALL","18 Years","65 Years",{"count":63,"type":64},90,"ESTIMATED","INTERVENTIONAL",[67],"PHASE2","sigma-1 receptor (S1R) agonistic property have been tested in clinical trials for the treatment of schizophrenia. In addition, previous studies found that some NMDA receptor (NMDAR)-enhancing agents were able to improve clinical symptoms of patients with chronic schizophrenia. Whether combined treatment of an S1R agonist and an NMDA-enhancing agent can be better than an S1R agonist alone deserves study.",[70],"Schizophrenia",[70,72,73],"NMDA","sigma-1 receptor","2026-03-21",{"date":76,"type":77},"2026-03-24","ACTUAL",{"date":79,"type":77},"2024-09-23",{"date":81,"type":64},"2029-03",{"name":5,"class":6},1]