[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100612376":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":35,"locations":43,"responsibleParty":60,"collaborators":64,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":25,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":25,"studyType":82,"phases":83,"briefSummary":86,"conditions":87,"keywords":93,"overallStatus":45,"whyStopped":25,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"Poznan University of Physical Education","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"MPRO supplementation","EXPERIMENTAL","The experimental procedure for each participant in this group will include a 2-week period of MPRO supplementation.\n\nThe entire study protocol will include familiarization and 4 main study visits (T1-T4; before\u002Fafter supplementation). Enrolled volunteers will be randomly assigned to the treatment order with specific codes by an impartial biostatistician. Each study visit will consist of anthropometric indices and body composition evaluation, three saliva and blood samplings (resting; 3 min and 60 min after exercise) and exercise performance evaluation. Additionally, all participants will donate their stool samples into specially prepared two empty tubes. Samples will be collected on the same days as saliva\u002Fblood samples, early in the morning. Moreover, during each study visit, participants will complete a specific, validated GI symptoms questionnaire and specific and validated stress and mood questionnaires to assess their stress and mood before and after MPRO supplementation.",[13],"Dietary Supplement: MPRO supplementation",{"label":15,"type":16,"description":17,"interventionNames":18},"PLA treatment","PLACEBO_COMPARATOR","The experimental procedure for each participant in this group will include a 2-week period of placebo supplementation.\n\nThe entire study protocol will include familiarization and 4 main study visits (T1-T4; before\u002Fafter supplementation). Enrolled volunteers will be randomly assigned to the treatment order with specific codes by an impartial biostatistician. Each study visit will consist of anthropometric indices and body composition evaluation, three saliva and blood samplings (resting; 3 min and 60 min after exercise) and exercise performance evaluation. Additionally, all participants will donate their stool samples into specially prepared two empty tubes. Samples will be collected on the same days as saliva\u002Fblood samples, early in the morning. Moreover, during each study visit, participants will complete a specific, validated GI symptoms questionnaire and specific and validated stress and mood questionnaires to assess their stress and mood before and after placebo supplementation.",[19],"Dietary Supplement: Placebo treatment",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","In the experimental procedure each athlete will be supplemented with a certificated, commercially available MPRO supplement SANPROBI® Barrier (Bifidobacterium lactis W52, Lactobacillus brevis W63, Lactobacillus casei W56, Lactococcus lactis W19, Lactococcus lactis W58, Lactobacillus acidophilus W37, Bifidobacterium bifidum W23, Bifidobacterium lactis W51, Lactobacillus salivarius W24).\n\nThe supplement will be provided in the capsule form and will be taken twice a day \\[4 capsules of MPRO\u002Fday (2×10to9 CFU\u002Fg, 500 milions CFU\u002Fcapsule) in two servings\u002Fday (2x2 capsules\\].",[9],null,{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Placebo treatment","In the control procedure each athlete will be supplemented with a placebo (PLA). The PLA group will receive corn starch mixed with maltodextrins. The PLA will be provided in the capsule form and will be taken twice a day (2x2 capsules\u002Fday).",[15],[31],{"name":32,"affiliation":33,"role":34},"Krzysztof Durkalec-Michalski, PhD","Department of Sports Dietetics, Poznan University of Physical Education Poznań","STUDY_CHAIR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":25,"email":40},"Natalia Główka, PhD","CONTACT","+48 691 756 944","glowka@awf.poznan.pl",{"name":32,"role":38,"phone":25,"phoneExt":25,"email":42},"durkalec-michalski@awf.poznan.pl",[44],{"facility":33,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Poznan","Wielkopolska","61-871","Poland","PL",{"type":52,"coordinates":53},"Point",[54,55],16.92993,52.40692,{"lat":55,"lon":54},[58,59],{"name":37,"role":38,"phone":39,"phoneExt":25,"email":40},{"name":32,"role":38,"phone":25,"phoneExt":25,"email":42},{"type":61,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"SPONSOR_INVESTIGATOR","Krzysztof Durkalec-Michalski","Prof.",[65],{"name":66,"class":67},"Institute of Human Genetics, Polish Academy of Sciences","UNKNOWN","100612376","phase-2-effect-of-a-short-term-multi-strain-probiotic-supplementation-in-endurance-athletes-100612376",false,"NCT07252778","Effect of a Short-term Multi-strain Probiotic Supplementation in Endurance Athletes","Effect of a Short-term Multi-strain Probiotic Supplementation on the Exercise- Associated Gastrointestinal Disturbances in Trained Female Athletes Under Controlled Conditions During Professional Training Cycle","Inclusion Criteria:\n\n* belonging to the national rowing team;\n* training experience ≥5 years;\n* a currently issued medical certificate confirming\n* good health and capacity to practice sports;\n* good health without chronic health disorders;\n* written informed consent to participate.\n\nExclusion Criteria:\n\n* injury, any health contraindication or failure to perform exercise procedures;\n* gastrointestinal infections, diseases, disorders;\n* past history of gastrointestinal surgery, and\n* other self-reported gastrointestinal issues;\n* reporting symptoms of infection or taking any medication (e.g. antibiotics) for 4 weeks before the study protocol;\n* current supplementation of prebiotics,\n* probiotics, synbiotics (last 4 weeks);\n* current intake of pharmaceutical agents (e.g., nonsteroidal anti-inflammatory drugs, laxatives, antidiarrhea agents, antacids, and\u002For antiemetics) (last 4 weeks);\n* failure to follow the study protocol;\n* declared general feeling of being unwell;\n* pregnancy or current pregnancy planning.",true,"FEMALE","16 Years","50 Years",{"count":80,"type":81},30,"ESTIMATED","INTERVENTIONAL",[84,85],"PHASE2","PHASE3","The aim of this project is to evaluate and identify the effect of a short-term 2-week multi-strain probiotic (MPRO) supplementation on the exercise-associated gastrointestinal (GI) symptoms and perturbations in high level female athletes of the Polish national team during strictly controlled conditions of a training camp, based on recommendations for best practices for probiotic (PRO) research in athletes and assessment of EX-associated GI perturbations.",[88,89,90,91,92],"Sports Nutrition","Biochemical Markers","Exercise Performance","Aerobic Capacity","Supplementation",[94,95,96,97,98],"Probiotics","Gastro-intestinal markers","Microbiota","Rowing","Females","2025-11-18",{"date":101,"type":102},"2025-11-28","ACTUAL",{"date":104,"type":81},"2025-11-20",{"date":106,"type":81},"2027-06-30",{"name":62,"class":6},1]