[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100591541":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":31,"centralContacts":31,"locations":41,"responsibleParty":60,"collaborators":31,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":31,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":31,"maxAge":31,"enrollmentInfo":72,"targetDuration":31,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":31,"overallStatus":43,"whyStopped":31,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Topical Bromelain in Orabase","EXPERIMENTAL","Participants in this group will receive topical bromelain incorporated into an orabase.\n\nPatients will be instructed to apply the formulation four times daily No additional topical medications will be permitted.",[13],"Dietary Supplement: Topical Bromelain",{"label":15,"type":16,"description":17,"interventionNames":18},"Topical Triamcinolone Acetonide in Orabase","ACTIVE_COMPARATOR","This group will receive topical 0.1% triamcinolone acetonide The treatment will be applied four times daily, following the same instructions and precautions as in Arm 1",[19],"Drug: 0.1% topical triamcinolone acetonide",{"label":21,"type":10,"description":22,"interventionNames":23},"Combination of Topical Bromelain and Triamcinolone Acetonide in Orabase","Participants in this arm will be treated with a combination formulation containing both topical bromelain and 0.1% triamcinolone acetonide in orabase.\n\nApplication instructions will be identical to those in the other arms: four times daily.",[24],"Combination Product: Combination of Topical Bromelain and Triamcinolone Acetonide in Orabase",[26,32,37],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DIETARY_SUPPLEMENT","Topical Bromelain","A natural enzyme-based formulation derived from pineapple, bromelain in orabase is being investigated for its anti-inflammatory and wound-healing properties. As a non-steroidal alternative, it offers a potentially safer treatment option with minimal side effects.",[9],null,{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":31},"DRUG","0.1% topical triamcinolone acetonide","A corticosteroid-based standard treatment for OLP, triamcinolone acetonide in orabase is used for its strong anti-inflammatory and immunosuppressive effects. It serves as the conventional treatment versus novel therapy in this study",[15],{"type":38,"name":21,"description":39,"armGroupLabels":40,"otherNames":31},"COMBINATION_PRODUCT","This novel formulation combines the enzymatic, healing properties of bromelain with the anti-inflammatory property of triamcinolone. It is designed to provide enhanced therapeutic effects through synergistic action, potentially reducing the required corticosteroid dose while improving clinical outcomes.",[21],[42],{"facility":5,"status":43,"city":44,"state":45,"zip":31,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"RECRUITING","Cairo","Cairo Governorate","Egypt","EG",{"type":49,"coordinates":50},"Point",[51,52],31.24967,30.06263,{"lat":52,"lon":51},[55],{"name":56,"role":57,"phone":58,"phoneExt":31,"email":59},"Lujain Taleb Aladwan, MSc","CONTACT","+201080837509","lujain.aladwan@dentistry.cu.edu.eg",{"type":61,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"PRINCIPAL_INVESTIGATOR","Lujain Taleb Suleiman Aladwan","Master's Student in Oral Medicine","100591541","phase-2-effect-of-topical-bromelain-versus-topical-corticosteroids-in-the-management-of-oral-lichen-planus-100591541",false,"NCT06981767","Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Oral Lichen Planus","Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Oral Lichen Planus : A Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients suffering from symptomatic OLP\n* Patients free from any visible oral lesions other than OLP.\n* Patients who agreed to take the supplied interventions.\n* Patient who will agree to participate in the study.\n* Patients who will accept to sign the informed consent.\n\nExclusion Criteria:\n\n* Patients suffering from any systemic disease.\n* Treatment with any systemic treatment such as systemic steroids, other immunosuppressive drugs or non-steroidal anti-inflammatory drugs at least eight weeks.\n* Treatment with any oral topical medications for at least four weeks prior to the study.\n* Pregnant and lactating mothers.","ALL",{"count":73,"type":74},42,"ESTIMATED","INTERVENTIONAL",[77],"PHASE2","Bromelain, an enzyme extract derived from pineapples, has shown promise due to its anti-inflammatory and wound-healing properties. However, its efficacy in treating oral mucosal ulcers remains unexplored. This study aims to provide clinical evidence on the efficacy of bromelain for managing OLP, potentially offering a safer and more effective treatment option.",[80],"Oral Lichen Planus","2026-06-08",{"date":83,"type":84},"2026-06-09","ACTUAL",{"date":86,"type":84},"2026-02-18",{"date":88,"type":74},"2026-08-15",{"name":5,"class":6},1]