[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100606394":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":49,"locations":58,"responsibleParty":274,"collaborators":278,"id":290,"slug":291,"hasResults":292,"nctId":293,"briefTitle":294,"officialTitle":295,"acronym":296,"eligibilityCriteria":297,"healthyVolunteers":292,"sex":298,"minAge":299,"maxAge":31,"enrollmentInfo":300,"targetDuration":31,"studyType":303,"phases":304,"briefSummary":307,"conditions":308,"keywords":315,"overallStatus":146,"whyStopped":31,"lastUpdateSubmitDate":318,"lastUpdatePostDateStruct":319,"startDateStruct":322,"completionDateStruct":324,"leadSponsor":326,"locationsCount":327},{"fullName":5,"class":6},"Karolinska Institutet","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Early Double sequential defibrillation","EXPERIMENTAL","If the patient is randomized to the DSD group, the ambulance crew team will apply the second defibrillator with electrodes placed in the A-P position as soon as possible.\n\nDefibrillation is performed by one person defibrillating both defibrillators in a sequential manner \"Double Sequential Defibrillation\" (DSD). All consecutive defibrillations will thereafter be performed with the DSD strategy until ROSC, termination of resuscitation or decision to move the patient to hospital.",[13],"Device: Double sequential defibirllation",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard defibrillation","ACTIVE_COMPARATOR","If the patient is randomized to the standard defibrillation group, the ambulance crew team will continue Advanced life support in accordance with standard of care and continue to perform standard defibibrillation using one defibrillator. All consecutive defibrillations will thereafter be performed with the standard defibrillation strategy until ROSC, termination of resuscitation or decision to move the patient to hospital.",[19],"Device: Standard defibrillation",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Double sequential defibirllation","A second defibrillator will be applyed with electrodes placed in the A-P position and defibrillation will be performed with two defibrllators in a sequential manner",[9],[27],"DSD",{"type":22,"name":15,"description":29,"armGroupLabels":30,"otherNames":31},"Standard defibrillation uning one defibrillator",[15],null,[33,37,40,44,46],{"name":34,"affiliation":35,"role":36},"Gabriel Riva, M.D. Ph.D.","Center for resuscitation Science. Department of clinical sience and education. Södersjukhuset, Karolinksa Institutet, Stockholm, Sweden","STUDY_DIRECTOR",{"name":38,"affiliation":35,"role":39},"Akil Awad, M.D. Ph.D.","PRINCIPAL_INVESTIGATOR",{"name":41,"affiliation":42,"role":43},"Carl Magnusson, R.N., Ph.D.","Shalgrenska University Hospital","STUDY_CHAIR",{"name":45,"affiliation":35,"role":43},"Andreas Claesson, R.N. Ph.D.",{"name":47,"affiliation":48,"role":43},"Johan Israelsson, R.N. Ph.D.","ICARE, Department of Health and Caring Sciences, Linnaeus University",[50,55],{"name":51,"role":52,"phone":53,"phoneExt":31,"email":54},"Gabriel Riva, M.D. Ph.D","CONTACT","+ 47 70 545 20 86","gabriel.riva@ki.se",{"name":38,"role":52,"phone":56,"phoneExt":31,"email":57},"(+46) 070 400 13 63","akil.awad@ki.se",[59,77,96,113,129,144,163,179,195,208,223,237,247,261],{"facility":60,"status":61,"city":62,"state":31,"zip":31,"country":63,"countryCode":64,"cosmosGeoPoint":65,"geoPoint":70,"contacts":71},"ARREST (AmsteRdam REsuscitation STudies)","NOT_YET_RECRUITING","Amsterdam","Netherlands","NL",{"type":66,"coordinates":67},"Point",[68,69],4.88969,52.37403,{"lat":69,"lon":68},[72,76],{"name":73,"role":52,"phone":74,"phoneExt":31,"email":75},"Christian Van der Werf, M.D. Ph.D.","(+31) 614 42 58 04","c.vanderwerf@amsterdamumc.nl",{"name":73,"role":39,"phone":31,"phoneExt":31,"email":31},{"facility":78,"status":61,"city":79,"state":80,"zip":81,"country":82,"countryCode":83,"cosmosGeoPoint":84,"geoPoint":88,"contacts":89},"Centro de Emergencias 061 Andalucía","Málaga","Andalusia","29560","Spain","ES",{"type":66,"coordinates":85},[86,87],-4.42034,36.72016,{"lat":87,"lon":86},[90,94],{"name":91,"role":52,"phone":92,"phoneExt":31,"email":93},"María Jose Luque-Hernández, M.D. Ph.D.","(+34) 617 56 33 52","mariajose.luque.sspa@juntadeandalucia.es",{"name":95,"role":39,"phone":31,"phoneExt":31,"email":31},"Maria Jose Luque-Hernández, M.D. Ph.D.",{"facility":97,"status":61,"city":98,"state":99,"zip":100,"country":82,"countryCode":83,"cosmosGeoPoint":101,"geoPoint":105,"contacts":106},"Médico Emergencias Osakidetza EMERGENTZIAK","Bilbao","Baque Country","48004",{"type":66,"coordinates":102},[103,104],-2.92528,43.26271,{"lat":104,"lon":103},[107,111],{"name":108,"role":52,"phone":109,"phoneExt":31,"email":110},"Cristian Fernández Barreras, M.D.","(+34) 99 68 11 82","cristian.fernandezbarreras@osakidetza.eus",{"name":112,"role":39,"phone":31,"phoneExt":31,"email":31},"Cristian Barreras, M.D.",{"facility":114,"status":61,"city":115,"state":116,"zip":117,"country":82,"countryCode":83,"cosmosGeoPoint":118,"geoPoint":122,"contacts":123},"Sistema de Emergencias Medicas de Catalunya","Barcelona","Catalonia","08908",{"type":66,"coordinates":119},[120,121],2.15899,41.38879,{"lat":121,"lon":120},[124,128],{"name":125,"role":52,"phone":126,"phoneExt":31,"email":127},"Xavier Fabrega, M.D. Ph.D.","(+34) 616 44 60 68","francescxavierjimenez@gencat.cat",{"name":125,"role":39,"phone":31,"phoneExt":31,"email":31},{"facility":130,"status":61,"city":131,"state":131,"zip":132,"country":82,"countryCode":83,"cosmosGeoPoint":133,"geoPoint":137,"contacts":138},"SUMMA 112 Emergency medical services","Madrid","28045",{"type":66,"coordinates":134},[135,136],-3.70256,40.4165,{"lat":136,"lon":135},[139,143],{"name":140,"role":52,"phone":141,"phoneExt":31,"email":142},"Carlos Rubio, M.D. Ph.D.","(+34) 639 91 74 03","carlos.rubio@salud.madrid.org",{"name":140,"role":39,"phone":31,"phoneExt":31,"email":31},{"facility":145,"status":146,"city":147,"state":148,"zip":31,"country":149,"countryCode":150,"cosmosGeoPoint":151,"geoPoint":155,"contacts":156},"Ambulanssjukvården, Region Halland","RECRUITING","Halmstad","Halland County","Sweden","SE",{"type":66,"coordinates":152},[153,154],12.85676,56.67446,{"lat":154,"lon":153},[157,161],{"name":158,"role":52,"phone":159,"phoneExt":31,"email":160},"Kristoffer Wibring, R.N., Ph.D.","(+46) 076 721 40","kristoffer.wibring@regionhalland.se",{"name":162,"role":39,"phone":31,"phoneExt":31,"email":31},"Kristoffer Wibring, R.N. Ph.D.",{"facility":164,"status":146,"city":165,"state":166,"zip":167,"country":149,"countryCode":150,"cosmosGeoPoint":168,"geoPoint":172,"contacts":173},"Ambulanssjukvården Region Värmland","Karlstad","Värmland County","65230",{"type":66,"coordinates":169},[170,171],13.50357,59.3793,{"lat":171,"lon":170},[174,178],{"name":175,"role":52,"phone":176,"phoneExt":31,"email":177},"Linus Lilja, M.D. Ph.D.","(46+) 010-83 157 16","linus.lilja@regionvarmland.se",{"name":175,"role":39,"phone":31,"phoneExt":31,"email":31},{"facility":180,"status":146,"city":181,"state":182,"zip":183,"country":149,"countryCode":150,"cosmosGeoPoint":184,"geoPoint":188,"contacts":189},"Ambulanshelikoptern (HEMS) Västra Götalandsregionen","Kungälv","Västra Götaland County","442 83",{"type":66,"coordinates":185},[186,187],11.98054,57.87096,{"lat":187,"lon":186},[190,194],{"name":191,"role":52,"phone":192,"phoneExt":31,"email":193},"Knut Taxbro, M.D. Ph.D.","(+46) 070 675 34 57","knut.taxbro@rjl.se",{"name":191,"role":39,"phone":31,"phoneExt":31,"email":31},{"facility":196,"status":146,"city":197,"state":31,"zip":31,"country":149,"countryCode":150,"cosmosGeoPoint":198,"geoPoint":202,"contacts":203},"Sjukvården i väster","Alingsås",{"type":66,"coordinates":199},[200,201],12.53345,57.93033,{"lat":201,"lon":200},[204,207],{"name":45,"role":52,"phone":205,"phoneExt":31,"email":206},"(+46) 0704940546","Andreas.claesson@ki.se",{"name":45,"role":39,"phone":31,"phoneExt":31,"email":31},{"facility":209,"status":146,"city":210,"state":31,"zip":211,"country":149,"countryCode":150,"cosmosGeoPoint":212,"geoPoint":216,"contacts":217},"Emergency medical services, Södra Älvsborgs Sjukhus, Region Västra Götaland","Borås","501 82",{"type":66,"coordinates":213},[214,215],12.9401,57.72101,{"lat":215,"lon":214},[218,222],{"name":219,"role":52,"phone":220,"phoneExt":31,"email":221},"Emil Bergerum, R.N.","0046 (0)33 - 616 10 00","emil.j.olsson@vgregion.se",{"name":219,"role":39,"phone":31,"phoneExt":31,"email":31},{"facility":224,"status":146,"city":225,"state":31,"zip":31,"country":149,"countryCode":150,"cosmosGeoPoint":226,"geoPoint":230,"contacts":231},"Prehospital Intensive Care Unit (PIV) AnOPIVA Östra Sjukhuset\u002FSU","Gothenburg",{"type":66,"coordinates":227},[228,229],11.96679,57.70716,{"lat":229,"lon":228},[232,236],{"name":233,"role":52,"phone":234,"phoneExt":31,"email":235},"Patrik Martner, M.D.","(+46) 070 485 77 52","patrik.martner@vgregion.se",{"name":233,"role":39,"phone":31,"phoneExt":31,"email":31},{"facility":42,"status":146,"city":225,"state":31,"zip":31,"country":149,"countryCode":150,"cosmosGeoPoint":238,"geoPoint":240,"contacts":241},{"type":66,"coordinates":239},[228,229],{"lat":229,"lon":228},[242,246],{"name":243,"role":52,"phone":31,"phoneExt":244,"email":245},"Carl Magnusson, R.N. Ph.D.","(+46) 070 886","carl.magnusson@vgregion.se",{"name":243,"role":39,"phone":31,"phoneExt":31,"email":31},{"facility":248,"status":146,"city":249,"state":31,"zip":31,"country":149,"countryCode":150,"cosmosGeoPoint":250,"geoPoint":254,"contacts":255},"Ambulanssjukvården Skaraborgs Sjukhus, Västra Götalandsregionen (SKAS)","Skövde",{"type":66,"coordinates":251},[252,253],13.84506,58.39118,{"lat":253,"lon":252},[256,260],{"name":257,"role":52,"phone":258,"phoneExt":31,"email":259},"Per Wennberg, R.N. Ph.D.","0046 70 545 20 86","per.wennberg@vgregion.se",{"name":257,"role":39,"phone":31,"phoneExt":31,"email":31},{"facility":262,"status":146,"city":263,"state":31,"zip":264,"country":149,"countryCode":150,"cosmosGeoPoint":265,"geoPoint":269,"contacts":270},"Emergency medical services NU-Sjukvården, Region Västra Götaland","Trollhättan","461 85",{"type":66,"coordinates":266},[267,268],12.28864,58.28365,{"lat":268,"lon":267},[271,273],{"name":243,"role":52,"phone":272,"phoneExt":31,"email":245},"0046 (0)10-435 10 35",{"name":243,"role":39,"phone":31,"phoneExt":31,"email":31},{"type":275,"investigatorFullName":276,"investigatorTitle":277,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"SPONSOR_INVESTIGATOR","Gabriel Riva","Principal Investigator",[279,281,284,286,288],{"name":280,"class":6},"Swedish Heart Lung Foundation",{"name":282,"class":283},"Region Stockholm","OTHER_GOV",{"name":285,"class":283},"Vastra Gotaland Region",{"name":287,"class":6},"Region Halland",{"name":289,"class":6},"Laerdal Foundation","100606394","phase-2-early-double-sequential-defibrillation-in-out-of-hospital-cardiac-arrest-100606394",false,"NCT07174986","Early Double Sequential Defibrillation in Out of Hospital Cardiac Arrest","\"A Randomized Trial Assessing the Effect of Early Double Sequential Defibrillation With Anterior-posterior and Anterior Lateral Pad Placement and Sequential Defibrillation Compared to Standard Pad Placement and Single Defibrillation in Patients With Out of Hospital Cardiac Arrest With Initial Shockable Rhythm and at Least One Failed Standard Defibrillation\"","DOUBLE D","Inclusion Criteria:\n\n* OHCA patients with VT\u002FVF at first rhythm analysis and at least one defibrillation performed in standard (A-L) position\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Obvious pregnancy\n* Known preexisting Do Not Attempt Resuscitation order","ALL","18 Years",{"count":301,"type":302},916,"ESTIMATED","INTERVENTIONAL",[305,306],"PHASE2","PHASE3","Some of the patients affected by Out-of-hospital cardiac arrest (OHCA) with ventricular fibrillation (VF)\u002Fventricular tachycardia (VT) do not respond to initial defibrillation. The survival decreases with number of defibrillations required to terminate VF\u002FVT. In 2022, one prospective cluster randomized trial showed increased survival among (OHCA) patients in refractory VF using Double Sequential Defibrillation (DSD). If DSD can increase survival among all patients in VF that dont respond to one defibrillation, i.e. before it has become refractory is not known.\n\nThe aim of this trial is to assess survival with a double defibrillation strategy initiated as soon as possible among patients with Out of Hospital Cardiac Arrest with initial shockable rhythm and at least one failed standard defibrillation, compared with continued resuscitation using standard defibrillation.",[309,310,311,312,313,314],"Out of Hospital Cardiac Arrest","Ventricular Fibrillation","Defibrillation","CPR","ACLS","Sudden Death",[316,317,313],"Double sequential defibrillation","Double sequential external defibrillation","2026-02-12",{"date":320,"type":321},"2026-02-17","ACTUAL",{"date":323,"type":321},"2025-09-08",{"date":325,"type":302},"2029-12",{"name":276,"class":6},14]