[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100497496":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":38,"locations":49,"responsibleParty":68,"collaborators":71,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":74,"sex":80,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":71,"studyType":86,"phases":87,"briefSummary":90,"conditions":91,"keywords":71,"overallStatus":52,"whyStopped":71,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Assiut University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"MgSo4","ACTIVE_COMPARATOR","A magnesium sulphate infusion (60 mg kg-1, total volume 100 ml, infusion rate 10 ml min-1) 10 min. will be administered before induction of anesthesia",[13],"Drug: Magnesium Sulphate",{"label":15,"type":16,"description":17,"interventionNames":18},"Saline Placebo","PLACEBO_COMPARATOR","an intravenous 0.9% saline infusion (total volume 100 ml, infusion rate 10 ml min-1) 10 min. will be administered before induction of anesthesia.",[19],"Drug: Saline",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Magnesium Sulphate","A magnesium sulphate infusion (60 mg kg-1, total volume 100 ml, infusion rate 10 ml min-1) will be administered to patients 10 min. before induction of anesthesia.",[9],[9],{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Saline","The patients will be pretreated with an intravenous 0.9% saline infusion (total volume 100 ml, infusion rate 10 ml min-1) 10 min before induction of anesthesia.",[15],[32],"Placebo Comparator",[34],{"name":35,"affiliation":36,"role":37},"Hala Abdel-Ghaffar, MD","Professor of anesthesia and intensive care, faculty of medicine, Assiut university, Assiut, Egypt.","PRINCIPAL_INVESTIGATOR",[39,45],{"name":40,"role":41,"phone":42,"phoneExt":43,"email":44},"Hala S Abdel-Ghaffar, MD","CONTACT","01003812011","+20","hallasaad@yahoo.com",{"name":46,"role":41,"phone":47,"phoneExt":43,"email":48},"Abu El Hassan A Rezk, MBB Ch","01026067713","drhassanramadan96@gmail.com",[50],{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"Assiut university main hospital, ENT operative theatre","RECRUITING","Asyut","Asyut Governorate","71515","Egypt","EG",{"type":59,"coordinates":60},"Point",[61,62],31.18368,27.18096,{"lat":62,"lon":61},[65,66],{"name":40,"role":41,"phone":42,"phoneExt":43,"email":44},{"name":67,"role":41,"phone":47,"phoneExt":43,"email":48},"Abu El Hassan A Rezk, MBBCh",{"type":37,"investigatorFullName":69,"investigatorTitle":70,"investigatorAffiliation":5,"oldNameTitle":71,"oldOrganization":71},"Hala Saad Abdel-Ghaffar","Professor",null,"100497496","phase-2-effect-of-mgso4-pretreatment-on-muscle-relaxation-100497496",false,"NCT05757999","Effect of MgSO4 Pretreatment on Muscle Relaxation","Effect of Magnesium Sulphate Pretreatment on Cis-Atracurium Induced Neuromuscular Block and Recovery Characteristics: A Randomized Controlled Trial.","MgSO4\u002FCisA","Inclusion Criteria:\n\n* Age group 18-60 years old\n* Both genders\n* Patients who will be scheduled to undergo elective otorhinolaryngological surgery.\n* Patients with BMI between 18.5 and 24.9 Kg\u002Fm2.\n* Patients with American Society of Anesthesiologist physical status classification of 1 or 2\n\nExclusion Criteria:\n\n* Patients who are less than 18 years old or more than 60 years old.\n* Patients on medications that interfered with muscle activity.\n* Allergy to medications used in this study.\n* Pregnancy or suspected pregnancy.\n* Neuro-muscular diseases.\n* Renal or hepatic impairment.\n* Hypermagnesemia (\\>2.5 mmol) or hypomagnesemia (\\\u003C1.7 mmol).\n* Patients refusing to study","ALL","18 Years","60 Years",{"count":84,"type":85},100,"ESTIMATED","INTERVENTIONAL",[88,89],"PHASE2","PHASE3","In this study, the effect of magnesium sulphate on the onset and duration of intense and moderate cis-atracurium induced neuromuscular blocking and on the period of no response to nerve stimulation will be evaluated in patients who will recieve magnesium sulphate (intervention group) and patients who will not recieve magnesium sulphate (comparator group).",[92],"Muscle Relaxation","2024-06-28",{"date":95,"type":96},"2024-07-01","ACTUAL",{"date":98,"type":96},"2023-07-23",{"date":100,"type":85},"2025-05",{"name":5,"class":6},1]